Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.

PubWeight™: 6.59‹?› | Rank: Top 1%

🔗 View Article (PMID 10555148)

Published in Cell on October 29, 1999

Authors

J O Lee1, H Yang, M M Georgescu, A Di Cristofano, T Maehama, Y Shi, J E Dixon, P Pandolfi, N P Pavletich

Author Affiliations

1: Cellular Biochemistry and Biophysics Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Articles citing this

(truncated to the top 100)

The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol (2012) 7.32

Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell (2007) 5.62

Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol (2000) 5.22

PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol (2009) 4.83

Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy. Cancer Discov (2013) 4.39

Automated inference of molecular mechanisms of disease from amino acid substitutions. Bioinformatics (2009) 4.31

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1). Mol Cell Biol (2000) 3.93

Cell signaling in space and time: where proteins come together and when they're apart. Science (2009) 3.88

Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors. Proc Natl Acad Sci U S A (2004) 3.49

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol Cell Biol (2000) 3.42

Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21

PTEN function: how normal cells control it and tumour cells lose it. Biochem J (2004) 3.06

PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A (2005) 2.93

Membrane-binding and activation mechanism of PTEN. Proc Natl Acad Sci U S A (2003) 2.92

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. Proc Natl Acad Sci U S A (2000) 2.65

Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A (2000) 2.59

Protean PTEN: form and function. Am J Hum Genet (2002) 2.43

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A (2008) 2.34

Genes and pathways driving glioblastomas in humans and murine disease models. Neurosurg Rev (2003) 2.32

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function. Cell (2014) 2.25

PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. EMBO J (2006) 2.16

PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers. Am J Pathol (2002) 2.16

PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1. Mol Cell Biol (2003) 2.14

A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Proc Natl Acad Sci U S A (2006) 2.12

A biosynthetic pathway for anandamide. Proc Natl Acad Sci U S A (2006) 2.08

Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proc Natl Acad Sci U S A (2006) 1.96

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity. EMBO J (2009) 1.94

The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif. Biochem J (2004) 1.87

Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. J Neurosci (2009) 1.80

Myocardial AKT: the omnipresent nexus. Physiol Rev (2011) 1.76

Sac phosphatase domain proteins. Biochem J (2000) 1.69

Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction. FEBS J (2013) 1.68

PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A (2005) 1.67

E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains. Proc Natl Acad Sci U S A (2007) 1.67

Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly. Am J Med Genet B Neuropsychiatr Genet (2007) 1.65

The spectrum of vascular anomalies in patients with PTEN mutations: implications for diagnosis and management. J Med Genet (2007) 1.64

PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. Curr Biol (2007) 1.62

AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake. PLoS One (2014) 1.62

The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma. Pigment Cell Melanoma Res (2009) 1.62

The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo. J Cell Biol (2004) 1.62

PTEN controls tumor-induced angiogenesis. Proc Natl Acad Sci U S A (2001) 1.62

Coupling between the voltage-sensing and phosphatase domains of Ci-VSP. J Gen Physiol (2009) 1.60

TPIP: a novel phosphoinositide 3-phosphatase. Biochem J (2001) 1.60

Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids. Biochem J (2003) 1.59

PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma. Oncogene (2011) 1.59

SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nat Commun (2012) 1.58

Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation. Mol Cell Biol (2005) 1.55

Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer. Oncogene (2013) 1.55

Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status. Cell Rep (2015) 1.51

Lafora disease: insights into neurodegeneration from plant metabolism. Trends Biochem Sci (2009) 1.50

The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase. EMBO J (2003) 1.49

Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury. Histol Histopathol (2005) 1.47

Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor. Proc Natl Acad Sci U S A (2005) 1.47

A tumor suppressor homolog, AtPTEN1, is essential for pollen development in Arabidopsis. Plant Cell (2002) 1.47

Bacillus subtilis arsenate reductase is structurally and functionally similar to low molecular weight protein tyrosine phosphatases. Proc Natl Acad Sci U S A (2001) 1.40

Multiscale mutation clustering algorithm identifies pan-cancer mutational clusters associated with pathway-level changes in gene expression. PLoS Comput Biol (2017) 1.39

C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound state. Biochemistry (2002) 1.39

PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression. Mol Cell Biol (2008) 1.38

Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs. Mol Biol Cell (2006) 1.38

PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control. Genes Cancer (2010) 1.38

Increased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitment. J Biol Chem (2005) 1.37

Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis. Am J Pathol (2010) 1.35

Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase. Biochem J (2000) 1.33

5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells. Mol Cell Biol (2000) 1.31

Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells. J Biol Chem (2008) 1.31

Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme. EMBO J (2001) 1.31

Biodiversity of voltage sensor domain proteins. Pflugers Arch (2007) 1.30

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions. Biochem J (2001) 1.29

PTEN function: the long and the short of it. Trends Biochem Sci (2014) 1.29

Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN. Oncogene (2009) 1.27

The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. Mol Biol Cell (2005) 1.26

Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function. EMBO J (2010) 1.26

Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice. Am J Physiol Heart Circ Physiol (2008) 1.25

PTEN: Multiple Functions in Human Malignant Tumors. Front Oncol (2015) 1.24

NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration. Mol Neurodegener (2010) 1.23

Protein kinases and phosphatases in the control of cell fate. Enzyme Res (2011) 1.23

Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation. Proc Natl Acad Sci U S A (2003) 1.21

Molecular underpinning of B-cell anergy. Immunol Rev (2010) 1.20

Relevance of PTEN loss in brain metastasis formation in breast cancer patients. Breast Cancer Res (2012) 1.20

Phosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation. J Exp Med (2001) 1.19

Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair. Br J Pharmacol (2007) 1.18

Phosphorylation keeps PTEN phosphatase closed for business. Proc Natl Acad Sci U S A (2009) 1.18

Regulation of T-cell responses by PTEN. Immunol Rev (2008) 1.15

Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc Natl Acad Sci U S A (2012) 1.15

Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes. Gene (2010) 1.15

Germline variation in cancer-susceptibility genes in a healthy, ancestrally diverse cohort: implications for individual genome sequencing. PLoS One (2014) 1.14

A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. J Cell Biol (2004) 1.14

Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol (2013) 1.13

Membrane association of the PTEN tumor suppressor: molecular details of the protein-membrane complex from SPR binding studies and neutron reflection. PLoS One (2012) 1.12

miR-19a acts as an oncogenic microRNA and is up-regulated in bladder cancer. J Exp Clin Cancer Res (2014) 1.12

SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer. Cancer Cell (2014) 1.11

Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation. Cancer Res (2010) 1.11

Formin homology 2 domains occur in multiple contexts in angiosperms. BMC Genomics (2004) 1.11

On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN). Proc Natl Acad Sci U S A (2011) 1.10

Crystal structure of the cytoplasmic phosphatase and tensin homolog (PTEN)-like region of Ciona intestinalis voltage-sensing phosphatase provides insight into substrate specificity and redox regulation of the phosphoinositide phosphatase activity. J Biol Chem (2011) 1.10

Modulation of acetylation: creating a pro-survival and anti-inflammatory phenotype in lethal hemorrhagic and septic shock. J Biomed Biotechnol (2011) 1.09

Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells. J Clin Invest (2010) 1.09

Structural basis for the glucan phosphatase activity of Starch Excess4. Proc Natl Acad Sci U S A (2010) 1.08

Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis. Proc Natl Acad Sci U S A (2013) 1.07

Structural basis for substrate recognition by a unique Legionella phosphoinositide phosphatase. Proc Natl Acad Sci U S A (2012) 1.07

Articles by these authors

Initial sequencing and analysis of the human genome. Nature (2001) 212.86

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science (2001) 22.06

Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. Science (1996) 19.48

HMG-1 as a late mediator of endotoxin lethality in mice. Science (1999) 17.72

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1998) 17.36

Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal Biochem (1991) 16.18

Health information on the Internet: accessibility, quality, and readability in English and Spanish. JAMA (2001) 15.23

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science (1994) 13.51

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature (2000) 11.49

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science (1996) 9.48

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ (2011) 9.44

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature (1995) 9.03

Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc Natl Acad Sci U S A (2000) 9.02

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell (2000) 7.82

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature (1999) 7.47

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med (2000) 7.38

KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science (1998) 7.32

Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell (2000) 6.92

Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res (2000) 6.68

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature (1996) 6.67

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature (2001) 6.62

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent. Cell (1997) 5.73

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. Science (1999) 5.72

The galvanization of biology: a growing appreciation for the roles of zinc. Science (1996) 5.67

Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia. Science (1990) 5.21

Regulation of flowering time by Arabidopsis photoreceptors. Science (1998) 5.11

VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae. J Cell Biol (1995) 5.04

CREB-binding protein/p300 are transcriptional coactivators of p65. Proc Natl Acad Sci U S A (1997) 4.71

Neuraxial block, death and serious cardiovascular morbidity in the POISE trial. Br J Anaesth (2013) 4.60

Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant. Proc Natl Acad Sci U S A (1991) 4.57

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature (2000) 4.52

YY1 is an initiator sequence-binding protein that directs and activates transcription in vitro. Nature (1991) 4.30

Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease. Science (2000) 4.22

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Science (1999) 4.21

Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature (2000) 4.01

Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain. Blood (2001) 3.93

The contribution of mild and moderate preterm birth to infant mortality. Fetal and Infant Health Study Group of the Canadian Perinatal Surveillance System. JAMA (2000) 3.91

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling. Cell (1998) 3.86

Structural basis of cyclin-dependent kinase activation by phosphorylation. Nat Struct Biol (1996) 3.81

Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence. Proc Natl Acad Sci U S A (1999) 3.79

PTEN and myotubularin: novel phosphoinositide phosphatases. Annu Rev Biochem (2001) 3.78

Components of a new human protein kinase signal transduction pathway. J Biol Chem (1995) 3.78

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms. Science (1995) 3.69

Structural basis of IAP recognition by Smac/DIABLO. Nature (2001) 3.66

PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol (1999) 3.62

Rhabdomyolysis. Intern Emerg Med (2007) 3.56

Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature (2000) 3.54

The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1. J Virol (2000) 3.43

In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. J Cell Biol (1998) 3.38

A Tyr/Ser protein phosphatase encoded by vaccinia virus. Nature (1991) 3.35

Enhancement of blue-light sensitivity of Arabidopsis seedlings by a blue light receptor cryptochrome 2. Proc Natl Acad Sci U S A (1998) 3.34

A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature (1997) 3.29

Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate. Nature (1994) 3.10

Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1. Proc Natl Acad Sci U S A (1993) 3.09

Perinuclear antineutrophil cytoplasmic antibodies in patients with Crohn's disease define a clinical subgroup. Gastroenterology (1996) 3.08

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci U S A (1996) 3.07

Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J Biol Chem (1993) 3.02

Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature (1998) 3.01

Structural basis of caspase-7 inhibition by XIAP. Cell (2001) 2.99

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1. Nature (1999) 2.95

Extracellular role of HMGB1 in inflammation and sepsis. J Intern Med (2004) 2.94

Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300. Genes Dev (1995) 2.93

Does oxidative damage to DNA increase with age? Proc Natl Acad Sci U S A (2001) 2.91

Fungi isolated from tobacco leaves and brown-spot lesions before and after flue-curing. Appl Microbiol (1968) 2.87

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci U S A (2001) 2.83

HMGB1 as a late mediator of lethal systemic inflammation. Am J Respir Crit Care Med (2001) 2.80

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF. Hum Mol Genet (2001) 2.79

Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector. Science (1999) 2.78

Antagonistic actions of Arabidopsis cryptochromes and phytochrome B in the regulation of floral induction. Development (1999) 2.76

Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Nat Genet (2001) 2.75

Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Genes Dev (1999) 2.73

Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate. J Biol Chem (1991) 2.72

Familial expression of anti-Saccharomyces cerevisiae mannan antibodies in affected and unaffected relatives of patients with Crohn's disease. Gut (2000) 2.71

Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol (1999) 2.61

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci U S A (2001) 2.61

Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A (2000) 2.59

Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors. J Biol Chem (2001) 2.57

Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes. Circulation (2000) 2.56

Role of the F-box protein Skp2 in lymphomagenesis. Proc Natl Acad Sci U S A (2001) 2.55

A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proc Natl Acad Sci U S A (1997) 2.55

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature (1998) 2.52

Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Circ Res (1999) 2.47

Marker antibody expression stratifies Crohn's disease into immunologically homogeneous subgroups with distinct clinical characteristics. Gut (2000) 2.47

High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Arthritis Rheum (2002) 2.45

Randomized phase III study 306: adjunctive perampanel for refractory partial-onset seizures. Neurology (2012) 2.45

The product of the pleiotropic Escherichia coli gene csrA modulates glycogen biosynthesis via effects on mRNA stability. J Bacteriol (1995) 2.40

Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding. Cell (2001) 2.39

Structure of the histone deacetylase SIRT2. Nat Struct Biol (2001) 2.37

Protein tyrosine phosphatases. Annu Rev Biochem (1993) 2.37

Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. J Physiol (2001) 2.37

Establishing human prostate cancer cell xenografts in bone: induction of osteoblastic reaction by prostate-specific antigen-producing tumors in athymic and SCID/bg mice using LNCaP and lineage-derived metastatic sublines. Int J Cancer (1998) 2.36

Predicting clopidogrel response using DNA samples linked to an electronic health record. Clin Pharmacol Ther (2011) 2.36

New vectors for high level expression of recombinant proteins in bacteria. Anal Biochem (1992) 2.34

The end of the (cell) line: methods for the study of apoptosis in vitro. Methods Cell Biol (1995) 2.32

Superior ex vivo cord blood expansion following co-culture with bone marrow-derived mesenchymal stem cells. Bone Marrow Transplant (2006) 2.29

Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell (2001) 2.29