Published in Biochemistry on July 25, 2006
Proline cis-trans isomerization controls autoinhibition of a signaling protein. Mol Cell (2007) 2.44
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling. Cell Commun Signal (2009) 1.79
Structural basis for regulation of the Crk signaling protein by a proline switch. Nat Chem Biol (2010) 1.30
Emerging roles for crk in human cancer. Genes Cancer (2010) 1.09
Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII. Nat Chem Biol (2012) 1.08
Roles for crk in cancer metastasis and invasion. Genes Cancer (2012) 0.96
Models of crk adaptor proteins in cancer. Genes Cancer (2012) 0.94
Tuning protein autoinhibition by domain destabilization. Nat Struct Mol Biol (2011) 0.92
The molecular mechanism of nuclear transport revealed by atomic-scale measurements. Elife (2015) 0.88
Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation. Oncogene (2011) 0.87
Domain cooperativity in multidomain proteins: what can we learn from molecular alignment in anisotropic media? J Biomol NMR (2011) 0.82
The adaptor protein Crk in immune response. Immunol Cell Biol (2013) 0.81
Structural determination of biomolecular interfaces by nuclear magnetic resonance of proteins with reduced proton density. J Biomol NMR (2010) 0.78
Iterative tyrosine phosphorylation controls non-canonical domain utilization in Crk. Oncogene (2014) 0.78
Contribution of Crk adaptor proteins to host cell and bacteria interactions. Biomed Res Int (2014) 0.76
Molecular dynamics of the proline switch and its role in Crk signaling. J Phys Chem B (2014) 0.75
The Role of Crk Adaptor Proteins in T-Cell Adhesion and Migration. Front Immunol (2015) 0.75
Prolyl isomerization as a molecular memory in the allosteric regulation of the signal adapter protein c-CrkII. J Biol Chem (2014) 0.75
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science (2013) 6.29
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature (2010) 5.23
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell (2009) 3.82
Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature (2008) 3.55
Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell (2011) 2.68
Protein ligation: an enabling technology for the biophysical analysis of proteins. Nat Methods (2006) 2.60
Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction. Nat Chem Biol (2011) 2.39
Mapping structural interactions using in-cell NMR spectroscopy (STINT-NMR). Nat Methods (2006) 2.15
Impact of Type 2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart. Am J Physiol Cell Physiol (2006) 2.08
Activation of protein splicing with light in yeast. Nat Methods (2008) 2.02
Two-dimensional IR spectroscopy and isotope labeling defines the pathway of amyloid formation with residue-specific resolution. Proc Natl Acad Sci U S A (2009) 2.02
Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation. Science (2006) 2.00
Perspectives on NMR in drug discovery: a technique comes of age. Nat Rev Drug Discov (2008) 1.95
Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins. Protein Sci (2005) 1.91
Peptide models provide evidence for significant structure in the denatured state of a rapidly folding protein: the villin headpiece subdomain. Biochemistry (2004) 1.89
A modular cross-linking approach for exploring protein interactions. J Am Chem Soc (2003) 1.85
Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus. Biochemistry (2002) 1.84
Dynamic NMR line-shape analysis demonstrates that the villin headpiece subdomain folds on the microsecond time scale. J Am Chem Soc (2003) 1.82
Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation. Nat Chem Biol (2010) 1.80
Post-translational enzyme activation in an animal via optimized conditional protein splicing. Nat Chem Biol (2006) 1.71
A cell-penetrating helical peptide as a potential HIV-1 inhibitor. J Mol Biol (2008) 1.70
The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity. Biochemistry (2010) 1.63
The unfolded state of the villin headpiece helical subdomain: computational studies of the role of locally stabilized structure. J Mol Biol (2006) 1.63
A single-point mutation converts the highly amyloidogenic human islet amyloid polypeptide into a potent fibrillization inhibitor. J Am Chem Soc (2007) 1.59
Effect of modulating unfolded state structure on the folding kinetics of the villin headpiece subdomain. Proc Natl Acad Sci U S A (2005) 1.55
A semisynthetic Eph receptor tyrosine kinase provides insight into ligand-induced kinase activation. Chem Biol (2011) 1.54
Semisynthesis of a segmental isotopically labeled protein splicing precursor: NMR evidence for an unusual peptide bond at the N-extein-intein junction. Proc Natl Acad Sci U S A (2004) 1.51
Residue specific resolution of protein folding dynamics using isotope-edited infrared temperature jump spectroscopy. Biochemistry (2007) 1.51
A role for helical intermediates in amyloid formation by natively unfolded polypeptides? Phys Biol (2009) 1.49
PET imaging of leptin biodistribution and metabolism in rodents and primates. Cell Metab (2009) 1.47
Characterizing a partially folded intermediate of the villin headpiece domain under non-denaturing conditions: contribution of His41 to the pH-dependent stability of the N-terminal subdomain. J Mol Biol (2005) 1.47
The role of His-18 in amyloid formation by human islet amyloid polypeptide. Biochemistry (2005) 1.46
Conditional protein splicing: a new tool to control protein structure and function in vitro and in vivo. J Am Chem Soc (2003) 1.46
Chromatin as an expansive canvas for chemical biology. Nat Chem Biol (2012) 1.45
Molecular mechanisms of agr quorum sensing in virulent staphylococci. Chembiochem (2007) 1.44
Genetically encoded 1,2-aminothiols facilitate rapid and site-specific protein labeling via a bio-orthogonal cyanobenzothiazole condensation. J Am Chem Soc (2011) 1.42
Chemical signaling among bacteria and its inhibition. Chem Biol (2003) 1.42
Biological applications of protein splicing. Cell (2010) 1.40
A pan-specific antibody for direct detection of protein histidine phosphorylation. Nat Chem Biol (2013) 1.40
Two-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitor. Nat Chem (2012) 1.39
Cyclic peptide inhibitors of staphylococcal virulence prepared by Fmoc-based thiolactone peptide synthesis. J Am Chem Soc (2008) 1.39
A critical assessment of the role of helical intermediates in amyloid formation by natively unfolded proteins and polypeptides. Protein Eng Des Sel (2009) 1.38
SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell (2013) 1.38
Multistate folding of the villin headpiece domain. J Mol Biol (2005) 1.36
Recovery and purification of highly aggregation-prone disulfide-containing peptides: application to islet amyloid polypeptide. Anal Biochem (2005) 1.36
Autoregulation of a bacterial sigma factor explored by using segmental isotopic labeling and NMR. Proc Natl Acad Sci U S A (2002) 1.36
Development of a tandem protein trans-splicing system based on native and engineered split inteins. J Am Chem Soc (2005) 1.36
Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt. Proc Natl Acad Sci U S A (2007) 1.35
Simultaneous triggering of protein activity and fluorescence. J Am Chem Soc (2004) 1.34
Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B. ACS Chem Biol (2009) 1.33
A ubiquitin-interacting motif from Hrs binds to and occludes the ubiquitin surface necessary for polyubiquitination in monoubiquitinated proteins. Biochem Biophys Res Commun (2002) 1.33
Auxiliary-mediated site-specific peptide ubiquitylation. Angew Chem Int Ed Engl (2007) 1.33
Rifampicin does not prevent amyloid fibril formation by human islet amyloid polypeptide but does inhibit fibril thioflavin-T interactions: implications for mechanistic studies of beta-cell death. Biochemistry (2008) 1.32
Hydrophobic interactions drive ligand-receptor recognition for activation and inhibition of staphylococcal quorum sensing. Proc Natl Acad Sci U S A (2004) 1.31
Solution structure of a hydrocarbon stapled peptide inhibitor in complex with monomeric C-terminal domain of HIV-1 capsid. J Biol Chem (2008) 1.30
Incorporation of pseudoproline derivatives allows the facile synthesis of human IAPP, a highly amyloidogenic and aggregation-prone polypeptide. Org Lett (2005) 1.29
Reversible and specific extracellular antagonism of receptor-histidine kinase signaling. J Biol Chem (2001) 1.28
Temperature-dependent dynamics of the villin headpiece helical subdomain, an unusually small thermostable protein. J Mol Biol (2002) 1.28
Traceless protein splicing utilizing evolved split inteins. Proc Natl Acad Sci U S A (2009) 1.28
Semisynthesis and folding of the potassium channel KcsA. J Am Chem Soc (2002) 1.27
Expressed protein ligation (EPL) in the study of signal transduction, ion conduction, and chromatin biology. Acc Chem Res (2009) 1.25
Interpretation of p-cyanophenylalanine fluorescence in proteins in terms of solvent exposure and contribution of side-chain quenchers: a combined fluorescence, IR and molecular dynamics study. Biochemistry (2009) 1.25
Aromatic interactions are not required for amyloid fibril formation by islet amyloid polypeptide but do influence the rate of fibril formation and fibril morphology. Biochemistry (2007) 1.24
agr receptor mutants reveal distinct modes of inhibition by staphylococcal autoinducing peptides. Proc Natl Acad Sci U S A (2009) 1.23
Identification of ligand specificity determinants in AgrC, the Staphylococcus aureus quorum-sensing receptor. J Biol Chem (2008) 1.23
Branched intermediate formation stimulates peptide bond cleavage in protein splicing. Nat Chem Biol (2010) 1.22
Mutational analysis demonstrates that specific electrostatic interactions can play a key role in the denatured state ensemble of proteins. J Mol Biol (2005) 1.21
The ability of rodent islet amyloid polypeptide to inhibit amyloid formation by human islet amyloid polypeptide has important implications for the mechanism of amyloid formation and the design of inhibitors. Biochemistry (2010) 1.21
Protein semi-synthesis in living cells. J Am Chem Soc (2003) 1.21
Chemical approaches for studying histone modifications. J Biol Chem (2010) 1.21
Low levels of asparagine deamidation can have a dramatic effect on aggregation of amyloidogenic peptides: implications for the study of amyloid formation. Protein Sci (2002) 1.20
Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet. Proc Natl Acad Sci U S A (2013) 1.20
2DIR spectroscopy of human amylin fibrils reflects stable β-sheet structure. J Am Chem Soc (2011) 1.20
Destabilization of human IAPP amyloid fibrils by proline mutations outside of the putative amyloidogenic domain: is there a critical amyloidogenic domain in human IAPP? J Mol Biol (2005) 1.19
Glycine as a D-amino acid surrogate in the K(+)-selectivity filter. Proc Natl Acad Sci U S A (2004) 1.19
The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation. Mol Cell (2013) 1.19
Azidohomoalanine: a conformationally sensitive IR probe of protein folding, protein structure, and electrostatics. Angew Chem Int Ed Engl (2010) 1.17
Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock. J Biol Chem (2011) 1.17
Rapid cooperative two-state folding of a miniature alpha-beta protein and design of a thermostable variant. J Mol Biol (2003) 1.17
Accurate sampling of high-frequency motions in proteins by steady-state (15)N-{(1)H} nuclear Overhauser effect measurements in the presence of cross-correlated relaxation. J Am Chem Soc (2009) 1.17
Ultrafast protein splicing is common among cyanobacterial split inteins: implications for protein engineering. J Am Chem Soc (2012) 1.16
Manipulating proteins with chemistry: a cross-section of chemical biology. Trends Biochem Sci (2005) 1.16
Chasing phosphohistidine, an elusive sibling in the phosphoamino acid family. ACS Chem Biol (2011) 1.16
Strategies for extracting structural information from 2D IR spectroscopy of amyloid: application to islet amyloid polypeptide. J Phys Chem B (2009) 1.16
Protein splicing triggered by a small molecule. J Am Chem Soc (2002) 1.14
Role of aromatic interactions in amyloid formation by peptides derived from human Amylin. Biochemistry (2004) 1.14
Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent. PLoS One (2009) 1.14
Analysis of the inhibition and remodeling of islet amyloid polypeptide amyloid fibers by flavanols. Biochemistry (2012) 1.13
Efficient microwave-assisted synthesis of human islet amyloid polypeptide designed to facilitate the specific incorporation of labeled amino acids. Org Lett (2010) 1.13
Site-specific (18)F-labeling of the protein hormone leptin using a general two-step ligation procedure. J Am Chem Soc (2008) 1.13
Photocontrol of Smad2, a multiphosphorylated cell-signaling protein, through caging of activating phosphoserines. Angew Chem Int Ed Engl (2004) 1.13