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A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet (2010) 8.48

Psoriasis is associated with increased beta-defensin genomic copy number. Nat Genet (2007) 8.07

Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis. Nat Genet (2009) 5.93

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet (2012) 4.13

Accurate, high-throughput typing of copy number variation using paralogue ratios from dispersed repeats. Nucleic Acids Res (2006) 2.64

tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia. Nat Genet (2008) 2.28

Neuromuscular involvement in various types of Ehlers-Danlos syndrome. Ann Neurol (2009) 2.26

Clinical, neuroradiological and genetic findings in pontocerebellar hypoplasia. Brain (2010) 2.15

Compound heterozygous mutations of the TNXB gene cause primary myopathy. Neuromuscul Disord (2013) 2.01

Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6. J Invest Dermatol (2010) 1.82

High expression levels of keratinocyte antimicrobial proteins in psoriasis compared with atopic dermatitis. J Invest Dermatol (2005) 1.78

Deficiency of tenascin-X causes abnormalities in dermal elastic fiber morphology. J Invest Dermatol (2004) 1.58

Increased angiogenesis and blood vessel maturation in acellular collagen-heparin scaffolds containing both FGF2 and VEGF. Biomaterials (2006) 1.44

Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors. J Invest Dermatol (2009) 1.26

Haploinsufficiency of TNXB is associated with hypermobility type of Ehlers-Danlos syndrome. Am J Hum Genet (2003) 1.26

Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. J Clin Invest (2013) 1.23

Transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identification of early mediators of host defense. Physiol Genomics (2005) 1.23

Tenascin-X, collagen, elastin, and the Ehlers-Danlos syndrome. Am J Med Genet C Semin Med Genet (2005) 1.16

Microbiome dynamics of human epidermis following skin barrier disruption. Genome Biol (2012) 1.15

Joint hypermobility syndromes: the pathophysiologic role of tenascin-X gene defects. Arthritis Rheum (2004) 1.13

Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem (2006) 1.10

Development and validation of human psoriatic skin equivalents. Am J Pathol (2008) 1.09

Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups. Am J Pathol (2011) 1.07

Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin. PLoS One (2009) 1.06

Accuracy and differential bias in copy number measurement of CCL3L1 in association studies with three auto-immune disorders. BMC Genomics (2011) 1.06

Attenuation of melanoma invasion by a secreted variant of activated leukocyte cell adhesion molecule. Cancer Res (2008) 1.03

Human single-chain antibodies reactive with native chondroitin sulfate detect chondroitin sulfate alterations in melanoma and psoriasis. J Invest Dermatol (2004) 1.03

Association of β-defensin copy number and psoriasis in three cohorts of European origin. J Invest Dermatol (2012) 1.02

A novel translation re-initiation mechanism for the p63 gene revealed by amino-terminal truncating mutations in Rapp-Hodgkin/Hay-Wells-like syndromes. Hum Mol Genet (2008) 1.02

Skin microbiome imbalance in patients with STAT1/STAT3 defects impairs innate host defense responses. J Innate Immun (2013) 1.02

Copy number variation upstream of PMP22 in Charcot-Marie-Tooth disease. Eur J Hum Genet (2009) 1.00

Wound healing in tenascin-X deficient mice suggests that tenascin-X is involved in matrix maturation rather than matrix deposition. Connect Tissue Res (2007) 0.98

A comprehensive analysis of pattern recognition receptors in normal and inflamed human epidermis: upregulation of dectin-1 in psoriasis. J Invest Dermatol (2010) 0.97

Microbiome and skin diseases. Curr Opin Allergy Clin Immunol (2013) 0.97

A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification. Hum Mol Genet (2002) 0.97

Interactions of human tenascin-X domains with dermal extracellular matrix molecules. Arch Dermatol Res (2006) 0.96

A proteomics platform combining depletion, multi-lectin affinity chromatography (M-LAC), and isoelectric focusing to study the breast cancer proteome. Anal Chem (2011) 0.96

Rho kinase inhibitor Y-27632 prolongs the life span of adult human keratinocytes, enhances skin equivalent development, and facilitates lentiviral transduction. Tissue Eng Part A (2012) 0.96

Differential gene expression in premalignant human epidermis revealed by cluster analysis of serial analysis of gene expression (SAGE) libraries. FASEB J (2001) 0.95

Full transcriptome analysis of rhabdomyosarcoma, normal, and fetal skeletal muscle: statistical comparison of multiple SAGE libraries. FASEB J (2005) 0.95

Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis. J Invest Dermatol (2010) 0.94

Tumor necrosis factor related apoptosis inducing ligand triggers apoptosis in dividing but not in differentiating human epidermal keratinocytes. J Invest Dermatol (2003) 0.93

Hypertrophic scar formation is associated with an increased number of epidermal Langerhans cells. J Pathol (2004) 0.92

Type 2 helper T-cell cytokines induce morphologic and molecular characteristics of atopic dermatitis in human skin equivalent. Am J Pathol (2011) 0.92

A partial transcriptome of human epidermis. Genomics (2002) 0.90

Discovery of small molecule vanin inhibitors: new tools to study metabolism and disease. ACS Chem Biol (2013) 0.90

Host defense effector molecules in mucosal secretions. FEMS Immunol Med Microbiol (2005) 0.90

Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of human lung. Oncol Rep (2002) 0.89

Drosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity. Antimicrob Agents Chemother (2008) 0.89

Strong induction of AIM2 expression in human epidermis in acute and chronic inflammatory skin conditions. Exp Dermatol (2012) 0.89

Sustained efficacy of the monoclonal anti-interleukin-1 beta antibody canakinumab in a 9-month trial in Schnitzler's syndrome. Ann Rheum Dis (2012) 0.88

Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines. J Invest Dermatol (2009) 0.88

The biology of cystatin M/E and its cognate target proteases. J Invest Dermatol (2009) 0.88

Genetically programmed differences in epidermal host defense between psoriasis and atopic dermatitis patients. PLoS One (2008) 0.87

Genetics of psoriasis: evidence for epistatic interaction between skin barrier abnormalities and immune deviation. J Invest Dermatol (2012) 0.87

Colocalization of cystatin M/E and cathepsin V in lamellar granules and corneodesmosomes suggests a functional role in epidermal differentiation. J Invest Dermatol (2006) 0.87

Phenotypical and functional differences in germinative subpopulations derived from normal and psoriatic epidermis. J Invest Dermatol (2005) 0.86

APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations. Proc Natl Acad Sci U S A (2013) 0.86

Transcriptional regulation of the elafin gene in human keratinocytes. J Invest Dermatol (2003) 0.86

Effect of daily stressors on psoriasis: a prospective study. J Invest Dermatol (2009) 0.86

Evidence that unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E deficient mice. Hum Mol Genet (2004) 0.86

The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea. FASEB J (2010) 0.85

EXOSC3 mutations in pontocerebellar hypoplasia type 1: novel mutations and genotype-phenotype correlations. Orphanet J Rare Dis (2014) 0.84

Colocalization of cystatin M/E and its target proteases suggests a role in terminal differentiation of human hair follicle and nail. J Invest Dermatol (2008) 0.84

Comparison of antiproliferative effects of experimental and established antipsoriatic drugs on human keratinocytes, using a simple 96-well-plate assay. In Vitro Cell Dev Biol Anim (2003) 0.83

TSEN54 mutations cause pontocerebellar hypoplasia type 5. Eur J Hum Genet (2011) 0.83

Increased expression of carbonic anhydrase II (CA II) in lesional skin of atopic dermatitis: regulation by Th2 cytokines. J Invest Dermatol (2007) 0.83

Statistical comparison of two or more SAGE libraries: one tag at a time. Methods Mol Biol (2008) 0.83

Successful canakinumab treatment identifies IL-1β as a pivotal mediator in Schnitzler syndrome. J Allergy Clin Immunol (2011) 0.82

Keratinocytes drive melanoma invasion in a reconstructed skin model. Melanoma Res (2010) 0.81

An overview of methods for the in vivo evaluation of tissue-engineered skin constructs. Tissue Eng Part B Rev (2010) 0.81

An in vitro wound healing model for evaluation of dermal substitutes. Wound Repair Regen (2013) 0.80

The human cystatin M/E gene (CST6): exclusion candidate gene for harlequin ichthyosis. J Invest Dermatol (2003) 0.79

Co-culture of healthy human keratinocytes and T-cells promotes keratinocyte chemokine production and RORγt-positive IL-17 producing T-cell populations. J Dermatol Sci (2012) 0.78

A simple technique for high-throughput screening of drugs that modulate normal and psoriasis-like differentiation in cultured human keratinocytes. Skin Pharmacol Appl Skin Physiol (2002) 0.78

Identification of avarol derivatives as potential antipsoriatic drugs using an in vitro model for keratinocyte growth and differentiation. Life Sci (2006) 0.78

Combination of pantothenamides with vanin inhibitors as a novel antibiotic strategy against gram-positive bacteria. Antimicrob Agents Chemother (2013) 0.78

Transcriptomics and proteomics of human skin. Brief Funct Genomic Proteomic (2003) 0.78

Well-defined clinical presentation of Ehlers-Danlos syndrome in patients with tenascin-X deficiency: a report of four cases. Clin Dysmorphol (2012) 0.78

Pattern recognition receptors in infectious skin diseases. Microbes Infect (2012) 0.78

Analysis of obstetric complications and uterine connective tissue in tenascin-X-deficient humans and mice. Cell Tissue Res (2008) 0.77

Epidermal expression of host response genes upon skin barrier disruption in normal skin and uninvolved skin of psoriasis and atopic dermatitis patients. J Invest Dermatol (2010) 0.77

Pattern recognition receptors in immune disorders affecting the skin. J Innate Immun (2012) 0.77

A thioesterase bypasses the requirement for exogenous fatty acids in the plsX deletion of Streptococcus pneumoniae. Mol Microbiol (2015) 0.77

The phenotype of the Gly94fsX222 PMP22 insertion. J Peripher Nerv Syst (2011) 0.76

Genotype-phenotype correlations in a prospective cohort study of paediatric plaque psoriasis: lack of correlation between HLA-C*06 and family history of psoriasis. Acta Derm Venereol (2014) 0.76

A molecular signature of epithelial host defense: comparative gene expression analysis of cultured bronchial epithelial cells and keratinocytes. BMC Genomics (2006) 0.76

Construction of a microstructured collagen membrane mimicking the papillary dermis architecture and guiding keratinocyte morphology and gene expression. Macromol Biosci (2012) 0.76

A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C. PLoS One (2012) 0.76

Extraction and structural analysis of glycosaminoglycans from formalin-fixed, paraffin-embedded tissues. Glycobiology (2012) 0.76

Pharmacological Inhibition of Vanin Activity Attenuates Transplant Vasculopathy in Rat Aortic Allografts. Transplantation (2016) 0.76

Congenital hypomyelinating neuropathy, a long term follow-up study in an affected family. Neuromuscul Disord (2007) 0.76

Abdominal aortic aneurysm is associated with high serum levels of tenascin-X and decreased aneurysmal tissue tenascin-X. Circulation (2006) 0.76

Cystatin M/E knockdown by lentiviral delivery of shRNA impairs epidermal morphogenesis of human skin equivalents. Exp Dermatol (2012) 0.76

Transplantation of reconstructed human skin on nude mice: a model system to study expression of human tenascin-X and elastic fiber components. Cell Tissue Res (2004) 0.75

X-linked Charcot-Marie-Tooth disease with novel c.47A>T GJB1 gene mutation. J Peripher Nerv Syst (2010) 0.75

Development of a keratinocyte-based screening model for antipsoriatic drugs using green fluorescent protein under the control of an endogenous promoter. J Biomol Screen (2002) 0.75