A novel sensor kinase-response regulator hybrid regulates type III secretion and is required for virulence in Pseudomonas aeruginosa.

PubWeight™: 1.62‹?› | Rank: Top 4%

🔗 View Article (PMC 3650721)

Published in Mol Microbiol on November 01, 2004

Authors

Michelle A Laskowski1, Ellice Osborn, Barbara I Kazmierczak

Author Affiliations

1: Program in Microbiology, Yale University School of Medicine, P O Box 208022, New Haven, CT 06520-8022, USA.

Articles citing this

A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria. Cell Host Microbe (2010) 4.98

The type III secretion system of Pseudomonas aeruginosa: infection by injection. Nat Rev Microbiol (2009) 3.56

Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes. Proc Natl Acad Sci U S A (2005) 3.31

Analysis of FimX, a phosphodiesterase that governs twitching motility in Pseudomonas aeruginosa. Mol Microbiol (2006) 2.22

Keeping their options open: acute versus persistent infections. J Bacteriol (2006) 2.14

Direct interaction between sensor kinase proteins mediates acute and chronic disease phenotypes in a bacterial pathogen. Genes Dev (2009) 1.82

FlhF is required for swimming and swarming in Pseudomonas aeruginosa. J Bacteriol (2006) 1.50

Metabolic regulation of type III secretion gene expression in Pseudomonas aeruginosa. Mol Microbiol (2006) 1.47

Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafish embryos. Cell Microbiol (2009) 1.45

The novel two-component regulatory system BfiSR regulates biofilm development by controlling the small RNA rsmZ through CafA. J Bacteriol (2010) 1.29

Structure of a peptidoglycan amidase effector targeted to Gram-negative bacteria by the type VI secretion system. Cell Rep (2012) 1.28

Regulatory RNAs and the HptB/RetS signalling pathways fine-tune Pseudomonas aeruginosa pathogenesis. Mol Microbiol (2010) 1.25

Mutational analysis of RetS, an unusual sensor kinase-response regulator hybrid required for Pseudomonas aeruginosa virulence. Infect Immun (2006) 1.23

Pseudomonas aeruginosa induces membrane blebs in epithelial cells, which are utilized as a niche for intracellular replication and motility. Infect Immun (2008) 1.22

Characterization of the histidine-containing phosphotransfer protein B-mediated multistep phosphorelay system in Pseudomonas aeruginosa PAO1. J Biol Chem (2008) 1.18

Type III secretion-dependent modulation of innate immunity as one of multiple factors regulated by Pseudomonas aeruginosa RetS. Infect Immun (2006) 1.17

Pseudomonas aeruginosa RsmA plays an important role during murine infection by influencing colonization, virulence, persistence, and pulmonary inflammation. Infect Immun (2007) 1.11

Cross talk between type III secretion and flagellar assembly systems in Pseudomonas aeruginosa. J Bacteriol (2007) 1.10

Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection. Mol Microbiol (2009) 1.09

PtrB of Pseudomonas aeruginosa suppresses the type III secretion system under the stress of DNA damage. J Bacteriol (2005) 1.06

SagS contributes to the motile-sessile switch and acts in concert with BfiSR to enable Pseudomonas aeruginosa biofilm formation. J Bacteriol (2011) 1.05

The posttranscriptional regulator RsmA plays a role in the interaction between Pseudomonas aeruginosa and human airway epithelial cells by positively regulating the type III secretion system. Infect Immun (2006) 1.05

The AlgZR two-component system recalibrates the RsmAYZ posttranscriptional regulatory system to inhibit expression of the Pseudomonas aeruginosa type III secretion system. J Bacteriol (2013) 0.96

PsrA is a positive transcriptional regulator of the type III secretion system in Pseudomonas aeruginosa. Infect Immun (2006) 0.94

Modulation of bacterial Type III secretion system by a spermidine transporter dependent signaling pathway. PLoS One (2007) 0.94

An indirect enzyme-linked immunosorbent assay for rapid and quantitative assessment of Type III virulence phenotypes of Pseudomonas aeruginosa isolates. Ann Clin Microbiol Antimicrob (2005) 0.90

Cheating by type 3 secretion system-negative Pseudomonas aeruginosa during pulmonary infection. Proc Natl Acad Sci U S A (2014) 0.90

MarA, SoxS and Rob of Escherichia coli - Global regulators of multidrug resistance, virulence and stress response. Int J Biotechnol Wellness Ind (2013) 0.87

The GTPase activity of FlhF is dispensable for flagellar localization, but not motility, in Pseudomonas aeruginosa. J Bacteriol (2012) 0.86

A conservative amino acid mutation in the master regulator FleQ renders Pseudomonas aeruginosa aflagellate. PLoS One (2014) 0.84

The RNA Helicase DeaD Stimulates ExsA Translation To Promote Expression of the Pseudomonas aeruginosa Type III Secretion System. J Bacteriol (2015) 0.83

BdlA, DipA and induced dispersion contribute to acute virulence and chronic persistence of Pseudomonas aeruginosa. PLoS Pathog (2014) 0.82

Eradication of Pseudomonas aeruginosa biofilms on cultured airway cells by a fosfomycin/tobramycin antibiotic combination. Pathog Dis (2013) 0.80

The Hybrid Histidine Kinase LadS Forms a Multicomponent Signal Transduction System with the GacS/GacA Two-Component System in Pseudomonas aeruginosa. PLoS Genet (2016) 0.78

Characterization of the AtsR hybrid sensor kinase phosphorelay pathway and identification of its response regulator in Burkholderia cenocepacia. J Biol Chem (2013) 0.78

Pseudomonas aeruginosa cytotoxicity is attenuated at high cell density and associated with the accumulation of phenylacetic acid. PLoS One (2013) 0.78

The global regulator Crc plays a multifaceted role in modulation of type III secretion system in Pseudomonas aeruginosa. Microbiologyopen (2013) 0.76

Sit and stay a while: how BfiSR controls irreversible attachment in Pseudomonas aeruginosa biofilms. J Bacteriol (2010) 0.75

Modulation of Type III Secretion System in Pseudomonas aeruginosa: Involvement of the PA4857 Gene Product. Front Microbiol (2016) 0.75

Human Tear Fluid Reduces Culturability of Contact Lens Associated Pseudomonas aeruginosa Biofilms but Induces Expression of the Virulence Associated Type III Secretion System. Ocul Surf (2016) 0.75

Dynamics of sequestration-based gene regulatory cascades. Nucleic Acids Res (2017) 0.75

The Pseudomonas aeruginosa Magnesium Transporter MgtE Inhibits Type III Secretion System Gene Expression by Stimulating rsmYZ Transcription. J Bacteriol (2017) 0.75

Articles cited by this

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31

Acetylornithinase of Escherichia coli: partial purification and some properties. J Biol Chem (1956) 93.84

The Pfam protein families database. Nucleic Acids Res (2002) 51.34

Improved prediction of signal peptides: SignalP 3.0. J Mol Biol (2004) 48.40

Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J Bacteriol (1995) 46.37

Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature (2000) 32.30

A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants. Gene (1998) 15.03

Molecular cloning of the plasmid RP4 primase region in a multi-host-range tacP expression vector. Gene (1986) 13.92

The roles of various fractions of Pseudomonas aeruginosa in its pathogenesis. 3. Identity of the lethal toxins produced in vitro and in vivo. J Infect Dis (1966) 6.39

Assembly and function of type III secretory systems. Annu Rev Microbiol (2000) 5.70

The pleiotropic two-component regulatory system PhoP-PhoQ. J Bacteriol (2001) 5.70

An improved system for gene replacement and xylE fusion analysis in Pseudomonas aeruginosa. Gene (1995) 5.18

ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury. Mol Microbiol (1997) 4.94

Bacteria-host communication: the language of hormones. Proc Natl Acad Sci U S A (2003) 4.38

The exoenzyme S regulon of Pseudomonas aeruginosa. Mol Microbiol (1997) 4.07

Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections. J Infect Dis (2001) 4.06

ExoY, an adenylate cyclase secreted by the Pseudomonas aeruginosa type III system. Proc Natl Acad Sci U S A (1998) 4.04

Signal transduction via the multi-step phosphorelay: not necessarily a road less traveled. Cell (1996) 3.80

Coordinate regulation of bacterial virulence genes by a novel adenylate cyclase-dependent signaling pathway. Dev Cell (2003) 3.72

Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa. Crit Care Med (2002) 3.63

Exoenzyme S of Pseudomonas aeruginosa is secreted by a type III pathway. Mol Microbiol (1996) 3.55

Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa. Microbiology (2001) 3.20

The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU. EMBO J (2003) 3.10

Isolation and characterization of transposon-induced mutants of Pseudomonas aeruginosa deficient in production of exoenzyme S. Infect Immun (1984) 3.01

PepA, a secreted protein of Pseudomonas aeruginosa, is necessary for cytotoxicity and virulence. Mol Microbiol (1998) 2.83

The N-terminal domain of Pseudomonas aeruginosa exoenzyme S is a GTPase-activating protein for Rho GTPases. J Biol Chem (1999) 2.78

Integration-proficient Pseudomonas aeruginosa vectors for isolation of single-copy chromosomal lacZ and lux gene fusions. Biotechniques (2000) 2.73

Identification of a novel response regulator required for the swarmer-to-stalked-cell transition in Caulobacter crescentus. J Bacteriol (1995) 2.68

Identification of type III secreted products of the Pseudomonas aeruginosa exoenzyme S regulon. J Bacteriol (1997) 2.58

Quorum sensing regulates type III secretion in Vibrio harveyi and Vibrio parahaemolyticus. J Bacteriol (2004) 2.55

Integration of multiple domains in a two-component sensor protein: the Bordetella pertussis BvgAS phosphorelay. EMBO J (1996) 2.41

Regulation of ExoS production and secretion by Pseudomonas aeruginosa in response to tissue culture conditions. Infect Immun (1999) 2.32

Analyses of the DNA-binding and transcriptional activation properties of ExsA, the transcriptional activator of the Pseudomonas aeruginosa exoenzyme S regulon. J Bacteriol (1995) 2.32

Transcriptional analysis of the Pseudomonas aeruginosa exoenzyme S structural gene. J Bacteriol (1995) 2.27

ExsD is a negative regulator of the Pseudomonas aeruginosa type III secretion regulon. Mol Microbiol (2002) 2.18

Identification of Pseudomonas aeruginosa genes required for epithelial cell injury. Mol Microbiol (1997) 2.03

The BvgAS virulence control system regulates type III secretion in Bordetella bronchiseptica. Mol Microbiol (1998) 1.99

Two-component systems in Pseudomonas aeruginosa: why so many? Trends Microbiol (2000) 1.94

The arginine finger domain of ExoT contributes to actin cytoskeleton disruption and inhibition of internalization of Pseudomonas aeruginosa by epithelial cells and macrophages. Infect Immun (2000) 1.90

Secretion of the toxin ExoU is a marker for highly virulent Pseudomonas aeruginosa isolates obtained from patients with hospital-acquired pneumonia. J Infect Dis (2003) 1.90

Morphogenetic expression of Bacteroides nodosus fimbriae in Pseudomonas aeruginosa. J Bacteriol (1987) 1.85

A novel anti-anti-activator mechanism regulates expression of the Pseudomonas aeruginosa type III secretion system. Mol Microbiol (2004) 1.84

In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors. J Biol Chem (2003) 1.84

Transcriptional organization of the trans-regulatory locus which controls exoenzyme S synthesis in Pseudomonas aeruginosa. J Bacteriol (1994) 1.82

The amino-terminal domain of Pseudomonas aeruginosa ExoS disrupts actin filaments via small-molecular-weight GTP-binding proteins. Mol Microbiol (1999) 1.81

Effect of metabolic imbalance on expression of type III secretion genes in Pseudomonas aeruginosa. Infect Immun (2004) 1.78

An adenylate cyclase-controlled signaling network regulates Pseudomonas aeruginosa virulence in a mouse model of acute pneumonia. Infect Immun (2004) 1.70

Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cells. Nat Cell Biol (2003) 1.66

Pseudomonas aeruginosa ExoT ADP-ribosylates CT10 regulator of kinase (Crk) proteins. J Biol Chem (2003) 1.60

Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol (2002) 1.56

Regulation of type III secretion systems. Curr Opin Microbiol (2002) 1.48

ExoT of cytotoxic Pseudomonas aeruginosa prevents uptake by corneal epithelial cells. Infect Immun (2000) 1.43

Genomic analysis of the histidine kinase family in bacteria and archaea. Microbiology (2001) 1.43

Construction of improved vectors for protein production in Pseudomonas aeruginosa. Gene (1996) 1.38

Pseudomonas aeruginosa ExoT acts in vivo as a GTPase-activating protein for RhoA, Rac1, and Cdc42. Infect Immun (2002) 1.29

Pseudomonas aeruginosa exoenzyme S disrupts Ras-mediated signal transduction by inhibiting guanine nucleotide exchange factor-catalyzed nucleotide exchange. J Biol Chem (1999) 1.28

The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities. Infect Immun (2004) 1.25

Dual function of PilS during transcriptional activation of the Pseudomonas aeruginosa pilin subunit gene. J Bacteriol (1996) 1.21

Pseudomonas aeruginosa exoenzyme S is a biglutamic acid ADP-ribosyltransferase. Infect Immun (1999) 1.19

An interactive web-based Pseudomonas aeruginosa genome database: discovery of new genes, pathways and structures. Microbiology (2000) 1.15

Connections between transcriptional regulation and type III secretion? Curr Opin Microbiol (2002) 1.12

An immunological analysis of Ty1 virus-like particle structure. Virology (1995) 1.09

Triggering the ExoS regulon of Pseudomonas aeruginosa: A GFP-reporter analysis of exoenzyme (Exo) S, ExoT and ExoU synthesis. Microb Pathog (2000) 1.08

Articles by these authors

Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med (2007) 4.95

Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients. Curr Opin Pediatr (2007) 1.65

FlhF is required for swimming and swarming in Pseudomonas aeruginosa. J Bacteriol (2006) 1.50

Innate immune responses to Pseudomonas aeruginosa infection. Microbes Infect (2011) 1.33

Pseudomonas aeruginosa exhibits sliding motility in the absence of type IV pili and flagella. J Bacteriol (2007) 1.28

Mutational analysis of RetS, an unusual sensor kinase-response regulator hybrid required for Pseudomonas aeruginosa virulence. Infect Immun (2006) 1.23

Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection. Mol Microbiol (2009) 1.09

Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. J Immunol (2011) 1.08

In vivo discrimination of type 3 secretion system-positive and -negative Pseudomonas aeruginosa via a caspase-1-dependent pathway. Infect Immun (2010) 1.01

Swarming motility, secretion of type 3 effectors and biofilm formation phenotypes exhibited within a large cohort of Pseudomonas aeruginosa clinical isolates. J Med Microbiol (2010) 1.01

Type IV pilus assembly in Pseudomonas aeruginosa over a broad range of cyclic di-GMP concentrations. J Bacteriol (2012) 0.94

Flagellar motility is a key determinant of the magnitude of the inflammasome response to Pseudomonas aeruginosa. Infect Immun (2013) 0.92

A biosynthetic strategy for re-engineering the Staphylococcus aureus cell wall with non-native small molecules. ACS Chem Biol (2010) 0.91

An indirect enzyme-linked immunosorbent assay for rapid and quantitative assessment of Type III virulence phenotypes of Pseudomonas aeruginosa isolates. Ann Clin Microbiol Antimicrob (2005) 0.90

The carbon monoxide releasing molecule CORM-2 attenuates Pseudomonas aeruginosa biofilm formation. PLoS One (2012) 0.87

The GTPase activity of FlhF is dispensable for flagellar localization, but not motility, in Pseudomonas aeruginosa. J Bacteriol (2012) 0.86

The ability of virulence factor expression by Pseudomonas aeruginosa to predict clinical disease in hospitalized patients. PLoS One (2012) 0.83

Inflammation: A Double-Edged Sword in the Response to Pseudomonas aeruginosa Infection. J Innate Immun (2017) 0.75