Genetic Susceptibility to Vitiligo: GWAS Approaches for Identifying Vitiligo Susceptibility Genes and Loci.

PubWeight™: 0.78‹?›

🔗 View Article (PMID 26870082)

Published in Front Genet on February 01, 2016

Authors

Changbing Shen1, Jing Gao2, Yujun Sheng1, Jinfa Dou1, Fusheng Zhou1, Xiaodong Zheng1, Randy Ko3, Xianfa Tang1, Caihong Zhu1, Xianyong Yin4, Liangdan Sun1, Yong Cui5, Xuejun Zhang6

Author Affiliations

1: Institute and Department of Dermatology, The First Affiliated Hospital, Anhui Medical University Hefei, China.
2: Department of Dermatology, The Second Affiliated Hospital, Anhui Medical University Hefei, China.
3: Department of Biochemistry, University of New Mexico Albuquerque, NM, USA.
4: Department of Genetics and Renaissance Computing Institute, University of North Carolina at Chapel Hill Chapel Hill, NC, USA.
5: Department of Dermatology, China-Japan Friendship Hospital Beijing, China.
6: Institute and Department of Dermatology, The First Affiliated Hospital, Anhui Medical UniversityHefei, China; Department of Dermatology, The Second Affiliated Hospital, Anhui Medical UniversityHefei, China.

Articles cited by this

(truncated to the top 100)

Finding the missing heritability of complex diseases. Nature (2009) 67.95

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature (2005) 15.28

A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet (2004) 13.71

Detecting gene-gene interactions that underlie human diseases. Nat Rev Genet (2009) 12.07

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet (2006) 8.65

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet (2008) 7.71

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet (2009) 5.75

The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome. Nat Genet (2007) 4.63

Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Am J Hum Genet (2004) 4.46

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet (2005) 4.36

The CC chemokine CCL20 and its receptor CCR6. Cytokine Growth Factor Rev (2003) 3.96

Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families. Pigment Cell Res (2003) 3.07

A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. Diabetes (2008) 2.90

Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature (2010) 2.85

Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science (2009) 2.76

Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo. Immunity (2006) 2.62

The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae. J Cell Biol (2009) 2.61

A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes (2008) 2.51

Phenotypic and functional analysis of CD8(+) T cells undergoing peripheral deletion in response to cross-presentation of self-antigen. J Exp Med (2001) 2.49

Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. N Engl J Med (2010) 2.47

BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis. Nature (2013) 2.36

Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cells. Immunity (2006) 2.21

Common and different genetic background for rheumatoid arthritis and coeliac disease. Hum Mol Genet (2009) 2.15

A genome-wide association study identifies two new risk loci for Graves' disease. Nat Genet (2011) 1.92

Xp54 and related (DDX6-like) RNA helicases: roles in messenger RNP assembly, translation regulation and RNA degradation. Nucleic Acids Res (2006) 1.83

Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. Nat Genet (2012) 1.81

Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations. Gut (2013) 1.79

Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC. Nat Genet (2010) 1.69

Granzyme B: pro-apoptotic, antiviral and antitumor functions. Curr Opin Immunol (2003) 1.67

Multiple Loci within the major histocompatibility complex confer risk of psoriasis. PLoS Genet (2009) 1.58

Fine-mapping of vitiligo susceptibility loci on chromosomes 7 and 9 and interactions with NLRP1 (NALP1). J Invest Dermatol (2009) 1.51

Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility. J Clin Endocrinol Metab (2007) 1.49

The SLP-76 family of adapter proteins. Semin Immunol (2004) 1.44

The genetics of generalized vitiligo. Curr Dir Autoimmun (2008) 1.42

The adaptor Lnk (SH2B3): an emerging regulator in vascular cells and a link between immune and inflammatory signaling. Biochem Pharmacol (2011) 1.35

Autoimmunity as an aetiological factor in vitiligo. J Eur Acad Dermatol Venereol (2007) 1.34

Caspase-7: a protease involved in apoptosis and inflammation. Int J Biochem Cell Biol (2009) 1.30

Common variants in FOXP1 are associated with generalized vitiligo. Nat Genet (2010) 1.25

The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesis. Proc Natl Acad Sci U S A (2009) 1.25

Analysis of a functional BTNL2 polymorphism in type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus. Hum Immunol (2006) 1.24

Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis. Arthritis Rheum (2009) 1.23

Tob genes in development and homeostasis. Dev Dyn (2007) 1.17

Six decades of vitiligo genetics: genome-wide studies provide insights into autoimmune pathogenesis. J Invest Dermatol (2011) 1.15

Novel vitiligo susceptibility loci on chromosomes 7 (AIS2) and 8 (AIS3), confirmation of SLEV1 on chromosome 17, and their roles in an autoimmune diathesis. Am J Hum Genet (2004) 1.15

Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP. J Invest Dermatol (2010) 1.14

Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8. J Invest Dermatol (2009) 1.14

The H syndrome is caused by mutations in the nucleoside transporter hENT3. Am J Hum Genet (2008) 1.11

Cytotoxic T lymphocyte reactivity to gp100, MelanA/MART-1, and tyrosinase, in HLA-A2-positive vitiligo patients. J Invest Dermatol (2003) 1.11

Atrophin proteins: an overview of a new class of nuclear receptor corepressors. Nucl Recept Signal (2008) 1.10

IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk. Eur J Hum Genet (2008) 1.08

Genome-wide analysis identifies a quantitative trait locus in the MHC class II region associated with generalized vitiligo age of onset. J Invest Dermatol (2011) 1.08

Next-generation DNA re-sequencing identifies common variants of TYR and HLA-A that modulate the risk of generalized vitiligo via antigen presentation. J Invest Dermatol (2012) 1.07

The genetics of generalized vitiligo: autoimmune pathways and an inverse relationship with malignant melanoma. Genome Med (2010) 1.07

Genetic variation of promoter sequence modulates XBP1 expression and genetic risk for vitiligo. PLoS Genet (2009) 1.07

A homozygous missense mutation in HERC2 associated with global developmental delay and autism spectrum disorder. Hum Mutat (2012) 1.05

Melanocortin 1 receptor variants: functional role and pigmentary associations. Photochem Photobiol (2011) 1.04

Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15. Oncogene (2000) 1.04

Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28. J Biol Chem (1995) 1.03

The widely expressed extracellular matrix protein SMOC-2 promotes keratinocyte attachment and migration. Exp Cell Res (2008) 1.02

Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis. BMC Med Genet (2009) 1.01

Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus. Arthritis Rheum (2011) 1.01

A novel linkage to generalized vitiligo on 4q13-q21 identified in a genomewide linkage analysis of Chinese families. Am J Hum Genet (2005) 1.00

IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunity. Semin Immunol (2009) 1.00

Functional evolution of the TICAM-1 pathway for extrinsic RNA sensing. Immunol Rev (2009) 0.99

Association of vitiligo with HLA-A2: a meta-analysis. J Eur Acad Dermatol Venereol (2007) 0.99

A genomewide screen for generalized vitiligo: confirmation of AIS1 on chromosome 1p31 and evidence for additional susceptibility loci. Am J Hum Genet (2003) 0.99

Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population. J Invest Dermatol (2012) 0.98

Mutation of HERC2 causes developmental delay with Angelman-like features. J Med Genet (2012) 0.98

Carriers of rare missense variants in IFIH1 are protected from psoriasis. J Invest Dermatol (2010) 0.97

Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74. Clin Endocrinol (Oxf) (2006) 0.97

Psoriasis regression analysis of MHC loci identifies shared genetic variants with vitiligo. PLoS One (2011) 0.96

Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis. Hum Mol Genet (2013) 0.95

MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis. Brain (2013) 0.94

Multifaceted regulation of T cells by CD44. Commun Integr Biol (2010) 0.94

Genetic epidemiology of vitiligo: a study of 815 probands and their families from south China. Int J Dermatol (2006) 0.92

MHC fine mapping of human type 1 diabetes using the T1DGC data. Diabetes Obes Metab (2009) 0.90

Caspase 7 is a positional candidate gene for IDDM 17 in a Bedouin Arab family. Ann N Y Acad Sci (2003) 0.90

Caspase 7 influences susceptibility to rheumatoid arthritis. Rheumatology (Oxford) (2007) 0.89

Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis. Arthritis Rheum (2008) 0.88

Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis. Mol Med (2009) 0.88

The analysis of genetics and associated autoimmune diseases in Chinese vitiligo patients. Arch Dermatol Res (2008) 0.88

Association of HLA class I antigens and HLA class II alleles with vitiligo in a Turkish population. Pigment Cell Res (2004) 0.88

Evidence for two susceptibility loci on chromosomes 22q12 and 6p21-p22 in Chinese generalized vitiligo families. J Invest Dermatol (2007) 0.87

Polymorphisms in the melanocortin-1 receptor (MC1R) and agouti signaling protein (ASIP) genes in Korean vitiligo patients. Pigment Cell Res (2003) 0.86

The centrosomal FOP protein is required for cell cycle progression and survival. Cell Cycle (2009) 0.86

Characteristics of genetic epidemiology and genetic models for vitiligo. J Am Acad Dermatol (2004) 0.86

Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans. Inflamm Bowel Dis (2015) 0.85

Identification of CDH23 mutations in Korean families with hearing loss by whole-exome sequencing. BMC Med Genet (2014) 0.85

SMOC2 gene variant and the risk of vitiligo in Jordanian Arabs. Eur J Dermatol (2010) 0.85

[Familial vitiligo]. Z Haut Geschlechtskr (1950) 0.85

Expression features of CXCR5 and its ligand, CXCL13 associated with poor prognosis of advanced colorectal cancer. Eur Rev Med Pharmacol Sci (2014) 0.85

Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia. Leuk Res (2009) 0.84

Association of HLA class I alleles with vitiligo in Chinese Hans. J Dermatol Sci (2004) 0.84

[Hereditary aspects of vitiligo]. Z Haut Geschlechtskr (1950) 0.84

Relationship between levels of soluble interleukin-2 receptors and the types and activity of vitiligo. J Dermatol (1997) 0.83

Functional characterization of two novel splicing mutations in the OCA2 gene associated with oculocutaneous albinism type II. Gene (2013) 0.83

Gene expression analysis of melanocortin system in vitiligo. J Dermatol Sci (2007) 0.82

The PTPN22-1858C>T (R620W) functional polymorphism is associated with generalized vitiligo in the Romanian population. Pigment Cell Melanoma Res (2008) 0.82