Published in Science on November 26, 2004
Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Biochim Biophys Acta (2007) 3.07
Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5. Mol Cell (2008) 2.00
Bistability, stochasticity, and oscillations in the mitogen-activated protein kinase cascade. Biophys J (2005) 1.69
Application of Petri net based analysis techniques to signal transduction pathways. BMC Bioinformatics (2006) 1.68
Mathematical models of specificity in cell signaling. Biophys J (2007) 1.31
Analysis of mitogen-activated protein kinase signaling specificity in response to hyperosmotic stress: use of an analog-sensitive HOG1 allele. Eukaryot Cell (2006) 1.25
The RA domain of Ste50 adaptor protein is required for delivery of Ste11 to the plasma membrane in the filamentous growth signaling pathway of the yeast Saccharomyces cerevisiae. Mol Cell Biol (2006) 1.23
Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain. Genes Dev (2006) 1.23
Nucleus-specific and cell cycle-regulated degradation of mitogen-activated protein kinase scaffold protein Ste5 contributes to the control of signaling competence. Mol Cell Biol (2008) 1.10
Dynamic studies of scaffold-dependent mating pathway in yeast. Biophys J (2006) 1.08
Modularization of biochemical networks based on classification of Petri net t-invariants. BMC Bioinformatics (2008) 0.96
Decomposition of overlapping protein complexes: a graph theoretical method for analyzing static and dynamic protein associations. Algorithms Mol Biol (2006) 0.92
A role for a complex between activated G protein-coupled receptors in yeast cellular mating. Proc Natl Acad Sci U S A (2007) 0.91
A novel class of peptide pheromone precursors in ascomycetous fungi. Mol Microbiol (2010) 0.87
The putative lipid transporter, Arv1, is required for activating pheromone-induced MAP kinase signaling in Saccharomyces cerevisiae. Genetics (2010) 0.85
Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast. PLoS One (2009) 0.85
Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity. Mol Biol Cell (2012) 0.85
Allatotropin: an ancestral myotropic neuropeptide involved in feeding. PLoS One (2013) 0.84
RGS proteins and septins cooperate to promote chemotropism by regulating polar cap mobility. Curr Biol (2015) 0.84
Dynamic localization of Fus3 mitogen-activated protein kinase is necessary to evoke appropriate responses and avoid cytotoxic effects. Mol Cell Biol (2010) 0.84
Ceramide signals for initiation of yeast mating-specific cell cycle arrest. Cell Cycle (2016) 0.83
Different modulation of the outputs of yeast MAPK-mediated pathways by distinct stimuli and isoforms of the dual-specificity phosphatase Msg5. Mol Genet Genomics (2009) 0.82
The homeodomain transcription factor Ste12: Connecting fungal MAPK signalling to plant pathogenicity. Commun Integr Biol (2010) 0.80
Pheromone- and RSP5-dependent ubiquitination of the G protein beta subunit Ste4 in yeast. J Biol Chem (2011) 0.79
Structurally unique interaction of RBD-like and PH domains is crucial for yeast pheromone signaling. Mol Biol Cell (2012) 0.76
Signal inhibition by a dynamically regulated pool of monophosphorylated MAPK. Mol Biol Cell (2015) 0.75
Miniaturized mass-spectrometry-based analysis system for fully automated examination of conditioned cell culture media. Int J Proteomics (2012) 0.75
Reconstructing the regulatory circuit of cell fate determination in yeast mating response. PLoS Comput Biol (2017) 0.75
Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell (2006) 3.11
Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5. Mol Cell (2008) 2.00
Mathematical and computational analysis of adaptation via feedback inhibition in signal transduction pathways. Biophys J (2007) 1.93
DEP-domain-mediated regulation of GPCR signaling responses. Cell (2006) 1.87
Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. Nat Struct Mol Biol (2012) 1.76
Bistability, stochasticity, and oscillations in the mitogen-activated protein kinase cascade. Biophys J (2005) 1.69
Protons as second messenger regulators of G protein signaling. Mol Cell (2013) 1.62
A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress-response pathway. Curr Biol (2007) 1.47
Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor. Curr Biol (2008) 1.41
The crystal structure of a self-activating G protein alpha subunit reveals its distinct mechanism of signal initiation. Sci Signal (2011) 1.40
Kinetic insulation as an effective mechanism for achieving pathway specificity in intracellular signaling networks. Proc Natl Acad Sci U S A (2007) 1.36
Analysis of RGS proteins in Saccharomyces cerevisiae. Methods Enzymol (2002) 1.33
Regulators of G protein signaling and transient activation of signaling: experimental and computational analysis reveals negative and positive feedback controls on G protein activity. J Biol Chem (2003) 1.29
Dose-to-duration encoding and signaling beyond saturation in intracellular signaling networks. PLoS Comput Biol (2008) 1.26
Direct identification of a G protein ubiquitination site by mass spectrometry. Biochemistry (2002) 1.22
The RACK1 ortholog Asc1 functions as a G-protein beta subunit coupled to glucose responsiveness in yeast. J Biol Chem (2007) 1.22
Identification of allosteric peptide agonists of CXCR4. J Biol Chem (2002) 1.19
Control of MAPK specificity by feedback phosphorylation of shared adaptor protein Ste50. J Biol Chem (2008) 1.16
MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression. Curr Opin Chem Biol (2005) 1.16
The yeast G protein alpha subunit Gpa1 transmits a signal through an RNA binding effector protein Scp160. Mol Cell (2003) 1.10
Structures of Get3, Get4, and Get5 provide new models for TA membrane protein targeting. Structure (2010) 1.10
Persistent activation by constitutive Ste7 promotes Kss1-mediated invasive growth but fails to support Fus3-dependent mating in yeast. Mol Cell Biol (2004) 1.07
Functional reconstitution of an atypical G protein heterotrimer and regulator of G protein signaling protein (RGS1) from Arabidopsis thaliana. J Biol Chem (2011) 1.06
Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae. Eukaryot Cell (2006) 1.06
Regulation of stress response signaling by the N-terminal dishevelled/EGL-10/pleckstrin domain of Sst2, a regulator of G protein signaling in Saccharomyces cerevisiae. J Biol Chem (2002) 1.04
Cell cycle-dependent phosphorylation and ubiquitination of a G protein alpha subunit. J Biol Chem (2011) 1.03
Regulation of Ste7 ubiquitination by Ste11 phosphorylation and the Skp1-Cullin-F-box complex. J Biol Chem (2003) 1.03
Yeast dynamically modify their environment to achieve better mating efficiency. Sci Signal (2011) 1.01
Differences in intradomain and interdomain motion confer distinct activation properties to structurally similar Gα proteins. Proc Natl Acad Sci U S A (2012) 1.00
Pheromone-regulated sumoylation of transcription factors that mediate the invasive to mating developmental switch in yeast. J Biol Chem (2005) 0.99
Pheromone-dependent ubiquitination of the mitogen-activated protein kinase kinase Ste7. J Biol Chem (2002) 0.99
Checkpoints in a yeast differentiation pathway coordinate signaling during hyperosmotic stress. PLoS Genet (2012) 0.97
Structure and function of Vps15 in the endosomal G protein signaling pathway. Biochemistry (2009) 0.96
Dominant-negative inhibition of pheromone receptor signaling by a single point mutation in the G protein alpha subunit. J Biol Chem (2004) 0.94
Differential regulation of G protein alpha subunit trafficking by mono- and polyubiquitination. J Biol Chem (2004) 0.93
G protein signaling in yeast: new components, new connections, new compartments. Science (2006) 0.92
Systematic analysis of essential genes reveals important regulators of G protein signaling. Mol Cell (2010) 0.91
G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase. J Biol Chem (2009) 0.91
Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination. J Biol Chem (2013) 0.88
Regulation of yeast G protein signaling by the kinases that activate the AMPK homolog Snf1. Sci Signal (2013) 0.88
Regulation of G protein and mitogen-activated protein kinase signaling by ubiquitination: insights from model organisms. Circ Res (2006) 0.87
Similarities between UDP-glucose and adenine nucleotide release in yeast: involvement of the secretory pathway. Biochemistry (2008) 0.87
Phosphorylation of the RGS protein Sst2 by the MAP kinase Fus3 and use of Sst2 as a model to analyze determinants of substrate sequence specificity. Biochemistry (2005) 0.86
Mathematical modeling of RGS and G-protein regulation in yeast. Methods Enzymol (2004) 0.86
Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity. Mol Biol Cell (2012) 0.85
RGS proteins: G protein-coupled receptors meet their match. Assay Drug Dev Technol (2003) 0.85
Identification of yeast pheromone pathway modulators by high-throughput agonist response profiling of a yeast gene knockout strain collection. Methods Enzymol (2004) 0.85
Selective regulation of MAP kinase signaling by an endomembrane phosphatidylinositol 4-kinase. J Biol Chem (2011) 0.83
Pheromone- and RSP5-dependent ubiquitination of the G protein beta subunit Ste4 in yeast. J Biol Chem (2011) 0.79
The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae. Mol Biol Cell (2012) 0.78
Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity. J Biol Chem (2013) 0.77
Proper protein glycosylation promotes mitogen-activated protein kinase signal fidelity. Biochemistry (2012) 0.76
PhDs: Acquired skills good for marketplace. Nature (2012) 0.75
Illuminating Gbeta5 signaling. Mol Pharmacol (2007) 0.75
Purification of RGS protein, Sst2, from Saccharomyces cerevisiae and Escherichia coli. Methods Enzymol (2002) 0.75