Current status of immunotherapy for the treatment of lung cancer.

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Published in J Thorac Dis on December 01, 2010

Authors

Sanjay Murala1, Vamsi Alli, Daniel Kreisel, Andrew E Gelman, Alexander S Krupnick

Author Affiliations

1: Thoracic Immunobiology Laboratory, Departments of Surgery, Pathology and Immunology of Washington University School of Medicine, St. Louis, Missouri, USA.

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Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. J Biol Chem (1990) 3.70

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