Published in Am J Pathol on November 01, 2004
Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res (2009) 6.43
Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer. Cancer Res (2009) 2.40
Mesenchymal cells of the intestinal lamina propria. Annu Rev Physiol (2011) 2.18
Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice. J Clin Invest (2009) 1.90
A multiscale mathematical model of cancer, and its use in analyzing irradiation therapies. Theor Biol Med Model (2006) 1.46
Survivin as a global target of intrinsic tumor suppression networks. Cell Cycle (2009) 1.36
Colon cancer stem cells: implications in carcinogenesis. Front Biosci (Landmark Ed) (2011) 1.23
Expression and prognostic value of tumor stem cell markers ALDH1 and CD133 in colorectal carcinoma. Oncol Lett (2013) 1.01
Characterization of LGR5 stem cells in colorectal adenomas and carcinomas. Sci Rep (2015) 0.95
Generation of a novel transgenic mouse model for bioluminescent monitoring of survivin gene activity in vivo at various pathophysiological processes: survivin expression overlaps with stem cell markers. Am J Pathol (2010) 0.93
Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial. BMC Med Genet (2015) 0.88
Survivin-induced Aurora-B kinase activation: A mechanism by which APC mutations contribute to increased mitoses during colon cancer development. Am J Pathol (2010) 0.88
Computational models reveal a passive mechanism for cell migration in the crypt. PLoS One (2013) 0.88
Role of Hypoxia-inducible factor-1 alpha and Survivin in colorectal carcinoma progression. Int J Colorectal Dis (2008) 0.84
Comparing a discrete and continuum model of the intestinal crypt. Phys Biol (2011) 0.84
Identification of a developmental gene expression signature, including HOX genes, for the normal human colonic crypt stem cell niche: overexpression of the signature parallels stem cell overpopulation during colon tumorigenesis. Stem Cells Dev (2013) 0.83
Increased levels of survivin, via association with heat shock protein 90, in mucosal T cells from patients with Crohn's disease. Gastroenterology (2012) 0.81
Combined changes in Wnt signaling response and contact inhibition induce altered proliferation in radiation-treated intestinal crypts. Mol Biol Cell (2016) 0.81
Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats. J Nutr Metab (2012) 0.78
Increased variability in Apc(Min)/+ intestinal tissue can be measured with microultrasound. Sci Rep (2016) 0.75
The role of cell proliferation and crypt fission in adenoma aggressiveness: a comparison of ileoanal pouch and rectal adenomas in familial adenomatous polyposis. Colorectal Dis (2011) 0.75
The Ki-67 protein: from the known and the unknown. J Cell Physiol (2000) 16.48
"Stemness": transcriptional profiling of embryonic and adult stem cells. Science (2002) 15.55
In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Proc Natl Acad Sci U S A (1999) 5.65
Intestinal stem cells protect their genome by selective segregation of template DNA strands. J Cell Sci (2002) 4.92
Colorectal cancer: molecules and populations. J Natl Cancer Inst (1999) 4.39
Top-down morphogenesis of colorectal tumors. Proc Natl Acad Sci U S A (2001) 3.51
Identification of a putative intestinal stem cell and early lineage marker; musashi-1. Differentiation (2003) 3.41
Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. Cancer Res (2001) 3.29
The APC gene product in normal and tumor cells. Proc Natl Acad Sci U S A (1993) 3.25
Stem cells in gastrointestinal epithelium: numbers, characteristics and death. Philos Trans R Soc Lond B Biol Sci (1998) 2.92
Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes. Cancer Res (1996) 2.89
Inhibition of apoptosis during development of colorectal cancer. Cancer Res (1995) 2.77
The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system. J Cell Biol (1992) 2.76
Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation. Mol Biol Cell (2002) 2.56
Stem cells: the intestinal stem cell as a paradigm. Carcinogenesis (2000) 2.52
Survivin and molecular pathogenesis of colorectal cancer. Lancet (2003) 2.25
Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission. Cancer Res (2003) 2.24
Differential expression of transforming growth factors alpha and beta in rat intestinal epithelial cells. J Clin Invest (1989) 1.91
Observations on the origin of adenomatous epithelium of the colon. Serial section of minute polyps in familial polyposis. Cancer (1963) 1.86
High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers. Proc Natl Acad Sci U S A (1997) 1.81
Inactivation of both APC alleles in human and mouse tumors. Cancer Res (1994) 1.75
Effects of growth factors on an intestinal epithelial cell line: transforming growth factor beta inhibits proliferation and stimulates differentiation. Biochem Biophys Res Commun (1987) 1.75
Transforming growth factor beta 1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest. Mol Cell Biol (1991) 1.66
Ultrastructural comparison of differentiation of stem cells of murine adenocarcinomas of colon and breast with their normal counterparts. J Natl Cancer Inst (1977) 1.51
Expression of survivin in normal, hyperplastic, and neoplastic colonic mucosa. Hum Pathol (2001) 1.51
Early alteration of cell-cycle-regulated gene expression in colorectal neoplasia. Am J Pathol (1996) 1.47
IN VITRO STUDY OF HUMAN RECTAL EPITHELIAL CELLS. I. ATYPICAL ZONE OF H3 THYMIDINE INCORPORATION IN MUCOSA OF MULTIPLE POLYPOSIS. J Clin Invest (1963) 1.41
Subcellular localization of the APC protein: immunoelectron microscopic study of the association of the APC protein with catenin. Oncogene (1995) 1.40
Computer modeling implicates stem cell overproduction in colon cancer initiation. Cancer Res (2001) 1.35
Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells. J Biol Chem (2002) 1.35
STUDIES ON THE MORPHOGENESIS OF ADENOMATOUS POLYPS IN THE HUMAN COLON. Cancer (1963) 1.32
Expression of Musashi-1 in human normal colon crypt cells: a possible stem cell marker of human colon epithelium. Dig Dis Sci (2003) 1.25
Prognostic value of bcl-2 oncoprotein expression in stage II colon carcinoma. Clin Cancer Res (1995) 1.21
Histogenesis of human colorectal adenomas and hyperplastic polyps: the role of cell proliferation and crypt fission. Gut (2002) 1.21
Morphogenesis of minute adenomas in familial polyposis coli. J Natl Cancer Inst (1984) 1.19
In vivo measurements in familial polyposis: kinetics and location of proliferating cells in colonic adenomas. Cancer Res (1982) 1.18
Histogenesis of adenomatous polyps in the human large intestine. Gastroenterology (1979) 1.18
Colonic crypt cell proliferation state assessed by whole crypt microdissection in sporadic neoplasia and familial adenomatous polyposis. Gut (2001) 1.16
Stimulation and inhibition of proliferation in the small intestinal crypts of the mouse after in vivo administration of growth factors. Gut (1995) 1.13
In situ detection of enterocytic apoptosis in normal colonic mucosa and in familial adenomatous polyposis. Gut (1995) 1.12
Prognostic significance of p27(Kip1) expression in colorectal cancer: a clinico-pathological characterization. J Pathol (1999) 1.10
Colorectal carcinomas with high microsatellite instability: defining a distinct immunologic and molecular entity with respect to prognostic markers. Hum Pathol (2000) 1.09
p27(Kip1) is an inducer of intestinal epithelial cell differentiation. Am J Physiol Cell Physiol (2000) 1.07
Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest. Mol Cell Biol (2002) 1.07
Asymmetric cell kinetics genes: the key to expansion of adult stem cells in culture. Stem Cells (2002) 1.04
Inward growth of colonic adenomatous polyps. Gastroenterology (1996) 1.01
Epithelial proliferation and morphogenesis of hyperplastic adenomatous and villous polyps of the human colon. Virchows Arch A Pathol Anat Histol (1974) 0.99
Correspondence re: T. Zhang et al., Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. Cancer Res., 61: 8664-8667, 2001. Cancer Res (2004) 0.94
p21WAF1/CIP1 expression in colorectal carcinoma correlates with advanced disease stage and p53 mutations. J Pathol (1999) 0.93
Cell proliferation in colorectal tumor progression: an immunohistochemical approach to intermediate biomarkers. J Cell Biochem Suppl (1992) 0.91
Loss of p21WAF1/Cip1 protein expression accompanies progression of sporadic colorectal neoplasms but not hereditary nonpolyposis colorectal cancers. Clin Cancer Res (1998) 0.90
Stem cell factor inhibits erythroid differentiation by modulating the activity of G1-cyclin-dependent kinase complexes: a role for p27 in erythroid differentiation coupled G1 arrest. Cell Growth Differ (2000) 0.89
The role of p53, p21WAF1/C1PI, and bcl-2 in radioresistant colorectal carcinoma. Hum Pathol (1997) 0.89
Transforming growth factor: signal transduction pathways, cell cycle mediation, and effects on hematopoiesis. J Hematother Stem Cell Res (2001) 0.88
Expression of survivin, YB-1, and KI-67 in sporadic adenomas and dysplasia-associated lesions or masses in ulcerative colitis. Appl Immunohistochem Mol Morphol (2001) 0.85
Isolation of nuclei from label-retaining cells and measurement of their turnover rates in rat colon. Am J Physiol Cell Physiol (2004) 0.83
Colon adenomatous polyps--do they grow inward? Lancet (1997) 0.81
The effects of transforming growth factor beta 3 on the growth of highly enriched hematopoietic progenitor cells derived from normal human bone marrow and peripheral blood. Cancer Res (1991) 0.78
MicroRNA gene expression deregulation in human breast cancer. Cancer Res (2005) 27.56
A global map of p53 transcription-factor binding sites in the human genome. Cell (2006) 20.65
ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature (2009) 18.38
The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics (2006) 12.45
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol (2007) 10.49
Metagenomic discovery of biomass-degrading genes and genomes from cow rumen. Science (2011) 6.93
Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res (2009) 6.43
Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection. Lancet (2003) 5.99
Whole-genome cartography of estrogen receptor alpha binding sites. PLoS Genet (2007) 5.85
The devil is in the third year: a longitudinal study of erosion of empathy in medical school. Acad Med (2009) 5.15
ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet (2010) 4.32
MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. J Pathol (2009) 3.29
Classification and risk stratification of invasive breast carcinomas using a real-time quantitative RT-PCR assay. Breast Cancer Res (2006) 2.95
Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure. J Clin Oncol (2011) 2.78
Rnnotator: an automated de novo transcriptome assembly pipeline from stranded RNA-Seq reads. BMC Genomics (2010) 2.62
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell (2011) 2.58
A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma. Radiother Oncol (2012) 2.54
Effects of propofol and ketamine as combined anesthesia for electroconvulsive therapy in patients with depressive disorder. J ECT (2012) 2.43
Direct-method SAD phasing of proteins enhanced by the use of intrinsic bimodal phase distributions in the subsequent phase-improvement process. Acta Crystallogr D Biol Crystallogr (2009) 2.28
Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer. Cancer Biol Ther (2009) 2.25
Consensus conference on breast conservation. J Am Coll Surg (2006) 2.17
Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18. J Biol Chem (2012) 2.16
The need for standardization of colonoscopic tattooing of colonic lesions. Dis Colon Rectum (2015) 1.99
Single-atom catalysis of CO oxidation using Pt1/FeOx. Nat Chem (2011) 1.98
Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease. Alcohol Clin Exp Res (2007) 1.97
Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res (2010) 1.96
Exclusion of breast cancer as an integral tumor of hereditary nonpolyposis colorectal cancer. Cancer Res (2002) 1.96
Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats. J Hepatol (2008) 1.90
The airborne metagenome in an indoor urban environment. PLoS One (2008) 1.81
Comparative study of four time series methods in forecasting typhoid fever incidence in China. PLoS One (2013) 1.78
Thymidine phosphorylase expression is associated with response to capecitabine plus irinotecan in patients with metastatic colorectal cancer. J Clin Oncol (2006) 1.78
Identification of ancient remains through genomic sequencing. Genome Res (2008) 1.72
Withaferin A targets heat shock protein 90 in pancreatic cancer cells. Biochem Pharmacol (2010) 1.69
Interval between palliative care referral and death among patients treated at a comprehensive cancer center. J Palliat Med (2005) 1.67
A novel systematic error compensation algorithm based on least squares support vector regression for star sensor image centroid estimation. Sensors (Basel) (2011) 1.64
Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. Gastroenterology (2007) 1.63
Sensitization to gamma-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells. Cancer Biol Ther (2009) 1.61
A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. J Med Chem (2011) 1.58
Model-based segmentation of medical imagery by matching distributions. IEEE Trans Med Imaging (2005) 1.57
SOX9 is expressed in normal prostate basal cells and regulates androgen receptor expression in prostate cancer cells. Cancer Res (2007) 1.57
Association of human polyomavirus JCV with colon cancer: evidence for interaction of viral T-antigen and beta-catenin. Cancer Res (2002) 1.54
Impurity effect on weak antilocalization in the topological insulator Bi2Te3. Phys Rev Lett (2011) 1.53
Nebulized versus subcutaneous morphine for patients with cancer dyspnea: a preliminary study. J Pain Symptom Manage (2005) 1.52
Thirty-day in-vivo performance of a wearable artificial pump-lung for ambulatory respiratory support. Ann Thorac Surg (2011) 1.52
Control of basal autophagy by calpain1 mediated cleavage of ATG5. Autophagy (2010) 1.51
Fatigue-induced damage in Zr-based bulk metallic glasses. Sci Rep (2013) 1.49
Anterior versus posterior approach for treatment of thoracolumbar burst fractures: a meta-analysis. Eur Spine J (2013) 1.49
Chronic oxidative stress as a mechanism for glucose toxicity of the beta cell in type 2 diabetes. Cell Biochem Biophys (2007) 1.49
Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007. Breast J (2009) 1.48
A novel combined SLAM based on RBPF-SLAM and EIF-SLAM for mobile system sensing in a large scale environment. Sensors (Basel) (2011) 1.46
How dysregulated colonic crypt dynamics cause stem cell overpopulation and initiate colon cancer. Cancer Res (2008) 1.45
Patient-controlled methylphenidate for cancer fatigue: a double-blind, randomized, placebo-controlled trial. J Clin Oncol (2006) 1.45
Highly efficient extraction of serum peptides by ordered mesoporous carbon. Angew Chem Int Ed Engl (2011) 1.43
Active contours for tracking distributions. IEEE Trans Image Process (2004) 1.42
A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther (2013) 1.42
Regulation of alpha-cell function by the beta-cell during hypoglycemia in Wistar rats: the "switch-off" hypothesis. Diabetes (2004) 1.41
Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling. Autophagy (2011) 1.40
Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo. Diabetes (2007) 1.39
Genome-wide identification of regulatory DNA elements and protein-binding footprints using signatures of open chromatin in Arabidopsis. Plant Cell (2012) 1.38
Laparoscopic treatment for small intestinal bleeding: a report of 77 cases. J Laparoendosc Adv Surg Tech A (2010) 1.38
Electromagnetic cellular interactions. Prog Biophys Mol Biol (2010) 1.35
Access to palliative care among patients treated at a comprehensive cancer center. Oncologist (2012) 1.34
Androgen receptor remains critical for cell-cycle progression in androgen-independent CWR22 prostate cancer cells. Am J Pathol (2006) 1.33
Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract. Hum Pathol (2005) 1.32
The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas. Clin Cancer Res (2005) 1.31
Redox homeostasis: the linchpin in stem cell self-renewal and differentiation. Cell Death Dis (2013) 1.31
New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential. Drug Resist Updat (2009) 1.27
One family cluster of avian influenza A(H7N9) virus infection in Shandong, China. BMC Infect Dis (2014) 1.26
HOX genes and their role in the development of human cancers. J Mol Med (Berl) (2014) 1.26
Snail is critical for tumor growth and metastasis of ovarian carcinoma. Int J Cancer (2010) 1.26
Longer time interval between completion of neoadjuvant chemoradiation and surgical resection does not improve downstaging of rectal carcinoma. Dis Colon Rectum (2003) 1.25
Single-atom catalysts: a new frontier in heterogeneous catalysis. Acc Chem Res (2013) 1.23
An audit of endoscopic complications in adult eosinophilic esophagitis. Clin Gastroenterol Hepatol (2007) 1.23
Targeted agent use in cancer patients at the end of life. J Pain Symptom Manage (2012) 1.22
MicroRNA expression profiling of male breast cancer. Breast Cancer Res (2009) 1.22
Mutational dynamics of the SARS coronavirus in cell culture and human populations isolated in 2003. BMC Infect Dis (2004) 1.21
Endoscopic management of benign tracheobronchial tumors. J Thorac Dis (2011) 1.21
Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII. Cancer Biol Ther (2006) 1.20
Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor. Clin Cancer Res (2008) 1.19
microRNA-150 inhibits human CD133-positive liver cancer stem cells through negative regulation of the transcription factor c-Myb. Int J Oncol (2011) 1.18
FGFR4 promotes stroma-induced epithelial-to-mesenchymal transition in colorectal cancer. Cancer Res (2013) 1.16
Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage. Alcohol Clin Exp Res (2009) 1.15
Autophagy is a protective response to ethanol neurotoxicity. Autophagy (2012) 1.15
Regulation of centrosome separation in yeast and vertebrates: common threads. Trends Cell Biol (2009) 1.15
Prognostic significance of circulating tumor cells in non-small-cell lung cancer patients: a meta-analysis. PLoS One (2013) 1.15
Oxidative stress and apoptosis induced by nanosized titanium dioxide in PC12 cells. Toxicology (2009) 1.15
Predictors of access to palliative care services among patients who died at a Comprehensive Cancer Center. J Palliat Med (2007) 1.14
One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis. Cancer Res (2008) 1.14
pH-sensitive nanoparticles for improving the oral bioavailability of cyclosporine A. Int J Pharm (2004) 1.14
Genetic polymorphisms in pre-microRNA genes as prognostic markers of colorectal cancer. Cancer Epidemiol Biomarkers Prev (2011) 1.14
A quantitative comparison of mechanical blood damage parameters in rotary ventricular assist devices: shear stress, exposure time and hemolysis index. J Biomech Eng (2012) 1.12
Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells. Mol Cell Proteomics (2011) 1.12
Multiple tumor types may originate from bone marrow-derived cells. Neoplasia (2006) 1.10
Generation of long insert pairs using a Cre-LoxP Inverse PCR approach. PLoS One (2012) 1.09