Published in Mol Cell Biol on December 01, 2004
Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site. Structure (2009) 2.33
The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus. Mol Biol Cell (2006) 2.01
Plant and animal pathogen recognition receptors signal through non-RD kinases. PLoS Pathog (2006) 1.87
The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function. PLoS One (2009) 1.63
Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance. PLoS Genet (2011) 1.56
Human VRK1 is an early response gene and its loss causes a block in cell cycle progression. PLoS One (2008) 1.36
Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells. Mol Cell Biol (2007) 1.31
p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop. Mol Cell Biol (2006) 1.26
Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1. Mol Cell Biol (2007) 1.10
Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein. PLoS One (2008) 1.10
Systematic analysis of human kinase genes: a large number of genes and alternative splicing events result in functional and structural diversity. BMC Bioinformatics (2005) 1.09
Analysis of kinase gene expression patterns across 5681 human tissue samples reveals functional genomic taxonomy of the kinome. PLoS One (2010) 1.02
PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis. Mol Cell Biol (2009) 1.00
Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation. Mol Cell Biol (2008) 0.99
Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response. J Biol Chem (2009) 0.97
Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia. Biol Reprod (2009) 0.97
A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection. J Biol Chem (2008) 0.96
Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells. PLoS One (2010) 0.95
Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway. PLoS One (2011) 0.95
Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities. Mol Cell Proteomics (2008) 0.92
Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression. Cell Death Dis (2013) 0.92
Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase. J Biol Chem (2011) 0.91
VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer. Mol Cell Biol (2010) 0.90
Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo. Oncogenesis (2013) 0.90
Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2. J Biol Chem (2012) 0.88
Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage. J Biol Chem (2012) 0.88
Differential inhibitor sensitivity between human kinases VRK1 and VRK2. PLoS One (2011) 0.87
The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53. PLoS One (2008) 0.85
Functional disruption of the moloney murine leukemia virus preintegration complex by vaccinia-related kinases. J Biol Chem (2010) 0.85
Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage-induced apoptosis. Mol Biol Cell (2011) 0.85
Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling. J Virol (2006) 0.84
VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage. Epigenetics (2015) 0.84
Luteolin suppresses cancer cell proliferation by targeting vaccinia-related kinase 1. PLoS One (2014) 0.83
HnRNP A1 phosphorylated by VRK1 stimulates telomerase and its binding to telomeric DNA sequence. Nucleic Acids Res (2012) 0.82
Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response. Oncotarget (2014) 0.79
Mitogen-activated protein kinase phosphatase 2 regulates histone H3 phosphorylation via interaction with vaccinia-related kinase 1. Mol Biol Cell (2012) 0.79
Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition. Oncotarget (2015) 0.78
VRK2 identifies a subgroup of primary high-grade astrocytomas with a better prognosis. BMC Clin Pathol (2013) 0.78
Biomarkers of head and neck cancer, tools or a gordian knot? Int J Clin Exp Med (2015) 0.78
Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals. J Biol Inorg Chem (2013) 0.77
Novel motor phenotypes in patients with VRK1 mutations without pontocerebellar hypoplasia. Neurology (2016) 0.76
Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells. Sci Rep (2015) 0.76
VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle. Sci Rep (2015) 0.76
Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation. Sci Rep (2016) 0.75
The changes of vaccinia related kinase 1 in grafted heart after rat heart transplantation. J Thorac Dis (2014) 0.75
Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations. Sci Rep (2017) 0.75
VRK1 promotes cisplatin resistance by up-regulating c-MYC via c-Jun activation and serves as a therapeutic target in esophageal squamous cell carcinoma. Oncotarget (2017) 0.75
The protein kinase complement of the human genome. Science (2002) 35.36
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature (2003) 26.58
Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science (1998) 17.91
Live or let die: the cell's response to p53. Nat Rev Cancer (2002) 15.06
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature (1995) 10.18
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science (1996) 9.48
The RB and p53 pathways in cancer. Cancer Cell (2002) 8.02
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res (1999) 7.82
Regulation of the G2/M transition by p53. Oncogene (2001) 7.02
The p53 pathway. J Pathol (1999) 6.79
An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat Genet (2003) 5.82
The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature (2004) 5.05
Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell (2003) 4.96
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat Cell Biol (2003) 4.77
"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J (2002) 4.17
A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05
Regulation and function of the p53 tumor suppressor protein. Curr Opin Cell Biol (2001) 3.46
Stress signals utilize multiple pathways to stabilize p53. Mol Cell Biol (2000) 3.12
Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2. EMBO J (1999) 3.00
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J Biol Chem (2003) 2.54
Regulation of p53 stability. Oncogene (1999) 2.54
Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms. EMBO Rep (2001) 2.27
Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding. J Biol Chem (2000) 2.08
Molecular mechanism of the interaction between MDM2 and p53. J Mol Biol (2002) 2.03
Multiple roles of the tumor suppressor p53. Curr Opin Oncol (2002) 1.99
Chk2 activation and phosphorylation-dependent oligomerization. Mol Cell Biol (2002) 1.88
Multisite phosphorylation and the integration of stress signals at p53. Cell Signal (1998) 1.73
Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53. Biochemistry (1997) 1.66
Mutation of mouse p53 Ser23 and the response to DNA damage. Mol Cell Biol (2002) 1.65
Phosphorylation site interdependence of human p53 post-translational modifications in response to stress. J Biol Chem (2003) 1.63
p53 Antiproliferative function is enhanced by aspartate substitution at threonine 18 and serine 20. Cancer Biol Ther (2002) 1.63
The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein. Oncogene (2000) 1.62
DNA-dependent acetylation of p53 by the transcription coactivator p300. J Biol Chem (2002) 1.59
The vaccinia virus B1R gene product is a serine/threonine protein kinase. J Virol (1992) 1.57
Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase. Genomics (1997) 1.55
Vaccinia virus gene B1R encodes a 34-kDa serine/threonine protein kinase that localizes in cytoplasmic factories and is packaged into virions. Virology (1992) 1.50
Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers. Biochem J (1999) 1.47
Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK. J Biol Chem (2004) 1.46
Role for p300 in stabilization of p53 in the response to DNA damage. J Biol Chem (1999) 1.43
c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK). Oncogene (2004) 1.42
Characterization of two protein kinases from Schizosaccharomyces pombe involved in the regulation of DNA repair. EMBO J (1994) 1.40
The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53. Mol Cell Biol (2003) 1.33
Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases. J Biol Chem (1994) 1.33
Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300. EMBO Rep (2001) 1.30
Questioning the role of checkpoint kinase 2 in the p53 DNA damage response. J Biol Chem (2003) 1.29
Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15. FEBS Lett (1999) 1.16
MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis. J Biol Chem (2003) 1.10
Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. Oncogene (2002) 1.09
Limited role of N-terminal phosphoserine residues in the activation of transcription by p53. Oncogene (2004) 1.09
Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1. Arch Biochem Biophys (2002) 1.05
Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development. FEBS Lett (2003) 1.02
Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain. EMBO Rep (2003) 1.01
Effect of phosphorylation on tetramerization of the tumor suppressor protein p53. J Protein Chem (1997) 0.91
Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2. Biochem J (2004) 0.90
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature (2010) 4.38
Prdm16 is a physiologic regulator of hematopoietic stem cells. Blood (2011) 1.86
Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity. Nat Cell Biol (2012) 1.56
Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell (2012) 1.54
The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer. Hum Mol Genet (2009) 1.47
Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK. J Biol Chem (2004) 1.46
c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK). Oncogene (2004) 1.42
Human VRK1 is an early response gene and its loss causes a block in cell cycle progression. PLoS One (2008) 1.36
Tetraspanin proteins as organisers of membrane microdomains and signalling complexes. Cell Signal (2003) 1.32
VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma. Mol Cancer Res (2006) 1.26
p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop. Mol Cell Biol (2006) 1.26
The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines. FEBS J (2006) 1.20
Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1. Mol Cell Biol (2007) 1.10
Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein. PLoS One (2008) 1.10
Roles of VRK1 as a new player in the control of biological processes required for cell division. Cell Signal (2011) 1.07
Identification of a dominant epitope in human vaccinia-related kinase 1 (VRK1) and detection of different intracellular subpopulations. Arch Biochem Biophys (2007) 1.07
Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1. Arch Biochem Biophys (2002) 1.05
Cancer as a reprogramming-like disease: implications in tumor development and treatment. Semin Cancer Biol (2010) 1.03
Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development. FEBS Lett (2003) 1.02
Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation. Mol Cell Biol (2008) 0.99
Alteration of the VRK1-p53 autoregulatory loop in human lung carcinomas. Lung Cancer (2007) 0.96
A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection. J Biol Chem (2008) 0.96
Apoptosis protection and survival signal by the CD53 tetraspanin antigen. Oncogene (2003) 0.96
Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway. PLoS One (2011) 0.95
Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities. Mol Cell Proteomics (2008) 0.92
The vaccinia virus B1R kinase induces p53 downregulation by an Mdm2-dependent mechanism. Virology (2004) 0.92
Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency. Nat Protoc (2012) 0.91
VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer. Mol Cell Biol (2010) 0.90
VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling. Cell Mol Life Sci (2012) 0.88
Transient activation of the c-Jun N-terminal kinase (JNK) activity by ligation of the tetraspan CD53 antigen in different cell types. Eur J Biochem (2002) 0.88
Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage. J Biol Chem (2012) 0.88
Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2. J Biol Chem (2012) 0.88
Differential inhibitor sensitivity between human kinases VRK1 and VRK2. PLoS One (2011) 0.87
Patterning pluripotency in embryonic stem cells. Stem Cells (2013) 0.86
JC virus in the pathogenesis of colorectal cancer, an etiological agent or another component in a multistep process? Virol J (2010) 0.86
The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53. PLoS One (2008) 0.85
SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal. Epigenetics (2013) 0.85
Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling. J Virol (2006) 0.84
VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage. Epigenetics (2015) 0.84
Microbial contamination of carcasses, meat, and equipment from an Iberian pork cutting plant. J Food Prot (2004) 0.83
Substrate profiling of human vaccinia-related kinases identifies coilin, a Cajal body nuclear protein, as a phosphorylation target with neurological implications. J Proteomics (2011) 0.81
Human JC polyomavirus in normal colorectal mucosa, hyperplastic polyps, sporadic adenomas, and adenocarcinomas in Portugal. J Med Virol (2013) 0.81
Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response. Oncotarget (2014) 0.79
Human TSG101 does not replace Saccharomyces cerevisiae VPS23 role in the quality control of plasma membrane proteins. FEMS Microbiol Lett (2003) 0.79
Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals. J Biol Inorg Chem (2013) 0.77
Induction of DNA synthesis by ligation of the CD53 tetraspanin antigen in primary cultures of mesangial cells. Kidney Int (2003) 0.76