Published in Immunity on November 01, 2003
The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol (2010) 4.26
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol (2006) 3.68
Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice. J Clin Invest (2007) 1.47
The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1. Mol Cell Biol (2006) 1.43
Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol Cell Biol (2006) 1.41
SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility. Proc Natl Acad Sci U S A (2009) 1.35
Neutrophil cell surface receptors and their intracellular signal transduction pathways. Int Immunopharmacol (2013) 1.23
The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells. Immunol Rev (2009) 1.23
Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis. J Exp Med (2009) 1.21
The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells. Mol Cell Biol (2009) 1.19
Integrin signalling and function in immune cells. Immunology (2012) 1.07
Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med (2012) 1.07
Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76. Cold Spring Harb Perspect Biol (2010) 1.02
Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate. Proc Natl Acad Sci U S A (2010) 0.97
Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection. Cell Host Microbe (2013) 0.97
Immunopathologies linked to integrin signalling. Semin Immunopathol (2010) 0.94
Vav/Phospholipase Cgamma2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis. Arthritis Rheum (2008) 0.94
Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis. J Allergy Clin Immunol (2009) 0.91
ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling. Blood (2010) 0.87
PRAM-1 is required for optimal integrin-dependent neutrophil function. Mol Cell Biol (2004) 0.86
Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells. Mol Cell Biol (2004) 0.82
Understanding signal integration through targeted mutations of an adapter protein. FEBS Lett (2010) 0.78
CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins. Biochem J (2013) 0.78
The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and Function. Immune Netw (2009) 0.75
T cell activation. Annu Rev Immunol (2009) 7.40
Perioperative mortality and long-term survival following live kidney donation. JAMA (2010) 7.34
Desensitization in HLA-incompatible kidney recipients and survival. N Engl J Med (2011) 6.72
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature (2009) 5.00
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol (2006) 3.68
Regulation of NKT cell development by SAP, the protein defective in XLP. Nat Med (2005) 3.62
Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science (2003) 3.60
Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood (2005) 3.57
Syk is required for integrin signaling in neutrophils. Immunity (2002) 3.39
Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood (2010) 3.35
Is geriatric medicine terminally ill? Ann Intern Med (2012) 3.28
The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A (2004) 3.15
Transfusion-related acute lung injury: incidence and risk factors. Blood (2011) 3.12
Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest (2009) 3.08
Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat Immunol (2005) 2.97
Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol (2002) 2.92
The ins and outs of leukocyte integrin signaling. Annu Rev Immunol (2009) 2.76
Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity (2008) 2.67
Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest (2006) 2.50
Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. Immunity (2007) 2.43
Disruption of diacylglycerol metabolism impairs the induction of T cell anergy. Nat Immunol (2006) 2.43
Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity (2011) 2.34
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers. J Clin Invest (2012) 2.33
MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. Cancer Cell (2010) 2.29
SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity (2004) 2.18
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond. Nat Rev Immunol (2006) 2.14
Adaptors as central mediators of signal transduction in immune cells. Nat Immunol (2003) 2.13
Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol (2003) 2.04
Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation. J Exp Med (2009) 2.03
Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. Nat Immunol (2003) 1.98
The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity (2010) 1.97
The multifaceted functions of neutrophils. Annu Rev Pathol (2013) 1.97
PI3Kβ plays a critical role in neutrophil activation by immune complexes. Sci Signal (2011) 1.95
Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI. Proc Natl Acad Sci U S A (2003) 1.94
Cutaneous malignant melanoma. Mayo Clin Proc (2006) 1.88
Src and Syk kinases: key regulators of phagocytic cell activation. Trends Immunol (2005) 1.81
Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice. Immunity (2013) 1.80
PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med (2008) 1.79
Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils. Immunity (2006) 1.79
Infusion of high-dose intravenous immunoglobulin fails to lower the strength of human leukocyte antigen antibodies in highly sensitized patients. Transplantation (2012) 1.78
Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proc Natl Acad Sci U S A (2007) 1.77
Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A (2011) 1.76
Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. J Clin Invest (2011) 1.75
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. Blood (2010) 1.75
Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76. Immunity (2008) 1.72
Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells. Immunity (2011) 1.72
ABO incompatible renal transplantation: a paradigm ready for broad implementation. Transplantation (2009) 1.71
Neutrophils mediate antibody-induced antitumor effects in mice. Blood (2013) 1.66
Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3. J Immunol (2009) 1.64
Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons. J Neurosci (2010) 1.62
Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury. J Clin Invest (2004) 1.58
Persistence of cooperatively stabilized signaling clusters drives T-cell activation. Mol Cell Biol (2006) 1.55
Molecular editing of cellular responses by the high-affinity receptor for IgE. Science (2014) 1.53
Pregnancy outcomes of liver transplant recipients: a systematic review and meta-analysis. Liver Transpl (2012) 1.52
Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. Dev Cell (2006) 1.50
The expanding role for ITAM-based signaling pathways in immune cells. Sci STKE (2007) 1.50
Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Rep (2012) 1.45
G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood (2005) 1.45
The SLP-76 family of adapter proteins. Semin Immunol (2004) 1.44
The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1. Mol Cell Biol (2006) 1.43
Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma. Clin Cancer Res (2013) 1.42
Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med (2010) 1.41
Atlas stumbled: kinesin light chain-1 variant E triggers a vicious cycle of axonal transport disruption and amyloid-β generation in Alzheimer's disease. Bioessays (2014) 1.41
Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol Cell Biol (2006) 1.41
Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J Immunol (2004) 1.40
Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors. Nat Immunol (2004) 1.39
Critical roles of the PI3K/Akt signaling pathway in T cell development. Immunol Lett (2008) 1.37
Declining outcomes in simultaneous liver-kidney transplantation in the MELD era: ineffective usage of renal allografts. Transplantation (2008) 1.35
Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection. J Exp Med (2005) 1.34
Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood (2009) 1.34
G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells. Blood (2003) 1.30
Activity-dependent release of tissue plasminogen activator from the dendritic spines of hippocampal neurons revealed by live-cell imaging. J Neurobiol (2006) 1.29
Interferon-γ production by neutrophils during bacterial pneumonia in mice. Am J Respir Crit Care Med (2010) 1.29
Functional hierarchy of the N-terminal tyrosines of SLP-76. J Immunol (2006) 1.29
Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. Mol Biol Cell (2009) 1.28
Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol Rev (2009) 1.25
Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol (2005) 1.25
The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B. Immunity (2005) 1.25
Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma. Eur J Immunol (2008) 1.24
Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling. J Exp Med (2002) 1.24
The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood (2007) 1.24
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med (2009) 1.24
Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens. J Biol Chem (2012) 1.23
The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation. Blood (2006) 1.23
The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells. Immunol Rev (2009) 1.23
Conversion of green fluorescent protein into a toxic, aggregation-prone protein by C-terminal addition of a short peptide. J Biol Chem (2005) 1.23
Phospholipase cbeta is critical for T cell chemotaxis. J Immunol (2007) 1.22
Immunoreceptor-like signaling by beta 2 and beta 3 integrins. Trends Cell Biol (2007) 1.21
Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function. J Biol Chem (2004) 1.21
Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading. Immunity (2003) 1.21
Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta. J Biol Chem (2002) 1.20