Published in J Appl Genet on January 01, 2004
δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders. J Biol Chem (2012) 1.23
Neuropsychological profile of adult patients with Niemann-Pick C1 (NPC1) mutations. J Inherit Metab Dis (2006) 1.15
Microarray expression analysis and identification of serum biomarkers for Niemann-Pick disease, type C1. Hum Mol Genet (2012) 1.10
Treatment of Niemann--pick type C disease by histone deacetylase inhibitors. Neurotherapeutics (2013) 1.02
Oxidative stress: a pathogenic mechanism for Niemann-Pick type C disease. Oxid Med Cell Longev (2012) 0.90
Alterations in oxidative markers in the cerebellum and peripheral organs in MPS I mice. Cell Mol Neurobiol (2008) 0.88
Altered vitamin E status in Niemann-Pick type C disease. J Lipid Res (2011) 0.84
Niemann-Pick type C disease proteins: orphan transporters or membrane rheostats? Future Lipidol (2007) 0.78
Vitamin E dietary supplementation improves neurological symptoms and decreases c-Abl/p73 activation in Niemann-Pick C mice. Nutrients (2014) 0.78
Why do cancers have high aerobic glycolysis? Nat Rev Cancer (2004) 20.60
A microenvironmental model of carcinogenesis. Nat Rev Cancer (2008) 4.40
Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol (2006) 3.98
Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res (2006) 3.90
De novo pathogenic SCN8A mutation identified by whole-genome sequencing of a family quartet affected by infantile epileptic encephalopathy and SUDEP. Am J Hum Genet (2012) 3.58
Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res (2009) 3.40
Adaptive therapy. Cancer Res (2009) 2.81
Radiomics: the process and the challenges. Magn Reson Imaging (2012) 2.65
Acidity generated by the tumor microenvironment drives local invasion. Cancer Res (2013) 2.63
The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice. Mol Cell Biol (2003) 2.52
Recent advances in BazookaSPECT: Real-time data processing and the development of a gamma-ray microscope. Nucl Instrum Methods Phys Res A (2008) 2.18
Changes in water mobility measured by diffusion MRI predict response of metastatic breast cancer to chemotherapy. Neoplasia (2005) 2.17
Tumor pH and its measurement. J Nucl Med (2010) 2.08
Renal and systemic pH imaging by contrast-enhanced MRI. Magn Reson Med (2003) 2.05
Speech delay and autism spectrum behaviors are frequently associated with duplication of the 7q11.23 Williams-Beuren syndrome region. Genet Med (2007) 1.98
Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development. Nat Genet (2005) 1.98
High resolution pH(e) imaging of rat glioma using pH-dependent relaxivity. Magn Reson Med (2006) 1.97
Glycolysis in cancer: a potential target for therapy. Int J Biochem Cell Biol (2007) 1.94
The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res (2009) 1.92
Hitting multiple targets with multimeric ligands. Expert Opin Ther Targets (2004) 1.86
Responsive MRI agents for sensing metabolism in vivo. Acc Chem Res (2009) 1.84
Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome. J Natl Cancer Inst (2003) 1.83
Exome sequencing reveals new causal mutations in children with epileptic encephalopathies. Epilepsia (2013) 1.78
Predicting functional gains in a stroke trial. Stroke (2007) 1.76
Imaging pH and metastasis. NMR Biomed (2011) 1.67
Lanthanide-based time-resolved fluorescence of in cyto ligand-receptor interactions. Anal Biochem (2004) 1.66
Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors. Neoplasia (2003) 1.63
Stability of FDG-PET Radiomics features: an integrated analysis of test-retest and inter-observer variability. Acta Oncol (2013) 1.62
Metabolic changes during carcinogenesis: potential impact on invasiveness. J Theor Biol (2006) 1.59
Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of alpha-MSH. Bioorg Med Chem Lett (2004) 1.58
Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro. Biochem Pharmacol (2003) 1.57
FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome. Hum Mol Genet (2003) 1.55
Quantitative imaging in cancer evolution and ecology. Radiology (2013) 1.55
Docetaxel induces cell death through mitotic catastrophe in human breast cancer cells. Mol Cancer Ther (2005) 1.54
Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. Neoplasia (2005) 1.54
Chy-3 mice are Vegfc haploinsufficient and exhibit defective dermal superficial to deep lymphatic transition and dermal lymphatic hypoplasia. Dev Dyn (2007) 1.53
Lateral phase separation in lipid-coated microbubbles. Langmuir (2006) 1.52
Of cancer and cave fish. Nat Rev Cancer (2011) 1.50
Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478. Neoplasia (2005) 1.45
Acid treatment of melanoma cells selects for invasive phenotypes. Clin Exp Metastasis (2008) 1.44
Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges". Int J Cancer (2014) 1.44
Drug resistance and cellular adaptation to tumor acidic pH microenvironment. Mol Pharm (2011) 1.42
Imaging the extracellular pH of tumors by MRI after injection of a single cocktail of T1 and T2 contrast agents. NMR Biomed (2011) 1.40
Determining suitable internal standards for mRNA quantification of increasing cancer progression in human breast cells by real-time reverse transcriptase polymerase chain reaction. Anal Biochem (2005) 1.38
Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents. Biochem Pharmacol (2003) 1.38
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Cancer Res (2012) 1.38
Automated Delineation of Lung Tumors from CT Images Using a Single Click Ensemble Segmentation Approach. Pattern Recognit (2013) 1.36
Multiscale modelling of vascular tumour growth in 3D: the roles of domain size and boundary conditions. PLoS One (2011) 1.36
Heterobivalent ligands crosslink multiple cell-surface receptors: the human melanocortin-4 and delta-opioid receptors. Angew Chem Int Ed Engl (2008) 1.36
A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep (2013) 1.33
Early response of prostate carcinoma xenografts to docetaxel chemotherapy monitored with diffusion MRI. Neoplasia (2002) 1.32
Synthesis and evaluation of bivalent NDP-alpha-MSH(7) peptide ligands for binding to the human melanocortin receptor 4 (hMC4R). Bioconjug Chem (2007) 1.31
Systemic buffers inhibit carcinogenesis in TRAMP mice. J Urol (2012) 1.28
Radial fast spin-echo method for T2-weighted imaging and T2 mapping of the liver. J Magn Reson Imaging (2002) 1.27
Astrocyte-only Npc1 reduces neuronal cholesterol and triples life span of Npc1-/- mice. J Neurosci Res (2008) 1.26
Development of a lanthanide-based assay for detection of receptor-ligand interactions at the delta-opioid receptor. Anal Biochem (2005) 1.25
Regulation of the Warburg effect in early-passage breast cancer cells. Neoplasia (2008) 1.23
Thermostability of firefly luciferases affects efficiency of detection by in vivo bioluminescence. Mol Imaging (2004) 1.23
A stimulus-responsive contrast agent for ultrasound molecular imaging. Biomaterials (2007) 1.22
Reduction of metastasis using a non-volatile buffer. Clin Exp Metastasis (2011) 1.21
Enhanced targeting with heterobivalent ligands. Mol Cancer Ther (2009) 1.21
Evolutionary dynamics of cancer prevention. Nat Rev Cancer (2010) 1.20
Expression-driven reverse engineering of targeted imaging and therapeutic agents. Expert Opin Ther Targets (2003) 1.19
Rigid linkers for bioactive peptides. Bioconjug Chem (2006) 1.19
Variance of SUVs for FDG-PET/CT is greater in clinical practice than under ideal study settings. Clin Nucl Med (2013) 1.19
Evolutionary approaches to prolong progression-free survival in breast cancer. Cancer Res (2012) 1.19
The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging. Clin Cancer Res (2005) 1.17
The clinical spectrum of homozygous HOXA1 mutations. Am J Med Genet A (2008) 1.16
DNA and polylysine adsorption and multilayer construction onto cationic lipid-coated microbubbles. Langmuir (2007) 1.16
Experimental non-alcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats. Eur J Pharmacol (2009) 1.16
Gold nanorods targeted to delta opioid receptor: plasmon-resonant contrast and photothermal agents. Mol Imaging (2008) 1.15
Redox-sensitive contrast agents for MRI based on reversible binding of thiols to serum albumin. Magn Reson Med (2006) 1.14
MRI-measured water mobility increases in response to chemotherapy via multiple cell-death mechanisms. NMR Biomed (2007) 1.14
Lanthanide-based luminescent assays for ligand-receptor interactions. Life Sci (2005) 1.13
View-ordering in radial fast spin-echo imaging. Magn Reson Med (2004) 1.12
Allopregnanolone treatment, both as a single injection or repetitively, delays demyelination and enhances survival of Niemann-Pick C mice. J Neurosci Res (2005) 1.12
Targeting the metabolic microenvironment of tumors. Adv Pharmacol (2012) 1.11
Animal anaesthesia for in vivo magnetic resonance. NMR Biomed (2003) 1.11
Promise and progress for functional and molecular imaging of response to targeted therapies. Pharm Res (2007) 1.11
Characterization of breast cancers and therapy response by MRS and quantitative gene expression profiling in the choline pathway. NMR Biomed (2009) 1.10
Design, synthesis, and biological studies of efficient multivalent melanotropin ligands: tools toward melanoma diagnosis and treatment. J Med Chem (2011) 1.10
A novel mouse model of Niemann-Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations. Hum Mol Genet (2011) 1.10
Noninvasive detection of breast cancer lymph node metastasis using carbonic anhydrases IX and XII targeted imaging probes. Clin Cancer Res (2011) 1.10
Gene expression profiling-based identification of cell-surface targets for developing multimeric ligands in pancreatic cancer. Mol Cancer Ther (2008) 1.10
Absence of RECQL4 mutations in poikiloderma with neutropenia in Navajo and non-Navajo patients. Am J Med Genet A (2003) 1.10
DNA constructs designed to produce short hairpin, interfering RNAs in transgenic mice sometimes show early lethality and an interferon response. J Appl Genet (2005) 1.07
Processing of radial fast spin-echo data for obtaining T2 estimates from a single k-space data set. Magn Reson Med (2005) 1.07
In vivo magnetic resonance imaging of tissue pH using a novel pH-sensitive contrast agent, GdDOTA-4AmP. Acad Radiol (2002) 1.06
Current advances in mathematical modeling of anti-cancer drug penetration into tumor tissues. Front Oncol (2013) 1.05
Athabascan brainstem dysgenesis syndrome. Am J Med Genet A (2003) 1.05
Molecular imaging and targeted therapies. Biochem Pharmacol (2010) 1.05
Decreased Npc1 gene dosage in mice is associated with weight gain. Obesity (Silver Spring) (2009) 1.04
Rescue of neurodegeneration in Niemann-Pick C mice by a prion-promoter-driven Npc1 cDNA transgene. Hum Mol Genet (2002) 1.03