Published in Cancer Res on November 01, 2004
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med (2007) 4.59
Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma. Nat Rev Cancer (2010) 4.10
NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells (2010) 3.42
Notch promotes radioresistance of glioma stem cells. Stem Cells (2010) 3.07
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res (2006) 3.06
Medulloblastomics: the end of the beginning. Nat Rev Cancer (2012) 3.01
Dual and opposing roles of primary cilia in medulloblastoma development. Nat Med (2009) 2.73
The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma. Proc Natl Acad Sci U S A (2009) 2.72
The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer (2011) 2.60
YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev (2009) 2.58
Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy. Theranostics (2012) 2.35
Control of the reversibility of cellular quiescence by the transcriptional repressor HES1. Science (2008) 2.29
Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood-brain barrier. Cancer Res (2009) 2.28
Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. EMBO J (2008) 2.25
Hedgehog signaling is dispensable for adult hematopoietic stem cell function. Cell Stem Cell (2009) 1.84
Pleiotropic role for MYCN in medulloblastoma. Genes Dev (2010) 1.84
Notch signaling enhances nestin expression in gliomas. Neoplasia (2006) 1.73
MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma. PLoS One (2009) 1.73
Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway. J Clin Invest (2010) 1.73
Medulloblastoma stem cells. J Clin Oncol (2008) 1.71
Genetically engineered mouse models of brain cancer and the promise of preclinical testing. Brain Pathol (2009) 1.66
Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations. J Clin Invest (2011) 1.65
The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance. Clin Cancer Res (2010) 1.58
Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas. Mol Cancer Ther (2008) 1.56
Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma. Cancer Metab (2013) 1.53
Development and cancer of the cerebellum. Trends Neurosci (2011) 1.47
N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. Genes Dev (2009) 1.45
Cerebellum development and medulloblastoma. Curr Top Dev Biol (2011) 1.40
Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study. J Clin Oncol (2011) 1.39
MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma. PLoS One (2011) 1.38
The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin. J Biol Chem (2009) 1.36
Turning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways. J Biol Chem (2009) 1.33
The perivascular niche microenvironment in brain tumor progression. Cell Cycle (2010) 1.30
Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression. Cancer Res (2013) 1.28
Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.28
Hedgehog signaling promotes medulloblastoma survival via Bc/II. Am J Pathol (2007) 1.22
Notch, neural stem cells, and brain tumors. Cold Spring Harb Symp Quant Biol (2008) 1.19
Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma. Neuro Oncol (2007) 1.16
Interaction of hypoxia-inducible factor-1α and Notch signaling regulates medulloblastoma precursor proliferation and fate. Stem Cells (2010) 1.15
Disease-specific gene repositioning in breast cancer. J Cell Biol (2009) 1.13
Biological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspective. Neuro Oncol (2008) 1.12
ADAM proteases: ligand processing and modulation of the Notch pathway. Cell Mol Life Sci (2008) 1.12
Role of MYC in Medulloblastoma. Cold Spring Harb Perspect Med (2013) 1.10
Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors. PLoS One (2011) 1.10
Notch signalling in cancer progression and bone metastasis. Br J Cancer (2011) 1.09
CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma. Cancer Res (2011) 1.09
The prenatal origins of cancer. Nat Rev Cancer (2014) 1.09
Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells. BMC Cancer (2011) 1.07
Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells. Trends Mol Med (2009) 1.07
Molecular subgroups of medulloblastoma. Expert Rev Neurother (2012) 1.05
Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion. Neoplasia (2008) 1.04
Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy. BMC Cancer (2008) 1.04
p27(Kip1), a double-edged sword in Shh-mediated medulloblastoma: Tumor accelerator and suppressor. Cell Cycle (2010) 1.02
Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization. Cancer Res (2009) 1.01
Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors. Development (2008) 1.01
Progesterone stimulates the proliferation of female and male cholangiocytes via autocrine/paracrine mechanisms. Am J Physiol Gastrointest Liver Physiol (2008) 1.00
Genetic drivers of metastatic dissemination in sonic hedgehog medulloblastoma. Acta Neuropathol Commun (2014) 1.00
NVP-LDE-225 (Erismodegib) inhibits epithelial-mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2Rγ null mice by regulating Bmi-1 and microRNA-128. Oncogenesis (2013) 0.97
Brain tumor susceptibility: the role of genetic factors and uses of mouse models to unravel risk. Brain Pathol (2009) 0.97
The Sex-determining region Y-box 4 and homeobox C6 transcriptional networks in prostate cancer progression: crosstalk with the Wnt, Notch, and PI3K pathways. Am J Pathol (2009) 0.97
Aggressive infantile embryonal tumors. J Child Neurol (2008) 0.96
Notch1 activation is a poor prognostic factor in patients with gastric cancer. Br J Cancer (2014) 0.95
Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups. Proc Natl Acad Sci U S A (2013) 0.95
Notching on Cancer's Door: Notch Signaling in Brain Tumors. Front Oncol (2015) 0.95
Mouse models of medulloblastoma. Chin J Cancer (2011) 0.94
Mechanisms and clinical prospects of Notch inhibitors in the therapy of hematological malignancies. Drug Resist Updat (2008) 0.94
Epigenetic silencing of miRNA-9 is associated with HES1 oncogenic activity and poor prognosis of medulloblastoma. Br J Cancer (2013) 0.94
The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15, and epigenetic modifications in medulloblastoma. Neuro Oncol (2012) 0.94
Hepatocyte growth factor and sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and growth. Cancer Res (2008) 0.94
The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation. PLoS One (2011) 0.94
Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma. Acta Neuropathol (2012) 0.93
Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells. Philos Trans R Soc Lond B Biol Sci (2008) 0.93
Sequential activation of Snail1 and N-Myc modulates sonic hedgehog-induced transformation of neural cells. Cancer Res (2011) 0.92
The rationale for targeted therapies in medulloblastoma. Neuro Oncol (2013) 0.92
Origins and clinical implications of the brain tumor stem cell hypothesis. J Neurooncol (2009) 0.92
Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas. Cancer Genet Cytogenet (2008) 0.92
Sonic hedgehog acts as a negative regulator of {beta}-catenin signaling in the adult tongue epithelium. Am J Pathol (2010) 0.92
Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis. Cell Rep (2015) 0.92
Sonic hedgehog-induced histone deacetylase activation is required for cerebellar granule precursor hyperplasia in medulloblastoma. PLoS One (2013) 0.91
Functional genomics identifies drivers of medulloblastoma dissemination. Cancer Res (2012) 0.91
A distinct Smoothened mutation causes severe cerebellar developmental defects and medulloblastoma in a novel transgenic mouse model. Mol Cell Biol (2012) 0.91
Hedgehog signaling patterns mesoderm in the sea urchin. Dev Biol (2009) 0.90
NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200. Neuro Oncol (2013) 0.90
Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation. Oncogene (2012) 0.89
¹H nuclear magnetic resonance spectroscopy characterisation of metabolic phenotypes in the medulloblastoma of the SMO transgenic mice. Br J Cancer (2010) 0.89
The different role of Notch1 and Notch2 in astrocytic gliomas. PLoS One (2013) 0.89
BMPs oppose Math1 in cerebellar development and in medulloblastoma. Genes Dev (2008) 0.88
Clinical implications of hedgehog signaling pathway inhibitors. Chin J Cancer (2011) 0.88
Targeting Notch pathway induces growth inhibition and differentiation of neuroblastoma cells. Neuro Oncol (2010) 0.88
WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma. Oncogene (2016) 0.87
NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivo. PLoS One (2013) 0.87
Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy. J Med Chem (2011) 0.87
F3/contactin and TAG1 play antagonistic roles in the regulation of sonic hedgehog-induced cerebellar granule neuron progenitor proliferation. Development (2011) 0.87
Targeted STAT3 disruption in myeloid cells alters immunosuppressor cell abundance in a murine model of spontaneous medulloblastoma. J Leukoc Biol (2013) 0.86
NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma. Acta Neuropathol Commun (2014) 0.86
WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation. PLoS One (2013) 0.86
Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma. Oncogene (2012) 0.86
Enteric neural crest differentiation in ganglioneuromas implicates Hedgehog signaling in peripheral neuroblastic tumor pathogenesis. PLoS One (2009) 0.85
REST is a novel prognostic factor and therapeutic target for medulloblastoma. Mol Cancer Ther (2012) 0.85
Molecular therapy targeting Sonic hedgehog and hepatocyte growth factor signaling in a mouse model of medulloblastoma. Mol Cancer Ther (2010) 0.85
Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature (2002) 15.36
Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport held in Zurich, November 2012. Br J Sports Med (2013) 6.69
Medulloblastoma growth inhibition by hedgehog pathway blockade. Science (2002) 6.53
Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med (2010) 5.84
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. J Clin Oncol (2010) 4.48
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell (2010) 4.21
Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature (2012) 4.13
Regional and cellular gene expression changes in human Huntington's disease brain. Hum Mol Genet (2006) 3.91
Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma. J Clin Oncol (2011) 3.56
Tumor paint: a chlorotoxin:Cy5.5 bioconjugate for intraoperative visualization of cancer foci. Cancer Res (2007) 3.25
Colonoscopy training in gastroenterology fellowships: determining competence. Gastrointest Endosc (2009) 3.15
Single-unit dominance after double-unit umbilical cord blood transplantation coincides with a specific CD8+ T-cell response against the nonengrafted unit. Blood (2009) 3.05
Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell (2008) 2.83
Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells. Blood (2005) 2.73
Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial. Lancet Neurol (2007) 2.68
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Hum Mol Genet (2007) 2.54
Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided the stage of fibrosis is considered. J Hepatol (2009) 2.30
Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood-brain barrier. Cancer Res (2009) 2.28
SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML. Blood (2013) 2.26
Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain. Hum Mol Genet (2002) 2.17
Regulation of thalamocortical patterning and synaptic maturation by NeuroD2. Neuron (2006) 2.15
Ex vivo expansion of human hematopoietic stem and progenitor cells. Blood (2011) 2.12
In vivo MRI detection of gliomas by chlorotoxin-conjugated superparamagnetic nanoprobes. Small (2008) 2.09
Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence. Cancer (2005) 2.08
Acute care clinical indicators associated with discharge outcomes in children with severe traumatic brain injury. Crit Care Med (2014) 2.04
Acute myeloid leukemia stem cells and CD33-targeted immunotherapy. Blood (2012) 2.03
Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability. Blood (2002) 2.00
The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread. Cancer Res (2008) 1.84
Significance testing for small microarray experiments. Stat Med (2005) 1.80
Design of highly emissive polymer dot bioconjugates for in vivo tumor targeting. Angew Chem Int Ed Engl (2011) 1.76
Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells. J Clin Invest (2002) 1.72
Guideline Adherence and Hospital Costs in Pediatric Severe Traumatic Brain Injury. Pediatr Crit Care Med (2016) 1.69
Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease. J Neurosci (2005) 1.68
Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell (2013) 1.68
BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. Nat Med (2003) 1.67
Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. J Neurosci (2007) 1.66
N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res (2006) 1.64
Diffusion tensor imaging of the superior cerebellar peduncle identifies patients with posterior fossa syndrome. Childs Nerv Syst (2013) 1.61
Cytogenetic prognostication within medulloblastoma subgroups. J Clin Oncol (2014) 1.56
Biomarkers: mining the biofluid proteome. Mol Cell Proteomics (2005) 1.55
Targeted cell uptake of a noninternalizing antibody through conjugation to iron oxide nanoparticles in primary central nervous system lymphoma. World Neurosurg (2013) 1.54
Chlorotoxin labeled magnetic nanovectors for targeted gene delivery to glioma. ACS Nano (2010) 1.52
PEG-mediated synthesis of highly dispersive multifunctional superparamagnetic nanoparticles: their physicochemical properties and function in vivo. ACS Nano (2010) 1.52
Incidence of hypo- and hypercarbia in severe traumatic brain injury before and after 2003 pediatric guidelines. Pediatr Crit Care Med (2008) 1.51
E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors. J Immunol (2008) 1.51
Gene expression in Huntington's disease skeletal muscle: a potential biomarker. Hum Mol Genet (2005) 1.51
Consensus statement on concussion in sport--the 4th International Conference on Concussion in Sport held in Zurich, November 2012. Clin J Sport Med (2013) 1.50
National variability in intracranial pressure monitoring and craniotomy for children with moderate to severe traumatic brain injury. Neurosurgery (2013) 1.48
Conservation of regional gene expression in mouse and human brain. PLoS Genet (2007) 1.47
High-dose chemo-radioimmunotherapy with autologous stem cell support for relapsed mantle cell lymphoma. Blood (2002) 1.45
Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses. Hum Mol Genet (2002) 1.45
A regression-based method to identify differentially expressed genes in microarray time course studies and its application in an inducible Huntington's disease transgenic model. Hum Mol Genet (2002) 1.43
Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia. Blood (2003) 1.43
PEI-PEG-Chitosan Copolymer Coated Iron Oxide Nanoparticles for Safe Gene Delivery: synthesis, complexation, and transfection. Adv Funct Mater (2009) 1.42
Nonprogrammable and programmable cerebrospinal fluid shunt valves: a 5-year study. J Neurosurg Pediatr (2012) 1.42
Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity. Hum Mol Genet (2005) 1.42
Intracerebral abscess associated with the Camino intracranial pressure monitor: case report and review of the literature. Neurosurgery (2012) 1.41
Is Chiari I malformation associated with fibromyalgia? Neurosurgery (2011) 1.41
Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor. Hum Mol Genet (2002) 1.41
Brainstem hypertrophy, acquired Chiari malformation, syringomyelia, and hydrocephalus: diagnostic dilemma. J Neurosurg Pediatr (2011) 1.40
Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease. Hum Mol Genet (2005) 1.39
Delivery of emergency neurosurgical care. J Am Coll Surg (2006) 1.38
Isolated sagittal and coronal craniosynostosis associated with TWIST box mutations. Am J Med Genet A (2007) 1.37
Review Article: Chiari Type I Malformation with or Without Syringomyelia: Prevalence and Genetics. J Genet Couns (2003) 1.37
Doxorubicin loaded iron oxide nanoparticles overcome multidrug resistance in cancer in vitro. J Control Release (2011) 1.36
Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells. J Exp Med (2005) 1.35
Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012. J Clin Oncol (2008) 1.33
Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects. Hum Mol Genet (2002) 1.33
Failure of autologous bone-assisted cranioplasty following decompressive craniectomy in children and adolescents. J Neurosurg (2004) 1.32
Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin-induced cytotoxicity. Blood (2004) 1.32
Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A. Genes Dev (2013) 1.31
Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells. J Clin Invest (2011) 1.29
Chlorotoxin bound magnetic nanovector tailored for cancer cell targeting, imaging, and siRNA delivery. Biomaterials (2010) 1.29
DNA methylation of developmental genes in pediatric medulloblastomas identified by denaturation analysis of methylation differences. Proc Natl Acad Sci U S A (2009) 1.26
Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. Genes Dev (2008) 1.25
Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data. BMC Bioinformatics (2006) 1.24
O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines. Clin Cancer Res (2005) 1.23
Tumor-targeted drug delivery and MRI contrast enhancement by chlorotoxin-conjugated iron oxide nanoparticles. Nanomedicine (Lond) (2008) 1.22
The dosage of the neuroD2 transcription factor regulates amygdala development and emotional learning. Proc Natl Acad Sci U S A (2005) 1.19
Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites. Nat Commun (2013) 1.18
Multidrug resistance protein attenuates gemtuzumab ozogamicin-induced cytotoxicity in acute myeloid leukemia cells. Blood (2003) 1.18
A class of models for analyzing GeneChip gene expression analysis array data. BMC Genomics (2005) 1.18