Published in Bioorg Med Chem Lett on November 15, 2004
Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. J Med Chem (2012) 1.35
Synthesis and Structural Characterization of 1-Arylimidazole-2-thiones and N,N'-Aryldiethoxyethylthioureas with Electronically Diverse Substituents: A Manifold of Hydrogen Bonding Networks. New J Chem (2014) 0.76
Crystal structure of 1-(2-amino-phen-yl)-3-phenyl-urea. Acta Crystallogr E Crystallogr Commun (2015) 0.75
RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu Rev Pharmacol Toxicol (2010) 4.86
Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression. Cell (2012) 2.83
Single-stranded siRNAs activate RNAi in animals. Cell (2012) 2.64
Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA. J Med Chem (2005) 2.05
Potent inhibition of microRNA in vivo without degradation. Nucleic Acids Res (2008) 1.98
Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals. Nucleic Acids Res (2006) 1.98
Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals. J Med Chem (2009) 1.61
SAR by MS: discovery of a new class of RNA-binding small molecules for the hepatitis C virus: internal ribosome entry site IIA subdomain. J Med Chem (2005) 1.59
Positional effect of chemical modifications on short interference RNA activity in mammalian cells. J Med Chem (2005) 1.57
Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat. Biochemistry (2010) 1.50
Competition for RISC binding predicts in vitro potency of siRNA. Nucleic Acids Res (2006) 1.44
Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues. J Org Chem (2010) 1.36
Rapid identification of Aspergillus terreus from bronchoalveolar lavage fluid by PCR and electrospray ionization with mass spectrometry. J Clin Microbiol (2012) 1.26
Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS. Nucleic Acids Res (2013) 1.23
Human RNase H1 discriminates between subtle variations in the structure of the heteroduplex substrate. Mol Pharmacol (2006) 1.18
Inhibitor-induced structural change in the HCV IRES domain IIa RNA. Proc Natl Acad Sci U S A (2010) 1.10
Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications. J Med Chem (2006) 1.04
Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site. Angew Chem Int Ed Engl (2004) 1.04
Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs. Biol Chem (2011) 1.03
TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry. Nucleic Acids Res (2012) 1.03
Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides. J Am Chem Soc (2011) 1.02
2-piperidin-4-yl-benzimidazoles with broad spectrum antibacterial activities. Bioorg Med Chem Lett (2003) 1.01
An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA. J Am Chem Soc (2010) 0.99
ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy. Nucleic Acids Res (2013) 0.99
Allele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs. Biochemistry (2014) 0.96
SAR by MS: a ligand based technique for drug lead discovery against structured RNA targets. J Med Chem (2002) 0.95
Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs. Nucleic Acids Symp Ser (Oxf) (2008) 0.94
Concurrent serotyping and genotyping of pneumococci by use of PCR and electrospray ionization mass spectrometry. J Clin Microbiol (2012) 0.94
The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis. Mol Pharmacol (2006) 0.94
Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: a synergistic hydrophobic effect against resistant bacteria. Bioorg Med Chem Lett (2010) 0.93
Lipid nanoparticles improve activity of single-stranded siRNA and gapmer antisense oligonucleotides in animals. ACS Chem Biol (2013) 0.93
Configuration of the 5'-methyl group modulates the biophysical and biological properties of locked nucleic acid (LNA) oligonucleotides. J Med Chem (2010) 0.91
Structure-activity relationship study on a simple cationic peptide motif for cellular delivery of antisense peptide nucleic acid. J Med Chem (2005) 0.90
Exploring the effect of sequence length and composition on allele-selective inhibition of human huntingtin expression by single-stranded silencing RNAs. Nucleic Acid Ther (2014) 0.90
Disaccharide mimetics of the aminoglycoside antibiotic neamine. Chembiochem (2004) 0.89
Evaluation of basic amphipathic peptides for cellular delivery of antisense peptide nucleic acids. J Med Chem (2006) 0.89
Identification of 2-aminobenzimidazole dimers as antibacterial agents. Bioorg Med Chem Lett (2003) 0.89
Synthesis and biological activity of 5-fluorotubercidin. Nucleosides Nucleotides Nucleic Acids (2004) 0.87
Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals. Mol Ther Nucleic Acids (2012) 0.86
Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin. J Med Chem (2007) 0.86
Peptide nucleic acids conjugated to short basic peptides show improved pharmacokinetics and antisense activity in adipose tissue. J Med Chem (2010) 0.86
Synthesis and antisense properties of fluoro cyclohexenyl nucleic acid (F-CeNA), a nuclease stable mimic of 2'-fluoro RNA. J Org Chem (2012) 0.86
Structural requirements for hybridization at the 5'-position are different in α-l-LNA as compared to β-D-LNA. Bioorg Med Chem Lett (2011) 0.83
Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs. Chem Commun (Camb) (2012) 0.83
Insights from crystal structures into the opposite effects on RNA affinity caused by the S- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic acid. Biochemistry (2011) 0.81
Synthesis and biological evaluations of novel benzimidazoles as potential antibacterial agents. Bioorg Med Chem Lett (2004) 0.80
Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry. Bioorg Med Chem Lett (2004) 0.80
Reexamination of neomycin B degradation: efficient preparation of its CD and D rings as protected glycosyl donors. Org Lett (2002) 0.80
Synthesis and biophysical characterization of R-6'-Me-α-L-LNA modified oligonucleotides. Bioorg Med Chem Lett (2010) 0.80
New inhibitors of bacterial protein synthesis from a combinatorial library of macrocycles. J Med Chem (2002) 0.80
Synthesis and biophysical evaluation of 3'-Me-α-L-LNA - Substitution in the minor groove of α-L-LNA duplexes. Bioorg Med Chem Lett (2011) 0.79
Synthesis of cis- and trans-α-l-[4.3.0]bicyclo-DNA monomers for antisense technology: methods for the diastereoselective formation of bicyclic nucleosides. J Org Chem (2013) 0.79
Replacing the 2'-oxygen with an exocyclic methylene group reverses the stabilization effects of α-L-LNA. Bioorg Med Chem Lett (2010) 0.78
Trisaccharide mimetics of the aminoglycoside antibiotic neomycin. Org Biomol Chem (2006) 0.78
Structure-based design of a highly constrained nucleic acid analogue: improved duplex stabilization by restricting sugar pucker and torsion angle γ. Angew Chem Int Ed Engl (2012) 0.78
A constrained tricyclic nucleic acid analogue of α-L-LNA: investigating the effects of dual conformational restriction on duplex thermal stability. J Org Chem (2013) 0.78
Design and synthesis of paromomycin-related heterocycle-substituted aminoglycoside mimetics based on a mass spectrometry RNA-binding assay. Angew Chem Int Ed Engl (2003) 0.78
Antibacterial activity of quinolone-macrocycle conjugates. Bioorg Med Chem Lett (2003) 0.77
Synthesis and duplex-stabilizing properties of fluorinated N-methanocarbathymidine analogues locked in the C3'-endo conformation. Angew Chem Int Ed Engl (2014) 0.77
Activity of siRNAs with 2-thio-2'-O-methyluridine modification in mammalian cells. Nucleosides Nucleotides Nucleic Acids (2009) 0.77
Biaryl guanidine inhibitors of in vitro HCV-IRES activity. Bioorg Med Chem Lett (2004) 0.77
Synthesis and biophysical properties of constrained D-altritol nucleic acids (cANA). Org Lett (2013) 0.77
Comparison of duplex stabilizing properties of 2'-fluorinated nucleic acid analogues with furanose and non-furanose sugar rings. J Org Chem (2014) 0.77
Differential effects on allele selective silencing of mutant huntingtin by two stereoisomers of α,β-constrained nucleic acid. ACS Chem Biol (2014) 0.76
The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides. Bioorg Med Chem Lett (2005) 0.76
Rapid PCR/ESI-MS-based molecular genotyping of Staphylococcus aureus from nasal swabs of emergency department patients. BMC Infect Dis (2014) 0.76
RNA interference by 2',5'-linked nucleic acid duplexes in mammalian cells. Bioorg Med Chem Lett (2006) 0.75
Synthesis, duplex stabilization and structural properties of a fluorinated carbocyclic LNA analogue. Chembiochem (2012) 0.75
Alternative syntheses of (S)-cEt-BNA: a key constrained nucleoside component of bioactive antisense gapmer sequences. J Org Chem (2014) 0.75
Optimizing the antibacterial activity of a lead structure discovered by "SAR by MS" technology. Bioorg Med Chem Lett (2004) 0.75