Published in Nat Genet on May 01, 1999
Genome-scale evolution: reconstructing gene orders in the ancestral species. Genome Res (2002) 5.19
A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet (2001) 3.26
An ordered comparative map of the cattle and human genomes. Genome Res (2000) 2.38
A radiation hybrid map of the cat genome: implications for comparative mapping. Genome Res (2000) 2.22
A question of size: the eukaryotic proteome and the problems in defining it. Nucleic Acids Res (2002) 2.07
Evolution of mammalian genome organization inferred from comparative gene mapping. Genome Biol (2001) 1.78
Production and characterization of maize chromosome 9 radiation hybrids derived from an oat-maize addition line. Genetics (2000) 1.42
A polymorphic dinucleotide repeat in the rat nucleolin gene forms Z-DNA and inhibits promoter activity. Proc Natl Acad Sci U S A (2001) 1.29
Automated construction of high-density comparative maps between rat, human, and mouse. Genome Res (2001) 1.24
Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human data. Genome Res (2004) 1.21
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Genome Res (2004) 1.21
Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps. Hum Genomics (2003) 1.17
Generation of a high-density rat EST map. Genome Res (2001) 1.15
Independent specialization of the human and mouse X chromosomes for the male germ line. Nat Genet (2013) 1.15
The first-generation whole-genome radiation hybrid map in the horse identifies conserved segments in human and mouse genomes. Genome Res (2003) 1.15
Integrated and sequence-ordered BAC- and YAC-based physical maps for the rat genome. Genome Res (2004) 1.11
A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes. Genome Res (2010) 1.07
Identification of the gene encoding Brain Cell Membrane Protein 1 (BCMP1), a putative four-transmembrane protein distantly related to the Peripheral Myelin Protein 22 / Epithelial Membrane Proteins and the Claudins. BMC Genomics (2001) 1.01
Quantitative trait locus mapping in laboratory mice derived from a replicated selection experiment for open-field activity. Genetics (2001) 1.01
A quantitative trait locus influencing anxiety in the laboratory rat. Genome Res (2002) 0.99
The origin of human chromosome 1 and its homologs in placental mammals. Genome Res (2003) 0.97
High-resolution radiation hybrid map of wheat chromosome 1D. Genetics (2006) 0.96
Manual 768 or 384 well microplate gel 'dry' electrophoresis for PCR checking and SNP genotyping. Nucleic Acids Res (2003) 0.92
Radiation hybrid mapping of the species cytoplasm-specific (scsae) gene in wheat. Genetics (2004) 0.91
Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits. Proc Natl Acad Sci U S A (2008) 0.88
Marker-assisted congenic screening (MACS): a database tool for the efficient production and characterization of congenic lines. Mamm Genome (2003) 0.86
Genetic identification of distinct loci controlling mammary tumor multiplicity, latency, and aggressiveness in the rat. Mamm Genome (2006) 0.82
Interspersed repetitive sequence (IRS)-PCR for typing of whole genome radiation hybrid panels. Nucleic Acids Res (2000) 0.80
A high-resolution 15,000(Rad) radiation hybrid panel for the domestic cat. Cytogenet Genome Res (2012) 0.80
Radiation hybrid maps of Medaka chromosomes LG 12, 17, and 22. DNA Res (2007) 0.80
Serum leptin concentration is linked to chromosomes 2 and 6 in the OLETF rat, an animal model of type 2 diabetes with mild obesity. Mamm Genome (2003) 0.79
Application of AFLP technology to radiation hybrid mapping. Chromosome Res (2004) 0.79
Estimation of the extent of synteny between Tetraodon nigroviridis and Homo sapiens genomes. J Mol Evol (2004) 0.77
Mapping of Mcs30, a new mammary carcinoma susceptibility quantitative trait locus (QTL30) on rat chromosome 12: identification of fry as a candidate Mcs gene. PLoS One (2013) 0.75
Construction of whole genome radiation hybrid panels and map of chromosome 5A of wheat using asymmetric somatic hybridization. PLoS One (2012) 0.75
Rattus norvegicus and the Industrial Revolution. Nat Genet (1999) 0.75
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med (1993) 102.56
Genetic alterations during colorectal-tumor development. N Engl J Med (1988) 26.82
Variable number of tandem repeat (VNTR) markers for human gene mapping. Science (1987) 25.71
Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J (1985) 20.39
Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell (1998) 19.05
Whole genome sequencing of meticillin-resistant Staphylococcus aureus. Lancet (2001) 18.55
A gene map of the human genome. Science (1996) 14.32
A physical map of 30,000 human genes. Science (1998) 12.43
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science (1989) 11.53
The outbreak of West Nile virus infection in the New York City area in 1999. N Engl J Med (2001) 11.48
A new system for grading recommendations in evidence based guidelines. BMJ (2001) 11.13
An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH. Cell (1980) 10.35
Explaining variation in general practitioner referrals to hospital. Fam Pract (1987) 10.27
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science (1991) 9.89
Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways. Cell (1980) 9.86
Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science (2001) 9.09
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev (1998) 8.51
Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004-BHS IV. J Hum Hypertens (2004) 8.32
Prevalence of antibodies to human immunodeficiency virus, gonorrhoea rates, and changed sexual behaviour in homosexual men in London. Lancet (1987) 7.71
A comprehensive genetic map of the mouse genome. Nature (1996) 6.94
Quantum computers. Nature (2010) 6.79
Altered immune responses in mice lacking inducible nitric oxide synthase. Nature (1995) 6.20
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature (2000) 6.01
When is cancer pain mild, moderate or severe? Grading pain severity by its interference with function. Pain (1995) 5.97
Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study. Lancet (2000) 5.93
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell (2000) 5.64
Allelotype of colorectal carcinomas. Science (1989) 5.54
Mechanisms of fear extinction. Mol Psychiatry (2006) 5.44
The action of tetrodotoxin on electrogenic components of squid giant axons. J Gen Physiol (1965) 5.42
Multi-system neurological disease is common in patients with OPA1 mutations. Brain (2010) 5.37
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet (2000) 5.26
Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science (1993) 5.22
A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science (1991) 5.14
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet (1992) 5.14
A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature (1988) 5.11
Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti. DNA Res (2000) 4.94
Assessing completeness of cancer registration in the north-western region of England by a method of independent comparison. Br J Cancer (1982) 4.90
Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature (1998) 4.89
14 years of follow-up from the Edinburgh randomised trial of breast-cancer screening. Lancet (1999) 4.80
Antibody diversity: somatic hypermutation of rearranged VH genes. Cell (1981) 4.65
Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science (1993) 4.63
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62
Effects of a decision support system on the diagnostic accuracy of users: a preliminary report. J Am Med Inform Assoc (1997) 4.61
Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals. J Natl Cancer Inst (1981) 4.60
Fourth International Consultation on Incontinence Recommendations of the International Scientific Committee: Evaluation and treatment of urinary incontinence, pelvic organ prolapse, and fecal incontinence. Neurourol Urodyn (2010) 4.48
The gene for familial polyposis coli maps to the long arm of chromosome 5. Science (1987) 4.48
Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression. Proc Natl Acad Sci U S A (1994) 4.44
Geobacter sulfurreducens sp. nov., a hydrogen- and acetate-oxidizing dissimilatory metal-reducing microorganism. Appl Environ Microbiol (1994) 4.44
Microchimerism and HLA-compatible relationships of pregnancy in scleroderma. Lancet (1998) 4.44
Transient regulation of protein synthesis in Escherichia coli upon shift-up of growth temperature. J Bacteriol (1978) 4.38
The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci (1999) 4.35
Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120. DNA Res (2001) 4.27
A primary genetic map of markers of human chromosome 10. Genomics (1988) 4.23
Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. Cancer Res (1992) 4.21
Smoking habits of oral contraceptive users. Lancet (1969) 4.20
Campylobacter pyloridis and associated gastritis: investigator blind, placebo controlled trial of bismuth salicylate and erythromycin ethylsuccinate. Br Med J (Clin Res Ed) (1986) 4.16
Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis. Nucleic Acids Res (2000) 4.11
Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Genome Res (2001) 4.03
Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev Biol (1999) 4.00
Major-histocompatibility-complex class I alleles and antigens in hematopoietic-cell transplantation. N Engl J Med (2001) 3.98
Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature (1988) 3.96
Detection in life of confirmed Alzheimer's disease using a simple measurement of medial temporal lobe atrophy by computed tomography. Lancet (1992) 3.94
Cell-mediated immunity to a human liver-specific antigen in patients with active chronic hepatitis and primary biliary cirrhosis. Lancet (1972) 3.90
An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy. Nature (1998) 3.86
Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science (1999) 3.85
Activation of the left amygdala to a cognitive representation of fear. Nat Neurosci (2001) 3.71
Health literacy and health-related knowledge among persons living with HIV/AIDS. Am J Prev Med (2000) 3.70
Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference. Development (2000) 3.70
Clinical features and management of hepatic portal venous gas: four case reports and cumulative review of the literature. Arch Surg (2001) 3.66
A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature (1992) 3.59
Campylobacter pyloridis in peptic ulcer disease: microbiology, pathology, and scanning electron microscopy. Gut (1985) 3.48
Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. EMBO Rep (2001) 3.47
Identification of the NH2-terminal blocking group of calcineurin B as myristic acid. FEBS Lett (1982) 3.42
Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. Hepatology (2000) 3.42
Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala. J Neurosci (1992) 3.40
Divided attention: evidence for coactivation with redundant signals. Cogn Psychol (1982) 3.28
Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci (2002) 3.28
Prospective randomized pilot trial of selective biliary cannulation using pancreatic guide-wire placement. Endoscopy (2003) 3.24
In vivo gene expression profile analysis of human breast cancer progression. Cancer Res (1999) 3.19
Rapid confirmation of single copy lambda prophage integration by PCR. Nucleic Acids Res (1994) 3.19
Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res (2001) 3.18
High molecular gas fractions in normal massive star-forming galaxies in the young Universe. Nature (2010) 3.18
A high-throughput SNP typing system for genome-wide association studies. J Hum Genet (2001) 3.18
Isolation and mapping of a polymorphic DNA sequence (pTHH22) on chromosome 9 [D9S12]. Nucleic Acids Res (1988) 3.17
Definition of subchromosomal intervals around the myotonic dystrophy gene region at 19q. Genomics (1989) 3.16
IL-6 is produced by osteoblasts and induces bone resorption. J Immunol (1990) 3.14
Gene organization deduced from the complete sequence of liverwort Marchantia polymorpha mitochondrial DNA. A primitive form of plant mitochondrial genome. J Mol Biol (1992) 3.11
TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling. J Biol Chem (1997) 3.03
Genetic studies of the Lac repressor. XV: 4000 single amino acid substitutions and analysis of the resulting phenotypes on the basis of the protein structure. J Mol Biol (1996) 2.98
Similar progression of diabetic retinopathy with insulin glargine and neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes: a long-term, randomised, open-label study. Diabetologia (2009) 2.98
Molecular detection of microscopic and submicroscopic deletions associated with Miller-Dieker syndrome. Am J Hum Genet (1988) 2.97
Mapping of mutation causing Friedreich's ataxia to human chromosome 9. Nature (1988) 2.96
Acceptors and rejectors of an invitation to undergo breast screening compared with those who referred themselves. J Epidemiol Community Health (1980) 2.95
Double dissociation between the involvement of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in startle increases produced by conditioned versus unconditioned fear. J Neurosci (1997) 2.90
A tripeptide 'anticodon' deciphers stop codons in messenger RNA. Nature (2000) 2.90
Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. Lancet (1993) 2.88
Determinants of participation in state-of-the-art cancer prevention, early detection/screening, and treatment trials among African-Americans. Cancer Nurs (1993) 2.87
Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell (1995) 2.81
Atypical adenomatous hyperplasia of the lung. Implications for the pathogenesis of peripheral lung adenocarcinoma. Am J Clin Pathol (1999) 2.81