Published in JAMA on April 08, 1992
Medium term treatment of stable stage cystic fibrosis with recombinant human DNase I. Thorax (1995) 1.72
DNA concentration and length in sputum of patients with cystic fibrosis during inhalation with recombinant human DNase. Thorax (1995) 1.67
In vivo effects of recombinant human DNase I on sputum in patients with cystic fibrosis. Thorax (1996) 1.09
Measuring and reporting quality of life outcomes in clinical trials in cystic fibrosis: a critical review. Health Qual Life Outcomes (2005) 1.02
The role of airway mucus in pulmonary toxicology. Environ Health Perspect (1994) 1.02
Recent advances in cystic fibrosis research. J R Soc Med (1993) 0.87
rhDNase in cystic fibrosis. Thorax (1995) 0.87
Human recombinant DNase in cystic fibrosis. J R Soc Med (1995) 0.86
Antibodies mediate formation of neutrophil extracellular traps in the middle ear and facilitate secondary pneumococcal otitis media. Infect Immun (2013) 0.86
Review of recombinant human deoxyribonuclease (rhDNase) in the management of patients with cystic fibrosis. Biologics (2008) 0.86
Intrapleural tissue plasminogen activator and deoxyribonuclease therapy for pleural infection. J Thorac Dis (2015) 0.82
Effect of nebulised recombinant DNase on neutrophil elastase load in cystic fibrosis. Thorax (1996) 0.81
The role of recombinant human DNase in the treatment of patients with cystic fibrosis: many promises, more problems. Thorax (1996) 0.80
Use of lung imaging studies as outcome measures for development of new therapies in cystic fibrosis. Proc Am Thorac Soc (2007) 0.77
Recombinant human DNase (rhDNase) in cystic fibrosis: is it cost effective? Arch Dis Child (1997) 0.77
Early and late outcome of cystic fibrosis screening. J R Soc Med (1994) 0.76
New respiratory therapies in cystic fibrosis. J R Soc Med (1994) 0.75
Targeting of dornase alpha therapy in adult cystic fibrosis. J R Soc Med (1998) 0.75
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med (2001) 44.67
Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell (1998) 19.05
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol (1999) 11.78
Explaining variation in general practitioner referrals to hospital. Fam Pract (1987) 10.27
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev (1998) 8.51
Prevalence of antibodies to human immunodeficiency virus, gonorrhoea rates, and changed sexual behaviour in homosexual men in London. Lancet (1987) 7.71
Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic Fibrosis Inhaled Tobramycin Study Group. N Engl J Med (1999) 6.23
Altered immune responses in mice lacking inducible nitric oxide synthase. Nature (1995) 6.20
Effects of the RAD52 Gene on Recombination in SACCHAROMYCES CEREVISIAE. Genetics (1980) 6.07
Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study. Lancet (2000) 5.93
Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol (2001) 4.97
Assessing completeness of cancer registration in the north-western region of England by a method of independent comparison. Br J Cancer (1982) 4.90
14 years of follow-up from the Edinburgh randomised trial of breast-cancer screening. Lancet (1999) 4.80
Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals. J Natl Cancer Inst (1981) 4.60
Risk adjustment of the postoperative mortality rate for the comparative assessment of the quality of surgical care: results of the National Veterans Affairs Surgical Risk Study. J Am Coll Surg (1997) 4.55
Fourth International Consultation on Incontinence Recommendations of the International Scientific Committee: Evaluation and treatment of urinary incontinence, pelvic organ prolapse, and fecal incontinence. Neurourol Urodyn (2010) 4.48
Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression. Proc Natl Acad Sci U S A (1994) 4.44
Microchimerism and HLA-compatible relationships of pregnancy in scleroderma. Lancet (1998) 4.44
The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci (1999) 4.35
Smoking habits of oral contraceptive users. Lancet (1969) 4.20
Informed consent for population-based research involving genetics. JAMA (2001) 4.10
Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev Biol (1999) 4.00
Major-histocompatibility-complex class I alleles and antigens in hematopoietic-cell transplantation. N Engl J Med (2001) 3.98
Detection in life of confirmed Alzheimer's disease using a simple measurement of medial temporal lobe atrophy by computed tomography. Lancet (1992) 3.94
Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science (1999) 3.85
Campylobacter pyloridis in peptic ulcer disease: microbiology, pathology, and scanning electron microscopy. Gut (1985) 3.48
Risk adjustment of the postoperative morbidity rate for the comparative assessment of the quality of surgical care: results of the National Veterans Affairs Surgical Risk Study. J Am Coll Surg (1997) 3.46
Identification of the NH2-terminal blocking group of calcineurin B as myristic acid. FEBS Lett (1982) 3.42
Research ethics. Research practice and participant preferences: the growing gulf. Science (2011) 3.27
Acceptors and rejectors of an invitation to undergo breast screening compared with those who referred themselves. J Epidemiol Community Health (1980) 2.95
Selective serotonin reuptake inhibitors: meta-analysis of discontinuation rates. Int Clin Psychopharmacol (1994) 2.92
Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis (1985) 2.90
Caesarean scar pregnancy. BJOG (2007) 2.77
Predicting successful vaginal birth after Cesarean section using a model based on Cesarean scar features examined by transvaginal sonography. Ultrasound Obstet Gynecol (2013) 2.73
Cultural basis for differences between US and French clinical recommendations for women at increased risk of breast and ovarian cancer. Lancet (1999) 2.71
Does it matter where you live? Treatment variation for breast cancer in Yorkshire. The Yorkshire Breast Cancer Group. Br J Cancer (1995) 2.71
Audit commission tackles anaesthetic services. BMJ (1998) 2.70
Contrast extravasation on CT predicts mortality in primary intracerebral hemorrhage. AJNR Am J Neuroradiol (2007) 2.69
Aerosolised pentamidine as sole therapy for Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. Lancet (1987) 2.68
Delay in breast cancer and the nature of presenting symptoms. Lancet (1981) 2.67
A preliminary study of aerosolized recombinant human deoxyribonuclease I in the treatment of cystic fibrosis. N Engl J Med (1992) 2.57
A radiation hybrid map of the rat genome containing 5,255 markers. Nat Genet (1999) 2.54
Exhaled breath condensate pH is a robust and reproducible assay of airway acidity. Eur Respir J (2003) 2.51
Efficacy and safety of short-term administration of aerosolised recombinant human DNase I in adults with stable stage cystic fibrosis. Lancet (1993) 2.50
The effect of adjunctive fresh frozen plasma administration on coagulation parameters and survival in a canine model of antivenom-treated brown snake envenoming. Anaesth Intensive Care (2005) 2.49
Prospective randomized clinical trial of the value of intraperitoneal drainage after pancreatic resection. Ann Surg (2001) 2.47
Oral contraceptives and venous thromboembolism: findings in a large prospective study. Br Med J (Clin Res Ed) (1986) 2.47
A national health service and the public health. Public Health (1988) 2.46
On-site HIV testing in resource-poor settings: is one rapid test enough? AIDS (1997) 2.39
The complexities of predictive genetic testing. BMJ (2001) 2.36
Randomised controlled trial of self management leaflets and booklets for minor illness provided by post. BMJ (2001) 2.35
Microchimerism of maternal origin persists into adult life. J Clin Invest (1999) 2.35
Anxiety disorders in cancer patients: their nature, associations, and relation to quality of life. J Clin Oncol (2002) 2.34
Antimicrobial resistance: Antibiotics and consultant oral microbiologist posts. Br Dent J (2016) 2.32
Turning interns into senior residents: preparing residents for their teaching and leadership roles. Acad Med (1995) 2.31
Aerosolized pentamidine for prophylaxis against Pneumocystis carinii pneumonia. The San Francisco community prophylaxis trial. N Engl J Med (1990) 2.29
Recommendations for conducting the in vivo alkaline Comet assay. 4th International Comet Assay Workshop. Mutagenesis (2003) 2.29
Clinical pharmacology clinics in general practice. Br Med J (1977) 2.28
Acute encephalopathy coincident with seroconversion for anti-HTLV-III. Lancet (1985) 2.26
Qualms about QALYs. Lancet (1987) 2.26
Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis. Pediatr Pulmonol (2001) 2.24
HFE gene and hereditary hemochromatosis: a HuGE review. Human Genome Epidemiology. Am J Epidemiol (2001) 2.24
Generation of purified neural precursors from embryonic stem cells by lineage selection. Curr Biol (1998) 2.20
Heavy metal tolerance in the fission yeast requires an ATP-binding cassette-type vacuolar membrane transporter. EMBO J (1992) 2.19
Childhood-onset schizophrenia. Progressive ventricular change during adolescence. Arch Gen Psychiatry (1997) 2.15
Isolation of stable mouse cell lines that express cell surface and secreted forms of the vesicular stomatitis virus glycoprotein. J Cell Biol (1983) 2.14
A quantitative assessment of residual protein levels on dental instruments reprocessed by manual, ultrasonic and automated cleaning methods. Br Dent J (2011) 2.13
Non-invasive markers of bone turnover and plasma cytokines differ in osteoporotic patients with multiple myeloma and monoclonal gammopathies of undetermined significance. Intern Med J (2001) 2.12
Cross infection control measures and the treatment of patients at risk of Creutzfeldt Jakob disease in UK general dental practice. Br Dent J (2001) 2.08
Outcome of elective prostatectomy. BMJ (1989) 2.08
The endocrinology of the menopausal transition: a cross-sectional study of a population-based sample. J Clin Endocrinol Metab (1995) 2.07
Primary care physicians' knowledge of and experience with pharmacogenetic testing. Clin Genet (2012) 2.07
Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways. Mech Dev (1994) 2.07
Sequence of the preprotoxin dsRNA gene of type I killer yeast: multiple processing events produce a two-component toxin. Cell (1984) 2.03
A verandah-trap hut for studying the house-frequenting habits of mosquitoes and for assessing insecticides. 3. The effect of DDT on behavior and mortality. Bull Entomol Res (1969) 2.03
The management of acute abdominal pain in children. J Paediatr Child Health (1996) 2.02
Relation of surgical volume to outcome in eight common operations: results from the VA National Surgical Quality Improvement Program. Ann Surg (1999) 1.98
Does the presence of a cesarean section scar influence the site of placental implantation and subsequent migration in future pregnancies: a prospective case-control study. Ultrasound Obstet Gynecol (2012) 1.98
Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin Cancer Res (1996) 1.95
The treatment of systemic lupus erythematosus (SLE) in NZB/W F1 hybrid mice; studies with recombinant murine DNase and with dexamethasone. Clin Exp Immunol (1996) 1.94
The cardiac conduction system in situs ambiguus. Circulation (1979) 1.92
Probe directed at a segment of Rickettsia rickettsii rRNA amplified with polymerase chain reaction. J Clin Microbiol (1989) 1.91
"Multidimensionally impaired disorder": is it a variant of very early-onset schizophrenia? J Am Acad Child Adolesc Psychiatry (1998) 1.90
Human immunodeficiency viruses in patients attending a sexually transmitted disease clinic in London, 1982-7. BMJ (1989) 1.89
Sleep and behavior problems among preschoolers. J Dev Behav Pediatr (1999) 1.86
Defining a pulmonary exacerbation in cystic fibrosis. J Pediatr (2001) 1.83
Atresia of the right atrioventricular orifice. Br Heart J (1977) 1.82
Critical incident reports concerning anaesthetic equipment: analysis of the UK National Reporting and Learning System (NRLS) data from 2006-2008*. Anaesthesia (2011) 1.81
Effect of chronic intermittent administration of inhaled tobramycin on respiratory microbial flora in patients with cystic fibrosis. J Infect Dis (1999) 1.79
Vocational training for general practice: a preliminary report. Br Med J (1971) 1.79
Detection of 31P nuclear magnetic resonance signals in brain by in vivo and freeze-trapped assays. Proc Natl Acad Sci U S A (1978) 1.78
Psychosocial, lifestyle, and health status variables in predicting high attendance among adults. Br J Gen Pract (2001) 1.76
Relative roles of plaques and tangles in the dementia of Alzheimer's disease: correlations using three sets of neuropathological criteria. Dementia (1995) 1.76
Essential function of LIF receptor in motor neurons. Nature (1995) 1.74
Risk of scrapie in British sheep of different prion protein genotype. J Gen Virol (2004) 1.73
Summing up. Postgrad Med J (1984) 1.72
Characterization of cDNAs encoding two isoforms of granule-bound starch synthase which show differential expression in developing storage organs of pea and potato. Plant J (1992) 1.72