Published in Semin Immunol on December 01, 2004
Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. Immunity (2009) 3.18
Scaffold proteins and immune-cell signalling. Nat Rev Immunol (2009) 1.84
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. Nat Genet (2012) 1.81
Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3. J Immunol (2009) 1.64
Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains. EMBO J (2006) 1.47
c-Cbl-mediated regulation of LAT-nucleated signaling complexes. Mol Cell Biol (2007) 1.46
Cooperative interactions at the SLP-76 complex are critical for actin polymerization. EMBO J (2010) 1.45
Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol Cell Biol (2006) 1.41
RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation. Mol Cell Biol (2007) 1.41
CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. Mol Cell Biol (2006) 1.35
Comparison of T cell receptor-induced proximal signaling and downstream functions in immortalized and primary T cells. PLoS One (2009) 1.14
SLP-76 couples Syk to the osteoclast cytoskeleton. J Immunol (2009) 1.09
Regulation of B-cell entry into the cell cycle. Immunol Rev (2008) 1.06
Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization. Mol Cell Biol (2011) 1.04
Adapters in the organization of mast cell signaling. Immunol Rev (2009) 1.03
Current aspects of vitiligo genetics. Postepy Dermatol Alergol (2014) 1.01
Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells. Mol Cell Biol (2006) 1.01
The importance of LAT in the activation, homeostasis, and regulatory function of T cells. J Biol Chem (2010) 0.98
Endocytic events in TCR signaling: focus on adapters in microclusters. Immunol Rev (2009) 0.96
Super-resolution characterization of TCR-dependent signaling clusters. Immunol Rev (2013) 0.93
Polycomb-mediated loss of microRNA let-7c determines inflammatory macrophage polarization via PAK1-dependent NF-κB pathway. Cell Death Differ (2014) 0.90
The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling. FASEB J (2010) 0.88
Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood (2013) 0.88
Rationale for Targeting CD6 as a Treatment for Autoimmune Diseases. Arthritis (2011) 0.87
The integration of signaling and the spatial organization of the T cell synapse. Front Immunol (2012) 0.86
In vivo significance of ITK-SLP-76 interaction in cytokine production. Mol Cell Biol (2010) 0.86
Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis. Int J Biochem Cell Biol (2009) 0.86
SLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteins. Mol Cell Proteomics (2009) 0.85
Cbl enforces Vav1 dependence and a restricted pathway of T cell development. PLoS One (2011) 0.84
Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-κB ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling pathway. J Biol Chem (2012) 0.83
Slp-76 is a critical determinant of NK-cell mediated recognition of missing-self targets. Eur J Immunol (2015) 0.82
Regulation of T cell development by c-Cbl: essential role of Lck. Int Immunol (2014) 0.79
Genetic Susceptibility to Vitiligo: GWAS Approaches for Identifying Vitiligo Susceptibility Genes and Loci. Front Genet (2016) 0.78
Pretreatment of activated human CD8 T cells with IL-12 leads to enhanced TCR-induced signaling and cytokine production. Mol Immunol (2016) 0.77
WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site. J Biol Chem (2014) 0.77
The Immunomodulatory Functions of Diacylglycerol Kinase ζ. Front Cell Dev Biol (2016) 0.76
Navigating the leukocyte signaling maze guided by Ariadne's thread. Nat Immunol (2009) 0.75
Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation. J Mol Biol (2015) 0.75
"Cell biology meets physiology: functional organization of vertebrate plasma membranes"--the immunological synapse. Curr Top Membr (2013) 0.75
WDR1 and CLNK gene polymorphisms correlate with serum glucose and high-density lipoprotein levels in Tibetan gout patients. Rheumatol Int (2015) 0.75
T cell activation. Annu Rev Immunol (2009) 7.40
Regulation of NKT cell development by SAP, the protein defective in XLP. Nat Med (2005) 3.62
Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science (2003) 3.60
Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood (2010) 3.35
Disruption of diacylglycerol metabolism impairs the induction of T cell anergy. Nat Immunol (2006) 2.43
Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity (2011) 2.34
MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. Cancer Cell (2010) 2.29
SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity (2004) 2.18
Adaptors as central mediators of signal transduction in immune cells. Nat Immunol (2003) 2.13
Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. Nat Immunol (2003) 1.98
Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proc Natl Acad Sci U S A (2007) 1.77
Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. J Clin Invest (2011) 1.75
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. Blood (2010) 1.75
Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76. Immunity (2008) 1.72
Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3. J Immunol (2009) 1.64
Persistence of cooperatively stabilized signaling clusters drives T-cell activation. Mol Cell Biol (2006) 1.55
Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. Dev Cell (2006) 1.50
The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1. Mol Cell Biol (2006) 1.43
Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol Cell Biol (2006) 1.41
Critical roles of the PI3K/Akt signaling pathway in T cell development. Immunol Lett (2008) 1.37
Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection. J Exp Med (2005) 1.34
Functional hierarchy of the N-terminal tyrosines of SLP-76. J Immunol (2006) 1.29
Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. Mol Biol Cell (2009) 1.28
Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling. J Exp Med (2002) 1.24
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med (2009) 1.24
The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation. Blood (2006) 1.23
Phospholipase cbeta is critical for T cell chemotaxis. J Immunol (2007) 1.22
Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function. J Biol Chem (2004) 1.21
Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation. J Immunol (2009) 1.20
Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta. J Biol Chem (2002) 1.20
T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool. Blood (2010) 1.19
SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils. Immunity (2003) 1.17
Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases. Cancer Res (2013) 1.16
Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells. J Immunol (2011) 1.16
Dendritic cells induce regulatory T cell proliferation through antigen-dependent and -independent interactions. J Immunol (2010) 1.14
Compartmentalization of ITAM and integrin signaling by adapter molecules. Immunol Rev (2007) 1.11
Control of T cell function by positive and negative regulators. Science (2002) 1.10
Decreased diacylglycerol metabolism enhances ERK activation and augments CD8+ T cell functional responses. J Biol Chem (2010) 1.09
Retracted Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nat Immunol (2013) 1.09
PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation. Mol Cell Biol (2012) 1.05
Differential requirement for the SAP-Fyn interaction during NK T cell development and function. J Immunol (2008) 1.03
Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells. J Exp Med (2006) 1.02
Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76. Cold Spring Harb Perspect Biol (2010) 1.02
Retracted The requirements for natural Th17 cell development are distinct from those of conventional Th17 cells. J Exp Med (2011) 1.01
Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells. Mol Cell Biol (2006) 1.01
Indirect involvement of allergen-captured mast cells in antigen presentation. Blood (2007) 1.00
Azathioprine: old drug, new actions. J Clin Invest (2003) 0.98
Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo. J Exp Med (2008) 0.95
Proximal signaling events in Fc epsilon RI-mediated mast cell activation. J Allergy Clin Immunol (2007) 0.95
Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif. EMBO J (2007) 0.93
Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation. Proc Natl Acad Sci U S A (2002) 0.92
Adhesion- and degranulation-promoting adapter protein is required for efficient thymocyte development and selection. J Immunol (2006) 0.92
Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis. J Allergy Clin Immunol (2009) 0.91
Diacylglycerol kinases: regulated controllers of T cell activation, function, and development. Int J Mol Sci (2013) 0.90
Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice. J Exp Med (2004) 0.90
The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling. Sci Signal (2013) 0.89
Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen. Blood (2002) 0.89
In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP-76/Gads interaction. Eur J Immunol (2007) 0.88
Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing. J Immunol (2007) 0.88
Cooperation of adapter molecules in proximal signaling cascades during allergic inflammation. Immunol Rev (2009) 0.87
Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation. Mol Cell Biol (2010) 0.87
PRAM-1 is required for optimal integrin-dependent neutrophil function. Mol Cell Biol (2004) 0.86
X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses. Immunol Res (2008) 0.85
Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production. Blood (2009) 0.85
Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation. J Biol Chem (2008) 0.84
Macrophage activation and Fcgamma receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors. J Leukoc Biol (2003) 0.83
Regulation of T cell integrin function by adapter proteins. Immunol Res (2008) 0.83
Integrins and ITAMs: more than just good neighbors. Nat Immunol (2006) 0.82
FoxO-dependent regulation of diacylglycerol kinase α gene expression. Mol Cell Biol (2012) 0.81
Cutting edge: rescue of pre-TCR but not mature TCR signaling in mice expressing membrane-targeted SLP-76. J Immunol (2009) 0.79
An integrated stochastic model of "inside-out" integrin activation and selective T-lymphocyte recruitment. Langmuir (2012) 0.79
Understanding signal integration through targeted mutations of an adapter protein. FEBS Lett (2010) 0.78
CD3varepsilon: PeRuSing for positive selection. Nat Immunol (2008) 0.78
The SLP-76 Src homology 2 domain is required for T cell development and activation. J Immunol (2011) 0.78
Transient PKCα shuttling to the immunological synapse is governed by DGKζ and regulates L-selectin shedding. J Cell Sci (2013) 0.78
PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization. Blood (2006) 0.78
Reversible lacrimal gland-protective regulatory T-cell dysfunction underlies male-specific autoimmune dacryoadenitis in the non-obese diabetic mouse model of Sjögren syndrome. Immunology (2015) 0.78
SLP-76 is required for optimal CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow. Eur J Immunol (2012) 0.77
Diacylglycerol kinase zeta negatively regulates CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow. Integr Biol (Camb) (2012) 0.76
Retraction. The requirements for natural Th17 cell development are distinct from those of conventional Th17 cells. J Exp Med (2014) 0.76
Navigating the leukocyte signaling maze guided by Ariadne's thread. Nat Immunol (2009) 0.75
Lymphocyte signaling in the Tuscan hills. Immunity (2009) 0.75
Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements. J Immunol (2003) 0.75
Impaired thymic selection in mice expressing altered levels of the SLP-76 adaptor protein. J Leukoc Biol (2007) 0.75
Antigen receptor signaling: the Tuscan connection. Nat Immunol (2007) 0.75