Aging, longevity, inflammation, and cancer.

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol (2009) 7.74

Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med (2010) 3.79

Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol (2008) 2.86

A systematic review of the association between circulating concentrations of C reactive protein and cancer. J Epidemiol Community Health (2007) 2.50

Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev (2010) 2.32

Rapamycin extends maximal lifespan in cancer-prone mice. Am J Pathol (2010) 2.22

Answering the ultimate question "what is the proximal cause of aging?". Aging (Albany NY) (2012) 2.04

C-reactive protein as a marker of melanoma progression. J Clin Oncol (2015) 2.00

Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing (2005) 1.99

2011: the immune hallmarks of cancer. Cancer Immunol Immunother (2011) 1.66

Effects of caloric restriction on inflammatory periodontal disease. Nutrition (2008) 1.43

Mechanistic simulations of inflammation: current state and future prospects. Math Biosci (2008) 1.40

An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people. J Gerontol A Biol Sci Med Sci (2007) 1.27

Rapamycin extends life- and health span because it slows aging. Aging (Albany NY) (2013) 1.19

Immunosuppressants in cancer prevention and therapy. Oncoimmunology (2013) 1.17

Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem (2009) 1.08

The aging lung. Clin Interv Aging (2013) 1.05

Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age. J Immunol (2013) 1.02

Aging and the pathogenic response to burn. Aging Dis (2011) 1.01

Biomarkers of inflammation and malnutrition associated with early death in healthy elderly people. J Am Geriatr Soc (2008) 0.99

Aging and inflammation: etiological culprits of cancer. Curr Aging Sci (2009) 0.97

Aging and animal models of systemic insult: trauma, burn, and sepsis. Shock (2009) 0.96

Pathophysiology of ageing, longevity and age related diseases. Immun Ageing (2007) 0.96

The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. Immun Ageing (2007) 0.94

Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes. Clin Exp Immunol (2014) 0.92

The effects of weight cycling on lifespan in male C57BL/6J mice. Int J Obes (Lond) (2012) 0.91

Rapamycin: killing two birds with one stone. Aging (Albany NY) (2011) 0.89

Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models. Aging Dis (2011) 0.89

Portrait of inflammatory response to ionizing radiation treatment. J Inflamm (Lond) (2015) 0.89

Interleukin-6 plasma level increases with age in an Italian elderly population ("The Treviso Longeva"-Trelong-study) with a sex-specific contribution of rs1800795 polymorphism. Age (Dordr) (2009) 0.88

The paradox of IL-10-mediated modulation in cervical cancer. Biomed Rep (2013) 0.85

Neutrophils confer T cell resistance to myeloid-derived suppressor cell-mediated suppression to promote chronic inflammation. J Immunol (2013) 0.85

Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases. BMC Cancer (2008) 0.84

Stem cell transplantation improves aging-related diseases. Front Cell Dev Biol (2014) 0.81

Global prostate cancer incidence and the migration, settlement, and admixture history of the Northern Europeans. Cancer Epidemiol (2010) 0.80

Impaired Immune Response in Elderly Burn Patients: New Insights Into the Immune-senescence Phenotype. Ann Surg (2016) 0.80

Network analysis reveals functional cross-links between disease and inflammation genes. Sci Rep (2013) 0.79

Zinc, oxidative stress, genetic background and immunosenescence: implications for healthy ageing. Immun Ageing (2006) 0.79

Survival of offspring who experience early parental death: early life conditions and later-life mortality. Soc Sci Med (2014) 0.79

Crocetin downregulates the proinflammatory cytokines in methylcholanthrene-induced rodent tumor model and inhibits COX-2 expression in cervical cancer cells. Biomed Res Int (2015) 0.79

BioAge: toward a multi-determined, mechanistic account of cognitive aging. Ageing Res Rev (2014) 0.79

A journey with Tony Hugli up the inflammatory cascade towards the auto-digestion hypothesis. Int Immunopharmacol (2007) 0.78

A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats. Indian J Pharmacol (2015) 0.78

A working model for the assessment of disruptions in social behavior among aged rats: The role of sex differences, social recognition, and sensorimotor processes. Exp Gerontol (2016) 0.77

Interleukin-1α, interleukin-1β and tumor necrosis factor-α genetic variants and risk of dementia in the very old: evidence from the "Monzino 80-plus" prospective study. Age (Dordr) (2011) 0.77

When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow? Curr Pharmacol Rep (2015) 0.77

Somatic intronic microsatellite loci differentiate glioblastoma from lower-grade gliomas. Oncotarget (2014) 0.77

Myeloid-derived suppressor cells, age and cancer. Oncoimmunology (2013) 0.76

Wound healing reaction: A switch from gestation to senescence. World J Exp Med (2014) 0.75

Transcriptome analysis of human ageing in male skin shows mid-life period of variability and central role of NF-κB. Sci Rep (2016) 0.75

Interleukin-18 polymorphism and physical functioning in older people: a replication study and meta-analysis. J Gerontol A Biol Sci Med Sci (2009) 0.75

IFN production ability and healthy ageing: mixed model analysis of a 24 year longitudinal study in Japan. BMJ Open (2013) 0.75

Social network ties and inflammation in U.S. adults with cancer. Biodemography Soc Biol (2014) 0.75

Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One (2010) 3.64

A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics (2005) 3.19

Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Exp Gerontol (2005) 3.06

Inflammatory networks in ageing, age-related diseases and longevity. Mech Ageing Dev (2006) 2.82

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am J Physiol Endocrinol Metab (2003) 2.51

Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. J Clin Endocrinol Metab (2003) 2.40

Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett (2005) 2.30

T cells and aging, January 2002 update. Front Biosci (2002) 2.14

Aging of the immune system as a prognostic factor for human longevity. Physiology (Bethesda) (2008) 2.09

Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing (2005) 1.99

Cytomegalovirus infection: a driving force in human T cell immunosenescence. Ann N Y Acad Sci (2007) 1.87

Inflammation markers predicting frailty and mortality in the elderly. Exp Mol Pathol (2006) 1.79

Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155. Nat Med (2011) 1.79

Low vitamin D status, high bone turnover, and bone fractures in centenarians. J Clin Endocrinol Metab (2003) 1.79

Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. Am J Physiol Endocrinol Metab (2002) 1.76

Massive load of functional effector CD4+ and CD8+ T cells against cytomegalovirus in very old subjects. J Immunol (2007) 1.73

Accelerated epigenetic aging in Down syndrome. Aging Cell (2015) 1.61

What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment? Mech Ageing Dev (2005) 1.57

Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. Proc Natl Acad Sci U S A (2003) 1.56

The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell (2013) 1.56

Plasma cytokine profiles in patients with celiac disease and selective IgA deficiency. Pediatr Allergy Immunol (2003) 1.55

Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech Ageing Dev (2005) 1.49

Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: effect of multiple gene interactions. Autoimmun Rev (2002) 1.48

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell (2013) 1.48

Methylation of ELOVL2 gene as a new epigenetic marker of age. Aging Cell (2012) 1.45

An APOE haplotype associated with decreased ε4 expression increases the risk of late onset Alzheimer's disease. J Alzheimers Dis (2011) 1.45

Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains. Neurobiol Aging (2006) 1.42

Aging of the human metaorganism: the microbial counterpart. Age (Dordr) (2011) 1.36

Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly. J Am Geriatr Soc (2004) 1.36

Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8+ T cells. Exp Gerontol (2004) 1.36

Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status. J Immunol (2010) 1.34

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. Aging Cell (2013) 1.33

Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring. Age (Dordr) (2012) 1.33

Association of the mitochondrial DNA haplogroup J with longevity is population specific. Eur J Hum Genet (2004) 1.32

The genetics of human longevity. Ann N Y Acad Sci (2006) 1.30

Identification of a geographic area characterized by extreme longevity in the Sardinia island: the AKEA study. Exp Gerontol (2004) 1.26

Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges. Bioessays (2013) 1.26

Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence. Exp Gerontol (2003) 1.25

Is human immunosenescence clinically relevant? Looking for 'immunological risk phenotypes'. Trends Immunol (2002) 1.24

Immune system, cell senescence, aging and longevity--inflamm-aging reappraised. Curr Pharm Des (2013) 1.23

A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people. Mech Ageing Dev (2009) 1.21

Inflamm-ageing. Curr Opin Clin Nutr Metab Care (2013) 1.20

HAPLOFIND: a new method for high-throughput mtDNA haplogroup assignment. Hum Mutat (2013) 1.20

Meeting report: mitochondrial DNA and cancer epidemiology. Cancer Res (2007) 1.20

Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging. Mech Ageing Dev (2012) 1.19

Report from the second cytomegalovirus and immunosenescence workshop. Immun Ageing (2011) 1.19

Genetic risk profiles for Alzheimer's disease: integration of APOE genotype and variants that up-regulate inflammation. Neurobiol Aging (2006) 1.17

B cells in the aged: CD27, CD5, and CD40 expression. Mech Ageing Dev (2003) 1.17

Immunogenetics, gender, and longevity. Ann N Y Acad Sci (2006) 1.16

MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling. Age (Dordr) (2012) 1.13

N-glycomic changes in serum proteins during human aging. Rejuvenation Res (2007) 1.13

Long-term immune-endocrine effects of bereavement: relationships with anxiety levels and mood. Psychiatry Res (2003) 1.13

Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population. Aging (Albany NY) (2009) 1.13

Role of Toll-like receptor 4 in acute myocardial infarction and longevity. JAMA (2004) 1.12

Inflammation, ageing and cancer. Mech Ageing Dev (2008) 1.12

Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism. PLoS One (2013) 1.11

Numerical and functional alterations of circulating gammadelta T lymphocytes in aged people and centenarians. J Leukoc Biol (2002) 1.11

Family clustering in Sardinian longevity: a genealogical approach. Exp Gerontol (2006) 1.10

N-glycomic biomarkers of biological aging and longevity: a link with inflammaging. Ageing Res Rev (2012) 1.10

Ageing and gut microbes: perspectives for health maintenance and longevity. Pharmacol Res (2012) 1.09

TLR4 polymorphisms and ageing: implications for the pathophysiology of age-related diseases. J Clin Immunol (2009) 1.08

Serum N-glycan profile shift during human ageing. Exp Gerontol (2010) 1.08

Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity? Exp Gerontol (2003) 1.07

Inflammation and life-span. Science (2005) 1.07

Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease. PLoS One (2010) 1.06

-174 G>C polymorphism of interleukin 6 gene promoter affects interleukin 6 serum level in patients with colorectal cancer. Clin Cancer Res (2003) 1.05

Single nucleotide polymorphisms (SNPs) of pro-inflammatory/anti-inflammatory and thrombotic/fibrinolytic genes in patients with acute ischemic stroke in relation to TOAST subtype. Cytokine (2012) 1.04

Retention of the p53 codon 72 arginine allele is associated with a reduction of disease-free and overall survival in arginine/proline heterozygous breast cancer patients. Clin Cancer Res (2003) 1.04

Mitochondrial DNA backgrounds might modulate diabetes complications rather than T2DM as a whole. PLoS One (2011) 1.04

The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians. Aging Cell (2004) 1.04

Association studies on human mitochondrial DNA: methodological aspects and results in the most common age-related diseases. Mitochondrion (2006) 1.04

Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity. Exp Gerontol (2004) 1.03

MicroRNAs linking inflamm-aging, cellular senescence and cancer. Ageing Res Rev (2013) 1.03

Biology of longevity: role of the innate immune system. Rejuvenation Res (2006) 1.03

Karyotype instability and anchorage-independent growth in telomerase-immortalized fibroblasts from two centenarian individuals. Biochem Biophys Res Commun (2003) 1.03

What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? Mech Ageing Dev (2005) 1.03

Age-dependent alteration in muscle regeneration: the critical role of tissue niche. Biogerontology (2013) 1.02

Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis. Exp Gerontol (2004) 1.01

Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians' offspring. Aging (Albany NY) (2012) 1.01

Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain. Neurobiol Aging (2003) 1.01

A study of serum immunoglobulin levels in elderly persons that provides new insights into B cell immunosenescence. Ann N Y Acad Sci (2006) 1.01

Oxidative stress and the ageing endocrine system. Nat Rev Endocrinol (2013) 1.00

Human longevity and 11p15.5: a study in 1321 centenarians. Eur J Hum Genet (2009) 1.00

Immunoproteasomes and immunosenescence. Ageing Res Rev (2003) 1.00

Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis. Ageing Res Rev (2008) 1.00

Alzheimer's disease and genetics of inflammation: a pharmacogenomic vision. Pharmacogenomics (2007) 1.00

Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily. Exp Gerontol (2007) 0.99

Association of metabolic syndrome with cognitive function: the role of sex and age. Clin Nutr (2008) 0.99

Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer. Crit Rev Microbiol (2010) 0.99

CCR5 receptor: biologic and genetic implications in age-related diseases. Ann N Y Acad Sci (2007) 0.98

Thymic output and functionality of the IL-7/IL-7 receptor system in centenarians: implications for the neolymphogenesis at the limit of human life. Aging Cell (2006) 0.98

Mitochondrial DNA involvement in human longevity. Biochim Biophys Acta (2006) 0.98