Published in World J Gastroenterol on December 15, 2004
Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy. Cancer Biol Ther (2015) 0.87
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (1997) 29.34
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet (1997) 15.38
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science (1998) 6.62
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell (1999) 6.59
Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res (1997) 4.32
The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells. Cancer Res (1998) 3.15
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells. Proc Natl Acad Sci U S A (1998) 3.05
The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. Cancer Res (1998) 2.32
PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1. Mol Cell Biol (2003) 2.14
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem (1999) 2.07
Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Cancer Res (1999) 1.95
Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J Cell Biol (1998) 1.85
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy. J Biol Chem (2001) 1.66
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. Cancer Res (1998) 1.52
PTEN mutations are common in sporadic microsatellite stable colorectal cancer. Oncogene (2004) 1.49
Genetic interactions between Pten and p53 in radiation-induced lymphoma development. Oncogene (2003) 1.28
PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells. Oncogene (2004) 1.27
PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment. Cancer Res (2003) 1.27
Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene. Oncogene (2000) 1.25
Regulation of constitutive expression of mouse PTEN by the 5'-untranslated region. Oncogene (2003) 1.16
Expression of PTEN in renal cell carcinoma and its relation to tumor behavior and growth. J Surg Oncol (2003) 1.11
PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression. Oncogene (2003) 1.06
Biphasic estradiol-induced AKT phosphorylation is modulated by PTEN via MAP kinase in HepG2 cells. Mol Biol Cell (2003) 1.06
PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells. Oncogene (2002) 1.05
Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo. Gene Ther (2003) 1.01
Colorectal carcinomas and PTEN/MMAC1 gene mutations. Clin Cancer Res (2001) 0.96
In vivo gene therapy of human bladder cancer with PTEN suppresses tumor growth, downregulates phosphorylated Akt, and increases sensitivity to doxorubicin. Gene Ther (2003) 0.93
Microsatellite instability, PTEN and p53 germline mutations in glioma families. Acta Oncol (2001) 0.92
Functional and molecular analyses of 10q deletions in human gliomas. Genes Chromosomes Cancer (1999) 0.91
Suppression of cell migration in ovarian cancer cells mediated by PTEN overexpression. Int J Oncol (2003) 0.91
Adenovirus-mediated PTEN treatment combined with caffeine produces a synergistic therapeutic effect in colorectal cancer cells. Cancer Gene Ther (2003) 0.89
PTEN gene mutation and high MIB-1 labeling index may contribute to dissemination in patients with glioblastoma. J Clin Neurosci (2004) 0.89
Transcriptional activation of p21WAF1 by PTEN/MMAC1 tumor suppressor. Mol Cell Biochem (2000) 0.89
PTEN expression is maintained in sporadic colorectal tumours. J Pathol (2001) 0.86
Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas. Br J Cancer (1999) 0.81
Growth suppression activity of the PTEN tumor suppressor gene in human endometrial cancer cells. Anticancer Res (2001) 0.81
[Expression of PTEN protein and its correlation with p27kip1 and cyclin D1 expression in primary breast cancer]. Zhonghua Zhong Liu Za Zhi (2003) 0.80
[Detection of mutation and protein expression of PTEN gene in endometrial carcinoma]. Ai Zheng (2004) 0.77
p53 and PTEN/MMAC1 mutational analysis of the small-intestinal cancer. Dig Liver Dis (2003) 0.76
hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. EMBO J (2006) 2.35
Heat shock protein 70 antisense oligonucleotide inhibits cell growth and induces apoptosis in human gastric cancer cell line SGC-7901. World J Gastroenterol (2005) 0.92
PLGA microsphere-mediated growth hormone release hormone expression induces intergenerational growth. Anim Biotechnol (2009) 0.77