Published in Blood on December 20, 2005
Evolution of adverse changes in stored RBCs. Proc Natl Acad Sci U S A (2007) 3.58
S-nitrosohemoglobin deficiency: a mechanism for loss of physiological activity in banked blood. Proc Natl Acad Sci U S A (2007) 2.77
Life history of eNOS: partners and pathways. Cardiovasc Res (2007) 2.53
Endothelial nitric oxide synthase in red blood cells: key to a new erythrocrine function? Redox Biol (2014) 2.18
Nitrite as regulator of hypoxic signaling in mammalian physiology. Med Res Rev (2009) 2.15
Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans. Proc Natl Acad Sci U S A (2007) 2.07
Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase. Circ Res (2008) 2.05
Host-parasite interactions revealed by Plasmodium falciparum metabolomics. Cell Host Microbe (2009) 2.00
Routine storage of red blood cell (RBC) units in additive solution-3: a comprehensive investigation of the RBC metabolome. Transfusion (2014) 1.77
Storage lesion: role of red blood cell breakdown. Transfusion (2011) 1.74
The functional nitrite reductase activity of the heme-globins. Blood (2008) 1.58
Hypoxic vasodilation by red blood cells: evidence for an s-nitrosothiol-based signal. Circ Res (2008) 1.42
C4d deposits on the surface of RBCs in trauma patients and interferes with their function. Crit Care Med (2014) 1.41
Anaerobic storage of red blood cells. Blood Transfus (2010) 1.34
Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells. Blood (2007) 1.27
Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers. Anesthesiology (2012) 1.20
Mechanisms tagging senescent red blood cells for clearance in healthy humans. Front Physiol (2013) 1.18
Strategies to increase nitric oxide signalling in cardiovascular disease. Nat Rev Drug Discov (2015) 1.18
Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective. Antioxid Redox Signal (2008) 1.16
Gene expression analysis of human red blood cells. Int J Med Sci (2009) 1.13
Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation. Am J Physiol Heart Circ Physiol (2009) 1.07
Metabolomics of ADSOL (AS-1) red blood cell storage. Transfus Med Rev (2014) 1.06
Nitric oxide formation versus scavenging: the red blood cell balancing act. J Physiol (2012) 1.04
Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis. Arterioscler Thromb Vasc Biol (2013) 1.04
Red blood cells in sports: effects of exercise and training on oxygen supply by red blood cells. Front Physiol (2013) 1.03
Calcium in red blood cells-a perilous balance. Int J Mol Sci (2013) 1.02
Is there a direct role for erythrocytes in the immune response? Vet Res (2011) 1.01
Anemia and splenomegaly in cGKI-deficient mice. Proc Natl Acad Sci U S A (2008) 1.00
RBC-NOS-dependent S-nitrosylation of cytoskeletal proteins improves RBC deformability. PLoS One (2013) 1.00
Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity. Proc Natl Acad Sci U S A (2013) 0.98
Dysregulation of L-arginine metabolism and bioavailability associated to free plasma heme. Am J Physiol Cell Physiol (2010) 0.97
RNA-Seq reveals an integrated immune response in nucleated erythrocytes. PLoS One (2011) 0.93
Hemoglobin redox reactions and red blood cell aging. Antioxid Redox Signal (2012) 0.91
Systemic lupus erythematosus serum deposits C4d on red blood cells, decreases red blood cell membrane deformability, and promotes nitric oxide production. Arthritis Rheum (2011) 0.91
Hemostatic risk factors in patients with coronary artery disease and type 2 diabetes - a two year follow-up of 243 patients. Cardiovasc Diabetol (2009) 0.90
Sepsis-induced myocardial dysfunction: pathophysiology and management. J Intensive Care (2016) 0.89
Platelet aggregation responses are critically regulated in vivo by endogenous nitric oxide but not by endothelial nitric oxide synthase. Br J Pharmacol (2009) 0.88
Nitric oxide signaling in the microcirculation. Crit Rev Biomed Eng (2011) 0.88
Role of endothelial nitric oxide synthase in diabetic nephropathy: lessons from diabetic eNOS knockout mice. J Diabetes Res (2014) 0.88
Hydroxyurea-induced expression of glutathione peroxidase 1 in red blood cells of individuals with sickle cell anemia. Antioxid Redox Signal (2010) 0.88
Arginine transport in human erythroid cells: discrimination of CAT1 and 4F2hc/y+LAT2 roles. Pflugers Arch (2009) 0.87
Vascular and perivascular nitric oxide release and transport: biochemical pathways of neuronal nitric oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3). Free Radic Biol Med (2006) 0.87
Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice. Am J Hematol (2009) 0.87
Shear stress activation of nitric oxide synthase and increased nitric oxide levels in human red blood cells. Nitric Oxide (2011) 0.86
Moderate exercise promotes human RBC-NOS activity, NO production and deformability through Akt kinase pathway. PLoS One (2012) 0.86
Increased erythrocytes by-products of arginine catabolism are associated with hyperglycemia and could be involved in the pathogenesis of type 2 diabetes mellitus. PLoS One (2013) 0.86
Skeletal muscle function during exercise-fine-tuning of diverse subsystems by nitric oxide. Int J Mol Sci (2013) 0.85
Nitric oxide synthetic pathway in red blood cells is impaired in coronary artery disease. PLoS One (2013) 0.85
Xuezhikang, extract of red yeast rice, improved abnormal hemorheology, suppressed caveolin-1 and increased eNOS expression in atherosclerotic rats. PLoS One (2013) 0.83
CO2 -dependent metabolic modulation in red blood cells stored under anaerobic conditions. Transfusion (2015) 0.82
Red blood cell endothelial nitric oxide synthase does not modulate red blood cell storage hemolysis. Transfusion (2012) 0.82
Circulating microparticles carry a functional endothelial nitric oxide synthase that is decreased in patients with endothelial dysfunction. J Am Heart Assoc (2012) 0.82
Lack of association between low density lipoprotein particle size and on-treatment platelet reactivity in patients with coronary artery disease. Korean Circ J (2012) 0.82
Signaling and stress: The redox landscape in NOS2 biology. Free Radic Biol Med (2015) 0.82
Depletion of circulating blood NOS3 increases severity of myocardial infarction and left ventricular dysfunction. Basic Res Cardiol (2013) 0.82
Protein disulfide isomerase may facilitate the efflux of nitrite derived S-nitrosothiols from red blood cells. Redox Biol (2013) 0.81
Nitric oxide production pathways in erythrocytes and plasma. Biorheology (2009) 0.81
Effects of erythrocyte aging on nitric oxide and nitrite metabolism. Antioxid Redox Signal (2013) 0.81
Rapid rather than gradual weight reduction impairs hemorheological parameters of Taekwondo athletes through reduction in RBC-NOS activation. PLoS One (2015) 0.81
Research opportunities in optimizing storage of red blood cell products. Transfusion (2013) 0.80
Role of hemoglobin oxygenation in the modulation of red blood cell mechanical properties by nitric oxide. Nitric Oxide (2009) 0.80
Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes. Am J Hematol (2014) 0.80
Lung Structure and the Intrinsic Challenges of Gas Exchange. Compr Physiol (2016) 0.79
The capacity of red blood cells to reduce nitrite determines nitric oxide generation under hypoxic conditions. PLoS One (2014) 0.79
Endothelial nitric oxide synthase in the microcirculation. Cell Mol Life Sci (2015) 0.79
C-peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patients. Exp Diabetes Res (2008) 0.79
Electron paramagnetic resonance investigation on modulatory effect of benidipine on membrane fluidity of erythrocytes in essential hypertension. Heart Vessels (2008) 0.79
Short-term effect of the HMG-CoA reductase inhibitor rosuvastatin on erythrocyte nitric oxide synthase activity. Vasc Health Risk Manag (2007) 0.79
Circulating NOS3 modulates left ventricular remodeling following reperfused myocardial infarction. PLoS One (2015) 0.79
Exercise and NO production: relevance and implications in the cardiopulmonary system. Front Cell Dev Biol (2015) 0.78
Effects of nitric oxide and its congeners on sickle red blood cell deformability. Transfusion (2015) 0.78
Hemorrhagic shock and nitric oxide release from erythrocytic nitric oxide synthase: a quantitative analysis. Microvasc Res (2009) 0.78
Hydroxyurea stimulates the release of ATP from rabbit erythrocytes through an increase in calcium and nitric oxide production. Eur J Pharmacol (2010) 0.78
Generation of a conditional allele for the mouse endothelial nitric oxide synthase gene. Genesis (2012) 0.77
The red-vine-leaf extract AS195 increases nitric oxide synthase-dependent nitric oxide generation and decreases oxidative stress in endothelial and red blood cells. Pharmacol Res Perspect (2016) 0.77
Reduced erythrocyte deformability associated with hypoargininemia during Plasmodium falciparum malaria. Sci Rep (2014) 0.77
Nitric oxide synthetic pathway in patients with microvascular angina and its relations with oxidative stress. Oxid Med Cell Longev (2014) 0.77
Erythrocytes do not activate purified and platelet soluble guanylate cyclases even in conditions favourable for NO synthesis. Cell Commun Signal (2016) 0.77
Effects of dexmedetomidine on the deformability of erythrocytes in vitro and in anesthesia. Exp Ther Med (2014) 0.77
eNOS T-786C polymorphism affects atorvastatin-induced changes in erythrocyte membrane fluidity. Eur J Clin Pharmacol (2008) 0.77
AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia. J Proteome Res (2016) 0.76
Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX). Hypertension (2016) 0.76
Inhibition of the prothrombinase complex on red blood cells by heparin and covalent antithrombin-heparin complex. J Biochem (2012) 0.76
Mechanical perturbations trigger endothelial nitric oxide synthase activity in human red blood cells. Sci Rep (2016) 0.76
Effect of storage levels of nitric oxide derivatives in blood components. F1000Res (2012) 0.75
Erythrocyte and blood antibacterial defense. Eur J Microbiol Immunol (Bp) (2014) 0.75
Balanced oxidative status by nesfatin-1 in intestinal ischemia-reperfusion. Int J Clin Exp Med (2015) 0.75
Levels of human erythrocyte membrane-bound and cytosolic glycohydrolases are associated with oxidative stress in erectile dysfunction patients. Dis Markers (2014) 0.75
Association between alcohol-induced erythrocyte membrane alterations and hemolysis in chronic alcoholics. J Clin Biochem Nutr (2016) 0.75
(-)-Epicatechin Prevents Blood Pressure Increase and Reduces Locomotor Hyperactivity in Young Spontaneously Hypertensive Rats. Oxid Med Cell Longev (2016) 0.75
NO Metabolites Levels in Human Red Blood Cells are Affected by Palytoxin, an Inhibitor of Na(+)/K(+)-ATPase Pump. Open Biochem J (2014) 0.75
Impaired blood rheology is associated with endothelial dysfunction in patients with coronary risk factors. Clin Hemorheol Microcirc (2015) 0.75
Erythrocytes in multiple sclerosis - forgotten contributors to the pathophysiology? Mult Scler J Exp Transl Clin (2016) 0.75
Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus. World J Diabetes (2017) 0.75
Chemical Transport Knockout for Oxidized Vitamin C, Dehydroascorbic Acid, Reveals Its Functions in vivo. EBioMedicine (2017) 0.75
A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell (2007) 5.85
Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies in Adults With Hypercholesterolemia: A Systematic Review and Meta-analysis. Ann Intern Med (2015) 4.62
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues. Nat Chem Biol (2005) 3.46
Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol Rev (2007) 3.19
Concern Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery. Eur Heart J (2009) 3.14
The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity (2011) 3.10
(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A (2006) 3.03
Potential risks of bone marrow cell transplantation into infarcted hearts. Blood (2007) 2.97
The emerging biology of the nitrite anion. Nat Chem Biol (2005) 2.88
Impaired progenitor cell activity in age-related endothelial dysfunction. J Am Coll Cardiol (2005) 2.86
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radic Biol Med (2003) 2.83
Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response. Circ Res (2004) 2.68
Cardioprotection: nitric oxide, protein kinases, and mitochondria. Circulation (2008) 2.64
Impact of left ventricular lead position in cardiac resynchronization therapy on left ventricular remodelling. A circumferential strain analysis based on 2D echocardiography. Eur Heart J (2007) 2.59
High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. Circulation (2006) 2.58
Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo. FASEB J (2002) 2.46
Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury. Circ Res (2004) 2.45
Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotection. Circ Res (2006) 2.37
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. J Clin Invest (2004) 2.36
Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo. Proc Natl Acad Sci U S A (2004) 2.33
Postoperative care and follow-up after coronary stenting. Dtsch Arztebl Int (2013) 2.32
Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol (2009) 2.29
Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis. J Cell Biol (2009) 2.24
ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ Res (2006) 2.23
Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium. J Exp Med (2006) 2.23
Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res (2010) 2.20
Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell (2010) 2.17
Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis. Proc Natl Acad Sci U S A (2003) 2.17
Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2008) 2.17
Nitrite as regulator of hypoxic signaling in mammalian physiology. Med Res Rev (2009) 2.15
Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial. J Am Coll Cardiol (2008) 2.12
Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator. Nat Med (2004) 2.09
Erythrocytes are the major intravascular storage sites of nitrite in human blood. Blood (2005) 2.08
Safety and efficacy of deep sedation as compared to general anaesthesia in percutaneous mitral valve repair using the MitraClip system. Catheter Cardiovasc Interv (2014) 2.05
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development (2002) 2.04
TNFalpha in atherosclerosis, myocardial ischemia/reperfusion and heart failure. Pharmacol Ther (2010) 2.01
Meta-analysis of impact of different types and doses of statins on new-onset diabetes mellitus. Am J Cardiol (2013) 2.00
Loss of cardioprotection with ageing. Cardiovasc Res (2009) 1.94
Plasma nitroso compounds are decreased in patients with endothelial dysfunction. J Am Coll Cardiol (2006) 1.91
Hemodialysis-induced release of hemoglobin limits nitric oxide bioavailability and impairs vascular function. J Am Coll Cardiol (2010) 1.89
Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion. Basic Res Cardiol (2010) 1.88
Oxidative modification of tropomyosin and myocardial dysfunction following coronary microembolization. Eur Heart J (2006) 1.87
Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans. Free Radic Biol Med (2005) 1.85
Coronary microembolization: from bedside to bench and back to bedside. Circulation (2009) 1.85
Mechanism of lipid-body formation in prokaryotes: how bacteria fatten up. Mol Microbiol (2005) 1.83
Nitrite reductase function of deoxymyoglobin: oxygen sensor and regulator of cardiac energetics and function. Circ Res (2007) 1.76
Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning. Cardiovasc Res (2005) 1.75
Ischemic postconditioning in pigs: no causal role for RISK activation. Circ Res (2008) 1.74
Cardiac-specific overexpression of inducible nitric oxide synthase does not result in severe cardiac dysfunction. Circ Res (2002) 1.74
The myocardial JAK/STAT pathway: from protection to failure. Pharmacol Ther (2008) 1.72
Translating cardioprotection for patient benefit: position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res (2013) 1.72
Concomitant presence of N-nitroso and S-nitroso proteins in human plasma. Free Radic Biol Med (2002) 1.71
Nitric oxide in myocardial ischemia/reperfusion injury. Cardiovasc Res (2004) 1.69
Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat Immunol (2007) 1.68
Inhibition of mitochondrial permeability transition pore opening: the Holy Grail of cardioprotection. Basic Res Cardiol (2010) 1.66
Myocardial hibernation: a delicate balance. Am J Physiol Heart Circ Physiol (2004) 1.65
Cardioprotection by ischemic postconditioning is lost in aged and STAT3-deficient mice. Circ Res (2007) 1.64
Vascular effects of cocoa rich in flavan-3-ols. JAMA (2003) 1.63
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol (2007) 1.63
Impact of the metabolic syndrome on angiographic and clinical events after coronary intervention using bare-metal or sirolimus-eluting stents. Am J Cardiol (2007) 1.62
Relation of circulating Matrix Gla-Protein and anticoagulation status in patients with aortic valve calcification. Thromb Haemost (2009) 1.58
Microdialysis-based analysis of interstitial NO in situ: NO synthase-independent NO formation during myocardial ischemia. Cardiovasc Res (2007) 1.58
Decreased plasminogen activator inhibitor and tissue metalloproteinase inhibitor expression may promote increased metalloproteinase activity with increasing duration of human atrial fibrillation. J Cardiovasc Electrophysiol (2007) 1.57
Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism. Nat Genet (2009) 1.55
Sirolimus-eluting stent treatment at high-volume centers confers lower mortality at 6-month follow-up: results from the prospective multicenter German Cypher Registry. Circulation (2009) 1.54
Prevention of the ischemia-induced decrease in mitochondrial Tom20 content by ischemic preconditioning. J Mol Cell Cardiol (2006) 1.53
Left ventricular remodeling impairs coronary flow reserve in hypertensive patients. J Hypertens (2002) 1.53
Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction. Am J Pathol (2002) 1.52
Basic fibroblast growth factor controls migration in human mesenchymal stem cells. Stem Cells (2006) 1.52
Incidence and clinical outcome of iatrogenic femoral arteriovenous fistulas: implications for risk stratification and treatment. J Am Coll Cardiol (2002) 1.50
Bidirectional role of tumor necrosis factor-alpha in coronary microembolization: progressive contractile dysfunction versus delayed protection against infarction. Circ Res (2006) 1.50
Chemical nature of nitric oxide storage forms in rat vascular tissue. Proc Natl Acad Sci U S A (2002) 1.49
The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization. FASEB J (2007) 1.49
Circulating nitrite contributes to cardioprotection by remote ischemic preconditioning. Circ Res (2014) 1.49
Apolipoprotein E induces antiinflammatory phenotype in macrophages. Arterioscler Thromb Vasc Biol (2011) 1.47