ENU induced mutations causing congenital cardiovascular anomalies.

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N-ethyl-N-nitrosourea mutagenesis: boarding the mouse mutant express. Microbiol Mol Biol Rev (2005) 1.54

Heterotaxy and complex structural heart defects in a mutant mouse model of primary ciliary dyskinesia. J Clin Invest (2007) 1.49

MMAPPR: mutation mapping analysis pipeline for pooled RNA-seq. Genome Res (2013) 1.39

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes Dev (2008) 1.32

Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy. Proc Natl Acad Sci U S A (2009) 1.19

Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome. Dis Model Mech (2010) 1.18

Partitioning the heart: mechanisms of cardiac septation and valve development. Development (2012) 1.13

Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol (2013) 1.09

Cardiovascular assessment of fetal mice by in utero echocardiography. Ultrasound Med Biol (2008) 1.08

Initiation and maturation of cilia-generated flow in newborn and postnatal mouse airway. Am J Physiol Lung Cell Mol Physiol (2009) 1.07

microMRI-HREM pipeline for high-throughput, high-resolution phenotyping of murine embryos. J Anat (2007) 1.04

Quantitative in vivo imaging of embryonic development: opportunities and challenges. Differentiation (2012) 0.99

Interrogating congenital heart defects with noninvasive fetal echocardiography in a mouse forward genetic screen. Circ Cardiovasc Imaging (2013) 0.94

Genome-wide identification of mouse congenital heart disease loci. Hum Mol Genet (2010) 0.94

Microcomputed tomography provides high accuracy congenital heart disease diagnosis in neonatal and fetal mice. Circ Cardiovasc Imaging (2013) 0.92

Removing the cloak of invisibility: phenotyping the mouse. Dis Model Mech (2008) 0.90

Imaging techniques for visualizing and phenotyping congenital heart defects in murine models. Birth Defects Res C Embryo Today (2013) 0.90

Trapping cardiac recessive mutants via expression-based insertional mutagenesis screening. Circ Res (2013) 0.89

Investigating the transcriptional control of cardiovascular development. Circ Res (2015) 0.87

Ion Torrent sequencing for conducting genome-wide scans for mutation mapping analysis. Mamm Genome (2013) 0.87

Cilia and models for studying structure and function. Proc Am Thorac Soc (2011) 0.87

Capturing structure and function in an embryonic heart with biophotonic tools. Front Physiol (2014) 0.87

Role of connexins in human congenital heart disease: the chicken and egg problem. Front Pharmacol (2013) 0.86

An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development. Mol Cell Biol (2008) 0.86

Using optical coherence tomography to rapidly phenotype and quantify congenital heart defects associated with prenatal alcohol exposure. Dev Dyn (2015) 0.85

Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease. PLoS One (2013) 0.85

A transient transgenic RNAi strategy for rapid characterization of gene function during embryonic development. PLoS One (2010) 0.83

ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning. Nat Commun (2015) 0.82

An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15. Mamm Genome (2009) 0.82

Investigating developmental cardiovascular biomechanics and the origins of congenital heart defects. Front Physiol (2014) 0.82

Diversity of congenital cardiac defects and skeletal deformities associated with the Holt-Oram syndrome. Int J Surg Case Rep (2014) 0.81

A new mouse mutant for the LDL receptor identified using ENU mutagenesis. J Lipid Res (2008) 0.78

Transgenerational cardiology: One way to a baby's heart is through the mother. Mol Cell Endocrinol (2016) 0.75

Skin as a living coloring book: how epithelial cells create patterns of pigmentation. Pigment Cell Melanoma Res (2014) 0.75

In utero measurement of heart rate in mouse by noninvasive M-mode echocardiography. J Vis Exp (2013) 0.75

Comparative analysis of metallic nanoparticles as exogenous soft tissue contrast for live in vivo micro-computed tomography imaging of avian embryonic morphogenesis. Dev Dyn (2016) 0.75

Expression of Connexin 43 in the hearts of rat embryos exposed to nitrofen and effects of vitamin A on it. Pediatr Surg Int (2006) 0.75

Phenotyping cardiac and structural birth defects in fetal and newborn mice. Birth Defects Res (2017) 0.75

The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37

Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell (2011) 6.80

FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc Natl Acad Sci U S A (2007) 3.32

Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell (2006) 2.26

Connexins and cell signaling in development and disease. Annu Rev Cell Dev Biol (2004) 2.25

Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart. Dev Biol (2005) 2.15

Experimental protection of mice against lethal Staphylococcus aureus infection by novel bacteriophage phi MR11. J Infect Dis (2003) 2.06

Model systems for the study of heart development and disease. Cardiac neural crest and conotruncal malformations. Semin Cell Dev Biol (2006) 2.03

Myocardial lineage development. Circ Res (2010) 1.98

Dramatic increase of Cesarean deliveries in the midst of health reforms in rural China. Soc Sci Med (2010) 1.91

Origin of coronary endothelial cells from epicardial mesothelium in avian embryos. Int J Dev Biol (2002) 1.87

The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex. PLoS Genet (2008) 1.80

Neural crest and cardiovascular development: a 20-year perspective. Birth Defects Res C Embryo Today (2003) 1.79

BMP and FGF regulate the differentiation of multipotential pericardial mesoderm into the myocardial or epicardial lineage. Dev Biol (2006) 1.77

Optical coherence tomography: a new high-resolution imaging technology to study cardiac development in chick embryos. Circulation (2002) 1.77

Novel method for high-throughput phenotyping of sleep in mice. Physiol Genomics (2006) 1.77

Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Science (2013) 1.76

Rapid high resolution three dimensional reconstruction of embryos with episcopic fluorescence image capture. Birth Defects Res C Embryo Today (2004) 1.74

Increased postoperative and respiratory complications in patients with congenital heart disease associated with heterotaxy. J Thorac Cardiovasc Surg (2010) 1.74

Heart field: from mesoderm to heart tube. Annu Rev Cell Dev Biol (2007) 1.68

Outflow tract cushions perform a critical valve-like function in the early embryonic heart requiring BMPRIA-mediated signaling in cardiac neural crest. Am J Physiol Heart Circ Physiol (2009) 1.66

TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3. Proc Natl Acad Sci U S A (2008) 1.65

Isl1 expression at the venous pole identifies a novel role for the second heart field in cardiac development. Circ Res (2007) 1.62

Origin and fate of cardiac mesenchyme. Dev Dyn (2008) 1.61

The role of secondary heart field in cardiac development. Dev Biol (2009) 1.60

Ablation of the secondary heart field leads to tetralogy of Fallot and pulmonary atresia. Dev Biol (2005) 1.60

Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells. J Biol Chem (2005) 1.59

c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development. Blood (2010) 1.55

Heterotaxy and complex structural heart defects in a mutant mouse model of primary ciliary dyskinesia. J Clin Invest (2007) 1.49

Heart fields: one, two or more? Dev Biol (2004) 1.48

Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. Science (2004) 1.47

Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2. Mol Cell Biochem (2011) 1.45

High prevalence of respiratory ciliary dysfunction in congenital heart disease patients with heterotaxy. Circulation (2012) 1.44

DYX1C1 is required for axonemal dynein assembly and ciliary motility. Nat Genet (2013) 1.44

Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx. Dev Biol (2006) 1.42

Cardiac neural crest is necessary for normal addition of the myocardium to the arterial pole from the secondary heart field. Dev Biol (2005) 1.41

IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport. Dev Cell (2012) 1.40

Double aortic arch with aortic atresia and left-sided type B interruption. Congenit Heart Dis (2010) 1.39

FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease. Int Immunol (2007) 1.39

Zebrafish cardiac development requires a conserved secondary heart field. Development (2011) 1.38

Shortened outflow tract leads to altered cardiac looping after neural crest ablation. Circulation (2002) 1.37

A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac development. Dev Dyn (2007) 1.37

Hemodynamics is a key epigenetic factor in development of the cardiac conduction system. Circ Res (2003) 1.35

Cardiovascular phenotyping of fetal mice by noninvasive high-frequency ultrasound facilitates recovery of ENU-induced mutations causing congenital cardiac and extracardiac defects. Physiol Genomics (2005) 1.35

The pathogenesis of atrial and atrioventricular septal defects with special emphasis on the role of the dorsal mesenchymal protrusion. Differentiation (2012) 1.34

A caudal proliferating growth center contributes to both poles of the forming heart tube. Circ Res (2008) 1.31

Activation of beta-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis. Clin Cancer Res (2010) 1.31

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev Biol (2008) 1.29

Connexin 43-mediated modulation of polarized cell movement and the directional migration of cardiac neural crest cells. Development (2006) 1.27

Fibulin-1 is required for morphogenesis of neural crest-derived structures. Dev Biol (2008) 1.26

Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease. Dev Biol (2011) 1.23

Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis. Exp Mol Pathol (2009) 1.22

Epicardium and myocardium separate from a common precursor pool by crosstalk between bone morphogenetic protein- and fibroblast growth factor-signaling pathways. Circ Res (2009) 1.21

Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy. Proc Natl Acad Sci U S A (2009) 1.19

Report of the National Heart, Lung, and Blood Institute and National Marfan Foundation Working Group on research in Marfan syndrome and related disorders. Circulation (2008) 1.18

Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome. Dis Model Mech (2010) 1.18

Validity and reproducibility of a semi-quantitative food frequency questionnaire for use among pregnant women in rural China. Asia Pac J Clin Nutr (2008) 1.18

Solving an enigma: arterial pole development in the zebrafish heart. Dev Biol (2006) 1.17

ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry. Am J Hum Genet (2013) 1.17

Identification and detection of the periostin gene in cardiac development. Anat Rec A Discov Mol Cell Evol Biol (2004) 1.17

The effects of multi-domain versus single-domain cognitive training in non-demented older people: a randomized controlled trial. BMC Med (2012) 1.16

Patterning of the heart field in the chick. Dev Biol (2008) 1.15

Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development. Dev Biol (2007) 1.15

Utilization of delivery care among rural women in China: does the health insurance make a difference? a cross-sectional study. BMC Public Health (2010) 1.14

Sonic hedgehog maintains proliferation in secondary heart field progenitors and is required for normal arterial pole formation. Dev Biol (2009) 1.13

High-frequency ultrasound database profiling growth, development, and cardiovascular function in C57BL/6J mouse fetuses. J Am Soc Echocardiogr (2004) 1.13

Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies. Matrix Biol (2010) 1.11

Connexin 43 regulates epicardial cell polarity and migration in coronary vascular development. Development (2009) 1.10

Cardiac neural crest in zebrafish embryos contributes to myocardial cell lineage and early heart function. Dev Dyn (2003) 1.09

Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol (2013) 1.09

Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation. Cardiovasc Res (2011) 1.08

Cardiovascular assessment of fetal mice by in utero echocardiography. Ultrasound Med Biol (2008) 1.08

The type II Arabidopsis formin14 interacts with microtubules and microfilaments to regulate cell division. Plant Cell (2010) 1.08

High-purity enrichment of functional cardiovascular cells from human iPS cells. Cardiovasc Res (2012) 1.07

Initiation and maturation of cilia-generated flow in newborn and postnatal mouse airway. Am J Physiol Lung Cell Mol Physiol (2009) 1.07

PCB126 exposure disrupts zebrafish ventricular and branchial but not early neural crest development. Toxicol Sci (2008) 1.07

Extracellular matrix and heart development. Birth Defects Res A Clin Mol Teratol (2011) 1.07

Wherefore heart thou? Embryonic origins of cardiogenic mesoderm. Dev Dyn (2002) 1.06

Complex expression dynamics and robustness in C. elegans insulin networks. Genome Res (2013) 1.06

Fetal mouse imaging using echocardiography: a review of current technology. Echocardiography (2006) 1.06

Expression of the BMP receptor Alk3 in the second heart field is essential for development of the dorsal mesenchymal protrusion and atrioventricular septation. Circ Res (2013) 1.05

Connexin43 modulates cell polarity and directional cell migration by regulating microtubule dynamics. PLoS One (2011) 1.05

Patterning of coronary arteries in wildtype and connexin43 knockout mice. Dev Dyn (2006) 1.03

Arterial pole progenitors interpret opposing FGF/BMP signals to proliferate or differentiate. Development (2010) 1.02