Published in J Clin Invest on March 01, 2011
Ex vivo expansion of human hematopoietic stem and progenitor cells. Blood (2011) 2.12
The bone marrow at the crossroads of blood and immunity. Nat Rev Immunol (2011) 2.07
Hematopoietic stem cell niche maintenance during homeostasis and regeneration. Nat Med (2014) 2.05
Notch signaling: switching an oncogene to a tumor suppressor. Blood (2014) 1.32
Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis. Cell Rep (2013) 1.32
Blockade of individual Notch ligands and receptors controls graft-versus-host disease. J Clin Invest (2013) 1.27
In vivo mapping of notch pathway activity in normal and stress hematopoiesis. Cell Stem Cell (2013) 1.14
NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation. J Clin Invest (2014) 1.03
The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs. Blood (2011) 1.02
Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions. Blood (2011) 0.99
Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling. Blood (2013) 0.98
Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia. J Exp Med (2013) 0.97
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells. J Clin Invest (2015) 0.97
Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells. Blood (2012) 0.95
NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One (2012) 0.87
LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance. Blood (2012) 0.87
Hematopoietic stem cell development, niches, and signaling pathways. Bone Marrow Res (2012) 0.87
Notch signaling in skeletal stem cells. Calcif Tissue Int (2013) 0.86
Regulation of dendritic cell differentiation in bone marrow during emergency myelopoiesis. J Immunol (2013) 0.85
The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells. Genes Dev (2014) 0.85
Human T-lymphoid progenitors generated in a feeder-cell-free Delta-like-4 culture system promote T-cell reconstitution in NOD/SCID/γc(-/-) mice. Stem Cells (2012) 0.84
The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis. Development (2015) 0.83
Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention. Stem Cells (2015) 0.81
Notch signaling in the malignant bone marrow microenvironment: implications for a niche-based model of oncogenesis. Ann N Y Acad Sci (2014) 0.80
The NOTCH signaling pathway in normal and malignant blood cell production. J Cell Commun Signal (2015) 0.80
The haematopoietic stem cell niche: new insights into the mechanisms regulating haematopoietic stem cell behaviour. Stem Cells Int (2011) 0.79
The regulation of normal and leukemic hematopoietic stem cells by niches. Cancer Microenviron (2012) 0.79
Contrasting roles for C/EBPα and Notch in irradiation-induced multipotent hematopoietic progenitor cell defects. Stem Cells (2015) 0.79
Abnormal liver differentiation and excessive angiogenesis in mice lacking Runx3. Histochem Cell Biol (2013) 0.78
Adult haematopoietic stem cell niches. Nat Rev Immunol (2017) 0.77
Notch signaling in hematopoietic cell transplantation and T cell alloimmunity. Blood Rev (2013) 0.76
Notch Stimulates Both Self-Renewal and Lineage Plasticity in a Subset of Murine CD9High Committed Megakaryocytic Progenitors. PLoS One (2016) 0.75
Developing HSCs become Notch independent by the end of maturation in the AGM region. Blood (2016) 0.75
Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors. Stem Cells (2017) 0.75
Notch and human hematopoietic stem cells. Blood (2014) 0.75
Notch Signaling and Alloreactivity. Transplantation (2016) 0.75
Evolved Cellular Mechanisms to Respond to Genotoxic Insults: Implications for Radiation-Induced Hematologic Malignancies. Radiat Res (2015) 0.75
PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma. Sci Rep (2017) 0.75
Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation. Sci Rep (2016) 0.75
Myeloproliferation and hematopoietic stem cell dysfunction due to defective Notch receptor modification by O-fucose glycans. Semin Immunopathol (2012) 0.75
Notch2 blockade enhances hematopoietic stem cell mobilization and homing. Haematologica (2017) 0.75
Osteoblastic cells regulate the haematopoietic stem cell niche. Nature (2003) 19.60
Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity (1999) 8.33
Coexistence of quiescent and active adult stem cells in mammals. Science (2010) 7.54
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol (2005) 6.49
Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med (2010) 5.84
Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity (1999) 5.34
Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med (2000) 4.55
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell (2010) 4.21
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity (2003) 3.73
Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev (2005) 3.27
Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell (2008) 3.08
Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science (2007) 2.92
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2. Nat Cell Biol (2000) 2.83
Notch signaling in stem cell systems. Stem Cells (2006) 2.82
Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood (2002) 2.66
Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling. J Cell Sci (2000) 2.57
Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood (2004) 2.44
Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem (2005) 2.33
The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells. Blood (1998) 2.05
Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J Exp Med (2001) 2.02
Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability. Blood (2002) 2.00
Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. J Exp Med (2001) 1.94
Balancing dormant and self-renewing hematopoietic stem cells. Curr Opin Genet Dev (2009) 1.77
Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol Biol Cell (2004) 1.71
Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors. Blood (2004) 1.68
HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding. Stem Cells (2006) 1.66
Notch signaling specifies megakaryocyte development from hematopoietic stem cells. Cell Stem Cell (2008) 1.58
Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches. Nat Immunol (2006) 1.57
HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo. Blood (2002) 1.51
Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells. J Exp Med (2005) 1.35
Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells. J Immunol (2003) 1.28
Purification of hematopoietic stem cells using the side population. Methods Enzymol (2006) 1.01
A re-evaluation of the contributions of Apterous and Notch to the dorsoventral lineage restriction boundary in the Drosophila wing. Development (2003) 0.98
Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1 B cells. Mol Cell Biol (2003) 0.97
Effects of Delta1 and Jagged1 on early human hematopoiesis: correlation with expression of notch signaling-related genes in CD34+ cells. Stem Cells (2006) 0.95
Biological functions of glycosyltransferase genes involved in O-fucose glycan synthesis. J Biochem (2008) 0.86
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49
Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76
Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med (2010) 5.84
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell (2010) 4.21
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev (2004) 3.95
Transcription factor RORα is critical for nuocyte development. Nat Immunol (2012) 3.72
The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res (2004) 3.33
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
Beta-catenin is dispensable for hematopoiesis and lymphopoiesis. J Exp Med (2004) 3.16
Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell (2008) 3.08
Single-unit dominance after double-unit umbilical cord blood transplantation coincides with a specific CD8+ T-cell response against the nonengrafted unit. Blood (2009) 3.05
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep (2008) 3.03
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. Genes Dev (2004) 3.00
Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology (2011) 2.94
Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes. J Cell Physiol (2005) 2.91
A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development (2002) 2.88
Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes. Immunity (2002) 2.83
Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell (2008) 2.83
Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells. Blood (2005) 2.73
gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell (2004) 2.68
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci U S A (2009) 2.63
The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. PLoS Genet (2006) 2.56
Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood (2004) 2.44
The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development (2005) 2.36
Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron (2008) 2.31
Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity (2010) 2.29
Essential role of endothelial Notch1 in angiogenesis. Circulation (2005) 2.28
SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML. Blood (2013) 2.26
Notch signaling is required for exocrine regeneration after acute pancreatitis. Gastroenterology (2007) 2.26
Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice. Hepatology (2008) 2.21
Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J Exp Med (2008) 2.17
Multiple functions of Notch signaling in self-renewing organs and cancer. FEBS Lett (2006) 2.14
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature (2012) 2.13
Ex vivo expansion of human hematopoietic stem and progenitor cells. Blood (2011) 2.12
Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence. Cancer (2005) 2.08
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood (2004) 2.06
Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis. Blood (2007) 2.06
Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms. Immunity (2008) 2.05
Acute myeloid leukemia stem cells and CD33-targeted immunotherapy. Blood (2012) 2.03
Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability. Blood (2002) 2.00
Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nat Neurosci (2009) 1.93
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92
Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res (2006) 1.91
Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma. Proc Natl Acad Sci U S A (2010) 1.84
Hedgehog signaling is dispensable for adult hematopoietic stem cell function. Cell Stem Cell (2009) 1.84
Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation. Genesis (2003) 1.84
Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes Dev (2005) 1.81
Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage. Hepatology (2007) 1.78
Notch inhibits osteoblast differentiation and causes osteopenia. Endocrinology (2008) 1.78
Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome. Development (2010) 1.78
Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev (2003) 1.76
Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling. Circ Res (2006) 1.75
Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice. Hepatology (2005) 1.73
Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation. J Exp Med (2007) 1.73
Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells. J Neurosci (2010) 1.72
Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells. J Clin Invest (2002) 1.72
Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1. EMBO J (2008) 1.71
Notch1 is required for neuronal and glial differentiation in the cerebellum. Development (2002) 1.69
Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal. EMBO J (2005) 1.68
Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Mol Cell Biol (2008) 1.68
Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell (2013) 1.68
Notch-induced T cell development requires phosphoinositide-dependent kinase 1. EMBO J (2007) 1.67
Notch signaling in solid tumors. Curr Top Dev Biol (2010) 1.66
Notch1 control of oligodendrocyte differentiation in the spinal cord. J Cell Biol (2002) 1.65
Loss of notch activity in the developing central nervous system leads to increased cell death. Dev Neurosci (2006) 1.65
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL. Blood (2010) 1.60
Notch signaling regulates bile duct morphogenesis in mice. PLoS One (2008) 1.59
Smooth muscle Notch1 mediates neointimal formation after vascular injury. Circulation (2009) 1.58
Multiple roles of Notch signaling in the regulation of epidermal development. Dev Cell (2008) 1.58
Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc Natl Acad Sci U S A (2006) 1.58
Loss of cutaneous TSLP-dependent immune responses skews the balance of inflammation from tumor protective to tumor promoting. Cancer Cell (2012) 1.56
Generation of new Notch2 mutant alleles. Genesis (2006) 1.56
Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation. Dev Biol (2005) 1.54
E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors. J Immunol (2008) 1.51
Slug is a novel downstream target of MyoD. Temporal profiling in muscle regeneration. J Biol Chem (2002) 1.50
Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism. Dev Cell (2007) 1.49
Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors. J Neurosci (2004) 1.48
Stem cells living with a Notch. Development (2013) 1.48
Notch1 is essential for postnatal hair follicle development and homeostasis. Dev Biol (2005) 1.48
DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport. J Clin Invest (2015) 1.45
Multiple functions of Snail family genes during palate development in mice. Development (2007) 1.45
High-dose chemo-radioimmunotherapy with autologous stem cell support for relapsed mantle cell lymphoma. Blood (2002) 1.45
Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia. Blood (2003) 1.43
Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner. Dev Dyn (2007) 1.40
Notch signaling in lymphopoiesis. Semin Immunol (2003) 1.37
Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development. Dev Dyn (2006) 1.37
Notch in T-ALL: new players in a complex disease. Trends Immunol (2011) 1.35
Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis. Immunity (2010) 1.35
Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells. J Exp Med (2005) 1.35
Mechanisms of T cell development and transformation. Annu Rev Cell Dev Biol (2011) 1.33