Mobilized bone marrow cells repair the infarcted heart, improving function and survival.

PubWeight™: 7.19‹?› | Rank: Top 1%

🔗 View Article (PMC 56963)

Published in Proc Natl Acad Sci U S A on August 14, 2001

Authors

D Orlic1, J Kajstura, S Chimenti, F Limana, I Jakoniuk, F Quaini, B Nadal-Ginard, D M Bodine, A Leri, P Anversa

Author Affiliations

1: Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA.

Associated clinical trials:

Bone Marrow Stem Cell Mobilisation Therapy for Acute Myocardial Infarction (AMI)(REVIVAL-2) | NCT00126100

CD133+ Cell Therapy for Refractory Coronary Heart Disease | NCT01049867

A Prospective, Open, Non-randomized Phase I/II Study of Therapeutic Angiogenesis in Diabetic Patients With Critic Ischemia of Lower Limbs While Administering Positive CD133 Mobilized With G-CSF | NCT00765050

Articles citing this

(truncated to the top 100)

Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A (2003) 7.87

Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest (2006) 4.51

Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest (2005) 4.25

Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J Clin Invest (2005) 4.10

The immune system and cardiac repair. Pharmacol Res (2008) 3.42

Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction. Circulation (2005) 3.33

Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells. Circulation (2005) 2.89

Bone marrow stem cells contribute to repair of the ischemically injured renal tubule. J Clin Invest (2003) 2.81

Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches. J Appl Physiol (1985) (2007) 2.52

Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction. Circ Res (2004) 2.50

Mesenchymal stem cells: Mechanisms of immunomodulation and homing. Cell Transplant (2010) 2.50

Enhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinase. Circulation (2009) 2.44

Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart. J Exp Med (2007) 2.25

Mobilization of bone marrow mesenchymal stem cells in vivo augments bone healing in a mouse model of segmental bone defect. Bone (2012) 2.24

Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium. J Exp Med (2006) 2.23

Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration. J Clin Invest (2003) 2.23

Dissecting the molecular relationship among various cardiogenic progenitor cells. Circ Res (2013) 2.06

Postinfarct cytokine therapy regenerates cardiac tissue and improves left ventricular function. Circ Res (2006) 1.98

Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation (2010) 1.97

Cardiomyocyte cell cycle activation improves cardiac function after myocardial infarction. Cardiovasc Res (2007) 1.90

Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads. Proc Natl Acad Sci U S A (2003) 1.87

The germline stem cell niche unit in mammalian testes. Physiol Rev (2012) 1.86

Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue. Curr Opin Hematol (2006) 1.86

Kinetics of liver repopulation after bone marrow transplantation. Am J Pathol (2002) 1.85

Regenerating new heart with stem cells. J Clin Invest (2013) 1.83

In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function. J Mol Cell Cardiol (2006) 1.81

Evolution of the c-kit-positive cell response to pathological challenge in the myocardium. Stem Cells (2008) 1.80

Granulocyte colony-stimulating factor for acute ischemic stroke: a randomized controlled trial. CMAJ (2006) 1.79

Remyelination of the spinal cord following intravenous delivery of bone marrow cells. Glia (2002) 1.68

VEGFR1/CXCR4-positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1-dependent mechanism. J Mol Med (Berl) (2008) 1.67

G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism. Blood (2006) 1.66

Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation. EMBO J (2003) 1.66

Recognition of a CXCR4 sulfotyrosine by the chemokine stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12). J Mol Biol (2006) 1.63

Ex vivo delivered stromal cell-derived factor-1alpha promotes stem cell homing and induces angiomyogenesis in the infarcted myocardium. J Mol Cell Cardiol (2007) 1.61

Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium. Circ Res (2010) 1.60

Adult murine skeletal muscle contains cells that can differentiate into beating cardiomyocytes in vitro. PLoS Biol (2005) 1.60

Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. J Clin Invest (2010) 1.57

Bone marrow-derived circulating progenitor cells fail to transdifferentiate into adipocytes in adult adipose tissues in mice. J Clin Invest (2007) 1.52

Progenitor cells isolated from the human heart: a potential cell source for regenerative therapy. Neth Heart J (2008) 1.51

The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice. Stem Cells (2008) 1.49

Plasminogen regulates cardiac repair after myocardial infarction through its noncanonical function in stem cell homing to the infarcted heart. J Am Coll Cardiol (2014) 1.45

Genetic enhancement of stem cell engraftment, survival, and efficacy. Circ Res (2008) 1.42

Identification and functionality of proteomes secreted by rat cardiac stem cells and neonatal cardiomyocytes. Proteomics (2010) 1.38

Bone marrow stem cell derived paracrine factors for regenerative medicine: current perspectives and therapeutic potential. Bone Marrow Res (2010) 1.34

Long-term myocardial functional improvement after autologous bone marrow mononuclear cells transplantation in patients with ST-segment elevation myocardial infarction: 4 years follow-up. Eur Heart J (2009) 1.34

Cell-mediated drug delivery. Expert Opin Drug Deliv (2011) 1.33

Peripheral blood stem cell mobilization: new regimens, new cells, where do we stand. Curr Opin Hematol (2008) 1.33

Adult bone marrow-derived cells: regenerative potential, plasticity, and tissue commitment. Basic Res Cardiol (2005) 1.32

Role of stem cells in cardiovascular biology. J Thromb Haemost (2011) 1.31

Cell-based therapy for prevention and reversal of myocardial remodeling. Am J Physiol Heart Circ Physiol (2012) 1.31

Little evidence of bone marrow-derived hepatocytes in the replacement of injured liver. Proc Natl Acad Sci U S A (2003) 1.29

Bone marrow-derived pluripotent very small embryonic-like stem cells (VSELs) are mobilized after acute myocardial infarction. J Mol Cell Cardiol (2008) 1.28

Bone marrow-derived mesenchymal stem cells repaired but did not prevent gentamicin-induced acute kidney injury through paracrine effects in rats. PLoS One (2012) 1.28

Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle. J Cell Biol (2004) 1.26

Heart valve tissue engineering: concepts, approaches, progress, and challenges. Ann Biomed Eng (2006) 1.26

Empowering adult stem cells for myocardial regeneration. Circ Res (2011) 1.25

G-CSF rescues the memory impairment of animal models of Alzheimer's disease. J Exp Med (2007) 1.24

Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Proc Natl Acad Sci U S A (2006) 1.23

Transplanted hematopoietic stem cells demonstrate impaired sarcoglycan expression after engraftment into cardiac and skeletal muscle. J Clin Invest (2004) 1.23

bcl-2 overexpression promotes myocyte proliferation. Proc Natl Acad Sci U S A (2002) 1.22

Stem cell- and scaffold-based tissue engineering approaches to osteochondral regenerative medicine. Semin Cell Dev Biol (2009) 1.21

Combined delivery approach of bone marrow mononuclear stem cells early and late after myocardial infarction: the MYSTAR prospective, randomized study. Nat Clin Pract Cardiovasc Med (2008) 1.20

Stem cells in the heart: what's the buzz all about? Part 2: Arrhythmic risks and clinical studies. Heart Rhythm (2008) 1.19

Optimized labeling of bone marrow mesenchymal cells with superparamagnetic iron oxide nanoparticles and in vivo visualization by magnetic resonance imaging. J Nanobiotechnology (2011) 1.19

Mesenchymal stem cells as therapeutics and vehicles for gene and drug delivery. Adv Drug Deliv Rev (2010) 1.18

Rebuilding the damaged heart: the potential of cytokines and growth factors in the treatment of ischemic heart disease. J Am Coll Cardiol (2010) 1.17

Therapeutic myocardial angiogenesis. Microvasc Res (2007) 1.16

Vascular endothelial growth factor in heart failure. Nat Rev Cardiol (2013) 1.16

Bone marrow cell therapy ameliorates and reverses chagasic cardiomyopathy in a mouse model. J Infect Dis (2008) 1.16

Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease. Dis Model Mech (2009) 1.16

CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res (2010) 1.15

Granulocyte colony-stimulating factor therapy for cardiac repair after acute myocardial infarction: a systematic review and meta-analysis of randomized controlled trials. Am Heart J (2008) 1.15

Bone-marrow-derived mesenchymal stem cells for organ repair. Stem Cells Int (2013) 1.14

Peripheral infusion of rat bone marrow derived endothelial progenitor cells leads to homing in acute lung injury. Respir Res (2007) 1.14

Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction. Circulation (2011) 1.14

Transplantation of autologous mononuclear bone marrow stem cells in patients with peripheral arterial disease (the TAM-PAD study). Clin Res Cardiol (2007) 1.13

G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis. J Exp Med (2006) 1.13

Adult stem cells and their trans-differentiation potential--perspectives and therapeutic applications. J Mol Med (Berl) (2008) 1.12

Intravenous and intramyocardial injection of apoptotic white blood cell suspensions prevents ventricular remodelling by increasing elastin expression in cardiac scar tissue after myocardial infarction. Basic Res Cardiol (2011) 1.12

Heme oxygenase-1 in inflammation and cardiovascular disease. Am J Cardiovasc Dis (2011) 1.10

The bone marrow--cardiac axis of myocardial regeneration. Prog Cardiovasc Dis (2007) 1.10

Chimeric maternal cells with tissue-specific antigen expression and morphology are common in infant tissues. Pediatr Dev Pathol (2009) 1.09

Injury-activated transforming growth factor β controls mobilization of mesenchymal stem cells for tissue remodeling. Stem Cells (2012) 1.08

Inhibition of histone deacetylase-induced myocardial repair is mediated by c-kit in infarcted hearts. J Biol Chem (2012) 1.08

Autophagic cardiomyocyte death in cardiomyopathic hamsters and its prevention by granulocyte colony-stimulating factor. Am J Pathol (2006) 1.08

Induction of smooth muscle cell-like phenotype in marrow-derived cells among regenerating urinary bladder smooth muscle cells. Am J Pathol (2005) 1.07

Myocyte proliferation in the developing heart. Dev Dyn (2011) 1.07

Adult bone-marrow stem cells and their potential in medicine. J R Soc Med (2004) 1.06

Notch1 in bone marrow-derived cells mediates cardiac repair after myocardial infarction. Circulation (2011) 1.06

Bone marrow mesenchymal stem cells can differentiate and assume corneal keratocyte phenotype. J Cell Mol Med (2012) 1.06

Bone marrow-derived cells do not repair endothelium in a mouse model of chronic endothelial cell dysfunction. Cardiovasc Res (2009) 1.05

Homing and differentiation of mesenchymal stem cells delivered intravenously to ischemic myocardium in vivo: a time-series study. Pflugers Arch (2006) 1.05

Transplantation of progenitor cells after reperfused acute myocardial infarction: evaluation of perfusion and myocardial viability with FDG-PET and thallium SPECT. Eur J Nucl Med Mol Imaging (2004) 1.04

The therapeutic potential of stem cells from adults. BMJ (2002) 1.03

Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle. Circ Res (2008) 1.03

Improved heart function follows enhanced inflammatory cell recruitment and angiogenesis in 11betaHSD1-deficient mice post-MI. Cardiovasc Res (2010) 1.03

Cardiomyocyte formation by skeletal muscle-derived multi-myogenic stem cells after transplantation into infarcted myocardium. PLoS One (2008) 1.02

Accumulation of fibronectin in the heart after myocardial infarction: a putative stimulator of adhesion and proliferation of adipose-derived stem cells. Cell Tissue Res (2008) 1.01

Coronary vessel development and insight towards neovascular therapy. Int J Exp Pathol (2009) 1.00

Biomimetic matrices for myocardial stabilization and stem cell transplantation. J Biomed Mater Res A (2010) 1.00

Articles cited by this

Bone marrow cells regenerate infarcted myocardium. Nature (2001) 21.24

Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med (2000) 11.35

Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med (2001) 10.36

Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med (2001) 10.03

Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation (1990) 9.74

Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature (1999) 7.73

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev (1995) 7.13

From marrow to brain: expression of neuronal phenotypes in adult mice. Science (2000) 6.53

Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science (2000) 6.16

Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science (1997) 5.54

Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science (1999) 5.22

Inhibition of Wnt activity induces heart formation from posterior mesoderm. Genes Dev (2001) 4.41

Heart failure from the point of view of quantitative anatomy. Am J Cardiol (1960) 3.89

flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development (1993) 3.66

Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat Med (1998) 3.28

Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circulation (1994) 3.24

Autologous transplantation of bone marrow cells improves damaged heart function. Circulation (1999) 3.17

Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest (1997) 2.93

Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. Blood (1996) 2.76

Myoblast transplantation for heart failure. Lancet (2001) 2.71

Congestive heart failure: fifty years of progress. Circulation (2000) 2.61

Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice. Proc Natl Acad Sci U S A (1996) 2.34

Skeletal myoblast transplantation for repair of myocardial necrosis. J Clin Invest (1996) 2.20

Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein. Circ Res (1998) 1.78

Transplantation of fetal myocardial tissue into the infarcted myocardium of rat. A potential method for repair of infarcted myocardium? Circulation (1996) 1.64

Cellular basis of chronic ventricular remodeling after myocardial infarction in rats. Circ Res (1991) 1.63

The cellular basis of pacing-induced dilated cardiomyopathy. Myocyte cell loss and myocyte cellular reactive hypertrophy. Circulation (1995) 1.56

Insulin-like growth factor-1 attenuates the detrimental impact of nonocclusive coronary artery constriction on the heart. Circ Res (1999) 1.56

Stem cell factor induction is associated with mast cell accumulation after canine myocardial ischemia and reperfusion. Circulation (1998) 1.39

Intermediate filaments in cardiac myogenesis: nestin in the developing mouse heart. J Histochem Cytochem (1995) 1.35

Echocardiographic and cardiac Doppler assessment of mice. J Am Soc Echocardiogr (1997) 1.34

Transmural replacement of myocardium after skeletal myoblast grafting into the heart. Too much of a good thing? Cardiovasc Pathol (2001) 1.16

Human and rat hepatic stellate cells produce stem cell factor: a possible mechanism for mast cell recruitment in liver fibrosis. J Hepatol (1999) 1.16

Structure, assembly, and dynamics of intermediate filaments. Subcell Biochem (1998) 1.13

Efficient retrovirus transduction of mouse pluripotent hematopoietic stem cells mobilized into the peripheral blood by treatment with granulocyte colony-stimulating factor and stem cell factor. Blood (1994) 1.13

Vascular endothelial growth factor increases the mitogenic response to fibroblast growth factor-2 in vascular smooth muscle cells in vivo via expression of fms-like tyrosine kinase-1. Circ Res (1997) 1.13

Recruitment of mast cells to muscle after mild damage. J Neurol Sci (1996) 1.01

Identification of human and mouse hematopoietic stem cell populations expressing high levels of mRNA encoding retrovirus receptors. Blood (1998) 0.94

Expression of stem cell factor in the lesional skin of systemic sclerosis. Dermatology (1998) 0.91

Articles by these authors

Bone marrow cells regenerate infarcted myocardium. Nature (2001) 21.24

Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med (2001) 10.03

Apoptosis in the failing human heart. N Engl J Med (1997) 6.35

Alternative splicing in the control of gene expression. Annu Rev Genet (1989) 6.18

Alternative splicing: a ubiquitous mechanism for the generation of multiple protein isoforms from single genes. Annu Rev Biochem (1987) 5.79

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell (1993) 4.90

Transcriptional and posttranscriptional control of c-myc during myogenesis: its mRNA remains inducible in differentiated cells and does not suppress the differentiated phenotype. Mol Cell Biol (1986) 4.46

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. Genes Dev (1991) 4.28

Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci U S A (1988) 4.23

Scanning from an independently specified branch point defines the 3' splice site of mammalian introns. Nature (1989) 4.18

Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Dev (1992) 4.10

Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated. J Biol Chem (1984) 4.01

Commitment, fusion and biochemical differentiation of a myogenic cell line in the absence of DNA synthesis. Cell (1978) 3.96

Type beta transforming growth factor is an inhibitor of myogenic differentiation. Proc Natl Acad Sci U S A (1986) 3.83

Cloning and characterization of PSF, a novel pre-mRNA splicing factor. Genes Dev (1993) 3.63

European S3-guidelines on the systemic treatment of psoriasis vulgaris. J Eur Acad Dermatol Venereol (2009) 3.56

Reversal of terminal differentiation and control of DNA replication: cyclin A and Cdk2 specifically localize at subnuclear sites of DNA replication. Cell (1993) 3.42

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest (1996) 3.42

Myocyte death in the failing human heart is gender dependent. Circ Res (1999) 3.38

Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ Res (1991) 3.32

Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circulation (1994) 3.24

Moloney murine sarcoma proviral DNA is a transcriptional unit. Nature (1980) 3.13

Myocardial cell death in human diabetes. Circ Res (2000) 3.12

Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem. Proc Natl Acad Sci U S A (1984) 3.05

Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science (1994) 3.05

Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene. Cell (1985) 3.02

Scanning and competition between AGs are involved in 3' splice site selection in mammalian introns. Mol Cell Biol (1993) 2.98

Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest (1997) 2.93

Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy. Circ Res (2001) 2.89

EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer. Blood (1997) 2.85

Mutually exclusive splicing of alpha-tropomyosin exons enforced by an unusual lariat branch point location: implications for constitutive splicing. Cell (1989) 2.84

A muscle-specific enhancer is located at the 3' end of the myosin light-chain 1/3 gene locus. Genes Dev (1988) 2.71

Myocyte proliferation in end-stage cardiac failure in humans. Proc Natl Acad Sci U S A (1998) 2.60

All members of the MHC multigene family respond to thyroid hormone in a highly tissue-specific manner. Science (1986) 2.57

Fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential RNA transcription and splicing. J Biol Chem (1984) 2.49

Gender differences and aging: effects on the human heart. J Am Coll Cardiol (1995) 2.49

Myocardial Akt activation and gender: increased nuclear activity in females versus males. Circ Res (2001) 2.43

hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors. Mol Cell Biol (1993) 2.41

Reversibility of muscle differentiation in the absence of commitment: analysis of a myogenic cell line temperature-sensitive for commitment. Cell (1983) 2.37

Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice. J Clin Invest (1990) 2.37

Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals. J Clin Invest (1987) 2.37

Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice. Proc Natl Acad Sci U S A (1996) 2.34

Molecular characterization of two myosin heavy chain genes expressed in the adult heart. Nature (1982) 2.28

Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac. Immunity (1997) 2.27

Gating mechanism of a cloned potassium channel expressed in frog oocytes and mammalian cells. Neuron (1990) 2.20

Transplanted adult bone marrow cells repair myocardial infarcts in mice. Ann N Y Acad Sci (2001) 2.17

A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage. Development (1993) 2.13

Ventricular myocytes are not terminally differentiated in the adult mammalian heart. Circ Res (1998) 2.11

Incremental reductions of positive charge within the S4 region of a voltage-gated K+ channel result in corresponding decreases in gating charge. Neuron (1992) 2.09

MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proc Natl Acad Sci U S A (1993) 2.07

Concordance between telepathologic diagnosis and conventional histopathologic diagnosis: a multiobserver store-and-forward study on 20 skin specimens. Arch Dermatol (2002) 2.07

Alpha-tropomyosin mutually exclusive exon selection: competition between branchpoint/polypyrimidine tracts determines default exon choice. Genes Dev (1991) 2.07

Aging, cardiac hypertrophy and ischemic cardiomyopathy do not affect the proportion of mononucleated and multinucleated myocytes in the human heart. J Mol Cell Cardiol (1996) 2.06

Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart. J Mol Cell Cardiol (1996) 2.05

Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD. Science (1994) 2.02

Stretch-induced programmed myocyte cell death. J Clin Invest (1995) 1.99

Generation of protein isoform diversity by alternative splicing: mechanistic and biological implications. Annu Rev Cell Biol (1987) 1.97

Complete nucleotide and encoded amino acid sequence of a mammalian myosin heavy chain gene. Evidence against intron-dependent evolution of the rod. J Mol Biol (1986) 1.97

Alpha-tropomyosin gene organization. Alternative splicing of duplicated isotype-specific exons accounts for the production of smooth and striated muscle isoforms. J Biol Chem (1987) 1.96

Programmed myocyte cell death affects the viable myocardium after infarction in rats. Exp Cell Res (1996) 1.95

IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress. Diabetes (2001) 1.92

Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon. EMBO J (1994) 1.91