Monitoring neural activity and [Ca2+] with genetically encoded Ca2+ indicators.

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. Nat Methods (2009) 13.39

Ultrasensitive fluorescent proteins for imaging neuronal activity. Nature (2013) 12.01

Genetic dissection of neural circuits. Neuron (2008) 7.97

Imaging cellular signals in the heart in vivo: Cardiac expression of the high-signal Ca2+ indicator GCaMP2. Proc Natl Acad Sci U S A (2006) 4.71

Sensory processing in the Drosophila antennal lobe increases reliability and separability of ensemble odor representations. Nat Neurosci (2007) 3.55

In vivo performance of genetically encoded indicators of neural activity in flies. J Neurosci (2005) 3.11

Structural basis for calcium sensing by GCaMP2. Structure (2008) 2.52

Fast nonnegative deconvolution for spike train inference from population calcium imaging. J Neurophysiol (2010) 2.51

Characterization and subcellular targeting of GCaMP-type genetically-encoded calcium indicators. PLoS One (2008) 2.31

Monitoring neural activity with bioluminescence during natural behavior. Nat Neurosci (2010) 2.24

A genetically encoded reporter of synaptic activity in vivo. Nat Methods (2009) 2.20

Genetically encoded Ca2+ indicators: using genetics and molecular design to understand complex physiology. J Physiol (2006) 2.12

A FRET-based calcium biosensor with fast signal kinetics and high fluorescence change. Biophys J (2005) 2.02

Chronic cellular imaging of mouse visual cortex during operant behavior and passive viewing. Front Cell Neurosci (2010) 1.99

Linking neural activity and molecular oscillations in the SCN. Nat Rev Neurosci (2011) 1.92

Spike inference from calcium imaging using sequential Monte Carlo methods. Biophys J (2009) 1.88

Olfactory processing and behavior downstream from highly selective receptor neurons. Nat Neurosci (2007) 1.85

Single fluorescent protein-based Ca2+ sensors with increased dynamic range. BMC Biotechnol (2007) 1.79

Reporting neural activity with genetically encoded calcium indicators. Brain Cell Biol (2008) 1.64

Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success. J Mol Cell Cardiol (2013) 1.61

Evaluating a genetically encoded optical sensor of neural activity using electrophysiology in intact adult fruit flies. Front Neural Circuits (2007) 1.54

Cracking neural circuits in a tiny brain: new approaches for understanding the neural circuitry of Drosophila. Trends Neurosci (2008) 1.44

Imaging light responses of targeted neuron populations in the rodent retina. J Neurosci (2011) 1.41

Inferring Neuronal Dynamics from Calcium Imaging Data Using Biophysical Models and Bayesian Inference. PLoS Comput Biol (2016) 1.41

Imaging neural activity using Thy1-GCaMP transgenic mice. Neuron (2012) 1.40

Calcium indicator loading of neurons using single-cell electroporation. Pflugers Arch (2007) 1.31

Zebrafish and motor control over the last decade. Brain Res Rev (2007) 1.27

Shining light on signaling and metabolic networks by genetically encoded biosensors. Curr Opin Plant Biol (2005) 1.25

Connectomics and epilepsy. Curr Opin Neurol (2013) 1.18

Presynaptic mitochondria in functionally different motor neurons exhibit similar affinities for Ca2+ but exert little influence as Ca2+ buffers at nerve firing rates in situ. J Neurosci (2010) 1.12

Quantitative comparison of genetically encoded Ca indicators in cortical pyramidal cells and cerebellar Purkinje cells. Front Cell Neurosci (2011) 1.12

Optical imaging of postsynaptic odor representation in the glomerular layer of the mouse olfactory bulb. J Neurophysiol (2009) 1.10

Balance of activity between LN(v)s and glutamatergic dorsal clock neurons promotes robust circadian rhythms in Drosophila. Neuron (2012) 1.09

Transgenic mice expressing a cameleon fluorescent Ca2+ indicator in astrocytes and Schwann cells allow study of glial cell Ca2+ signals in situ and in vivo. J Neurosci Methods (2009) 1.07

Quantitative imaging for discovery and assembly of the metabo-regulome. New Phytol (2008) 1.03

A model of the roles of essential kinases in the induction and expression of late long-term potentiation. Biophys J (2006) 1.00

Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon. Brain Cell Biol (2008) 0.99

Loss of the ciliary kinase Nek8 causes left-right asymmetry defects. J Am Soc Nephrol (2013) 0.97

Imaging calcium signals in vivo: a powerful tool in physiology and pharmacology. Br J Pharmacol (2011) 0.97

Inference of neuronal network spike dynamics and topology from calcium imaging data. Front Neural Circuits (2013) 0.97

Nuclear calcium sensors reveal that repetition of trains of synaptic stimuli boosts nuclear calcium signaling in CA1 pyramidal neurons. Biophys J (2010) 0.97

Estimating firing rates from calcium signals in locust projection neurons in vivo. Front Neural Circuits (2007) 0.96

Rational design of new binding specificity by simultaneous mutagenesis of calmodulin and a target peptide. Biochemistry (2006) 0.96

Live-cell transforms between Ca2+ transients and FRET responses for a troponin-C-based Ca2+ sensor. Biophys J (2007) 0.95

From art to engineering? The rise of in vivo mammalian electrophysiology via genetically targeted labeling and nonlinear imaging. PLoS Biol (2005) 0.95

Quantitative comparison of novel GCaMP-type genetically encoded Ca(2+) indicators in mammalian neurons. Front Cell Neurosci (2012) 0.95

Activity-dependent modulation of neural circuit synaptic connectivity. Front Mol Neurosci (2009) 0.93

Putting a finishing touch on GECIs. Front Mol Neurosci (2014) 0.92

Probing neuronal activities with genetically encoded optical indicators: from a historical to a forward-looking perspective. Pflugers Arch (2012) 0.92

Genetically encoded probes for measurement of intracellular calcium. Methods Cell Biol (2010) 0.91

Optical imaging as a link between cellular neurophysiology and circuit modeling. Front Cell Neurosci (2009) 0.90

Nonlinearity of two-photon Ca2+ imaging yields distorted measurements of tuning for V1 neuronal populations. J Neurophysiol (2011) 0.89

A chemist and biologist talk to each other about caged neurotransmitters. Beilstein J Org Chem (2013) 0.88

Tools, methods, and applications for optophysiology in neuroscience. Front Mol Neurosci (2013) 0.88

A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging. Front Pharmacol (2014) 0.87

Rapidly inducible, genetically targeted inactivation of neural and synaptic activity in vivo. Curr Opin Neurobiol (2007) 0.86

Global Ca2+ signaling drives ribbon-independent synaptic transmission at rod bipolar cell synapses. J Neurosci (2014) 0.86

Neural representations of airflow in Drosophila mushroom body. PLoS One (2008) 0.86

Molecular constraints on synaptic tagging and maintenance of long-term potentiation: a predictive model. PLoS Comput Biol (2012) 0.85

Relating a calcium indicator signal to the unperturbed calcium concentration time-course. Theor Biol Med Model (2007) 0.85

Methods of dendritic spine detection: from Golgi to high-resolution optical imaging. Neuroscience (2012) 0.84

Fragile X mental retardation protein is required for programmed cell death and clearance of developmentally-transient peptidergic neurons. Dev Biol (2011) 0.83

Genetically encoded fluorescent sensors for studying healthy and diseased nervous systems. Drug Discov Today Dis Models (2008) 0.83

Genetic strategies to investigate neuronal circuit properties using stem cell-derived neurons. Front Cell Neurosci (2012) 0.82

Simulations suggest pharmacological methods for rescuing long-term potentiation. J Theor Biol (2014) 0.81

The role of astrocytes in CNS tumors: pre-clinical models and novel imaging approaches. Front Cell Neurosci (2013) 0.81

A neuron-based screening platform for optimizing genetically-encoded calcium indicators. PLoS One (2013) 0.80

Imaging neuronal responses in slice preparations of vomeronasal organ expressing a genetically encoded calcium sensor. J Vis Exp (2011) 0.79

Detection of calcium transients in embryonic stem cells and their differentiated progeny. Cell Mol Neurobiol (2009) 0.78

Calcium imaging of vomeronasal organ response using slice preparations from transgenic mice expressing G-CaMP2. Methods Mol Biol (2013) 0.78

A cell-based functional assay using a green fluorescent protein-based calcium indicator dCys-GCaMP. Assay Drug Dev Technol (2014) 0.78

Calcium's role as nuanced modulator of cellular physiology in the brain. Biochem Biophys Res Commun (2016) 0.77

Trapping the nematode on a micro chip for the future of science. HFSP J (2007) 0.75

A model of the intracellular response of an olfactory neuron in Caenorhabditis elegans to odor stimulation. PLoS One (2012) 0.75

Fast online deconvolution of calcium imaging data. PLoS Comput Biol (2017) 0.75

Substitution with a Single Cysteine in the Green Fluorescent Protein-Based Calcium Indicator GCaMP3 Enhances Calcium Sensitivity. J Fluoresc (2017) 0.75

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. Nat Methods (2009) 13.39

Ultrasensitive fluorescent proteins for imaging neuronal activity. Nature (2013) 12.01

Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature (2002) 11.85

ScanImage: flexible software for operating laser scanning microscopes. Biomed Eng Online (2003) 8.59

Genetic dissection of neural circuits. Neuron (2008) 7.97

Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections. Nat Neurosci (2007) 7.65

Experience-dependent structural synaptic plasticity in the mammalian brain. Nat Rev Neurosci (2009) 7.54

Transient and persistent dendritic spines in the neocortex in vivo. Neuron (2005) 6.30

Structure and function of dendritic spines. Annu Rev Physiol (2002) 6.17

Optimization of a GCaMP calcium indicator for neural activity imaging. J Neurosci (2012) 6.09

Sparse optical microstimulation in barrel cortex drives learned behaviour in freely moving mice. Nature (2008) 6.08

The subcellular organization of neocortical excitatory connections. Nature (2009) 5.98

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window. Nat Protoc (2009) 5.68

Experience-dependent and cell-type-specific spine growth in the neocortex. Nature (2006) 5.63

Principles of two-photon excitation microscopy and its applications to neuroscience. Neuron (2006) 5.50

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat Neurosci (2012) 4.87

The life cycle of Ca(2+) ions in dendritic spines. Neuron (2002) 4.52

Locally dynamic synaptic learning rules in pyramidal neuron dendrites. Nature (2007) 4.48

Rapid redistribution of synaptic PSD-95 in the neocortex in vivo. PLoS Biol (2006) 4.12

Activation of CaMKII in single dendritic spines during long-term potentiation. Nature (2009) 3.76

Circuit analysis of experience-dependent plasticity in the developing rat barrel cortex. Neuron (2003) 3.65

Cell type-specific structural plasticity of axonal branches and boutons in the adult neocortex. Neuron (2006) 3.61

Mechanisms of CaMKII action in long-term potentiation. Nat Rev Neurosci (2012) 3.59

Spine growth precedes synapse formation in the adult neocortex in vivo. Nat Neurosci (2006) 3.57

Mechanically driven ATP synthesis by F1-ATPase. Nature (2004) 3.45

Geometric and functional organization of cortical circuits. Nat Neurosci (2005) 3.22

Learning-related fine-scale specificity imaged in motor cortex circuits of behaving mice. Nature (2010) 3.18

Neural activity in barrel cortex underlying vibrissa-based object localization in mice. Neuron (2010) 3.16

A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo. J Neurosci (2012) 3.13

Facilitation at single synapses probed with optical quantal analysis. Nat Neurosci (2002) 3.13

Interdigitated paralemniscal and lemniscal pathways in the mouse barrel cortex. PLoS Biol (2006) 2.89

A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. PLoS Comput Biol (2009) 2.88

The spread of Ras activity triggered by activation of a single dendritic spine. Science (2008) 2.87

Laminar and columnar organization of ascending excitatory projections to layer 2/3 pyramidal neurons in rat barrel cortex. J Neurosci (2005) 2.81

Imaging calcium concentration dynamics in small neuronal compartments. Sci STKE (2004) 2.80

Vibrissa-based object localization in head-fixed mice. J Neurosci (2010) 2.69

Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton. Neuron (2004) 2.68

Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging. Nat Neurosci (2006) 2.66

NMDA receptor subunit-dependent [Ca2+] signaling in individual hippocampal dendritic spines. J Neurosci (2005) 2.65

Catalysis and rotation of F1 motor: cleavage of ATP at the catalytic site occurs in 1 ms before 40 degree substep rotation. Proc Natl Acad Sci U S A (2003) 2.65

The functional microarchitecture of the mouse barrel cortex. PLoS Biol (2007) 2.64

Nonlinear dendritic integration of sensory and motor input during an active sensing task. Nature (2012) 2.56

Stereotyped odor-evoked activity in the mushroom body of Drosophila revealed by green fluorescent protein-based Ca2+ imaging. J Neurosci (2004) 2.44

Local, persistent activation of Rho GTPases during plasticity of single dendritic spines. Nature (2011) 2.42

A genetically encoded fluorescent sensor of ERK activity. Proc Natl Acad Sci U S A (2008) 2.34

Experience strengthening transmission by driving AMPA receptors into synapses. Science (2003) 2.34

Characterization and subcellular targeting of GCaMP-type genetically-encoded calcium indicators. PLoS One (2008) 2.31

Rapid and reversible chemical inactivation of synaptic transmission in genetically targeted neurons. Neuron (2005) 2.26

Diverse modes of axon elaboration in the developing neocortex. PLoS Biol (2005) 2.26

Activity in motor-sensory projections reveals distributed coding in somatosensation. Nature (2012) 2.24

Rapid functional maturation of nascent dendritic spines. Neuron (2009) 2.21

Long-range neuronal circuits underlying the interaction between sensory and motor cortex. Neuron (2011) 2.20

Myosin-dependent targeting of transmembrane proteins to neuronal dendrites. Nat Neurosci (2009) 2.14

Ephus: multipurpose data acquisition software for neuroscience experiments. Front Neural Circuits (2010) 2.12

The number of glutamate receptors opened by synaptic stimulation in single hippocampal spines. J Neurosci (2004) 1.83

Plasticity of calcium channels in dendritic spines. Nat Neurosci (2003) 1.82

Highly sensitive and quantitative FRET-FLIM imaging in single dendritic spines using improved non-radiative YFP. Brain Cell Biol (2008) 1.76

Metaplasticity at single glutamatergic synapses. Neuron (2010) 1.74

Circuit and plasticity defects in the developing somatosensory cortex of FMR1 knock-out mice. J Neurosci (2008) 1.72

Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas. PLoS Biol (2011) 1.71

Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs. Nat Neurosci (2004) 1.65

Reverse engineering the mouse brain. Nature (2009) 1.58

Nonlinear [Ca2+] signaling in dendrites and spines caused by activity-dependent depression of Ca2+ extrusion. J Neurosci (2006) 1.55

AMPA receptors are exocytosed in stimulated spines and adjacent dendrites in a Ras-ERK-dependent manner during long-term potentiation. Proc Natl Acad Sci U S A (2010) 1.55

Precise development of functional and anatomical columns in the neocortex. Neuron (2004) 1.51

Neural coding during active somatosensation revealed using illusory touch. Nat Neurosci (2013) 1.49

An image analysis algorithm for dendritic spines. Neural Comput (2002) 1.48

From cudgel to scalpel: toward precise neural control with optogenetics. Nat Methods (2010) 1.45

Organization of cortical and thalamic input to pyramidal neurons in mouse motor cortex. J Neurosci (2013) 1.44

Subcellular dynamics of type II PKA in neurons. Neuron (2009) 1.43

Imaging neural activity using Thy1-GCaMP transgenic mice. Neuron (2012) 1.40

A protocol for preparing GFP-labeled neurons previously imaged in vivo and in slice preparations for light and electron microscopic analysis. Nat Protoc (2009) 1.40

Structural plasticity underlies experience-dependent functional plasticity of cortical circuits. J Neurosci (2010) 1.40

Postsynaptic signaling during plasticity of dendritic spines. Trends Neurosci (2012) 1.32

The functional asymmetry of auditory cortex is reflected in the organization of local cortical circuits. Nat Neurosci (2010) 1.31

Activity-dependent synaptogenesis in the adult Mammalian cortex. Neuron (2002) 1.30

The functional properties of barrel cortex neurons projecting to the primary motor cortex. J Neurosci (2010) 1.30

Dendrodendritic synaptic signals in olfactory bulb granule cells: local spine boost and global low-threshold spike. J Neurosci (2005) 1.30

Automated tracking of whiskers in videos of head fixed rodents. PLoS Comput Biol (2012) 1.29

TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. Environ Health Perspect (2011) 1.29

Mechanisms of lateral inhibition in the olfactory bulb: efficiency and modulation of spike-evoked calcium influx into granule cells. J Neurosci (2003) 1.26

Multiple new site-specific recombinases for use in manipulating animal genomes. Proc Natl Acad Sci U S A (2011) 1.23

Nonviral direct conversion of primary mouse embryonic fibroblasts to neuronal cells. Mol Ther Nucleic Acids (2012) 1.20

Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities. J Neurosci (2013) 1.19

Activity-dependent plasticity of the NMDA-receptor fractional Ca2+ current. Neuron (2007) 1.17

Regular spiking and intrinsic bursting pyramidal cells show orthogonal forms of experience-dependent plasticity in layer V of barrel cortex. Neuron (2012) 1.16

Regional differences in hippocampal calcium handling provide a cellular mechanism for limiting plasticity. Proc Natl Acad Sci U S A (2009) 1.15

Development of intrinsic properties and excitability of layer 2/3 pyramidal neurons during a critical period for sensory maps in rat barrel cortex. J Neurophysiol (2004) 1.13

The mechanical variables underlying object localization along the axis of the whisker. J Neurosci (2013) 1.11

Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders. J Neurosci (2010) 1.08

Self-phase modulation signatures of neuronal activity. Opt Lett (2008) 1.08

Experience-dependent changes in basal dendritic branching of layer 2/3 pyramidal neurons during a critical period for developmental plasticity in rat barrel cortex. Cereb Cortex (2004) 1.06

Long-distance integration of nuclear ERK signaling triggered by activation of a few dendritic spines. Science (2013) 1.05

Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner. Proc Natl Acad Sci U S A (2011) 1.05

Thalamocortical input onto layer 5 pyramidal neurons measured using quantitative large-scale array tomography. Front Neural Circuits (2013) 1.00

Plasticity of dendritic spines: subcompartmentalization of signaling. Annu Rev Physiol (2013) 0.99