Published in Angew Chem Int Ed Engl on November 05, 2004
Caged compounds: photorelease technology for control of cellular chemistry and physiology. Nat Methods (2007) 3.22
Illuminating the chemistry of life: design, synthesis, and applications of "caged" and related photoresponsive compounds. ACS Chem Biol (2009) 2.67
The chemical biology of protein phosphorylation. Annu Rev Biochem (2009) 1.59
Biological applications of protein splicing. Cell (2010) 1.40
Light activation as a method of regulating and studying gene expression. Curr Opin Chem Biol (2009) 1.25
Sequential activation and deactivation of protein function using spectrally differentiated caged phosphoamino acids. J Am Chem Soc (2011) 1.09
Light-triggered polymerase chain reaction. Chem Commun (Camb) (2007) 1.04
Covalent capture of phospho-dependent protein oligomerization by site-specific incorporation of a diazirine photo-cross-linker. J Am Chem Soc (2007) 0.91
Light-triggered myosin activation for probing dynamic cellular processes. Angew Chem Int Ed Engl (2011) 0.91
Semisynthesis of unnatural amino acid mutants of paxillin: protein probes for cell migration studies. Protein Sci (2007) 0.90
Protein phosphorylation by semisynthesis: from paper to practice. Methods Enzymol (2009) 0.87
Caged O-phosphorothioyl amino acids as building blocks for Fmoc-based solid phase peptide synthesis. Tetrahedron (2007) 0.80
Light-mediated remote control of signaling pathways. Biochim Biophys Acta (2009) 0.79
Molecular tools for cell and systems biology. HFSP J (2007) 0.77
2005 Irving Sigal Young Investigator Award. Protein Sci (2005) 0.75
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Optical control and study of biological processes at the single-cell level in a live organism. Rep Prog Phys (2013) 0.75
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science (2013) 6.29
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature (2010) 5.23
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell (2009) 3.82
Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature (2008) 3.55
Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell (2011) 2.68
Protein ligation: an enabling technology for the biophysical analysis of proteins. Nat Methods (2006) 2.60
Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction. Nat Chem Biol (2011) 2.39
Activation of protein splicing with light in yeast. Nat Methods (2008) 2.02
Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation. Science (2006) 2.00
A modular cross-linking approach for exploring protein interactions. J Am Chem Soc (2003) 1.85
Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus. Biochemistry (2002) 1.84
Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation. Nat Chem Biol (2010) 1.80
Post-translational enzyme activation in an animal via optimized conditional protein splicing. Nat Chem Biol (2006) 1.71
A semisynthetic Eph receptor tyrosine kinase provides insight into ligand-induced kinase activation. Chem Biol (2011) 1.54
Semisynthesis of a segmental isotopically labeled protein splicing precursor: NMR evidence for an unusual peptide bond at the N-extein-intein junction. Proc Natl Acad Sci U S A (2004) 1.51
PET imaging of leptin biodistribution and metabolism in rodents and primates. Cell Metab (2009) 1.47
Conditional protein splicing: a new tool to control protein structure and function in vitro and in vivo. J Am Chem Soc (2003) 1.46
Chromatin as an expansive canvas for chemical biology. Nat Chem Biol (2012) 1.45
Molecular mechanisms of agr quorum sensing in virulent staphylococci. Chembiochem (2007) 1.44
Genetically encoded 1,2-aminothiols facilitate rapid and site-specific protein labeling via a bio-orthogonal cyanobenzothiazole condensation. J Am Chem Soc (2011) 1.42
Chemical signaling among bacteria and its inhibition. Chem Biol (2003) 1.42
Biological applications of protein splicing. Cell (2010) 1.40
A pan-specific antibody for direct detection of protein histidine phosphorylation. Nat Chem Biol (2013) 1.40
Cyclic peptide inhibitors of staphylococcal virulence prepared by Fmoc-based thiolactone peptide synthesis. J Am Chem Soc (2008) 1.39
SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell (2013) 1.38
Autoregulation of a bacterial sigma factor explored by using segmental isotopic labeling and NMR. Proc Natl Acad Sci U S A (2002) 1.36
Development of a tandem protein trans-splicing system based on native and engineered split inteins. J Am Chem Soc (2005) 1.36
Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt. Proc Natl Acad Sci U S A (2007) 1.35
Simultaneous triggering of protein activity and fluorescence. J Am Chem Soc (2004) 1.34
Auxiliary-mediated site-specific peptide ubiquitylation. Angew Chem Int Ed Engl (2007) 1.33
Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B. ACS Chem Biol (2009) 1.33
Hydrophobic interactions drive ligand-receptor recognition for activation and inhibition of staphylococcal quorum sensing. Proc Natl Acad Sci U S A (2004) 1.31
Reversible and specific extracellular antagonism of receptor-histidine kinase signaling. J Biol Chem (2001) 1.28
Traceless protein splicing utilizing evolved split inteins. Proc Natl Acad Sci U S A (2009) 1.28
Semisynthesis and folding of the potassium channel KcsA. J Am Chem Soc (2002) 1.27
Expressed protein ligation (EPL) in the study of signal transduction, ion conduction, and chromatin biology. Acc Chem Res (2009) 1.25
agr receptor mutants reveal distinct modes of inhibition by staphylococcal autoinducing peptides. Proc Natl Acad Sci U S A (2009) 1.23
Identification of ligand specificity determinants in AgrC, the Staphylococcus aureus quorum-sensing receptor. J Biol Chem (2008) 1.23
Branched intermediate formation stimulates peptide bond cleavage in protein splicing. Nat Chem Biol (2010) 1.22
Protein semi-synthesis in living cells. J Am Chem Soc (2003) 1.21
Chemical approaches for studying histone modifications. J Biol Chem (2010) 1.21
Glycine as a D-amino acid surrogate in the K(+)-selectivity filter. Proc Natl Acad Sci U S A (2004) 1.19
The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation. Mol Cell (2013) 1.19
Ultrafast protein splicing is common among cyanobacterial split inteins: implications for protein engineering. J Am Chem Soc (2012) 1.16
Manipulating proteins with chemistry: a cross-section of chemical biology. Trends Biochem Sci (2005) 1.16
Chasing phosphohistidine, an elusive sibling in the phosphoamino acid family. ACS Chem Biol (2011) 1.16
Protein splicing triggered by a small molecule. J Am Chem Soc (2002) 1.14
Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent. PLoS One (2009) 1.14
Site-specific (18)F-labeling of the protein hormone leptin using a general two-step ligation procedure. J Am Chem Soc (2008) 1.13
A full-length group 1 bacterial sigma factor adopts a compact structure incompatible with DNA binding. Chem Biol (2008) 1.11
Kinetic control of one-pot trans-splicing reactions by using a wild-type and designed split intein. Angew Chem Int Ed Engl (2011) 1.09
Semisynthesis of a functional K+ channel. Angew Chem Int Ed Engl (2004) 1.07
ASH2L regulates ubiquitylation signaling to MLL: trans-regulation of H3 K4 methylation in higher eukaryotes. Mol Cell (2013) 1.06
Semisynthetic proteins in mechanistic studies: using chemistry to go where nature can't. Curr Opin Chem Biol (2006) 1.02
Development of stable phosphohistidine analogues. J Am Chem Soc (2010) 1.02
Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel. J Am Chem Soc (2006) 1.02
Spreading chromatin into chemical biology. Chembiochem (2011) 1.02
Solution structure and folding characteristics of the C-terminal SH3 domain of c-Crk-II. Biochemistry (2006) 1.00
Streamlined expressed protein ligation using split inteins. J Am Chem Soc (2012) 0.99
Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2. J Am Chem Soc (2014) 0.98
H3R42me2a is a histone modification with positive transcriptional effects. Proc Natl Acad Sci U S A (2013) 0.97
Semisynthesis of phosphovariants of Smad2 reveals a substrate preference of the activated T beta RI kinase. Biochemistry (2004) 0.97
A ligation and photorelease strategy for the temporal and spatial control of protein function in living cells. Angew Chem Int Ed Engl (2005) 0.97
Toward fully synthetic N-linked glycoproteins. Angew Chem Int Ed Engl (2003) 0.97
Activation of protein splicing by protease- or light-triggered O to N acyl migration. Angew Chem Int Ed Engl (2008) 0.96
Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4. J Am Chem Soc (2011) 0.96
Method for the synthesis of mono-ADP-ribose conjugated peptides. J Am Chem Soc (2010) 0.94
Activation of an autoregulated protein kinase by conditional protein splicing. Angew Chem Int Ed Engl (2004) 0.93
Segmental isotopic labeling for structural biological applications of NMR. Methods Mol Biol (2004) 0.92
Tuning protein autoinhibition by domain destabilization. Nat Struct Mol Biol (2011) 0.92
Extein residues play an intimate role in the rate-limiting step of protein trans-splicing. J Am Chem Soc (2013) 0.92
Covalent capture of phospho-dependent protein oligomerization by site-specific incorporation of a diazirine photo-cross-linker. J Am Chem Soc (2007) 0.91
A semisynthetic strategy to generate phosphorylated and acetylated histone H2B. Chembiochem (2009) 0.91
An amalgamation of solid phase peptide synthesis and ribosomal peptide synthesis. Biopolymers (2008) 0.90
Stability of nucleosomes containing homogenously ubiquitylated H2A and H2B prepared using semisynthesis. J Am Chem Soc (2012) 0.88
Naturally split inteins assemble through a "capture and collapse" mechanism. J Am Chem Soc (2013) 0.88
Recent advances in the application of expressed protein ligation to protein engineering. Curr Opin Biotechnol (2002) 0.87
Domain-specific incorporation of noninvasive optical probes into recombinant proteins. J Am Chem Soc (2004) 0.86
Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe. Chem Biol (2009) 0.86
Tunable photoactivation of a post-translationally modified signaling protein and its unmodified counterpart in live cells. Chembiochem (2007) 0.86
Toward the semisynthesis of multidomain transmembrane receptors: modification of Eph tyrosine kinases. Protein Sci (2008) 0.86
Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2. J Biol Chem (2012) 0.85
Histone H3K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes. Mol Cell Biol (2013) 0.83
Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cells. Nat Chem Biol (2013) 0.83
Split Inteins: Nature's Protein Ligases. Isr J Chem (2011) 0.83
A phosphohistidine proteomics strategy based on elucidation of a unique gas-phase phosphopeptide fragmentation mechanism. J Am Chem Soc (2014) 0.83
A second-generation phosphohistidine analog for production of phosphohistidine antibodies. Org Lett (2014) 0.81
Semisynthesis of ubiquitylated proteins. Methods Enzymol (2009) 0.80
Efficient semisynthesis of a tetraphosphorylated analogue of the Type I TGFbeta receptor. Org Lett (2002) 0.80
Increasing AIP Macrocycle Size Reveals Key Features of agr Activation in Staphylococcus aureus. Chembiochem (2015) 0.80
Chemical biology: cutting out the middle man. Nature (2006) 0.78
Systems- and molecular-level elucidation of signaling processes through chemistry. Sci Signal (2008) 0.77
"The splice is right": how protein splicing is opening new doors in protein science. Chem Commun (Camb) (2003) 0.76
Non-natural amino acids. Preface. Methods Enzymol (2009) 0.76
From EPOthilone to EPO: Aa challenge for natural product synthesis. Proc Natl Acad Sci U S A (2012) 0.75