Published in J Mol Biol on November 26, 2004
Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction. Biochem J (2005) 2.79
webPIPSA: a web server for the comparison of protein interaction properties. Nucleic Acids Res (2008) 1.19
Rapid comparison of properties on protein surface. Proteins (2008) 1.17
Folding, misfolding, and amyloid protofibril formation of WW domain FBP28. Biophys J (2006) 1.13
qPIPSA: relating enzymatic kinetic parameters and interaction fields. BMC Bioinformatics (2007) 1.01
The interaction properties of the human Rab GTPase family--comparative analysis reveals determinants of molecular binding selectivity. PLoS One (2012) 0.96
A regression framework incorporating quantitative and negative interaction data improves quantitative prediction of PDZ domain-peptide interaction from primary sequence. Bioinformatics (2010) 0.94
Immunophysical properties and prediction of activities for vaccinia virus complement control protein and smallpox inhibitor of complement enzymes using molecular dynamics and electrostatics. Biophys J (2006) 0.94
Using genome-wide measurements for computational prediction of SH2-peptide interactions. Nucleic Acids Res (2009) 0.92
Electrostatic similarity of proteins: application of three dimensional spherical harmonic decomposition. J Chem Phys (2008) 0.85
Clustering of HIV-1 Subtypes Based on gp120 V3 Loop electrostatic properties. BMC Biophys (2012) 0.85
Evolutionary and biophysical relationships among the papillomavirus E2 proteins. Front Biosci (Landmark Ed) (2009) 0.84
ArhGAP9, a novel MAP kinase docking protein, inhibits Erk and p38 activation through WW domain binding. J Mol Signal (2007) 0.80
WW domains of the yes-kinase-associated-protein (YAP) transcriptional regulator behave as independent units with different binding preferences for PPxY motif-containing ligands. PLoS One (2015) 0.78
Prediction of peptides binding to the PKA RIIalpha subunit using a hierarchical strategy. Bioinformatics (2011) 0.78
The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A (2004) 26.56
An improved map of conserved regulatory sites for Saccharomyces cerevisiae. BMC Bioinformatics (2006) 11.13
Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature (2010) 9.81
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00
Visualizing genomes: techniques and challenges. Nat Methods (2010) 6.66
ENCODE whole-genome data in the UCSC Genome Browser. Nucleic Acids Res (2009) 5.98
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol (2002) 5.02
Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. Proc Natl Acad Sci U S A (2006) 4.84
Structure of a protein determined by solid-state magic-angle-spinning NMR spectroscopy. Nature (2002) 4.29
A novel cyclosporine a drug-delivery system for prevention of human corneal rejection after high-risk keratoplasty: a clinical study. Ophthalmology (2012) 3.24
The UCSC Cancer Genomics Browser. Nat Methods (2009) 3.08
The Human Epigenome Browser at Washington University. Nat Methods (2011) 2.62
Formation of tight junction: determinants of homophilic interaction between classic claudins. FASEB J (2007) 2.43
Track data hubs enable visualization of user-defined genome-wide annotations on the UCSC Genome Browser. Bioinformatics (2013) 2.42
Using nitrile-derivatized amino acids as infrared probes of local environment. J Am Chem Soc (2003) 2.30
Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production. J Biol Chem (2005) 2.21
A software tool for the prediction of Xaa-Pro peptide bond conformations in proteins based on 13C chemical shift statistics. J Biomol NMR (2002) 2.21
The ins and outs of cytochrome P450s. Biochim Biophys Acta (2006) 2.09
A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. Endocrinology (2008) 2.03
Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance. Nat Genet (2013) 1.95
Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells. Gastroenterology (2005) 1.95
Perspectives on NMR in drug discovery: a technique comes of age. Nat Rev Drug Discov (2008) 1.95
Determination of solid-state NMR structures of proteins by means of three-dimensional 15N-13C-13C dipolar correlation spectroscopy and chemical shift analysis. Biochemistry (2003) 1.87
GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS. J Virol (2006) 1.86
Biomolecular diffusional association. Curr Opin Struct Biol (2002) 1.78
Detergent extraction identifies different VirB protein subassemblies of the type IV secretion machinery in the membranes of Agrobacterium tumefaciens. Proc Natl Acad Sci U S A (2002) 1.73
General structural motifs of amyloid protofilaments. Proc Natl Acad Sci U S A (2006) 1.72
Exploring long-range genome interactions using the WashU Epigenome Browser. Nat Methods (2013) 1.71
Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns. J Med Chem (2006) 1.71
Quantification of PDZ domain specificity, prediction of ligand affinity and rational design of super-binding peptides. J Mol Biol (2004) 1.68
DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nat Genet (2013) 1.64
Comparative epigenomic annotation of regulatory DNA. Cell (2012) 1.62
Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A (2009) 1.61
Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites. Oncogene (2002) 1.57
Solid-state NMR and SAXS studies provide a structural basis for the activation of alphaB-crystallin oligomers. Nat Struct Mol Biol (2010) 1.53
Combined penetrating keratoplasty and keratolimbal allograft transplantation in comparison with corneoscleral transplantation in the treatment of severe eye burns. Clin Experiment Ophthalmol (2008) 1.46
WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains. Protein Sci (2003) 1.46
Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine. Proc Natl Acad Sci U S A (2002) 1.44
The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with ZO-1. J Biol Chem (2004) 1.42
Computational approaches to identifying and characterizing protein binding sites for ligand design. J Mol Recognit (2010) 1.40
Diffusional encounter of barnase and barstar. Biophys J (2005) 1.40
Redesigning dehalogenase access tunnels as a strategy for degrading an anthropogenic substrate. Nat Chem Biol (2009) 1.39
Recognition of proline-rich motifs by protein-protein-interaction domains. Angew Chem Int Ed Engl (2005) 1.39
A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR). J Biol Chem (2006) 1.38
Structure and dynamics of the membrane-bound cytochrome P450 2C9. PLoS Comput Biol (2011) 1.37
Assigning large proteins in the solid state: a MAS NMR resonance assignment strategy using selectively and extensively 13C-labelled proteins. J Biomol NMR (2009) 1.37
Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung. Am J Respir Cell Mol Biol (2009) 1.36
N-terminal domain of alphaB-crystallin provides a conformational switch for multimerization and structural heterogeneity. Proc Natl Acad Sci U S A (2011) 1.36
Proton-detected solid-state NMR spectroscopy of fibrillar and membrane proteins. Angew Chem Int Ed Engl (2011) 1.36
The ClC-3 chloride channel promotes acidification of lysosomes in CHO-K1 and Huh-7 cells. Am J Physiol Cell Physiol (2002) 1.35
Visualization of macromolecular structures. Nat Methods (2010) 1.34
Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors. J Biol Chem (2004) 1.33
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome Res (2013) 1.33
alphaB-crystallin: a hybrid solid-state/solution-state NMR investigation reveals structural aspects of the heterogeneous oligomer. J Mol Biol (2008) 1.31
Estimating absolute methylation levels at single-CpG resolution from methylation enrichment and restriction enzyme sequencing methods. Genome Res (2013) 1.31
Do mammalian cytochrome P450s show multiple ligand access pathways and ligand channelling? EMBO Rep (2005) 1.31
EVH1 domains: structure, function and interactions. FEBS Lett (2002) 1.31
Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers. Carcinogenesis (2006) 1.29
Dynamic nuclear polarization of deuterated proteins. Angew Chem Int Ed Engl (2010) 1.29
Rapid proton-detected NMR assignment for proteins with fast magic angle spinning. J Am Chem Soc (2014) 1.29
DSMM: a Database of Simulated Molecular Motions. Nucleic Acids Res (2003) 1.28
Characterization of membrane proteins in isolated native cellular membranes by dynamic nuclear polarization solid-state NMR spectroscopy without purification and reconstitution. Angew Chem Int Ed Engl (2011) 1.28
Large protein complexes with extreme rotational correlation times investigated in solution by magic-angle-spinning NMR spectroscopy. J Am Chem Soc (2009) 1.28
Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex. Proc Natl Acad Sci U S A (2009) 1.27
The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death. Proc Natl Acad Sci U S A (2011) 1.26
Rifaximin is a gut-specific human pregnane X receptor activator. J Pharmacol Exp Ther (2007) 1.26
Delay of phagosome maturation by a mycobacterial lipid is reversed by nitric oxide. Cell Microbiol (2008) 1.26
An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production. Circ Res (2008) 1.26
ACTIN BINDING PROTEIN 29 from Lilium pollen plays an important role in dynamic actin remodeling. Plant Cell (2007) 1.25
A global suppressor motif for p53 cancer mutants. Proc Natl Acad Sci U S A (2004) 1.24
Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms. Endocr Rev (2009) 1.24
Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease. J Med Chem (2008) 1.22
Determinants of functionality in the ubiquitin conjugating enzyme family. Structure (2004) 1.22
RNA interference of achaete-scute homolog 1 in mouse prostate neuroendocrine cells reveals its gene targets and DNA binding sites. Proc Natl Acad Sci U S A (2004) 1.22
SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses. Proc Natl Acad Sci U S A (2011) 1.21
Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway. Angew Chem Int Ed Engl (2004) 1.21
Complete chloroplast genome sequence of a tree fern Alsophila spinulosa: insights into evolutionary changes in fern chloroplast genomes. BMC Evol Biol (2009) 1.21
Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography. Antimicrob Agents Chemother (2007) 1.20
webPIPSA: a web server for the comparison of protein interaction properties. Nucleic Acids Res (2008) 1.19
Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury. Am J Respir Cell Mol Biol (2010) 1.19
A red cy3-based biarsenical fluorescent probe targeted to a complementary binding peptide. J Am Chem Soc (2007) 1.19
Synthesis of an Array Comprising 837 Variants of the hYAP WW Protein Domain This work was supported by the DFG (INK 16/B1-1), by the Fonds der Chemischen Industrie, and by the Universitätsklinikum Charité Berlin. Angew Chem Int Ed Engl (2001) 1.18
Biochemical network-based drug-target prediction. Curr Opin Biotechnol (2010) 1.15
Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface. J Biol Chem (2004) 1.14
Supramolecular hydrogel of a D-amino acid dipeptide for controlled drug release in vivo. Langmuir (2009) 1.13
[2,3-(13)C]-labeling of aromatic residues--getting a head start in the magic-angle-spinning NMR assignment of membrane proteins. J Am Chem Soc (2007) 1.13
Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G). Mol Pharmacol (2005) 1.13
A tightly regulated molecular toggle controls AAA+ disaggregase. Nat Struct Mol Biol (2012) 1.13
1H detection in MAS solid-state NMR spectroscopy of biomacromolecules employing pulsed field gradients for residual solvent suppression. J Am Chem Soc (2003) 1.12
Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models. PLoS One (2009) 1.12
Targeting Smad4 links microRNA-146a to the TGF-beta pathway during retinoid acid induction in acute promyelocytic leukemia cell line. Int J Hematol (2010) 1.12
Solution structure and backbone dynamics of the Trypanosoma cruzi cysteine protease inhibitor chagasin. J Mol Biol (2006) 1.11
Safety and efficacy of US-guided high-intensity focused ultrasound for treatment of submucosal fibroids. Eur Radiol (2012) 1.11
Molecular determinants of the interaction between Clostridium perfringens enterotoxin fragments and claudin-3. J Biol Chem (2009) 1.11
The gate that governs sulfotransferase selectivity. Biochemistry (2012) 1.11