Published in Cell on September 22, 2006
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell (2009) 5.97
Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Biochim Biophys Acta (2007) 3.07
A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics (2011) 2.34
Negative feedback that improves information transmission in yeast signalling. Nature (2008) 2.21
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling. Cell Biochem Biophys (2009) 1.79
Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins. Br J Pharmacol (2012) 1.69
Crystal structure of the multifunctional Gbeta5-RGS9 complex. Nat Struct Mol Biol (2008) 1.52
Retina-specific GTPase accelerator RGS11/G beta 5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons. J Neurosci (2009) 1.38
How regulators of G protein signaling achieve selective regulation. J Mol Biol (2006) 1.34
Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi. FEMS Microbiol Rev (2008) 1.33
Dose-to-duration encoding and signaling beyond saturation in intracellular signaling networks. PLoS Comput Biol (2008) 1.26
Targeting of RGS7/Gbeta5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP. J Neurosci (2008) 1.26
Robust spatial sensing of mating pheromone gradients by yeast cells. PLoS One (2008) 1.24
G protein signaling governing cell fate decisions involves opposing Galpha subunits in Cryptococcus neoformans. Mol Biol Cell (2007) 1.24
Direct spatial control of Epac1 by cyclic AMP. Mol Cell Biol (2009) 1.17
Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling. Mol Pharmacol (2010) 1.15
A unique role of RGS9-2 in the striatum as a positive or negative regulator of opiate analgesia. J Neurosci (2011) 1.09
The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7. Biochemistry (2009) 1.09
A framework for mapping, visualisation and automatic model creation of signal-transduction networks. Mol Syst Biol (2012) 1.07
Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled. Proc Natl Acad Sci U S A (2012) 1.07
GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes. J Cell Biol (2012) 1.06
Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. Structure (2010) 1.04
The RGS protein Crg2 regulates both pheromone and cAMP signalling in Cryptococcus neoformans. Mol Microbiol (2008) 1.04
Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein-coupled receptor Ste2. Mol Cell Biol (2014) 1.02
Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response. J Biol Chem (2016) 1.00
Polarization of the yeast pheromone receptor requires its internalization but not actin-dependent secretion. Mol Biol Cell (2010) 0.98
Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential. J Physiol (2012) 0.98
Chemical gradients and chemotropism in yeast. Cold Spring Harb Perspect Biol (2009) 0.98
Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis. Blood (2009) 0.96
cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane. Proc Natl Acad Sci U S A (2012) 0.96
Structure, function, and localization of Gβ5-RGS complexes. Prog Mol Biol Transl Sci (2009) 0.95
Molecular organization of the complex between the muscarinic M3 receptor and the regulator of G protein signaling, Gbeta(5)-RGS7. Biochemistry (2010) 0.90
Active Galpha(q) subunits and M3 acetylcholine receptors promote distinct modes of association of RGS2 with the plasma membrane. FEBS Lett (2007) 0.87
RSBP-1 is a membrane-targeting subunit required by the Galpha(q)-specific but not the Galpha(o)-specific R7 regulator of G protein signaling in Caenorhabditis elegans. Mol Biol Cell (2009) 0.85
β-arrestin2 plays permissive roles in the inhibitory activities of RGS9-2 on G protein-coupled receptors by maintaining RGS9-2 in the open conformation. Mol Cell Biol (2011) 0.85
Functional and physical interactions among Saccharomyces cerevisiae α-factor receptors. Eukaryot Cell (2012) 0.84
RGS proteins and septins cooperate to promote chemotropism by regulating polar cap mobility. Curr Biol (2015) 0.84
μ-Opioid receptors and regulators of G protein signaling (RGS) proteins: from a symposium on new concepts in mu-opioid pharmacology. Drug Alcohol Depend (2011) 0.84
R7BP modulates opiate analgesia and tolerance but not withdrawal. Neuropsychopharmacology (2011) 0.84
Cellular noise suppression by the regulator of G protein signaling Sst2. Mol Cell (2014) 0.84
How a mycoparasite employs g-protein signaling: using the example of trichoderma. J Signal Transduct (2010) 0.83
Transcriptome and functional analysis of mating in the basidiomycete Schizophyllum commune. Eukaryot Cell (2011) 0.83
Nucleus accumbens-specific interventions in RGS9-2 activity modulate responses to morphine. Neuropsychopharmacology (2014) 0.83
Synthetic morphology using alternative inputs. PLoS One (2009) 0.81
D(2)-Dopamine receptors target regulator of G protein signaling 9-2 to detergent-resistant membrane fractions. J Neurochem (2011) 0.81
A physiologically required G protein-coupled receptor (GPCR)-regulator of G protein signaling (RGS) interaction that compartmentalizes RGS activity. J Biol Chem (2013) 0.81
SEA you later alli-GATOR--a dynamic regulator of the TORC1 stress response pathway. J Cell Sci (2015) 0.81
The late endosomal HOPS complex anchors active G-protein signaling essential for pathogenesis in magnaporthe oryzae. PLoS Pathog (2013) 0.79
Gβ promotes pheromone receptor polarization and yeast chemotropism by inhibiting receptor phosphorylation. Sci Signal (2016) 0.78
Differential Phosphorylation Provides a Switch to Control How α-Arrestin Rod1 Down-regulates Mating Pheromone Response in Saccharomyces cerevisiae. Genetics (2016) 0.78
The effects of replacing Sst2 with the heterologous RGS4 on polarization and mating in yeast. Biophys J (2010) 0.78
The DEP domain-containing protein TOE-2 promotes apoptosis in the Q lineage of C. elegans through two distinct mechanisms. Development (2014) 0.78
Role of the guanine nucleotide exchange factor Rom2 in cell wall integrity maintenance of Aspergillus fumigatus. Eukaryot Cell (2012) 0.78
Structure-function analysis of Rgs1 in Magnaporthe oryzae: role of DEP domains in subcellular targeting. PLoS One (2012) 0.77
Multiple regulatory roles of the carboxy terminus of Ste2p a yeast GPCR. Pharmacol Res (2011) 0.77
Biophysical and molecular-dynamics studies of phosphatidic acid binding by the Dvl-2 DEP domain. Biophys J (2014) 0.77
A putative novel protein, DEPDC1B, is overexpressed in oral cancer patients, and enhanced anchorage-independent growth in oral cancer cells that is mediated by Rac1 and ERK. J Biomed Sci (2014) 0.77
Plasma membrane aminoglycerolipid flippase function is required for signaling competence in the yeast mating pheromone response pathway. Mol Biol Cell (2014) 0.76
Modulation of receptor dynamics by the regulator of G protein signaling Sst2. Mol Biol Cell (2015) 0.76
G protein beta 5 is targeted to D2-dopamine receptor-containing biochemical compartments and blocks dopamine-dependent receptor internalization. PLoS One (2014) 0.76
Variable Dependence of Signaling Output on Agonist Occupancy of Ste2p, a G Protein-coupled Receptor in Yeast. J Biol Chem (2016) 0.75
The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR. J Biol Chem (2015) 0.75
The two faces of TOE-2. Worm (2015) 0.75
In Silico Approach for SAR Analysis of the Predicted Model of DEPDC1B: A Novel Target for Oral Cancer. Adv Bioinformatics (2016) 0.75
Analysis of random PCR-originated mutants of the yeast Ste2 and Ste3 receptors. Microbiologyopen (2016) 0.75
Yeast GPCR signaling reflects the fraction of occupied receptors, not the number. Mol Syst Biol (2016) 0.75
Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions. Nat Commun (2016) 0.75
The checkpoint-dependent nuclear accumulation of Rho1p exchange factor Rgf1p is important for tolerance to chronic replication stress. Mol Biol Cell (2014) 0.75
High levels of DEPDC1B predict shorter biochemical recurrence-free survival of patients with prostate cancer. Oncol Lett (2017) 0.75
Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell (2006) 3.11
Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Biochim Biophys Acta (2007) 3.07
Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export. Nat Cell Biol (2006) 2.58
Saccharomyces cerevisiae septins: supramolecular organization of heterooligomers and the mechanism of filament assembly. Proc Natl Acad Sci U S A (2008) 2.46
Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol (2004) 2.42
Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae. Biochim Biophys Acta (2007) 2.08
Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5. Mol Cell (2008) 2.00
Some assembly required: yeast septins provide the instruction manual. Trends Cell Biol (2005) 1.96
Mathematical and computational analysis of adaptation via feedback inhibition in signal transduction pathways. Biophys J (2007) 1.93
Septin function in Candida albicans morphogenesis. Mol Biol Cell (2002) 1.90
Lipid raft polarization contributes to hyphal growth in Candida albicans. Eukaryot Cell (2004) 1.82
Stress resistance and signal fidelity independent of nuclear MAPK function. Proc Natl Acad Sci U S A (2008) 1.82
Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2011) 1.79
Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Mol Biol Cell (2002) 1.77
Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. Nat Struct Mol Biol (2012) 1.76
Bistability, stochasticity, and oscillations in the mitogen-activated protein kinase cascade. Biophys J (2005) 1.69
Coupling morphogenesis to mitotic entry. Proc Natl Acad Sci U S A (2004) 1.68
Protein-protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae. Mol Biol Cell (2004) 1.63
Protons as second messenger regulators of G protein signaling. Mol Cell (2013) 1.62
Candida albicans septin mutants are defective for invasive growth and virulence. Infect Immun (2003) 1.58
Phosphatidylinositol-4,5-bisphosphate promotes budding yeast septin filament assembly and organization. J Mol Biol (2010) 1.53
When the stress of your environment makes you go HOG wild. Science (2004) 1.51
A protein kinase network regulates the function of aminophospholipid flippases. Proc Natl Acad Sci U S A (2009) 1.50
A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress-response pathway. Curr Biol (2007) 1.47
Yeast phosphatidylinositol 4-kinase, Pik1, has essential roles at the Golgi and in the nucleus. J Cell Biol (2005) 1.44
Septins: molecular partitioning and the generation of cellular asymmetry. Cell Div (2009) 1.42
Septin function in yeast model systems and pathogenic fungi. Eukaryot Cell (2005) 1.41
Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor. Curr Biol (2008) 1.41
Subunit-dependent modulation of septin assembly: budding yeast septin Shs1 promotes ring and gauze formation. J Cell Biol (2011) 1.40
The crystal structure of a self-activating G protein alpha subunit reveals its distinct mechanism of signal initiation. Sci Signal (2011) 1.40
Differential roles of PDK1- and PDK2-phosphorylation sites in the yeast AGC kinases Ypk1, Pkc1 and Sch9. Microbiology (2004) 1.37
Kinetic insulation as an effective mechanism for achieving pathway specificity in intracellular signaling networks. Proc Natl Acad Sci U S A (2007) 1.36
Analysis of RGS proteins in Saccharomyces cerevisiae. Methods Enzymol (2002) 1.33
Septin filament formation is essential in budding yeast. Dev Cell (2011) 1.33
Identification of an N-acetylglucosamine transporter that mediates hyphal induction in Candida albicans. Mol Biol Cell (2006) 1.32
Regulators of G protein signaling and transient activation of signaling: experimental and computational analysis reveals negative and positive feedback controls on G protein activity. J Biol Chem (2003) 1.29
Septin stability and recycling during dynamic structural transitions in cell division and development. Curr Biol (2008) 1.27
Pheromone signaling mechanisms in yeast: a prototypical sex machine. Science (2004) 1.27
Dose-to-duration encoding and signaling beyond saturation in intracellular signaling networks. PLoS Comput Biol (2008) 1.26
Analysis of mitogen-activated protein kinase signaling specificity in response to hyperosmotic stress: use of an analog-sensitive HOG1 allele. Eukaryot Cell (2006) 1.25
The Sur7 protein regulates plasma membrane organization and prevents intracellular cell wall growth in Candida albicans. Mol Biol Cell (2008) 1.24
Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain. Genes Dev (2006) 1.23
The RA domain of Ste50 adaptor protein is required for delivery of Ste11 to the plasma membrane in the filamentous growth signaling pathway of the yeast Saccharomyces cerevisiae. Mol Cell Biol (2006) 1.23
Direct identification of a G protein ubiquitination site by mass spectrometry. Biochemistry (2002) 1.22
The RACK1 ortholog Asc1 functions as a G-protein beta subunit coupled to glucose responsiveness in yeast. J Biol Chem (2007) 1.22
Three-dimensional ultrastructure of the septin filament network in Saccharomyces cerevisiae. Mol Biol Cell (2011) 1.20
Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast. Biochem J (2005) 1.20
Identification of allosteric peptide agonists of CXCR4. J Biol Chem (2002) 1.19
Control of MAPK specificity by feedback phosphorylation of shared adaptor protein Ste50. J Biol Chem (2008) 1.16
MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression. Curr Opin Chem Biol (2005) 1.16
Roles of phosphoinositides and of Spo14p (phospholipase D)-generated phosphatidic acid during yeast sporulation. Mol Biol Cell (2003) 1.13
Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling. Proc Natl Acad Sci U S A (2010) 1.13
Sterol-rich plasma membrane domains in fungi. Eukaryot Cell (2007) 1.12
The yeast G protein alpha subunit Gpa1 transmits a signal through an RNA binding effector protein Scp160. Mol Cell (2003) 1.10
Nucleus-specific and cell cycle-regulated degradation of mitogen-activated protein kinase scaffold protein Ste5 contributes to the control of signaling competence. Mol Cell Biol (2008) 1.10
Structures of Get3, Get4, and Get5 provide new models for TA membrane protein targeting. Structure (2010) 1.10
Recognition of yeast by murine macrophages requires mannan but not glucan. Eukaryot Cell (2010) 1.07
Direct phosphorylation and activation of a Nim1-related kinase Gin4 by Elm1 in budding yeast. J Biol Chem (2006) 1.07
Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1). J Biol Chem (2007) 1.07
Persistent activation by constitutive Ste7 promotes Kss1-mediated invasive growth but fails to support Fus3-dependent mating in yeast. Mol Cell Biol (2004) 1.07
Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae. Eukaryot Cell (2006) 1.06
Functional reconstitution of an atypical G protein heterotrimer and regulator of G protein signaling protein (RGS1) from Arabidopsis thaliana. J Biol Chem (2011) 1.06
Iqg1p links spatial and secretion landmarks to polarity and cytokinesis. J Cell Biol (2002) 1.06
Structure of a Ca2+-myristoyl switch protein that controls activation of a phosphatidylinositol 4-kinase in fission yeast. J Biol Chem (2011) 1.05
Comparison of class A and D G protein-coupled receptors: common features in structure and activation. Biochemistry (2005) 1.05
Regulation of stress response signaling by the N-terminal dishevelled/EGL-10/pleckstrin domain of Sst2, a regulator of G protein signaling in Saccharomyces cerevisiae. J Biol Chem (2002) 1.04
Regulation of Ste7 ubiquitination by Ste11 phosphorylation and the Skp1-Cullin-F-box complex. J Biol Chem (2003) 1.03
Cell cycle-dependent phosphorylation and ubiquitination of a G protein alpha subunit. J Biol Chem (2011) 1.03
Single-cell analysis reveals that insulation maintains signaling specificity between two yeast MAPK pathways with common components. Sci Signal (2010) 1.03
Cell cycle dynamics and quorum sensing in Candida albicans chlamydospores are distinct from budding and hyphal growth. Eukaryot Cell (2005) 1.02
Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein-coupled receptor Ste2. Mol Cell Biol (2014) 1.02
Yeast dynamically modify their environment to achieve better mating efficiency. Sci Signal (2011) 1.01
Differences in intradomain and interdomain motion confer distinct activation properties to structurally similar Gα proteins. Proc Natl Acad Sci U S A (2012) 1.00
N-acetylglucosamine (GlcNAc) induction of hyphal morphogenesis and transcriptional responses in Candida albicans are not dependent on its metabolism. J Biol Chem (2011) 1.00
Reuse, replace, recycle. Specificity in subunit inheritance and assembly of higher-order septin structures during mitotic and meiotic division in budding yeast. Cell Cycle (2009) 1.00
Pheromone-regulated sumoylation of transcription factors that mediate the invasive to mating developmental switch in yeast. J Biol Chem (2005) 0.99
Pheromone-dependent ubiquitination of the mitogen-activated protein kinase kinase Ste7. J Biol Chem (2002) 0.99
Membrane-active compounds activate the transcription factors Pdr1 and Pdr3 connecting pleiotropic drug resistance and membrane lipid homeostasis in saccharomyces cerevisiae. Mol Biol Cell (2007) 0.99
A photostable green fluorescent protein variant for analysis of protein localization in Candida albicans. Eukaryot Cell (2009) 0.99
Checkpoints in a yeast differentiation pathway coordinate signaling during hyperosmotic stress. PLoS Genet (2012) 0.97
Functional expression of mammalian receptors and membrane channels in different cells. J Struct Biol (2007) 0.96
Structure and function of Vps15 in the endosomal G protein signaling pathway. Biochemistry (2009) 0.96
The cytoplasmic end of transmembrane domain 3 regulates the activity of the Saccharomyces cerevisiae G-protein-coupled alpha-factor receptor. Genetics (2002) 0.96
Identification of GIG1, a GlcNAc-induced gene in Candida albicans needed for normal sensitivity to the chitin synthase inhibitor nikkomycin Z. Eukaryot Cell (2010) 0.95
Jekyll and Hyde in the microbial world. Science (2004) 0.95
Aromatic residues at the extracellular ends of transmembrane domains 5 and 6 promote ligand activation of the G protein-coupled alpha-factor receptor. Biochemistry (2003) 0.95
A Candida albicans temperature-sensitive cdc12-6 mutant identifies roles for septins in selection of sites of germ tube formation and hyphal morphogenesis. Eukaryot Cell (2012) 0.94
Dominant-negative inhibition of pheromone receptor signaling by a single point mutation in the G protein alpha subunit. J Biol Chem (2004) 0.94
BAR domain proteins Rvs161 and Rvs167 contribute to Candida albicans endocytosis, morphogenesis, and virulence. Infect Immun (2009) 0.94
Differential regulation of G protein alpha subunit trafficking by mono- and polyubiquitination. J Biol Chem (2004) 0.93
Conservation of regulatory function in calcium-binding proteins: human frequenin (neuronal calcium sensor-1) associates productively with yeast phosphatidylinositol 4-kinase isoform, Pik1. J Biol Chem (2003) 0.93
Reciprocal phosphorylation of yeast glycerol-3-phosphate dehydrogenases in adaptation to distinct types of stress. Mol Cell Biol (2012) 0.92
N-acetylglucosamine (GlcNAc) triggers a rapid, temperature-responsive morphogenetic program in thermally dimorphic fungi. PLoS Genet (2013) 0.92
A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle. Virology (2013) 0.92
G protein signaling in yeast: new components, new connections, new compartments. Science (2006) 0.92
Systematic analysis of essential genes reveals important regulators of G protein signaling. Mol Cell (2010) 0.91
G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase. J Biol Chem (2009) 0.91
Molecular interactions of yeast frequenin (Frq1) with the phosphatidylinositol 4-kinase isoform, Pik1. J Biol Chem (2002) 0.90