Published in J Cell Biol on October 18, 2004
c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature (2014) 3.78
Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice. J Clin Invest (2009) 1.69
Endothelial-cardiomyocyte interactions in cardiac development and repair. Annu Rev Physiol (2006) 1.68
Cardiogenic differentiation and transdifferentiation of progenitor cells. Circ Res (2008) 1.54
An emerging consensus on cardiac regeneration. Nat Med (2014) 1.50
Cell-to-cell cross-talk between mesenchymal stem cells and cardiomyocytes in co-culture. J Cell Mol Med (2007) 1.46
Structural coupling of cardiomyocytes and noncardiomyocytes: quantitative comparisons using a novel micropatterned cell pair assay. Am J Physiol Heart Circ Physiol (2008) 1.28
Stem cells in the heart: what's the buzz all about? Part 2: Arrhythmic risks and clinical studies. Heart Rhythm (2008) 1.19
Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart. Nat Protoc (2014) 0.99
TNF receptors differentially signal and are differentially expressed and regulated in the human heart. Am J Transplant (2009) 0.94
BMP-2 and FGF-2 synergistically facilitate adoption of a cardiac phenotype in somatic bone marrow c-kit+/Sca-1+ stem cells. Clin Transl Sci (2008) 0.89
Directed Fusion of Mesenchymal Stem Cells with Cardiomyocytes via VSV-G Facilitates Stem Cell Programming. Stem Cells Int (2012) 0.87
Rapid fusion between mesenchymal stem cells and cardiomyocytes yields electrically active, non-contractile hybrid cells. Sci Rep (2015) 0.84
Tracking fusion of human mesenchymal stem cells after transplantation to the heart. Stem Cells Transl Med (2015) 0.83
A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure. PLoS One (2011) 0.80
Characterization of contracting cardiomyocyte colonies in the primary culture of neonatal rat myocardial cells: a model of in vitro cardiomyogenesis. Cell Cycle (2014) 0.79
Direct cardiomyocyte reprogramming: a new direction for cardiovascular regenerative medicine. Cold Spring Harb Perspect Med (2013) 0.77
Fabrication of mouse embryonic stem cell-derived layered cardiac cell sheets using a bioreactor culture system. PLoS One (2012) 0.77
Anti-inflammatory peptides from cardiac progenitors ameliorate dysfunction after myocardial infarction. J Am Heart Assoc (2014) 0.76
An efficient protocol for deriving liver stem cells from neonatal mice: validating its differentiation potential. Anal Cell Pathol (Amst) (2015) 0.75
The immature heart: the roles of bone marrow stromal stem cells in growth and myocardial repair. Open Cardiovasc Med J (2007) 0.75
Viral-mediated fusion of mesenchymal stem cells with cells of the infarcted heart hinders healing via decreased vascularization and immune modulation. Sci Rep (2016) 0.75
A novel approach to studying transformation of human stem cells into cardiac cells in vivo. Can J Cardiol (2006) 0.75
Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene (1991) 38.64
Bone marrow cells regenerate infarcted myocardium. Nature (2001) 21.24
Pluripotency of mesenchymal stem cells derived from adult marrow. Nature (2002) 19.57
Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell (2003) 18.09
'Green mice' as a source of ubiquitous green cells. FEBS Lett (1997) 17.06
Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med (2001) 10.03
Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med (2003) 8.46
Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A (2003) 7.87
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature (2002) 7.28
Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest (2001) 7.20
Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A (2001) 7.19
Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature (2003) 6.92
Conditions controlling the proliferation of haemopoietic stem cells in vitro. J Cell Physiol (1977) 6.82
Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci U S A (2000) 6.59
Changing potency by spontaneous fusion. Nature (2002) 6.46
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature (2003) 6.35
Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circ Res (2001) 6.15
Cytoplasmic activation of human nuclear genes in stable heterocaryons. Cell (1983) 5.71
Plasticity of adult stem cells. Cell (2004) 5.13
Transplanted bone marrow regenerates liver by cell fusion. Nature (2003) 5.06
Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. J Am Coll Cardiol (2003) 4.91
A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission. Biochem Biophys Res Commun (1997) 4.47
Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation (2002) 4.12
Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J Biol Chem (2003) 3.41
Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol. Circ Res (1982) 3.09
Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nat Cell Biol (2003) 3.03
Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res (1995) 2.79
Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes. Circulation (2003) 2.69
Myocyte proliferation in end-stage cardiac failure in humans. Proc Natl Acad Sci U S A (1998) 2.60
Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation. J Am Coll Cardiol (2003) 2.35
Skeletal muscle stem cells do not transdifferentiate into cardiomyocytes after cardiac grafting. J Mol Cell Cardiol (2002) 2.29
Bone marrow is a reservoir of repopulating mesangial cells during glomerular remodeling. J Am Soc Nephrol (2001) 1.98
Stretching cardiac myocytes stimulates protooncogene expression. J Biol Chem (1990) 1.87
Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: implications for myocardium regeneration. Proc Natl Acad Sci U S A (2001) 1.81
Critical role of cyclin D1 nuclear import in cardiomyocyte proliferation. Circ Res (2003) 1.70
Myocyte and myogenic stem cell transplantation in the heart. Cardiovasc Res (2003) 1.66
Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo. J Clin Invest (1997) 1.62
Cardiac hypertrophy. Mechanical, neural, and endocrine dependence. Circulation (1991) 1.58
G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells. J Clin Invest (2002) 1.41
Evidence for fusion between cardiac and skeletal muscle cells. Circ Res (2004) 1.34
Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol Cell Biol (2001) 1.32
Stem cells to tissue: molecular, cellular and anatomical heterogeneity in skeletal muscle. Curr Opin Genet Dev (2003) 1.22
Leukemia inhibitory factor enhances survival of cardiomyocytes and induces regeneration of myocardium after myocardial infarction. Circulation (2003) 1.18
p21(CIP1) Controls proliferating cell nuclear antigen level in adult cardiomyocytes. Mol Cell Biol (2003) 1.14
Plasticity of cell fate: insights from heterokaryons. Semin Cell Dev Biol (1999) 1.04
Beating is necessary for transdifferentiation of skeletal muscle-derived cells into cardiomyocytes. FASEB J (2003) 0.97
Cell grafting for cardiac repair. Methods Mol Biol (2003) 0.95
Cardiac muscle diseases in genetically engineered mice: evolution of molecular physiology. Am J Physiol (1995) 0.92
Reversibility of the differentiated state in somatic cells. Curr Opin Cell Biol (1993) 0.91
Heterokaryons of cardiac myocytes and fibroblasts reveal the lack of dominance of the cardiac muscle phenotype. Mol Cell Biol (1994) 0.88
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature (2005) 11.22
Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol (2006) 10.71
Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med (2007) 8.06
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol (2007) 5.60
Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res (2003) 5.30
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014). Hypertens Res (2014) 4.83
p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature (2007) 4.63
Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res (2007) 4.53
PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med (2004) 4.50
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature (2012) 4.46
Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability. Circ Res (2006) 4.41
Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation (2002) 4.12
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med (2008) 3.69
Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis. Proc Natl Acad Sci U S A (2006) 3.54
Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. J Cell Biochem (2007) 3.53
Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J Biol Chem (2003) 3.41
Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. J Clin Invest (2007) 3.13
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat Cell Biol (2004) 3.03
Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling. Circulation (2008) 2.95
Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochem Biophys Res Commun (2004) 2.86
GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res (2006) 2.85
The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circ Res (2006) 2.85
Effects of pitavastatin in Japanese patients with chronic heart failure: the Pitavastatin Heart Failure Study (PEARL Study). Circ J (2013) 2.75
Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart. Circulation (2005) 2.75
A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med (2009) 2.65
G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med (2005) 2.64
Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice. Proc Natl Acad Sci U S A (2002) 2.56
STRESS signaling pathways that modulate cardiac myocyte apoptosis. J Mol Cell Cardiol (2004) 2.53
Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle. Nat Med (2004) 2.52
Circulating p53-responsive microRNAs are predictive indicators of heart failure after acute myocardial infarction. Circ Res (2013) 2.52
Mechanisms of necroptosis in T cells. J Exp Med (2011) 2.51
Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J (2004) 2.50
Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nat Med (2008) 2.49
Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. Nat Med (2012) 2.48
A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell (2008) 2.47
Attenuated defense response and low basal blood pressure in orexin knockout mice. Am J Physiol Regul Integr Comp Physiol (2003) 2.45
Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart. Circ Res (2008) 2.44
Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis. Circ Res (2005) 2.44
Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res (2005) 2.44
Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. J Clin Invest (2003) 2.43
FoxO transcription factors promote autophagy in cardiomyocytes. J Biol Chem (2009) 2.40
Molecular pathways underlying cardiac remodeling during pathophysiological stimulation. Circulation (2010) 2.37
Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death. Circ Res (2002) 2.35
A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proc Natl Acad Sci U S A (2006) 2.32
Vascular cell senescence: contribution to atherosclerosis. Circ Res (2007) 2.32
Critical roles of muscle-secreted angiogenic factors in therapeutic neovascularization. Circ Res (2006) 2.31
Animal models of heart failure: a scientific statement from the American Heart Association. Circ Res (2012) 2.31
Roles of cardiac transcription factors in cardiac hypertrophy. Circ Res (2003) 2.31
Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Mol Cell Biol (2002) 2.30
Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J (2007) 2.30
Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo. J Biol Chem (2004) 2.24
Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation (2010) 2.23
Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host Microbe (2009) 2.21
Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma. J Hepatol (2011) 2.18
Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction. Circ J (2012) 2.15
Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest (2007) 2.12
Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo. Circulation (2002) 2.12
Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. J Clin Invest (2010) 2.12
Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease. Circ Res (2010) 2.12
Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy. Circulation (2006) 2.07
Signaling effectors underlying pathologic growth and remodeling of the heart. J Clin Invest (2013) 2.06
Adaptive servo-ventilation therapy for patients with chronic heart failure in a confirmatory, multicenter, randomized, controlled study. Circ J (2015) 2.03
Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. J Cell Biol (2007) 2.02
Laparoscopy-assisted hybrid left-side donor hepatectomy. World J Surg (2013) 2.02
Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart. FASEB J (2006) 2.02
FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. J Biol Chem (2010) 2.00
Molecular basis of physiological heart growth: fundamental concepts and new players. Nat Rev Mol Cell Biol (2013) 1.99
Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells. Am J Physiol Cell Physiol (2009) 1.93
Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts. Cardiovasc Res (2010) 1.93
Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proc Natl Acad Sci U S A (2007) 1.93
Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. J Biol Chem (2006) 1.92
Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature (2011) 1.91
Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes. Proc Natl Acad Sci U S A (2002) 1.88
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat Genet (2013) 1.86
Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle. J Gen Physiol (2006) 1.86