A dynamic role of HAUSP in the p53-Mdm2 pathway.

Modes of p53 regulation. Cell (2009) 9.31

p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57

Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer (2009) 4.06

USP10 regulates p53 localization and stability by deubiquitinating p53. Cell (2010) 3.17

The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol (2010) 3.08

Monoubiquitylation promotes mitochondrial p53 translocation. EMBO J (2007) 2.62

p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54

The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity. J Virol (2005) 2.49

Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35

Protein partners of deubiquitinating enzymes. Biochem J (2008) 2.15

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO J (2007) 2.07

DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. Sci Signal (2010) 2.04

Regulation of human p53 activity and cell localization by alternative splicing. Mol Cell Biol (2004) 2.01

Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? Mol Cancer Res (2009) 1.87

A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae. J Virol (2005) 1.85

A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell (2012) 1.79

Regulation of NF-κB by deubiquitinases. Immunol Rev (2012) 1.78

Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo. Mol Cell Biol (2007) 1.76

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The ubiquitin system, disease, and drug discovery. BMC Biochem (2008) 1.73

Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol Cell (2009) 1.72

Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism. J Biol Chem (2006) 1.62

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1. Mol Cell Biol (2004) 1.56

Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7. J Virol (2005) 1.54

The p53--Mdm2--HAUSP complex is involved in p53 stabilization by HAUSP. Oncogene (2007) 1.54

p53 regulation by ubiquitin. FEBS Lett (2011) 1.51

Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. Nat Cell Biol (2011) 1.49

Inactivation of HAUSP in vivo modulates p53 function. Oncogene (2009) 1.48

53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms. Mol Cell (2016) 1.44

Deubiquitinating enzymes as novel anticancer targets. Future Oncol (2007) 1.43

A strategy for modulation of enzymes in the ubiquitin system. Science (2013) 1.43

Regulation of proteolysis by human deubiquitinating enzymes. Biochim Biophys Acta (2013) 1.42

ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. Mol Cell (2012) 1.40

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. EMBO J (2011) 1.38

The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. EMBO J (2008) 1.37

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol (2014) 1.35

Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc. Neoplasia (2006) 1.34

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. Nucleic Acids Res (2011) 1.32

M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. Proc Natl Acad Sci U S A (2012) 1.32

Reverse the curse--the role of deubiquitination in cell cycle control. Curr Opin Cell Biol (2008) 1.31

Epstein-Barr nuclear antigen 1 contributes to nasopharyngeal carcinoma through disruption of PML nuclear bodies. PLoS Pathog (2008) 1.31

Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor. EMBO J (2010) 1.28

JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress. EMBO J (2011) 1.28

USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. EMBO J (2011) 1.26

Deubiquitinases as a signaling target of oxidative stress. Cell Rep (2012) 1.25

Regulation of p53 stability and function by the deubiquitinating enzyme USP42. EMBO J (2011) 1.24

USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin. J Cell Biol (2009) 1.23

The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X. Traffic (2008) 1.22

WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex. J Biol Chem (2010) 1.20

Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7. Nat Chem Biol (2012) 1.20

Patented small molecule inhibitors in the ubiquitin proteasome system. BMC Biochem (2007) 1.19

Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2. J Virol (2009) 1.18

Deubiquitylating enzymes and disease. BMC Biochem (2008) 1.17

EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication. PLoS Pathog (2009) 1.16

p53 mediates interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human urothelial cells. FEBS Lett (2007) 1.14

TSPYL5 suppresses p53 levels and function by physical interaction with USP7. Nat Cell Biol (2010) 1.13

Molecular basis and regulation of OTULIN-LUBAC interaction. Mol Cell (2014) 1.12

PACT is a negative regulator of p53 and essential for cell growth and embryonic development. Proc Natl Acad Sci U S A (2007) 1.12

Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases. Expert Rev Mol Med (2011) 1.12

Versatile functions of p53 protein in multicellular organisms. Biochemistry (Mosc) (2007) 1.11

Degradation of MDM2 by the interaction between berberine and DAXX leads to potent apoptosis in MDM2-overexpressing cancer cells. Cancer Res (2010) 1.10

A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. PLoS Biol (2010) 1.08

Multitasking with ubiquitin through multivalent interactions. Trends Biochem Sci (2010) 1.07

DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control. BMC Biol (2013) 1.06

New insights into p53 activation. Cell Res (2010) 1.06

Uncovering ubiquitin and ubiquitin-like signaling networks. Chem Rev (2011) 1.06

USP7/HAUSP stimulates repair of oxidative DNA lesions. Nucleic Acids Res (2010) 1.06

Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol (2013) 1.05

MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. Oncotarget (2015) 1.05

An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes. Front Mol Neurosci (2014) 1.01

The herpesvirus associated ubiquitin specific protease, USP7, is a negative regulator of PML proteins and PML nuclear bodies. PLoS One (2011) 1.00

MDM2 and MDMX: Alone and together in regulation of p53. Transl Cancer Res (2012) 1.00

DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase. Cell Cycle (2015) 0.99

Histone H2B ubiquitination: the cancer connection. Genes Dev (2008) 0.99

Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modifications. Mol Cell Biol (2007) 0.99

Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme. J Biol Chem (2011) 0.98

Contributions of Epstein-Barr nuclear antigen 1 (EBNA1) to cell immortalization and survival. Viruses (2012) 0.97

A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model. Cell Cycle (2008) 0.97

The Mdm network and its regulation of p53 activities: a rheostat of cancer risk. Hum Mutat (2014) 0.97

The role of deubiquitinating enzymes in chromatin regulation. FEBS Lett (2010) 0.96

Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. Mol Cell Biol (2006) 0.96

USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis. Cell Death Dis (2013) 0.96

Targeting the ubiquitin pathway for cancer treatment. Biochim Biophys Acta (2014) 0.93

Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets. Cancer Biol Ther (2010) 0.93

Biosynthetic enzyme GMP synthetase cooperates with ubiquitin-specific protease 7 in transcriptional regulation of ecdysteroid target genes. Mol Cell Biol (2009) 0.92

The ubiquitin-specific protease USP7 modulates the replication of Kaposi's sarcoma-associated herpesvirus latent episomal DNA. J Virol (2012) 0.92

SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. Genes Dev (2013) 0.92

Mdm2 links genotoxic stress and metabolism to p53. Protein Cell (2011) 0.92

Interaction of the deubiquitinating enzyme Ubp2 and the e3 ligase Rsp5 is required for transporter/receptor sorting in the multivesicular body pathway. PLoS One (2009) 0.92

Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway. Mol Cell Biol (2013) 0.91

Deubiquitylating enzyme UBP64 controls cell fate through stabilization of the transcriptional repressor tramtrack. Mol Cell Biol (2007) 0.91

Deubiquitinating enzymes as oncotargets. Oncotarget (2015) 0.91

Does control of mutant p53 by Mdm2 complicate cancer therapy? Genes Dev (2008) 0.90

Roles of HAUSP-mediated p53 regulation in central nervous system development. Cell Death Differ (2011) 0.90

Deubiquitylation machinery is required for embryonic polarity in Caenorhabditis elegans. PLoS Genet (2012) 0.89

Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein. J Biol Chem (2014) 0.89

USP7 modulates UV-induced PCNA monoubiquitination by regulating DNA polymerase eta stability. Oncogene (2014) 0.87

A role for USP7 in DNA replication. Mol Cell Biol (2013) 0.86

Supervillin-mediated suppression of p53 protein enhances cell survival. J Biol Chem (2013) 0.86

USP7 is essential for maintaining Rad18 stability and DNA damage tolerance. Oncogene (2015) 0.86

Modes of p53 regulation. Cell (2009) 9.31

Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71

Acetylation is indispensable for p53 activation. Cell (2008) 5.70

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64

p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol (2003) 5.46

SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96

SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60

Non-transcriptional control of DNA replication by c-Myc. Nature (2007) 4.55

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33

Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14

Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem (2002) 3.37

How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17

Non-invasive prenatal measurement of the fetal genome. Nature (2012) 3.11

Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06

Parc: a cytoplasmic anchor for p53. Cell (2003) 3.06

Acetylation inactivates the transcriptional repressor BCL6. Nat Genet (2002) 3.00

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72

A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64

SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59

p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46

Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35

Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome. Genome Res (2013) 2.29

Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot. EMBO J (2004) 2.08

Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood (2006) 2.06

Microfluidics for flow cytometric analysis of cells and particles. Physiol Meas (2005) 2.00

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem (2003) 1.92

Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol (2006) 1.91

Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82

SnapShot: p53 posttranslational modifications. Cell (2008) 1.75

Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol Cell (2009) 1.72

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature (2010) 1.71

Improving genome assemblies by sequencing PCR products with PacBio. Biotechniques (2012) 1.70

Computer-controlled microcirculatory support system for endothelial cell culture and shearing. Anal Chem (2005) 1.70

Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression. Mol Cell (2013) 1.67

The impact of acetylation and deacetylation on the p53 pathway. Protein Cell (2011) 1.66

Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54

α-adducin Gly460Trp polymorphism and essential hypertension risk in Chinese: a meta-analysis. Hypertens Res (2011) 1.51

p53 regulation by ubiquitin. FEBS Lett (2011) 1.51

Translation of ASH1 mRNA is repressed by Puf6p-Fun12p/eIF5B interaction and released by CK2 phosphorylation. Genes Dev (2008) 1.50

p53-Dependent and p53-independent activation of autophagy by ARF. Cancer Res (2008) 1.50

Clinical relevance of the TLR4 11367 polymorphism in patients with major trauma. Arch Surg (2009) 1.42

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat Cell Biol (2013) 1.36

ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription. Mol Cell Biol (2007) 1.35

Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics (2008) 1.33

Dynamics in the p53-Mdm2 ubiquitination pathway. Cell Cycle (2004) 1.33

Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys. J Pharmacol Exp Ther (2009) 1.29

Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J Biol Chem (2008) 1.27

FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. J Biol Chem (2006) 1.26

Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation. Cell Metab (2011) 1.23

MSL2 promotes Mdm2-independent cytoplasmic localization of p53. J Biol Chem (2008) 1.21

Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. Biochem Biophys Res Commun (2004) 1.18

Mechanism of fast peptide recognition by SH3 domains. Angew Chem Int Ed Engl (2008) 1.17

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci U S A (2011) 1.17

Artificial polyploidy improves bacterial single cell genome recovery. PLoS One (2012) 1.10

Cyclophilin A binds to linear peptide motifs containing a consensus that is present in many human proteins. J Biol Chem (2005) 1.09

Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells. Am J Pathol (2010) 1.08

Anti-tumor activities and apoptosis-regulated mechanisms of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice. World J Gastroenterol (2007) 1.08

New insights into p53 activation. Cell Res (2010) 1.06

Identification and comparative analysis of the Eriocheir sinensis microRNA transcriptome response to Spiroplasma eriocheiris infection using a deep sequencing approach. Fish Shellfish Immunol (2011) 1.06

Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci U S A (2011) 1.04

Potential roles of N-glycosylation in cell adhesion. Glycoconj J (2012) 1.04

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Draft Genome Sequence of Methylomicrobium buryatense Strain 5G, a Haloalkaline-Tolerant Methanotrophic Bacterium. Genome Announc (2013) 1.04

Handheld recirculation system and customized media for microfluidic cell culture. Lab Chip (2005) 1.03

Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor. Mol Biol Cell (2008) 1.03

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway. J Virol (2009) 1.03

Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor β1 (TGF-β1) in epithelial cell lines. J Biol Chem (2012) 1.03

Monoubiquitination: the signal for p53 nuclear export? Cell Cycle (2004) 1.02

SIRT1-mediated acute cardioprotection. Am J Physiol Heart Circ Physiol (2011) 1.02

SIRT1: Regulator of p53 Deacetylation. Genes Cancer (2013) 1.01

Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice. J Biol Chem (2011) 1.00

p53-mediated heterochromatin reorganization regulates its cell fate decisions. Nat Struct Mol Biol (2012) 1.00

To be, or not to be: functional dilemma of p53 metabolic regulation. Curr Opin Oncol (2014) 1.00

Adhesive water networks facilitate binding of protein interfaces. Nat Commun (2011) 1.00

p53 Activation: a case against Sir. Cancer Cell (2008) 0.99

A critical role for noncoding 5S rRNA in regulating Mdmx stability. Mol Cell (2011) 0.98

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RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation. Cell Res (2013) 0.98

RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage. Proc Natl Acad Sci U S A (2010) 0.98

An acyl-ghrelin-specific neutralizing antibody inhibits the acute ghrelin-mediated orexigenic effects in mice. Mol Pharmacol (2009) 0.97

RNA asymmetric distribution and daughter/mother differentiation in yeast. Curr Opin Microbiol (2003) 0.97

An oncogenic protein Golgi phosphoprotein 3 up-regulates cell migration via sialylation. J Biol Chem (2014) 0.96