Published in Aging Cell on December 01, 2004
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Functionally specialized junctions between endothelial cells of lymphatic vessels. J Exp Med (2007) 4.10
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A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics (2005) 3.19
Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Exp Gerontol (2005) 3.06
Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am J Physiol Endocrinol Metab (2003) 2.51
Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. J Clin Endocrinol Metab (2003) 2.40
Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett (2005) 2.30
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Aging of the immune system as a prognostic factor for human longevity. Physiology (Bethesda) (2008) 2.09
Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing (2005) 1.99
Aging, longevity, inflammation, and cancer. Ann N Y Acad Sci (2004) 1.96
Cytomegalovirus infection: a driving force in human T cell immunosenescence. Ann N Y Acad Sci (2007) 1.87
Inflammation markers predicting frailty and mortality in the elderly. Exp Mol Pathol (2006) 1.79
Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155. Nat Med (2011) 1.79
Low vitamin D status, high bone turnover, and bone fractures in centenarians. J Clin Endocrinol Metab (2003) 1.79
Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. Am J Physiol Endocrinol Metab (2002) 1.76
Massive load of functional effector CD4+ and CD8+ T cells against cytomegalovirus in very old subjects. J Immunol (2007) 1.73
Accelerated epigenetic aging in Down syndrome. Aging Cell (2015) 1.61
What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment? Mech Ageing Dev (2005) 1.57
Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. Proc Natl Acad Sci U S A (2003) 1.56
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell (2013) 1.56
Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech Ageing Dev (2005) 1.49
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell (2013) 1.48
Methylation of ELOVL2 gene as a new epigenetic marker of age. Aging Cell (2012) 1.45
An APOE haplotype associated with decreased ε4 expression increases the risk of late onset Alzheimer's disease. J Alzheimers Dis (2011) 1.45
Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains. Neurobiol Aging (2006) 1.42
Aging of the human metaorganism: the microbial counterpart. Age (Dordr) (2011) 1.36
Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly. J Am Geriatr Soc (2004) 1.36
Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8+ T cells. Exp Gerontol (2004) 1.36
Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status. J Immunol (2010) 1.34
Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring. Age (Dordr) (2012) 1.33
Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. Aging Cell (2013) 1.33
Association of the mitochondrial DNA haplogroup J with longevity is population specific. Eur J Hum Genet (2004) 1.32
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Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees. Cell Tissue Res (2008) 1.26
Identification of a geographic area characterized by extreme longevity in the Sardinia island: the AKEA study. Exp Gerontol (2004) 1.26
Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges. Bioessays (2013) 1.26
Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence. Exp Gerontol (2003) 1.25
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Inflamm-ageing. Curr Opin Clin Nutr Metab Care (2013) 1.20
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Meeting report: mitochondrial DNA and cancer epidemiology. Cancer Res (2007) 1.20
Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging. Mech Ageing Dev (2012) 1.19
Report from the second cytomegalovirus and immunosenescence workshop. Immun Ageing (2011) 1.19
Impact of telemonitoring at home on the management of elderly patients with congestive heart failure. J Telemed Telecare (2008) 1.17
Immunogenetics, gender, and longevity. Ann N Y Acad Sci (2006) 1.16
MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling. Age (Dordr) (2012) 1.13
N-glycomic changes in serum proteins during human aging. Rejuvenation Res (2007) 1.13
Long-term immune-endocrine effects of bereavement: relationships with anxiety levels and mood. Psychiatry Res (2003) 1.13
Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population. Aging (Albany NY) (2009) 1.13
Role of Toll-like receptor 4 in acute myocardial infarction and longevity. JAMA (2004) 1.12
JAM-A promotes neutrophil chemotaxis by controlling integrin internalization and recycling. J Cell Sci (2009) 1.12
Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism. PLoS One (2013) 1.11
Numerical and functional alterations of circulating gammadelta T lymphocytes in aged people and centenarians. J Leukoc Biol (2002) 1.11
Family clustering in Sardinian longevity: a genealogical approach. Exp Gerontol (2006) 1.10
N-glycomic biomarkers of biological aging and longevity: a link with inflammaging. Ageing Res Rev (2012) 1.10
Ageing and gut microbes: perspectives for health maintenance and longevity. Pharmacol Res (2012) 1.09
Genetic polymorphism in long-lived people: cues for the presence of an insulin/IGF-pathway-dependent network affecting human longevity. Mol Cell Endocrinol (2008) 1.09
Leukocyte telomere shortening in elderly Type2DM patients with previous myocardial infarction. Atherosclerosis (2009) 1.09
Serum N-glycan profile shift during human ageing. Exp Gerontol (2010) 1.08
Inflammation and life-span. Science (2005) 1.07
Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity? Exp Gerontol (2003) 1.07
Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease. PLoS One (2010) 1.06
-174 G>C polymorphism of interleukin 6 gene promoter affects interleukin 6 serum level in patients with colorectal cancer. Clin Cancer Res (2003) 1.05
Retention of the p53 codon 72 arginine allele is associated with a reduction of disease-free and overall survival in arginine/proline heterozygous breast cancer patients. Clin Cancer Res (2003) 1.04
Mitochondrial DNA backgrounds might modulate diabetes complications rather than T2DM as a whole. PLoS One (2011) 1.04
Association studies on human mitochondrial DNA: methodological aspects and results in the most common age-related diseases. Mitochondrion (2006) 1.04
Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity. Exp Gerontol (2004) 1.03
Karyotype instability and anchorage-independent growth in telomerase-immortalized fibroblasts from two centenarian individuals. Biochem Biophys Res Commun (2003) 1.03
What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? Mech Ageing Dev (2005) 1.03