Published in Cancer Res on January 03, 2013
Metabolic targets for cancer therapy. Nat Rev Drug Discov (2013) 2.32
Disrupting proton dynamics and energy metabolism for cancer therapy. Nat Rev Cancer (2013) 1.93
Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer. Proc Natl Acad Sci U S A (2014) 1.65
Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI. Magn Reson Med (2013) 1.48
The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem Sci (2016) 1.36
Broad targeting of angiogenesis for cancer prevention and therapy. Semin Cancer Biol (2015) 1.24
The Warburg effect version 2.0: metabolic reprogramming of cancer stem cells. Cell Cycle (2013) 1.20
Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes. Cancer Res (2015) 1.12
Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors. Front Physiol (2014) 1.11
Simulating cancer growth with multiscale agent-based modeling. Semin Cancer Biol (2014) 1.09
Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas. Acta Neuropathol (2014) 1.04
Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling. Cell Rep (2016) 1.03
Cathepsin B: multiple roles in cancer. Proteomics Clin Appl (2014) 1.03
Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane. Cancer Metab (2014) 0.99
The Na⁺/H⁺ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells. Oncotarget (2015) 0.98
Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis. Oncotarget (2014) 0.98
Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane. Nat Commun (2015) 0.96
Two-wave nanotherapy to target the stroma and optimize gemcitabine delivery to a human pancreatic cancer model in mice. ACS Nano (2013) 0.96
Acid-mediated tumor proteolysis: contribution of cysteine cathepsins. Neoplasia (2013) 0.96
The chemistry, physiology and pathology of pH in cancer. Philos Trans R Soc Lond B Biol Sci (2014) 0.94
Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes In Vivo. Clin Cancer Res (2015) 0.94
Acidosis promotes invasiveness of breast cancer cells through ROS-AKT-NF-κB pathway. Oncotarget (2014) 0.92
Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy. Cancer Metastasis Rev (2014) 0.91
MUC16-mediated activation of mTOR and c-Myc reprograms pancreatic cancer metabolism. Oncotarget (2015) 0.91
Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy. Cancer Res (2015) 0.90
Noncanonical amino acids to improve the pH response of pHLIP insertion at tumor acidity. Angew Chem Int Ed Engl (2015) 0.89
Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies. Oxid Med Cell Longev (2015) 0.88
Regulation of breast tumorigenesis through acid sensors. Oncogene (2015) 0.87
pHLIP-FIRE, a cell insertion-triggered fluorescent probe for imaging tumors demonstrates targeted cargo delivery in vivo. ACS Chem Biol (2014) 0.86
The Intercellular Metabolic Interplay between Tumor and Immune Cells. Front Immunol (2014) 0.86
Imaging Sites of Inhibition of Proteolysis in Pathomimetic Human Breast Cancer Cultures by Light-Activated Ruthenium Compound. PLoS One (2015) 0.86
Inhibition of cancer cell proliferation and breast tumor targeting of pHLIP-monomethyl auristatin E conjugates. Mol Pharm (2015) 0.85
Regulation and roles of bicarbonate transporters in cancer. Front Physiol (2014) 0.85
Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction. Front Cell Dev Biol (2016) 0.84
Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture. Integr Biol (Camb) (2014) 0.84
Mechanisms of buffer therapy resistance. Neoplasia (2014) 0.83
Differences in miRNA expression in early stage lung adenocarcinomas that did and did not relapse. PLoS One (2014) 0.82
Systemic Activin signaling independently regulates sugar homeostasis, cellular metabolism, and pH balance in Drosophila melanogaster. Proc Natl Acad Sci U S A (2014) 0.82
Lanthanide(III) complexes of rhodamine-DO3A conjugates as agents for dual-modal imaging. Inorg Chem (2013) 0.82
Metabolism and its sequelae in cancer evolution and therapy. Cancer J (2015) 0.81
From micelles to fibers: balancing self-assembling and random coiling domains in pH-responsive silk-collagen-like protein-based polymers. Biomacromolecules (2014) 0.81
Regulatory circuits of T cell function in cancer. Nat Rev Immunol (2016) 0.81
Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo. Proc Natl Acad Sci U S A (2016) 0.81
Increased H⁺ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression. Elife (2015) 0.80
A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer. PLoS One (2014) 0.80
Glucose is a key driver for GLUT1-mediated nanoparticles internalization in breast cancer cells. Sci Rep (2016) 0.80
TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells. Oncogene (2015) 0.80
Simultaneously targeting tissue transglutaminase and kidney type glutaminase sensitizes cancer cells to acid toxicity and offers new opportunities for therapeutic intervention. Mol Pharm (2014) 0.80
Imaging the intratumoral-peritumoral extracellular pH gradient of gliomas. NMR Biomed (2016) 0.79
1,2,3,4,6-Penta-O-galloylglucose within Galla Chinensis Inhibits Human LDH-A and Attenuates Cell Proliferation in MDA-MB-231 Breast Cancer Cells. Evid Based Complement Alternat Med (2015) 0.79
Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor. Prostate (2015) 0.79
Growth and remodelling for profound circular wounds in skin. Biomech Model Mechanobiol (2014) 0.79
Acidic extracellular pH of tumors induces octamer-binding transcription factor 4 expression in murine fibroblasts in vitro and in vivo. Sci Rep (2016) 0.79
Towards longitudinal mapping of extracellular pH in gliomas. NMR Biomed (2016) 0.79
Evaluating pH in the Extracellular Tumor Microenvironment Using CEST MRI and Other Imaging Methods. Adv Radiol (2015) 0.78
Phenotypic changes of acid adapted cancer cells push them toward aggressiveness in their evolution in the tumor microenvironment. Cell Cycle (2016) 0.78
Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI. Chem Commun (Camb) (2015) 0.78
Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival. Mol Cell Biol (2015) 0.78
Reasons for cancer metastasis: A holistic perspective. Mol Clin Oncol (2015) 0.78
Influence of the microenvironment on cell fate determination and migration. Physiol Genomics (2014) 0.78
High-Throughput Screening to Identify Plant Derived Human LDH-A Inhibitors. European J Med Plants (2013) 0.78
Real-time measurement of hyperpolarized lactate production and efflux as a biomarker of tumor aggressiveness in an MR compatible 3D cell culture bioreactor. NMR Biomed (2015) 0.78
Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer. Oncotarget (2016) 0.78
Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells. Mol Cancer (2017) 0.78
A platform for high-throughput bioenergy production phenotype characterization in single cells. Sci Rep (2017) 0.77
Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity. Cold Spring Harb Perspect Med (2016) 0.77
Pathology to enhance precision medicine in oncology: lessons from landscape ecology. Adv Anat Pathol (2015) 0.77
Targeting acidity in diseased tissues: mechanism and applications of the membrane-inserting peptide, pHLIP. Arch Biochem Biophys (2014) 0.77
Assessing Metabolic Changes in Response to mTOR Inhibition in a Mantle Cell Lymphoma Xenograft Model Using AcidoCEST MRI. Mol Imaging (2016) 0.77
GSH-dependent antioxidant defense contributes to the acclimation of colon cancer cells to acidic microenvironment. Cell Cycle (2016) 0.77
Normal Wound Healing and Tumor Angiogenesis as a Game of Competitive Inhibition. PLoS One (2016) 0.77
Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors. Mol Cancer (2016) 0.76
Exosomes: novel implications in diagnosis and treatment of gastrointestinal cancer. Langenbecks Arch Surg (2016) 0.76
ERK-mediated NF-κB activation through ASIC1 in response to acidosis. Oncogenesis (2016) 0.76
'Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells'. Oncotarget (2016) 0.76
Protonation and Trapping of a Small pH-Sensitive Near-Infrared Fluorescent Molecule in the Acidic Tumor Environment Delineate Diverse Tumors in Vivo. Mol Pharm (2015) 0.76
Alteration of ASIC1 expression in clear cell renal cell carcinoma. Onco Targets Ther (2015) 0.76
Clinical Translation of Tumor Acidosis Measurements with AcidoCEST MRI. Mol Imaging Biol (2016) 0.75
Ratiometric Organic Fibers for Localized and Reversible Ion Sensing with Micrometer-Scale Spatial Resolution. Small (2015) 0.75
Ratiometric fluorescent pH-sensitive polymers for high-throughput monitoring of extracellular pH. RSC Adv (2016) 0.75
Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion. Cancer Res (2017) 0.75
Temperature induces significant changes in both glycolytic reserve and mitochondrial spare respiratory capacity in colorectal cancer cell lines. Exp Cell Res (2017) 0.75
Plasmonic/Magnetic Multifunctional nanoplatform for Cancer Theranostics. Sci Rep (2016) 0.75
Multifunctional and Spatially Controlled Bioconjugation to Melt Coextruded Nanofibers. Polym Chem (2015) 0.75
A Quick Responsive Fluorogenic pH Probe for Ovarian Tumor Imaging. Theranostics (2015) 0.75
Gene expression in local stroma reflects breast tumor states and predicts patient outcome. Sci Rep (2016) 0.75
Low pH impairs complement-dependent cytotoxicity against IgG-coated target cells. Oncotarget (2016) 0.75
Proton-Electron Double-Resonance Imaging of pH using phosphonated trityl probe. Appl Magn Reson (2014) 0.75
Residue-specific structures and membrane locations of pH-low insertion peptide by solid-state nuclear magnetic resonance. Nat Commun (2015) 0.75
Respiration gating and Bloch fitting improve pH measurements with acidoCEST MRI in an ovarian orthotopic tumor model. Proc SPIE Int Soc Opt Eng (2016) 0.75
Extracellular Proton Concentrations Impacts LN229 Glioblastoma Tumor Cell Fate via Differential Modulation of Surface Lipids. Front Oncol (2017) 0.75
Caged [(18)F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography. Bioconjug Chem (2015) 0.75
A collagen-binding EGFR antibody fragment targeting tumors with a collagen-rich extracellular matrix. Sci Rep (2016) 0.75
Responsive Hydrogel Nanoparticles for Pulmonary Delivery. J Drug Deliv Sci Technol (2015) 0.75
Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer. Int J Mol Sci (2017) 0.75
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy. Chem Soc Rev (2016) 0.75
Rat Aquaporin-5 Is pH-Gated Induced by Phosphorylation and Is Implicated in Oxidative Stress. Int J Mol Sci (2016) 0.75
Polymer nanoassemblies with solvato- and halo-fluorochromism for drug release monitoring and metastasis imaging. Ther Deliv (2015) 0.75
Pathomimetic cancer avatars for live-cell imaging of protease activity. Biochimie (2015) 0.75
Design of a VLP-nanovehicle for CYP450 enzymatic activity delivery. J Nanobiotechnology (2015) 0.75
Why do cancers have high aerobic glycolysis? Nat Rev Cancer (2004) 20.60
Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer (2003) 13.01
Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer (2002) 7.79
Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst (1997) 5.07
Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res (2006) 3.90
The relevance of tumour pH to the treatment of malignant disease. Radiother Oncol (1984) 3.44
Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res (2009) 3.40
The effects of extracellular pH on immune function. J Leukoc Biol (2001) 3.23
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Cancer Res (2006) 3.10
Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Am J Pathol (2001) 2.86
Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res (2009) 2.62
Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography. J Clin Oncol (2002) 2.56
Causes and consequences of tumour acidity and implications for treatment. Mol Med Today (2000) 2.44
Acidic pH enhances the invasive behavior of human melanoma cells. Clin Exp Metastasis (1996) 2.44
Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res (2001) 2.11
A reaction-diffusion model of cancer invasion. Cancer Res (1996) 2.01
31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate. Am J Physiol (1994) 2.00
'The metabolism of tumours': 70 years later. Novartis Found Symp (2001) 1.99
Pericellular pH affects distribution and secretion of cathepsin B in malignant cells. Cancer Res (1994) 1.91
In vivo imaging of extracellular pH using 1H MRSI. Magn Reson Med (1999) 1.86
Tumor angiogenesis and accessibility: role of vascular endothelial growth factor. Semin Oncol (2002) 1.76
Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF. J Biol Chem (2001) 1.72
An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis. Oncogene (1999) 1.64
Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors. Neoplasia (2003) 1.63
Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells. Br J Cancer (1991) 1.52
Acid treatment of melanoma cells selects for invasive phenotypes. Clin Exp Metastasis (2008) 1.44
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Cancer Res (2012) 1.38
Acidic environment causes apoptosis by increasing caspase activity. Br J Cancer (1999) 1.35
Cathepsin B and its endogenous inhibitors: the role in tumor malignancy. Cancer Metastasis Rev (1990) 1.32
How cancer spreads. Sci Am (1996) 1.31
Systemic buffers inhibit carcinogenesis in TRAMP mice. J Urol (2012) 1.28
Visualizing protease activity in living cells: from two dimensions to four dimensions. Curr Protoc Cell Biol (2008) 1.26
History of the Pasteur effect and its pathobiology. Mol Cell Biochem (1974) 1.25
Cathepsin D in cancer metastasis: a protease and a ligand. APMIS (1999) 1.24
Reduction of metastasis using a non-volatile buffer. Clin Exp Metastasis (2011) 1.21
Simultaneous measurement of intracellular pH and Ca2+ using the fluorescence of SNARF-1 and fura-2. Am J Physiol (1991) 1.20
Determination of local oxygen consumption rates in tumors. Cancer Res (1994) 1.15
Proton dynamics in cancer. J Transl Med (2010) 1.14
The potential role of transformation-induced metabolic changes in tumor-host interaction. Cancer Res (1995) 1.00
Temporal effects of 5.0 Gy radiation in healing subcutaneous microvasculature of a dorsal flap window chamber. Radiat Res (1987) 0.90
Why do cancers have high aerobic glycolysis? Nat Rev Cancer (2004) 20.60
DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer. N Engl J Med (2007) 8.28
Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer (2006) 5.06
A microenvironmental model of carcinogenesis. Nat Rev Cancer (2008) 4.40
Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol (2006) 3.98
Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res (2006) 3.90
Causes and consequences of increased glucose metabolism of cancers. J Nucl Med (2008) 3.79
Environment-mediated drug resistance: a major contributor to minimal residual disease. Nat Rev Cancer (2009) 3.49
Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res (2009) 3.40
Dynamic imaging of protease activity with fluorescently quenched activity-based probes. Nat Chem Biol (2005) 2.90
Adaptive therapy. Cancer Res (2009) 2.81
Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling. J Natl Cancer Inst (2002) 2.77
Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat Rev Cancer (2012) 2.71
pH imaging. A review of pH measurement methods and applications in cancers. IEEE Eng Med Biol Mag (2004) 2.68
Radiomics: the process and the challenges. Magn Reson Imaging (2012) 2.65
Gene gain and loss during evolution of obligate parasitism in the white rust pathogen of Arabidopsis thaliana. PLoS Biol (2011) 2.38
Changes in water mobility measured by diffusion MRI predict response of metastatic breast cancer to chemotherapy. Neoplasia (2005) 2.17
Tumor pH and its measurement. J Nucl Med (2010) 2.08
Renal and systemic pH imaging by contrast-enhanced MRI. Magn Reson Med (2003) 2.05
High resolution pH(e) imaging of rat glioma using pH-dependent relaxivity. Magn Reson Med (2006) 1.97
Glycolysis in cancer: a potential target for therapy. Int J Biochem Cell Biol (2007) 1.94
The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res (2009) 1.92
Cysteine cathepsins in human cancer. Biol Chem (2004) 1.91
Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res (2012) 1.89
Hitting multiple targets with multimeric ligands. Expert Opin Ther Targets (2004) 1.86
Responsive MRI agents for sensing metabolism in vivo. Acc Chem Res (2009) 1.84
Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis? J Bioenerg Biomembr (2007) 1.83
Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. Semin Cancer Biol (2008) 1.76
Unraveling gene-gene interactions regulated by ligands of the aryl hydrocarbon receptor. Environ Health Perspect (2004) 1.70
High-temperature piezoelectric sensing. Sensors (Basel) (2013) 1.70
A theoretical quantitative model for evolution of cancer chemotherapy resistance. Biol Direct (2010) 1.69
Pericellular cathepsin B and malignant progression. Cancer Metastasis Rev (2003) 1.68
Hypoxia and adaptive landscapes in the evolution of carcinogenesis. Cancer Metastasis Rev (2007) 1.68
Imaging pH and metastasis. NMR Biomed (2011) 1.67
Lanthanide-based time-resolved fluorescence of in cyto ligand-receptor interactions. Anal Biochem (2004) 1.66
Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors. Neoplasia (2003) 1.63
Stability of FDG-PET Radiomics features: an integrated analysis of test-retest and inter-observer variability. Acta Oncol (2013) 1.62
Beyond mammography: new frontiers in breast cancer screening. Am J Med (2013) 1.61
Ciclesonide, a novel inhaled steroid, does not affect hypothalamic-pituitary-adrenal axis function in patients with moderate-to-severe persistent asthma. Chest (2005) 1.60
Metabolic changes during carcinogenesis: potential impact on invasiveness. J Theor Biol (2006) 1.59
Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of alpha-MSH. Bioorg Med Chem Lett (2004) 1.58
Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro. Biochem Pharmacol (2003) 1.57
Quantitative imaging in cancer evolution and ecology. Radiology (2013) 1.55
Docetaxel induces cell death through mitotic catastrophe in human breast cancer cells. Mol Cancer Ther (2005) 1.54
Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. Neoplasia (2005) 1.54
Prediction of drug response in breast cancer using integrative experimental/computational modeling. Cancer Res (2009) 1.53
How little is enough? The evidence for post-vasectomy testing. J Urol (2005) 1.53
Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am J Pathol (2004) 1.52
Lateral phase separation in lipid-coated microbubbles. Langmuir (2006) 1.52
Of cancer and cave fish. Nat Rev Cancer (2011) 1.50
p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. Neoplasia (2008) 1.48
Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478. Neoplasia (2005) 1.45
Acid treatment of melanoma cells selects for invasive phenotypes. Clin Exp Metastasis (2008) 1.44
Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges". Int J Cancer (2014) 1.44
Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells. J Cell Sci (2005) 1.43
Drug resistance and cellular adaptation to tumor acidic pH microenvironment. Mol Pharm (2011) 1.42
Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ. Cancer Res (2009) 1.41
Imaging the extracellular pH of tumors by MRI after injection of a single cocktail of T1 and T2 contrast agents. NMR Biomed (2011) 1.40
Determining suitable internal standards for mRNA quantification of increasing cancer progression in human breast cells by real-time reverse transcriptase polymerase chain reaction. Anal Biochem (2005) 1.38
Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents. Biochem Pharmacol (2003) 1.38
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Cancer Res (2012) 1.38
Automated Delineation of Lung Tumors from CT Images Using a Single Click Ensemble Segmentation Approach. Pattern Recognit (2013) 1.36
Multiscale modelling of vascular tumour growth in 3D: the roles of domain size and boundary conditions. PLoS One (2011) 1.36
Heterobivalent ligands crosslink multiple cell-surface receptors: the human melanocortin-4 and delta-opioid receptors. Angew Chem Int Ed Engl (2008) 1.36
Cathepsin B and its role(s) in cancer progression. Biochem Soc Symp (2003) 1.36
Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation. Exp Cell Res (2009) 1.35
Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time. Proc Natl Acad Sci U S A (2011) 1.33
A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep (2013) 1.33
Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue. Am J Pathol (2005) 1.32
Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells from extrinsic cell death: a potential oncogenic activity of tissue inhibitor of metalloproteinase-1. Cancer Res (2005) 1.32
Early response of prostate carcinoma xenografts to docetaxel chemotherapy monitored with diffusion MRI. Neoplasia (2002) 1.32
Synthesis and evaluation of bivalent NDP-alpha-MSH(7) peptide ligands for binding to the human melanocortin receptor 4 (hMC4R). Bioconjug Chem (2007) 1.31
Trends in internal hernia incidence after laparoscopic Roux-en-Y gastric bypass. Obes Surg (2007) 1.29
Functional imaging of proteolysis: stromal and inflammatory cells increase tumor proteolysis. Mol Imaging (2003) 1.29
Systemic buffers inhibit carcinogenesis in TRAMP mice. J Urol (2012) 1.28
Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Cancer Res (2006) 1.26
Visualizing protease activity in living cells: from two dimensions to four dimensions. Curr Protoc Cell Biol (2008) 1.26
Molecular regulation of human cathepsin B: implication in pathologies. Biol Chem (2003) 1.26
Development of a lanthanide-based assay for detection of receptor-ligand interactions at the delta-opioid receptor. Anal Biochem (2005) 1.25
Regulation of the Warburg effect in early-passage breast cancer cells. Neoplasia (2008) 1.23
The role of acidity in solid tumour growth and invasion. J Theor Biol (2005) 1.23