Mechanisms of necroptosis in T cells.

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell (2011) 4.78

Many stimuli pull the necrotic trigger, an overview. Cell Death Differ (2011) 2.55

Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways. Nat Rev Immunol (2011) 2.40

Caspase 8 inhibits programmed necrosis by processing CYLD. Nat Cell Biol (2011) 2.37

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res (2013) 2.26

Programmed necrosis: backup to and competitor with apoptosis in the immune system. Nat Immunol (2011) 2.09

RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts. Mol Cell (2011) 2.06

RIP3: a molecular switch for necrosis and inflammation. Genes Dev (2013) 1.94

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol (2015) 1.77

It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival. Nat Rev Mol Cell Biol (2011) 1.76

IAPs limit activation of RIP kinases by TNF receptor 1 during development. EMBO J (2012) 1.61

Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell Rep (2013) 1.59

Mitochondria and cell signalling. J Cell Sci (2012) 1.52

CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis. PLoS One (2013) 1.48

MicroRNA-23a Curbs Necrosis during Early T Cell Activation by Enforcing Intracellular Reactive Oxygen Species Equilibrium. Immunity (2016) 1.41

Apoptosis, autophagy, necroptosis, and cancer metastasis. Mol Cancer (2015) 1.39

The two faces of receptor interacting protein kinase-1. Mol Cell (2014) 1.37

RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. PLoS One (2011) 1.33

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proc Natl Acad Sci U S A (2011) 1.30

Programmed necrosis in the cross talk of cell death and inflammation. Annu Rev Immunol (2014) 1.27

Viral modulation of programmed necrosis. Curr Opin Virol (2013) 1.20

Ripped to death. Trends Cell Biol (2011) 1.14

Regulated necrosis: disease relevance and therapeutic opportunities. Nat Rev Drug Discov (2016) 1.09

Necroptosis: is there a role for mitochondria? Front Physiol (2014) 1.08

A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes. Cell Death Differ (2012) 1.07

Polar opposites: Erk direction of CD4 T cell subsets. J Immunol (2012) 1.06

Programmed necrosis and autophagy in immune function. Immunol Rev (2012) 1.05

New components of the necroptotic pathway. Protein Cell (2012) 1.04

Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate. Biochim Biophys Acta (2011) 1.04

Fueling the flames: Mammalian programmed necrosis in inflammatory diseases. Cold Spring Harb Perspect Biol (2012) 1.03

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection. J Exp Med (2015) 1.02

True grit: programmed necrosis in antiviral host defense, inflammation, and immunogenicity. J Immunol (2014) 0.99

Functions of caspase 8: the identified and the mysterious. Semin Immunol (2014) 0.99

Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation. J Immunol (2014) 0.97

Structural basis of signal transduction in the TNF receptor superfamily. Adv Immunol (2013) 0.97

Necroptosis in development, inflammation and disease. Nat Rev Mol Cell Biol (2016) 0.96

Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor. Mol Cancer (2014) 0.95

Macroautophagy in T lymphocyte development and function. Front Immunol (2012) 0.93

Necroptosis: The Trojan horse in cell autonomous antiviral host defense. Virology (2015) 0.91

Commensal microbiota are required for systemic inflammation triggered by necrotic dendritic cells. Cell Rep (2013) 0.91

CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN. Cell Rep (2016) 0.90

Manipulation of apoptosis and necroptosis signaling by herpesviruses. Med Microbiol Immunol (2015) 0.88

Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis. Immunity (2014) 0.86

The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis. Cell Commun Signal (2013) 0.85

Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development. Hum Mol Genet (2012) 0.85

Necroptotic signaling in adaptive and innate immunity. Semin Cell Dev Biol (2014) 0.84

A TCR affinity threshold regulates memory CD4 T cell differentiation following vaccination. J Immunol (2012) 0.83

The effect of cell death in the initiation of lupus nephritis. Clin Exp Immunol (2015) 0.81

Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model. Aging (Albany NY) (2015) 0.81

The serine threonine kinase RIP3: lost and found. BMB Rep (2015) 0.80

A novel function of RIP1 in postnatal development and immune homeostasis by protecting against RIP3-dependent necroptosis and FADD-mediated apoptosis. Front Cell Dev Biol (2015) 0.80

Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice. J Cell Biol (2011) 0.79

ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts. Cell Death Dis (2015) 0.79

Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy. Oncotarget (2016) 0.78

Biomarkers for glioma immunotherapy: the next generation. J Neurooncol (2015) 0.78

Caspase-8 inhibition represses initial human monocyte activation in septic shock model. Oncotarget (2016) 0.78

Necroptosis-independent signaling by the RIP kinases in inflammation. Cell Mol Life Sci (2016) 0.77

Autophagic cell death RIPs into tumors. Cell Death Differ (2013) 0.77

Ensembling and filtering: an effective and rapid in silico multitarget drug-design strategy to identify RIPK1 and RIPK3 inhibitors. J Mol Model (2015) 0.77

DED or alive: assembly and regulation of the death effector domain complexes. Cell Death Dis (2015) 0.77

RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection. PLoS Pathog (2017) 0.76

Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death. PLoS Pathog (2016) 0.76

Expression of TNF-alpha-dependent apoptosis-related genes in the peripheral blood of Malagasy subjects with tuberculosis. PLoS One (2013) 0.76

Lupus erythematosus revisited. Semin Immunopathol (2015) 0.76

Linearly Patterned Programmed Cell Necrosis Induced by Chronic Hypoxia Plays a Role in Melanoma Angiogenesis. J Cancer (2016) 0.76

c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathway. J Immunol (2015) 0.76

Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control. Oncotarget (2016) 0.76

IAPs, TNF, inflammation and Jürg Tschopp; a personal perspective. Cell Death Differ (2012) 0.76

Caspase-8: regulating life and death. Immunol Rev (2017) 0.75

REDD1 Is Essential for Optimal T Cell Proliferation and Survival. PLoS One (2015) 0.75

Cyclophilin D regulates necrosis, but not apoptosis, of murine eosinophils. Am J Physiol Gastrointest Liver Physiol (2016) 0.75

Targeting Thioredoxin-1 by dimethyl fumarate induces ripoptosome-mediated cell death. Sci Rep (2017) 0.75

Cell death and immunity: caspase 8 and RIPK3 play with life and death. Nat Rev Immunol (2011) 0.75

Participation of Necroptosis in the Host Response to Acute Bacterial Pneumonia. J Innate Immun (2017) 0.75

Caspase-8: not so silently deadly. Clin Transl Immunology (2017) 0.75

Differences and Similarities in TRAIL- and Tumor Necrosis Factor-Mediated Necroptotic Signaling in Cancer Cells. Mol Cell Biol (2016) 0.75

The caspase-8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response. Arthritis Res Ther (2017) 0.75

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol (2005) 11.63

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell (2009) 11.36

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell (2009) 11.26

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature (2005) 11.22

Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science (2004) 10.77

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science (2009) 9.29

Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol (2008) 9.24

Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature (2005) 8.51

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell (2008) 7.61

Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu Rev Immunol (1991) 6.89

Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature (2009) 6.74

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature (2004) 5.85

Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol (2007) 5.60

Autophagic programmed cell death by selective catalase degradation. Proc Natl Acad Sci U S A (2006) 4.81

Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol Cell Biol (2004) 4.05

Apoptotic pathways: ten minutes to dead. Cell (2005) 3.96

Control of T cell viability. Annu Rev Immunol (2004) 3.89

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev (2003) 3.79

Requirement for caspase-8 in NF-kappaB activation by antigen receptor. Science (2005) 3.64

Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J Immunol (2009) 2.61

FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc Natl Acad Sci U S A (2008) 2.52

Genetic disorders of programmed cell death in the immune system. Annu Rev Immunol (2006) 2.31

Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A (2008) 2.20

Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. J Immunol (2005) 2.18

Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death. EMBO J (1994) 2.05

Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis. Mol Cell Biol (2006) 2.03

Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage. Immunity (2010) 1.70

Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis. Proc Natl Acad Sci U S A (2010) 1.67

Selective autophagy regulates various cellular functions. Genes Cells (2010) 1.58

T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J Exp Med (2004) 1.55

The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells. J Immunol (2006) 1.52

Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder. J Exp Med (2005) 1.40

FADD-deficient T cells exhibit a disaccord in regulation of the cell cycle machinery. J Biol Chem (2001) 1.25

A Fas-associated death domain protein/caspase-8-signaling axis promotes S-phase entry and maintains S6 kinase activity in T cells responding to IL-2. J Immunol (2007) 1.13

Fas-mediated apoptosis regulates the composition of peripheral alphabeta T cell repertoire by constitutively purging out double negative T cells. PLoS One (2008) 1.05

Intertwined pathways of programmed cell death in immunity. Immunol Rev (2010) 1.04

Cutting edge: FADD is not required for antigen receptor-mediated NF-kappaB activation. J Immunol (2005) 1.03

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Autophagy regulates lipid metabolism. Nature (2009) 13.33

Autophagy: renovation of cells and tissues. Cell (2011) 11.59

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature (2005) 11.22

Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol (2006) 10.71

Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol (2008) 9.24

Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med (2007) 8.06

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol (2010) 7.62

Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature (2007) 7.21

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell (2009) 6.88

Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature (2009) 6.74

Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol (2007) 5.60

Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab (2008) 5.55

Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res (2003) 5.30

Autophagy-deficient mice develop multiple liver tumors. Genes Dev (2011) 4.64

Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res (2007) 4.53

PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med (2004) 4.50

Autophagy is required to maintain muscle mass. Cell Metab (2009) 4.46

Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability. Circ Res (2006) 4.41

Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab (2008) 4.33

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol (2009) 4.31

Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem (2008) 4.20

The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell (2008) 3.72

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med (2008) 3.69

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature (2011) 3.61

Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. J Cell Biochem (2007) 3.53

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci U S A (2009) 3.41

Foxo transcription factors control regulatory T cell development and function. Immunity (2010) 3.17

The CD95 receptor: apoptosis revisited. Cell (2007) 3.13

Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. J Clin Invest (2007) 3.13

The role of erk1 and erk2 in multiple stages of T cell development. Immunity (2005) 2.96

Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling. Circulation (2008) 2.95

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells (2010) 2.91

Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochem Biophys Res Commun (2004) 2.86

MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility. Science (2009) 2.86

GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res (2006) 2.85

The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circ Res (2006) 2.85

Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity (2006) 2.77

Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart. Circulation (2005) 2.75

Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. J Biol Chem (2002) 2.66

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol (2011) 2.64

Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J Immunol (2009) 2.61

Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol (2008) 2.57

Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice. Proc Natl Acad Sci U S A (2002) 2.56

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria. Nat Commun (2012) 2.55

STRESS signaling pathways that modulate cardiac myocyte apoptosis. J Mol Cell Cardiol (2004) 2.53

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med (2012) 2.51

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nat Med (2008) 2.49

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. Nat Med (2012) 2.48

A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell (2008) 2.47

Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy. Aging (Albany NY) (2009) 2.45

Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart. Circ Res (2008) 2.44

Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis. Circ Res (2005) 2.44

Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res (2005) 2.44

Excess peroxisomes are degraded by autophagic machinery in mammals. J Biol Chem (2005) 2.44

Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. J Clin Invest (2003) 2.43

FoxO transcription factors promote autophagy in cardiomyocytes. J Biol Chem (2009) 2.40

A semisynthetic epitope for kinase substrates. Nat Methods (2007) 2.40

Molecular pathways underlying cardiac remodeling during pathophysiological stimulation. Circulation (2010) 2.37

Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death. Circ Res (2002) 2.35

A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proc Natl Acad Sci U S A (2006) 2.32

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol (2010) 2.32

Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol (2009) 2.32

Animal models of heart failure: a scientific statement from the American Heart Association. Circ Res (2012) 2.31

Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Mol Cell Biol (2002) 2.30

Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J (2007) 2.30

Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo. J Biol Chem (2004) 2.24

Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation (2010) 2.23

Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host Microbe (2009) 2.21

Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A (2008) 2.20

Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. J Immunol (2005) 2.18

Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. J Biol Chem (2005) 2.14

Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest (2007) 2.12

Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. J Clin Invest (2010) 2.12

Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy. Circulation (2006) 2.07

Signaling effectors underlying pathologic growth and remodeling of the heart. J Clin Invest (2013) 2.06

Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain. J Neurosci (2012) 2.06

Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart. FASEB J (2006) 2.02

FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. J Biol Chem (2010) 2.00

Molecular basis of physiological heart growth: fundamental concepts and new players. Nat Rev Mol Cell Biol (2013) 1.99

Autophagy in proximal tubules protects against acute kidney injury. Kidney Int (2012) 1.98

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell (2013) 1.95

Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells. Am J Physiol Cell Physiol (2009) 1.93

Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts. Cardiovasc Res (2010) 1.93

Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proc Natl Acad Sci U S A (2007) 1.93

Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. J Biol Chem (2006) 1.92

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature (2011) 1.91

Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes. Proc Natl Acad Sci U S A (2002) 1.88

Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle. J Gen Physiol (2006) 1.86

Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc Natl Acad Sci U S A (2007) 1.86

Re-employment of developmental transcription factors in adult heart disease. Semin Cell Dev Biol (2006) 1.82

Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy. J Biol Chem (2004) 1.82

A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease. Autophagy (2009) 1.81

Functions of autophagy in normal and diseased liver. Autophagy (2013) 1.81

Selective degradation of p62 by autophagy. Semin Immunopathol (2010) 1.80

Suppression of autophagy in osteocytes mimics skeletal aging. J Biol Chem (2013) 1.80

A murine model of inducible, cardiac-specific deletion of STAT3: its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning. J Mol Cell Cardiol (2011) 1.79

Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo. J Biol Chem (2005) 1.78