The genetics of human longevity.

PubWeight™: 1.30‹?› | Rank: Top 10%

🔗 View Article (PMID 16803995)

Published in Ann N Y Acad Sci on May 01, 2006

Authors

Miriam Capri1, Stefano Salvioli, Federica Sevini, Silvana Valensin, Laura Celani, Daniela Monti, Graham Pawelec, Giovanna De Benedictis, Efstathios S Gonos, Claudio Franceschi

Author Affiliations

1: CIG - Centro Interdipartimentale L. Galvani, University of Bologna, Italy.

Articles citing this

Puzzles, promises and a cure for ageing. Nature (2008) 3.23

Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. Am J Epidemiol (2008) 1.53

Genetic determinants of exceptional human longevity: insights from the Okinawa Centenarian Study. Age (Dordr) (2006) 1.31

Curcumin in cell death processes: a challenge for CAM of age-related pathologies. Evid Based Complement Alternat Med (2007) 1.31

Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants. Aging (Albany NY) (2011) 1.29

The insulin signaling cascade from nematodes to mammals: insights into innate immunity of Anopheles mosquitoes to malaria parasite infection. Dev Comp Immunol (2006) 1.21

Versatile functions of p53 protein in multicellular organisms. Biochemistry (Mosc) (2007) 1.11

NF-kappaB signaling in the aging process. J Clin Immunol (2009) 1.10

IL1B gene promoter haplotype pairs predict clinical levels of interleukin-1beta and C-reactive protein. Hum Genet (2008) 1.06

Dissecting the effects of mtDNA variations on complex traits using mouse conplastic strains. Genome Res (2008) 1.00

Aging alters functionally human dermal papillary fibroblasts but not reticular fibroblasts: a new view of skin morphogenesis and aging. PLoS One (2008) 0.97

Pathophysiology of ageing, longevity and age related diseases. Immun Ageing (2007) 0.96

Nectarine promotes longevity in Drosophila melanogaster. Free Radic Biol Med (2011) 0.96

Gene expression changes in long-term culture of T-cell clones: genomic effects of chronic antigenic stress in aging and immunosenescence. Aging Cell (2007) 0.92

The mitochondrial genome, a growing interest inside an organelle. Int J Nanomedicine (2008) 0.92

Association between FOXO3A gene polymorphisms and human longevity: a meta-analysis. Asian J Androl (2014) 0.92

Insulin signaling and life span. Pflugers Arch (2009) 0.90

NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies. Immun Ageing (2013) 0.89

Parental longevity and diabetes risk in the Diabetes Prevention Program. J Gerontol A Biol Sci Med Sci (2011) 0.89

Association of circulating C-reactive protein and interleukin-6 with longevity into the 80s and 90s: The Rancho Bernardo Study. J Clin Endocrinol Metab (2010) 0.89

A LINE-1 component to human aging: do LINE elements exact a longevity cost for evolutionary advantage? Mech Ageing Dev (2010) 0.88

Optimal therapy of type 2 diabetes: a controversial challenge. Aging (Albany NY) (2014) 0.85

Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes. Age (Dordr) (2011) 0.85

Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults. PLoS One (2012) 0.84

Circulating endothelial progenitor cells: a new approach to anti-aging medicine? J Transl Med (2009) 0.84

Mitochondrial polymorphisms are associated both with increased and decreased longevity. Hum Hered (2008) 0.83

Trans-ethnical shift of the risk genotype in the CETP I405V with longevity: a Chinese case-control study and meta-analysis. PLoS One (2013) 0.83

Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes. Oncotarget (2012) 0.82

Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans. Exp Mol Med (2009) 0.82

SELDI-TOF-MS ProteinChip array profiling of T-cell clones propagated in long-term culture identifies human profilin-1 as a potential bio-marker of immunosenescence. Proteome Sci (2007) 0.81

Human longevity: Genetics or Lifestyle? It takes two to tango. Immun Ageing (2016) 0.81

Old age as a privilege of the "selfish ones". Aging Dis (2010) 0.79

WRN polymorphisms affect expression levels of plasminogen activator inhibitor type 1 in cultured fibroblasts. BMC Cardiovasc Disord (2008) 0.79

Gender-specific DNA methylome analysis of a Han Chinese longevity population. Biomed Res Int (2014) 0.79

Serum perfluoroalkyl acids concentrations and memory impairment in a large cross-sectional study. BMJ Open (2013) 0.75

Aging and Veterinary Care of Cats, Dogs, and Horses through the Records of Three University Veterinary Hospitals. Front Vet Sci (2017) 0.75

The Right and Wrong of Growing Old: Assessing the Argument from Evolution. Philos Technol (2012) 0.75

Paraoxonase (PON1) polymorphisms Q192R and L55M are not associated with human longevity: A meta-analysis. Z Gerontol Geriatr (2015) 0.75

Articles by these authors

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev (2006) 5.61

Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival. Nat Med (2012) 5.44

Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One (2010) 3.64

A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics (2005) 3.19

Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Exp Gerontol (2005) 3.06

Cancer classification using the Immunoscore: a worldwide task force. J Transl Med (2012) 2.88

Epigenetic and immune function profiles associated with posttraumatic stress disorder. Proc Natl Acad Sci U S A (2010) 2.85

Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. J Immunol (2006) 2.81

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am J Physiol Endocrinol Metab (2003) 2.51

Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers. Clin Cancer Res (2011) 2.44

Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. J Clin Endocrinol Metab (2003) 2.40

Defining the critical hurdles in cancer immunotherapy. J Transl Med (2011) 2.32

Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett (2005) 2.30

An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans. J Gerontol A Biol Sci Med Sci (2005) 2.15

T cells and aging, January 2002 update. Front Biosci (2002) 2.14

Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1). Exp Gerontol (2003) 2.11

Aging of the immune system as a prognostic factor for human longevity. Physiology (Bethesda) (2008) 2.09

Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States. PLoS One (2011) 2.08

Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing (2005) 1.99

Functional T cells targeting NY-ESO-1 or Melan-A are predictive for survival of patients with distant melanoma metastasis. J Clin Oncol (2012) 1.97

Aging, longevity, inflammation, and cancer. Ann N Y Acad Sci (2004) 1.96

Aging and innate immunity. Immunity (2006) 1.95

Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old. J Clin Immunol (2003) 1.94

Cytomegalovirus infection: a driving force in human T cell immunosenescence. Ann N Y Acad Sci (2007) 1.87

The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning. Mech Ageing Dev (2006) 1.85

Inflammation markers predicting frailty and mortality in the elderly. Exp Mol Pathol (2006) 1.79

Low vitamin D status, high bone turnover, and bone fractures in centenarians. J Clin Endocrinol Metab (2003) 1.79

Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. Am J Physiol Endocrinol Metab (2002) 1.76

Immunosenescence and vaccine failure in the elderly. Aging Clin Exp Res (2009) 1.75

Massive load of functional effector CD4+ and CD8+ T cells against cytomegalovirus in very old subjects. J Immunol (2007) 1.73

Clusterin/apolipoprotein J in human aging and cancer. Int J Biochem Cell Biol (2002) 1.70

Accelerated epigenetic aging in Down syndrome. Aging Cell (2015) 1.61

Is human aging still mysterious enough to be left only to scientists? Bioessays (2002) 1.59

Immunosenescence and vaccination in nursing home residents. Clin Infect Dis (2009) 1.57

What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment? Mech Ageing Dev (2005) 1.57

Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people. Immun Ageing (2008) 1.57

Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. Proc Natl Acad Sci U S A (2003) 1.56

The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell (2013) 1.56

Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress. Cancer Res (2004) 1.55

Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly. Exp Gerontol (2004) 1.55

The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines. Vaccine (2012) 1.54

Human cytomegalovirus infection and T cell immunosenescence: a mini review. Mech Ageing Dev (2006) 1.53

Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation. J Biol Chem (2003) 1.51

No Immune Risk Profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study. Exp Gerontol (2007) 1.51

Biomarkers of human immunosenescence: impact of Cytomegalovirus infection. Curr Opin Immunol (2009) 1.51

Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech Ageing Dev (2005) 1.49

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell (2013) 1.48

Methylation of ELOVL2 gene as a new epigenetic marker of age. Aging Cell (2012) 1.45

An APOE haplotype associated with decreased ε4 expression increases the risk of late onset Alzheimer's disease. J Alzheimers Dis (2011) 1.45

Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients. J Immunother (2009) 1.44

Overexpression of proteasome beta5 assembled subunit increases the amount of proteasome and confers ameliorated response to oxidative stress and higher survival rates. J Biol Chem (2005) 1.43

Hallmark features of immunosenescence are absent in familial longevity. J Immunol (2010) 1.43

Myeloid-derived suppressor cells predict survival of patients with advanced melanoma: comparison with regulatory T cells and NY-ESO-1- or melan-A-specific T cells. Clin Cancer Res (2013) 1.43

Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains. Neurobiol Aging (2006) 1.42

Multi-parametric phospho-flow cytometry: a crucial tool for T lymphocyte signaling studies. Cytometry A (2013) 1.41

Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases. Free Radic Res (2006) 1.40

Aging of the human metaorganism: the microbial counterpart. Age (Dordr) (2011) 1.36

Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly. J Am Geriatr Soc (2004) 1.36

Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8+ T cells. Exp Gerontol (2004) 1.36

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell (2012) 1.35

Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status. J Immunol (2010) 1.34

Ciclopirox: recent nonclinical and clinical data relevant to its use as a topical antimycotic agent. Drugs (2010) 1.33

Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring. Age (Dordr) (2012) 1.33

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. Aging Cell (2013) 1.33

Association of the mitochondrial DNA haplogroup J with longevity is population specific. Eur J Hum Genet (2004) 1.32

Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans. J Gen Virol (2011) 1.29

Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up-regulation of Clusterin/Apolipoprotein J. Int J Cancer (2007) 1.27

Proteasome dysfunction in mammalian aging: steps and factors involved. Exp Gerontol (2005) 1.27

Identification of a geographic area characterized by extreme longevity in the Sardinia island: the AKEA study. Exp Gerontol (2004) 1.26

Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges. Bioessays (2013) 1.26

Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence. Exp Gerontol (2003) 1.25

Early changes in intramitochondrial cardiolipin distribution during apoptosis. Cell Growth Differ (2002) 1.25

Pretreatment frequency of circulating IL-17+ CD4+ T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients. Int J Cancer (2009) 1.24

Immune system, cell senescence, aging and longevity--inflamm-aging reappraised. Curr Pharm Des (2013) 1.23

Dysregulation of T-cell function in the elderly : scientific basis and clinical implications. Drugs Aging (2005) 1.23