Myocardial hibernation: a delicate balance.

PubWeight™: 1.65‹?› | Rank: Top 3%

🔗 View Article (PMID 15563526)

Published in Am J Physiol Heart Circ Physiol on November 24, 2004

Authors

Gerd Heusch1, Rainer Schulz, Shahbudin H Rahimtoola

Author Affiliations

1: Institut für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany. gerd.heusch@uni-essen.de

Articles citing this

Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction. Circulation (2010) 3.42

Return to the fetal gene program protects the stressed heart: a strong hypothesis. Heart Fail Rev (2007) 2.67

Collateral circulation: past and present. Basic Res Cardiol (2008) 2.60

ESC working group cellular biology of the heart: position paper: improving the preclinical assessment of novel cardioprotective therapies. Cardiovasc Res (2014) 2.24

Nitrite as regulator of hypoxic signaling in mammalian physiology. Med Res Rev (2009) 2.15

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease. Nat Rev Drug Discov (2009) 2.10

Return to the fetal gene program: a suggested metabolic link to gene expression in the heart. Ann N Y Acad Sci (2010) 1.74

TNFα in myocardial ischemia/reperfusion, remodeling and heart failure. Heart Fail Rev (2011) 1.47

Cardiovascular remodelling in coronary artery disease and heart failure. Lancet (2014) 1.47

Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation. Proc Natl Acad Sci U S A (2007) 1.43

Revascularization of chronic hibernating myocardium stimulates myocyte proliferation and partially reverses chronic adaptations to ischemia. J Am Coll Cardiol (2015) 1.42

Coronary microvascular resistance: methods for its quantification in humans. Basic Res Cardiol (2009) 1.26

Myocardial perfusion and contraction in acute ischemia and chronic ischemic heart disease. J Mol Cell Cardiol (2011) 1.08

Cardioprotection in stunned and hibernating myocardium. Heart Fail Rev (2007) 1.05

Epigenetic regulation of BMP7 in the regenerative response to ischemia. J Am Soc Nephrol (2008) 1.03

Reductions in mitochondrial O(2) consumption and preservation of high-energy phosphate levels after simulated ischemia in chronic hibernating myocardium. Am J Physiol Heart Circ Physiol (2009) 0.97

Nogo-A knockdown inhibits hypoxia/reoxygenation-induced activation of mitochondrial-dependent apoptosis in cardiomyocytes. J Mol Cell Cardiol (2011) 0.93

Hexokinase-mitochondrial interaction in cardiac tissue: implications for cardiac glucose uptake, the 18FDG lumped constant and cardiac protection. J Bioenerg Biomembr (2009) 0.90

PET imaging of cardiac hypoxia: opportunities and challenges. J Mol Cell Cardiol (2011) 0.89

The detection of the nitrite reductase and NO-generating properties of haemoglobin by mitochondrial inhibition. Cardiovasc Res (2010) 0.89

Chronic ischemic left ventricular dysfunction: from pathophysiology to imaging and its integration into clinical practice. JACC Cardiovasc Imaging (2008) 0.88

Metabolic homeostasis is maintained in myocardial hibernation by adaptive changes in the transcriptome and proteome. J Mol Cell Cardiol (2011) 0.88

Anti-inflammatory and pro-angiogenic effects of beta blockers in a canine model of chronic ischemic cardiomyopathy: comparison between carvedilol and metoprolol. Basic Res Cardiol (2013) 0.83

Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice. Cardiovasc Diabetol (2011) 0.83

Long-term preservation of myocardial energetic in chronic hibernating myocardium. Am J Physiol Heart Circ Physiol (2010) 0.82

The physiological significance of a coronary stenosis differentially affects contractility and mitochondrial function in viable chronically dysfunctional myocardium. Basic Res Cardiol (2013) 0.81

Temporal changes of strain parameters in the progress of chronic ischemia: with comparison to transmural infarction. Int J Cardiovasc Imaging (2012) 0.80

Telomerase Is Essential for Zebrafish Heart Regeneration. Cell Rep (2015) 0.80

Myocardial remodeling, an overview. Heart Fail Rev (2011) 0.79

The cornucopia of "pleiotropic" actions of statins: myogenesis as a new mechanism for statin-induced benefits? Circ Res (2009) 0.79

Can late gadolinium enhancement by cardiovascular magnetic resonance identify coronary artery disease as the etiology of new onset congestive heart failure? Int J Cardiovasc Imaging (2007) 0.78

Myocardial ischemic protection in natural mammalian hibernation. Basic Res Cardiol (2015) 0.77

Regional mapping of myocardial hibernation phenotype in idiopathic end-stage dilated cardiomyopathy. J Cell Mol Med (2014) 0.77

Multimodality imaging of chronic ischemia. Cardiol Res Pract (2010) 0.76

Prolyl hydroxylation regulates protein degradation, synthesis, and splicing in human induced pluripotent stem cell-derived cardiomyocytes. Cardiovasc Res (2016) 0.76

Metabolomic analysis of two different models of delayed preconditioning. J Mol Cell Cardiol (2012) 0.75

High plasma coenzyme Q10 concentration is correlated with good left ventricular performance after primary angioplasty in patients with acute myocardial infarction. Medicine (Baltimore) (2016) 0.75

Quantitative analysis of SPECT imaging parameters in patients with resting perfusion defects on myocardial perfusion scintigraphy. Indian J Nucl Med (2010) 0.75

Articles by these authors

(truncated to the top 100)

A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell (2007) 5.85

Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol Rev (2007) 3.19

Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation. J Am Coll Cardiol (2006) 2.95

Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radic Biol Med (2003) 2.83

Cardioprotection: nitric oxide, protein kinases, and mitochondria. Circulation (2008) 2.64

High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. Circulation (2006) 2.58

Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury. Circ Res (2004) 2.45

Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotection. Circ Res (2006) 2.37

Red blood cells express a functional endothelial nitric oxide synthase. Blood (2005) 2.30

ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ Res (2006) 2.23

Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res (2010) 2.20

Effects of digoxin at low serum concentrations on mortality and hospitalization in heart failure: a propensity-matched study of the DIG trial. Int J Cardiol (2007) 2.05

TNFalpha in atherosclerosis, myocardial ischemia/reperfusion and heart failure. Pharmacol Ther (2010) 2.01

Loss of cardioprotection with ageing. Cardiovasc Res (2009) 1.94

Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion. Basic Res Cardiol (2010) 1.88

Oxidative modification of tropomyosin and myocardial dysfunction following coronary microembolization. Eur Heart J (2006) 1.87

Coronary microembolization: from bedside to bench and back to bedside. Circulation (2009) 1.85

Prosthetic heart valves and pregnancy. Circulation (2003) 1.79

Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning. Cardiovasc Res (2005) 1.75

Ischemic postconditioning in pigs: no causal role for RISK activation. Circ Res (2008) 1.74

The myocardial JAK/STAT pathway: from protection to failure. Pharmacol Ther (2008) 1.72

Translating cardioprotection for patient benefit: position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res (2013) 1.72

Inhibition of mitochondrial permeability transition pore opening: the Holy Grail of cardioprotection. Basic Res Cardiol (2010) 1.66

Cardioprotection by ischemic postconditioning is lost in aged and STAT3-deficient mice. Circ Res (2007) 1.64

Microdialysis-based analysis of interstitial NO in situ: NO synthase-independent NO formation during myocardial ischemia. Cardiovasc Res (2007) 1.58

Prevention of the ischemia-induced decrease in mitochondrial Tom20 content by ischemic preconditioning. J Mol Cell Cardiol (2006) 1.53

Bidirectional role of tumor necrosis factor-alpha in coronary microembolization: progressive contractile dysfunction versus delayed protection against infarction. Circ Res (2006) 1.50

TNFα in myocardial ischemia/reperfusion, remodeling and heart failure. Heart Fail Rev (2011) 1.47

Prosthetic heart valve. Circulation (2011) 1.46

Myocardial dysfunction with coronary microembolization: signal transduction through a sequence of nitric oxide, tumor necrosis factor-alpha, and sphingosine. Circ Res (2002) 1.45

No ischemic preconditioning in heterozygous connexin43-deficient mice. Am J Physiol Heart Circ Physiol (2002) 1.38

Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations. Basic Res Cardiol (2010) 1.37

Hibernating myocardium: diagnosis and patient outcomes. Curr Probl Cardiol (2007) 1.36

Impairment of diazoxide-induced formation of reactive oxygen species and loss of cardioprotection in connexin 43 deficient mice. Circ Res (2005) 1.34

Calcific aortic stenosis: an update. Nat Clin Pract Cardiovasc Med (2007) 1.33

Coronary microembolization: the role of TNF-alpha in contractile dysfunction. J Mol Cell Cardiol (2002) 1.32

Ischemic postconditioning: experimental models and protocol algorithms. Basic Res Cardiol (2009) 1.27

Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction. Eur Heart J (2008) 1.21

Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria. Basic Res Cardiol (2009) 1.20

B-type natriuretic peptide limits infarct size in rat isolated hearts via KATP channel opening. Am J Physiol Heart Circ Physiol (2003) 1.19

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res Cardiol (2012) 1.17

New insights into the S-nitrosothiol-ascorbate reaction. The formation of nitroxyl. Org Biomol Chem (2009) 1.14

Connexin43 in cardiomyocyte mitochondria contributes to mitochondrial potassium uptake. Cardiovasc Res (2009) 1.14

Effectiveness of digoxin in reducing one-year mortality in chronic heart failure in the Digitalis Investigation Group trial. Am J Cardiol (2008) 1.14

Plasma nitrosothiols contribute to the systemic vasodilator effects of intravenously applied NO: experimental and clinical Study on the fate of NO in human blood. Circ Res (2002) 1.11

Retracted Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial KATP channels in mouse cardiomyocytes. J Clin Invest (2010) 1.10

Loss of ischemic preconditioning's cardioprotection in aged mouse hearts is associated with reduced gap junctional and mitochondrial levels of connexin 43. Am J Physiol Heart Circ Physiol (2006) 1.10

Positive effects of nitric oxide on left ventricular function in humans. Eur Heart J (2006) 1.10

The in-situ pig heart with regional ischemia/reperfusion - ready for translation. J Mol Cell Cardiol (2011) 1.08

The angiotensin II type 1-receptor blocker candesartan increases cerebral blood flow, reduces infarct size, and improves neurologic outcome after transient cerebral ischemia in rats. J Cereb Blood Flow Metab (2004) 1.08

No loss of cardioprotection by postconditioning in connexin 43-deficient mice. Basic Res Cardiol (2006) 1.06

Cyclosporine A at reperfusion reduces infarct size in pigs. Cardiovasc Drugs Ther (2010) 1.04

Reduced coronary and inotropic reserves with coronary microembolization. Am J Physiol Heart Circ Physiol (2002) 1.03

Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption. J Cell Mol Med (2012) 1.01

Tumor necrosis factor-alpha and its receptors 1 and 2: Yin and Yang in myocardial infarction? Circulation (2009) 1.01

The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning. Br J Pharmacol (2014) 1.01

HFA1 encoding an organelle-specific acetyl-CoA carboxylase controls mitochondrial fatty acid synthesis in Saccharomyces cerevisiae. J Biol Chem (2004) 1.00

Treatment of obstructive thrombosed prosthetic heart valve. J Am Coll Cardiol (2013) 1.00

Preprocedural statin medication reduces the extent of periprocedural non-Q-wave myocardial infarction. Circulation (2002) 1.00

Pathophysiology of myocardial infarction: protection by ischemic pre- and postconditioning. Herz (2008) 0.99

Retracted Glycogen synthase kinase 3β transfers cytoprotective signaling through connexin 43 onto mitochondrial ATP-sensitive K+ channels. Proc Natl Acad Sci U S A (2012) 0.98

Glucocorticoid treatment prevents progressive myocardial dysfunction resulting from experimental coronary microembolization. Circulation (2004) 0.97

Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation. Circ Res (2010) 0.97

Mechanisms involved in postconditioning protection of cardiomyocytes against acute reperfusion injury. J Mol Cell Cardiol (2013) 0.96

Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol (2011) 0.95

Clinical relevance of hibernating myocardium in ischemic left ventricular dysfunction. Am J Med (2010) 0.94

Nitrite in organ protection. Br J Pharmacol (2014) 0.93

A radical view on the contractile machinery in human heart failure. J Am Coll Cardiol (2011) 0.92

Increased inducible nitric oxide synthase and arginase II expression in heart failure: no net nitrite/nitrate production and protein S-nitrosylation. Am J Physiol Heart Circ Physiol (2010) 0.92

Cholesterol diet leads to attenuation of ischemic preconditioning-induced cardiac protection: the role of connexin 43. Am J Physiol Heart Circ Physiol (2011) 0.92

Coronary microembolization. J Mol Cell Cardiol (2004) 0.91

Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS. Am J Physiol Heart Circ Physiol (2005) 0.91

Parathyroid hormone-related peptide improves contractile function of stunned myocardium in rats and pigs. Am J Physiol Heart Circ Physiol (2003) 0.91

Attenuation of ischemic preconditioning in pigs by scavenging of free oxyradicals with ascorbic acid. Am J Physiol Heart Circ Physiol (2002) 0.90

TNF-alpha antibodies are as effective as ischemic preconditioning in reducing infarct size in rabbits. Am J Physiol Heart Circ Physiol (2002) 0.90

Mitochondrial respiration and membrane potential after low-flow ischemia are not affected by ischemic preconditioning. J Mol Cell Cardiol (2007) 0.89

Hypoxia-reoxygenation-induced endothelial barrier failure: role of RhoA, Rac1 and myosin light chain kinase. J Physiol (2012) 0.89

Reduction of infarct size by gentle reperfusion without activation of reperfusion injury salvage kinases in pigs. Cardiovasc Res (2010) 0.89

Reduction of cerebral infarct size by the AT1-receptor blocker candesartan, the HMG-CoA reductase inhibitor rosuvastatin and their combination. An experimental study in rats. Neurosci Lett (2006) 0.88

Acute thrombotic complete occlusion of the aorta: accurate, immediate clinical decision-making by echocardiography. Am J Med (2009) 0.88

Myocardial hibernation. Ital Heart J (2002) 0.88

Monoamine oxidases are mediators of endothelial dysfunction in the mouse aorta. Hypertension (2013) 0.88

Was it digoxin toxicity?...very likely. J Card Fail (2005) 0.88

Remote preconditioning. J Mol Cell Cardiol (2002) 0.88

Valve prosthesis-patient mismatch (VP-PM): a long-term perspective. J Am Coll Cardiol (2012) 0.87

Formation of reactive oxygen species at increased contraction frequency in rat cardiomyocytes. Cardiovasc Res (2006) 0.87

Inhibition of the Na+/H+ exchanger attenuates the deterioration of ventricular function during pacing-induced heart failure in rabbits. Cardiovasc Res (2004) 0.86

Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol (2013) 0.86

Constrictive pericarditis masquerading as chronic idiopathic pleural effusion: importance of physical examination. Am J Med (2006) 0.86

Mitochondria in postconditioning. Antioxid Redox Signal (2010) 0.86

The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation. Curr Pharm Des (2013) 0.86

Inducible nitric oxide synthase expression and cardiomyocyte dysfunction during sustained moderate ischemia in pigs. Circ Res (2008) 0.86

Rheumatic heart disease and risk of incident heart failure among community-dwelling older adults: a prospective cohort study. Ann Med (2011) 0.86

Impaired resting perfusion in viable myocardium distal to chronic coronary stenosis in rats. Am J Physiol Heart Circ Physiol (2005) 0.85

No ischemic preconditioning in heterozygous connexin 43-deficient mice--a further in vivo study. Basic Res Cardiol (2003) 0.85

C-reactive protein: just a biomarker of inflammation or a pathophysiological player in myocardial function and morphology? Hypertension (2011) 0.84

Serum but not myocardial TNF-alpha concentration is increased in pacing-induced heart failure in rabbits. Am J Physiol Regul Integr Comp Physiol (2003) 0.84

Retraction for Rottlaender et al., "Glycogen synthase kinase 3β transfers cytoprotective signaling through connexin 43 onto mitochondrial ATP-sensitive K+ channels". Proc Natl Acad Sci U S A (2012) 0.83

Inhibition of AP-1 signaling by JDP2 overexpression protects cardiomyocytes against hypertrophy and apoptosis induction. Cardiovasc Res (2013) 0.83

Involvement of endogenous prostaglandins in ischemic preconditioning in pigs. Cardiovasc Res (2002) 0.83