Published in Curr Pharm Des on January 01, 2004
Nantenine as an acetylcholinesterase inhibitor: SAR, enzyme kinetics and molecular modeling investigations. J Enzyme Inhib Med Chem (2010) 0.91
Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706. Front Mol Neurosci (2011) 0.86
Flos Puerariae Extract Ameliorates Cognitive Impairment in Streptozotocin-Induced Diabetic Mice. Evid Based Complement Alternat Med (2015) 0.76
Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo. PLoS One (2012) 0.76
Insights and ideas garnered from marine metabolites for development of dual-function acetylcholinesterase and amyloid-β aggregation inhibitors. Mar Drugs (2014) 0.75
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). J Biol Chem (2002) 1.99
Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis. J Biol Chem (2007) 1.64
In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model. J Neurosci (2014) 1.63
Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. J Biol Chem (2007) 1.47
Wnt signaling in neuroprotection and stem cell differentiation. Prog Neurobiol (2008) 1.46
Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses. Proc Natl Acad Sci U S A (2010) 1.39
Wnt-5a/JNK signaling promotes the clustering of PSD-95 in hippocampal neurons. J Biol Chem (2009) 1.38
Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons. Exp Cell Res (2004) 1.34
Peroxisomal proliferation protects from beta-amyloid neurodegeneration. J Biol Chem (2005) 1.31
STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits. Brain (2008) 1.25
Structure and function of amyloid in Alzheimer's disease. Prog Neurobiol (2004) 1.25
Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons. J Neurosci (2010) 1.21
Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure. J Biol Chem (2009) 1.19
Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation. J Cell Sci (2003) 1.17
Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease. Brain Res Brain Res Rev (2004) 1.17
Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway. J Biol Chem (2005) 1.14
Regulation of NMDA-receptor synaptic transmission by Wnt signaling. J Neurosci (2011) 1.12
Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons. J Neurosci (2007) 1.10
ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity. Mol Neurodegener (2007) 1.10
Structure-function implications in Alzheimer's disease: effect of Abeta oligomers at central synapses. Curr Alzheimer Res (2008) 1.08
Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function. Neural Dev (2009) 1.08
ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association. Traffic (2005) 1.07
Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway. FASEB J (2002) 1.06
Wnt-5a occludes Abeta oligomer-induced depression of glutamatergic transmission in hippocampal neurons. Mol Neurodegener (2010) 1.05
Wnt signaling in the regulation of adult hippocampal neurogenesis. Front Cell Neurosci (2013) 1.04
Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Abeta oligomers. J Cell Physiol (2008) 1.03
WNT signaling in neuronal maturation and synaptogenesis. Front Cell Neurosci (2013) 1.01
Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease. Proc Natl Acad Sci U S A (2012) 1.00
Recent rodent models for Alzheimer's disease: clinical implications and basic research. J Neural Transm (Vienna) (2011) 0.99
Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans. Aging Cell (2009) 0.98
Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics. Front Cell Neurosci (2013) 0.98
c-Abl modulates AICD dependent cellular responses: transcriptional induction and apoptosis. J Cell Physiol (2009) 0.98
The role of Wnt signaling in neuroprotection. Drug News Perspect (2009) 0.95
PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes. J Neurosci Res (2003) 0.95
Acetylcholinesterase-Abeta complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss. Am J Pathol (2004) 0.94
Heparin activates Wnt signaling for neuronal morphogenesis. J Cell Physiol (2008) 0.92
Wnt signaling in skeletal muscle dynamics: myogenesis, neuromuscular synapse and fibrosis. Mol Neurobiol (2013) 0.92
Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. J Neurosci (2010) 0.92
Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway. J Cell Physiol (2009) 0.91
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases. Biometals (2003) 0.91
Two different heparin-binding domains in the triple-helical domain of ColQ, the collagen tail subunit of synaptic acetylcholinesterase. J Biol Chem (2003) 0.91
Wnt signaling: role in LTP, neural networks and memory. Ageing Res Rev (2013) 0.91
SIRT1 regulates dendritic development in hippocampal neurons. PLoS One (2012) 0.90
Circadian stress tolerance in adult Caenorhabditis elegans. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2008) 0.90
The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease? Biochemistry (2011) 0.90
Adult hippocampal neurogenesis in aging and Alzheimer's disease. Birth Defects Res C Embryo Today (2010) 0.90
Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Abeta peptide. Implications for the pathogenesis of Alzheimer's disease. Mol Neurodegener (2010) 0.89
Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer's Disease. Front Physiol (2012) 0.89
Wnt-5a is a synaptogenic factor with neuroprotective properties against Aβ toxicity. Neurodegener Dis (2012) 0.89
Wnt signaling modulates pre- and postsynaptic maturation: therapeutic considerations. Dev Dyn (2010) 0.89
The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer's mouse model. Curr Alzheimer Res (2010) 0.88
Induction of cellular prion protein gene expression by copper in neurons. Am J Physiol Cell Physiol (2005) 0.87
M1 muscarinic receptor activation protects neurons from beta-amyloid toxicity. A role for Wnt signaling pathway. Neurobiol Dis (2004) 0.87
Genome-wide identification of new Wnt/beta-catenin target genes in the human genome using CART method. BMC Genomics (2010) 0.87
Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706. Front Mol Neurosci (2011) 0.86
The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from beta-amyloid neurotoxicity by acting on Wnt signaling components. Neurobiol Dis (2005) 0.86
Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification. Mol Neurodegener (2009) 0.86
Role of Sirt1 during the ageing process: relevance to protection of synapses in the brain. Mol Neurobiol (2014) 0.85
The GABA(A)ρ receptors in hippocampal spontaneous activity and their distribution in hippocampus, amygdala and visual cortex. Neurosci Lett (2011) 0.85
Tetrahydrohyperforin increases adult hippocampal neurogenesis in wild-type and APPswe/PS1ΔE9 mice. J Alzheimers Dis (2013) 0.85
Laminin affects polymerization, depolymerization and neurotoxicity of Abeta peptide. Peptides (2002) 0.84
Vitamin E but not 17beta-estradiol protects against vascular toxicity induced by beta-amyloid wild type and the Dutch amyloid variant. J Neurosci (2002) 0.83
Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons. Mol Neurodegener (2010) 0.83
Anti-ribosomal P protein autoantibodies from patients with neuropsychiatric lupus impair memory in mice. Arthritis Rheumatol (2015) 0.83
The functional links between prion protein and copper. Biol Res (2006) 0.82
Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in Niemann-Pick type C disease. Mol Neurodegener (2012) 0.82
Tetrahydrohyperforin induces mitochondrial dynamics and prevents mitochondrial Ca2+ overload after Aβ and Aβ-AChE complex challenge in rat hippocampal neurons. J Alzheimers Dis (2013) 0.82
Acetylcholinesterase induces neuronal cell loss, astrocyte hypertrophy and behavioral deficits in mammalian hippocampus. J Neurochem (2003) 0.82
Frizzled receptors in neurons: from growth cones to the synapse. Cytoskeleton (Hoboken) (2012) 0.82
Is there a role for copper in neurodegenerative diseases? Mol Aspects Med (2005) 0.81
Structural and functional organization of synaptic acetylcholinesterase. Brain Res Brain Res Rev (2004) 0.81
Inclusion body myositis: a view from the Caenorhabditis elegans muscle. Mol Neurobiol (2008) 0.81
Acetylcholinesterase interaction with Alzheimer amyloid beta. Subcell Biochem (2005) 0.81
Copper reduces Aβ oligomeric species and ameliorates neuromuscular synaptic defects in a C. elegans model of inclusion body myositis. J Neurosci (2011) 0.81
Release of acetylcholinesterase (AChE) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice. Chem Biol Interact (2008) 0.81
Stepwise construction of triple-helical heparin binding sites using peptide models. Biochim Biophys Acta (2004) 0.81
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents. J Med Chem (2014) 0.81
Accelerating Alzheimer's research through 'natural' animal models. Curr Opin Psychiatry (2015) 0.80
Frizzled-5 receptor is involved in neuronal polarity and morphogenesis of hippocampal neurons. PLoS One (2013) 0.79
Role of copper in prion diseases: deleterious or beneficial? Curr Pharm Des (2006) 0.79
The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo. FASEB J (2004) 0.79
ATP induces NO production in hippocampal neurons by P2X(7) receptor activation independent of glutamate signaling. PLoS One (2013) 0.79
Tetrahydrohyperforin decreases cholinergic markers associated with amyloid-β plaques, 4-hydroxynonenal formation, and caspase-3 activation in AβPP/PS1 mice. J Alzheimers Dis (2013) 0.79
Beta-amyloid oligomers affect the structure and function of the postsynaptic region: role of the Wnt signaling pathway. Neurodegener Dis (2008) 0.78
Thiazolidinediones promote axonal growth through the activation of the JNK pathway. PLoS One (2013) 0.78
Acetylcholinesterase induces the expression of the beta-amyloid precursor protein in glia and activates glial cells in culture. Neurobiol Dis (2003) 0.78
Overexpression of amyloid precursor protein increases copper content in HEK293 cells. Biochem Biophys Res Commun (2009) 0.77
Peroxisome proliferator-activated receptors and Alzheimer's disease: hitting the blood-brain barrier. Mol Neurobiol (2013) 0.77
Blood cells cholinesterase activity in early stage Alzheimer's disease and vascular dementia. Dement Geriatr Cogn Disord (2005) 0.76
The human prion octarepeat fragment prevents and reverses the inhibitory action of copper in the P2X4 receptor without modifying the zinc action. J Neurochem (2003) 0.76
Monitoring mitochondrial membranes permeability in live neurons and mitochondrial swelling through electron microscopy analysis. Methods Mol Biol (2015) 0.76
Brain metabolite clearance: impact on Alzheimer's disease. Metab Brain Dis (2014) 0.76
The protein oxidation repair enzyme methionine sulfoxide reductase a modulates Aβ aggregation and toxicity in vivo. Antioxid Redox Signal (2015) 0.75
Ethanol specifically decreases peroxisome proliferator activated receptor beta in B12 oligodendrocyte-like cells. J Neurochem (2003) 0.75
The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X(4) Receptors. Int J Alzheimers Dis (2011) 0.75
Reusing and composing models of cell fate regulation of human bone precursor cells. Biosystems (2012) 0.75
Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons. Metab Brain Dis (2014) 0.75
Contributions by researchers of "Ciencia de Frontera" of the Chilean Academy of Sciences. Biol Res (2011) 0.75