Published in APMIS on November 25, 2004
Role of chemokines in tumor growth. Cancer Lett (2007) 3.36
Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function. Circ Res (2008) 3.07
International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev (2013) 2.11
Cytokine patterns differ seasonally between women with and without uterine leiomyomata. Am J Reprod Immunol (2013) 1.99
Clinical and correlative results of SWOG S0354: a phase II trial of CNTO328 (siltuximab), a monoclonal antibody against interleukin-6, in chemotherapy-pretreated patients with castration-resistant prostate cancer. Clin Cancer Res (2010) 1.37
The chemokine system in arteriogenesis and hind limb ischemia. J Vasc Surg (2007) 1.34
Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival. Int J Colorectal Dis (2010) 1.31
Autonomously vascularized cellular constructs in tissue engineering: opening a new perspective for biomedical science. J Cell Mol Med (2007) 1.31
ELR-negative CXC chemokine CXCL11 (IP-9/I-TAC) facilitates dermal and epidermal maturation during wound repair. Am J Pathol (2008) 1.29
Matrix metalloproteinase-1 and thrombin differentially activate gene expression in endothelial cells via PAR-1 and promote angiogenesis. Am J Pathol (2008) 1.25
Elevated epithelial expression of interleukin-8 correlates with myofibroblast reactive stroma in benign prostatic hyperplasia. Urology (2008) 1.24
CXC chemokines and their receptors: a case for a significant biological role in cutaneous wound healing. Histol Histopathol (2008) 1.23
Proangiogenic role of neutrophil-like inflammatory heterophils during neovascularization induced by growth factors and human tumor cells. Blood (2005) 1.17
Murine CXCL14 is dispensable for dendritic cell function and localization within peripheral tissues. Mol Cell Biol (2006) 1.09
Chemokine signaling specificity: essential role for the N-terminal domain of chemokine receptors. Biochemistry (2007) 1.06
Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stromal estrogen receptor signaling. Proc Natl Acad Sci U S A (2015) 1.06
New concepts in phospholipase D signaling in inflammation and cancer. ScientificWorldJournal (2010) 1.01
CXCL4 and CXCL10 predict risk of fatal cerebral malaria. Dis Markers (2011) 1.00
CXCL10/IP-10: a missing link between inflammation and anti-angiogenesis in preeclampsia? J Matern Fetal Neonatal Med (2007) 0.99
Opposing roles of murine duffy antigen receptor for chemokine and murine CXC chemokine receptor-2 receptors in murine melanoma tumor growth. Cancer Res (2007) 0.98
The angiogenic response of the aorta to injury and inflammatory cytokines requires macrophages. J Immunol (2008) 0.96
Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization. J Biol Chem (2011) 0.96
Endothelial cells overexpressing interleukin-8 receptors reduce inflammatory and neointimal responses to arterial injury. Circulation (2012) 0.95
Adenovirus small E1A employs the lysine acetylases p300/CBP and tumor suppressor Rb to repress select host genes and promote productive virus infection. Cell Host Microbe (2014) 0.95
Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis. Arthritis Res Ther (2012) 0.94
Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors. Br J Cancer (2011) 0.92
Heparanase enhances myeloma progression via CXCL10 downregulation. Leukemia (2014) 0.90
In vivo imaging of transiently transgenized mice with a bovine interleukin 8 (CXCL8) promoter/luciferase reporter construct. PLoS One (2012) 0.90
Macrophage-derived biomarkers of idiopathic pulmonary fibrosis. Pulm Med (2010) 0.89
Inhibition of angiogenesis- and inflammation-inducing factors in human colon cancer cells in vitro and in ovo by free and nanoparticle-encapsulated redox dye, DCPIP. J Nanobiotechnology (2010) 0.88
Differential gene expression from microarray analysis distinguishes woven and lamellar bone formation in the rat ulna following mechanical loading. PLoS One (2011) 0.88
Chemokine upregulation in response to anal sphincter and pudendal nerve injury: potential signals for stem cell homing. Int J Colorectal Dis (2011) 0.87
The transcription factor DLX3 regulates the osteogenic differentiation of human dental follicle precursor cells. Stem Cells Dev (2012) 0.86
Detectability and reproducibility of plasma levels of chemokines and soluble receptors. Results Immunol (2013) 0.85
Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model. Cell Mol Immunol (2013) 0.84
Isolation of osteoprogenitors from human jaw periosteal cells: a comparison of two magnetic separation methods. PLoS One (2012) 0.84
Alterations of gene expression and protein synthesis in co-cultured adipose tissue-derived stem cells and squamous cell-carcinoma cells: consequences for clinical applications. Stem Cell Res Ther (2014) 0.84
Evidence of positive selection at codon sites localized in extracellular domains of mammalian CC motif chemokine receptor proteins. BMC Evol Biol (2010) 0.83
Possible angiogenic roles for claudin-4 in ovarian cancer. Cancer Biol Ther (2009) 0.82
Regulation of deoxycholate induction of CXCL8 by the adenomatous polyposis coli gene in colorectal cancer. Int J Cancer (2009) 0.82
KDR-LacZ-expressing cells are involved in ovarian and testis-specific vascular development, suggesting a role for VEGFA in the regulation of this vasculature. Cell Tissue Res (2010) 0.82
Synovial angiostatic non-ELR CXC chemokines in inflammatory arthritides: does CXCL4 designate chronicity of synovitis? Rheumatol Int (2007) 0.82
Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy. J Matern Fetal Neonatal Med (2007) 0.82
Upregulation of chemokine (C-C motif) ligand 20 in adult epidermal keratinocytes in direct current electric fields. Arch Dermatol Res (2009) 0.81
Multiple roles for chemokines in the pathogenesis of SIV infection. Curr HIV Res (2009) 0.80
RECK controls breast cancer metastasis by modulating a convergent, STAT3-dependent neoangiogenic switch. Oncogene (2014) 0.80
Is there a role for treating inflammation in moyamoya disease?: a review of histopathology, genetics, and signaling cascades. Front Neurol (2013) 0.80
Chemokine Regulation of Angiogenesis During Wound Healing. Adv Wound Care (New Rochelle) (2015) 0.80
The role of CXCR2 chemokine receptors in the oral squamous cell carcinoma. Invest New Drugs (2011) 0.80
Proteomes and signalling pathways of antler stem cells. PLoS One (2012) 0.79
Generation of controllable gradients in cell density. Angew Chem Int Ed Engl (2012) 0.79
The chemokine receptor CXCR4 and its ligand CXCL12 are activated during implantation and placentation in sheep. Reprod Biol Endocrinol (2011) 0.78
Vascular endothelial growth factor (VEGF) and platelet (PF-4) factor 4 inputs modulate human microvascular endothelial signaling in a three-dimensional matrix migration context. Mol Cell Proteomics (2013) 0.77
IL-27 activates human trophoblasts to express IP-10 and IL-6: implications in the immunopathophysiology of preeclampsia. Mediators Inflamm (2014) 0.77
Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis. Osteoarthritis Cartilage (2015) 0.77
Structural Diversity in Conserved Regions Like the DRY-Motif among Viral 7TM Receptors-A Consequence of Evolutionary Pressure? Adv Virol (2012) 0.77
Pigment epithelium-derived factor (PEDF): a novel trophoblast-derived factor limiting feto-placental angiogenesis in late pregnancy. Angiogenesis (2016) 0.76
Large-Scale Discovery and Validation Studies Demonstrate Significant Reductions in Circulating Levels of IL8, IL-1Ra, MCP-1, and MIP-1β in Patients With Type 1 Diabetes. J Clin Endocrinol Metab (2015) 0.76
The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding. Hum Reprod Update (2016) 0.76
Altered Myokine Secretion Is an Intrinsic Property of Skeletal Muscle in Type 2 Diabetes. PLoS One (2016) 0.76
Subcutaneous Transplantation of Neural Precursor Cells in Experimental Autoimmune Encephalomyelitis Reduces Chemotactic Signals in the Central Nervous System. Stem Cells Transl Med (2015) 0.76
The Influence of Chronic Wound Extracts on Inflammatory Cytokine and Histatin Stability. PLoS One (2016) 0.75
Chemokines as Therapeutic Targets to Improve Healing Efficiency of Chronic Wounds. Adv Wound Care (New Rochelle) (2015) 0.75
Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. J Biol Chem (2016) 0.75
GDM alters paracrine regulation of feto-placental angiogenesis via the trophoblast. Lab Invest (2017) 0.75
The impact of obesity on prostate cancer recurrence observed after exclusion of diabetics. Cancer Causes Control (2015) 0.75
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. Nat Genet (2010) 5.44
Ligand binding and micro-switches in 7TM receptor structures. Trends Pharmacol Sci (2009) 2.33
High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist. Mol Endocrinol (2003) 1.97
GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes. Endocrinology (2013) 1.89
High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3. Mol Pharmacol (2005) 1.86
Localization of HCMV UL33 and US27 in endocytic compartments and viral membranes. Traffic (2002) 1.65
GPR39 signaling is stimulated by zinc ions but not by obestatin. Endocrinology (2006) 1.60
Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities. J Virol (2002) 1.56
Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor. J Biol Chem (2003) 1.50
Common structural basis for constitutive activity of the ghrelin receptor family. J Biol Chem (2004) 1.49
Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor. Biochemistry (2003) 1.40
The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma. J Immunol (2005) 1.35
Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation. J Biol Chem (2006) 1.35
The minor binding pocket: a major player in 7TM receptor activation. Trends Pharmacol Sci (2010) 1.35
A gut feeling for obesity: 7TM sensors on enteroendocrine cells. Cell Metab (2008) 1.35
Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity. J Biol Chem (2006) 1.32
A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin. Endocrinology (2012) 1.31
A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors. J Biol Chem (2009) 1.25
Oxyntomodulin differentially affects glucagon-like peptide-1 receptor beta-arrestin recruitment and signaling through Galpha(s). J Pharmacol Exp Ther (2007) 1.22
Structural biology: A moving story of receptors. Nature (2008) 1.22
The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis. J Biol Chem (2003) 1.20
GPR119 as a fat sensor. Trends Pharmacol Sci (2012) 1.20
Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation. Trends Pharmacol Sci (2004) 1.15
Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab (2013) 1.14
Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor. J Biol Chem (2007) 1.13
AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. Biochem Pharmacol (2005) 1.11
NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype. Mol Pharmacol (2002) 1.08
Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor. Mol Endocrinol (2007) 1.07
Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling. Mol Endocrinol (2005) 1.07
Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74. Virology (2004) 1.06
CC and CX3C chemokines differentially interact with the N terminus of the human cytomegalovirus-encoded US28 receptor. J Biol Chem (2004) 1.01
Enteroendocrine cell types revisited. Curr Opin Pharmacol (2013) 1.00
Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding. J Biol Chem (2008) 0.99
Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation. J Biol Chem (2010) 0.99
Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype. Mol Endocrinol (2004) 0.97
Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem (2007) 0.96
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction. Endocrinology (2009) 0.96
Ghrelin receptor mutations--too little height and too much hunger. J Clin Invest (2006) 0.95
Long-acting lipidated analogue of human pancreatic polypeptide is slowly released into circulation. J Med Chem (2011) 0.94
Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors. J Biol Chem (2002) 0.94
Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe. Ann N Y Acad Sci (2003) 0.93
Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor. Mol Pharmacol (2008) 0.93
Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist. J Biol Chem (2011) 0.92
GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors. Curr Top Med Chem (2006) 0.91
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39. FEBS Lett (2008) 0.90
Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry. FEBS Lett (2003) 0.90
GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue. Mol Endocrinol (2007) 0.89
Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3. J Biol Chem (2007) 0.89
Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI. Mol Pharmacol (2006) 0.88
Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8. Mol Pharmacol (2007) 0.88
Bioorthogonal fluorescent labeling of functional G-protein-coupled receptors. Chembiochem (2014) 0.87
Distinct in vitro interaction pattern of dopamine receptor subtypes with adaptor proteins involved in post-endocytotic receptor targeting. FEBS Lett (2004) 0.87
The virus-encoded chemokine vMIP-II inhibits virus-induced Tc1-driven inflammation. J Virol (2003) 0.87
Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer. Mol Pharmacol (2007) 0.87
MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. Diabetes (2010) 0.86
PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation. J Biol Chem (2012) 0.85
A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39. Biochemistry (2008) 0.84
β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia. Int J Endocrinol (2011) 0.84
The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins. J Biol Chem (2004) 0.84
Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor. Mol Pharmacol (2006) 0.84
Virally encoded chemokines and chemokine receptors in the role of viral infections. Contrib Microbiol (2003) 0.84
Single-chain vascular endothelial growth factor variant with antagonist activity. J Biol Chem (2002) 0.83
Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist. J Virol (2004) 0.83
Dissecting signaling and functions of adhesion G protein-coupled receptors. Ann N Y Acad Sci (2012) 0.83
The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR. Biochemistry (2006) 0.83
A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6. J Biol Chem (2003) 0.83
Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop. J Biol Chem (2012) 0.83
G protein-coupled receptor modulation with pepducins: moving closer to the clinic. Ann N Y Acad Sci (2011) 0.82
The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor. J Biol Chem (2012) 0.81
An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J Med Chem (2012) 0.81
Unique interaction pattern for a functionally biased ghrelin receptor agonist. J Biol Chem (2011) 0.81
PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions. PLoS One (2013) 0.80
Interaction of a non-peptide agonist with angiotensin II AT1 receptor mutants. Can J Physiol Pharmacol (2002) 0.79
Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism. FASEB J (2011) 0.79
Construction of covalently coupled, concatameric dimers of 7TM receptors. J Recept Signal Transduct Res (2009) 0.79
Conformational constraining of inactive and active States of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V. Mol Pharmacol (2006) 0.78
Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity. PLoS One (2010) 0.77
Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor. J Virol (2007) 0.77
Viral leads for chemokine-modulatory drugs. Trends Pharmacol Sci (2003) 0.77
Model-based Discovery of Synthetic Agonists for the Zn<sup<2+</sup>-sensing G Protein Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions. J Med Chem (2017) 0.75