Published in Stem Cells on January 01, 2004
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell (2007) 22.89
Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res (2009) 6.43
Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer. Mol Cancer Res (2009) 4.36
Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells (2007) 3.47
Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PLoS One (2010) 3.38
Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function. Nature (2012) 3.34
Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J Clin Oncol (2008) 2.87
Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head Neck (2010) 2.76
Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer. Cancer Res (2009) 2.40
ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome. Lab Invest (2009) 2.25
The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance. Chem Biol Interact (2011) 2.15
Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer. Cancer Epidemiol Biomarkers Prev (2010) 1.85
Cancer stem cell-directed therapies: recent data from the laboratory and clinic. Mol Ther (2008) 1.83
Cancer stem cells in breast: current opinion and future challenges. Pathobiology (2008) 1.77
ALDH1 expression correlates with favorable prognosis in ovarian cancers. Mod Pathol (2009) 1.70
25 years of epidermal stem cell research. J Invest Dermatol (2011) 1.70
ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets. Stem Cells (2012) 1.70
Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells. Proc Natl Acad Sci U S A (2011) 1.68
High aldehyde dehydrogenase activity: a novel functional marker of murine prostate stem/progenitor cells. Stem Cells (2009) 1.67
In situ identification of putative cancer stem cells by multiplexing ALDH1, CD44, and cytokeratin identifies breast cancer patients with poor prognosis. Am J Pathol (2010) 1.62
More than markers: biological significance of cancer stem cell-defining molecules. Mol Cancer Ther (2010) 1.60
Targeting the osteosarcoma cancer stem cell. J Orthop Surg Res (2010) 1.52
c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion. J Biol Chem (2010) 1.40
Breast cancer stem cells: tools and models to rely on. BMC Cancer (2009) 1.38
Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid. J Immunol (2010) 1.29
Oncolytic reovirus effectively targets breast cancer stem cells. Mol Ther (2009) 1.27
Antigen and lymphopenia-driven donor T cells are differentially diminished by post-transplantation administration of cyclophosphamide after hematopoietic cell transplantation. Biol Blood Marrow Transplant (2013) 1.16
Ablation of breast cancer stem cells with radiation. Transl Oncol (2011) 1.15
The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets. EMBO Mol Med (2012) 1.15
Aldehyde dehydrogenase 1A1 in stem cells and cancer. Oncotarget (2016) 1.06
Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells. J Mol Signal (2011) 1.05
Towards a clinically relevant lentiviral transduction protocol for primary human CD34 hematopoietic stem/progenitor cells. PLoS One (2009) 1.03
Concise Review: Targeting Cancer Stem Cells Using Immunologic Approaches. Stem Cells (2015) 0.97
A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo. Clin Cancer Res (2011) 0.96
Schlafen-3 decreases cancer stem cell marker expression and autocrine/juxtacrine signaling in FOLFOX-resistant colon cancer cells. Am J Physiol Gastrointest Liver Physiol (2011) 0.95
Androgen deprivation and stem cell markers in prostate cancers. Int J Clin Exp Pathol (2009) 0.93
Inhibition of histone deacetylase impacts cancer stem cells and induces epithelial-mesenchyme transition of head and neck cancer. PLoS One (2013) 0.92
Downregulation of ALDH1A1 expression in non-small cell lung carcinomas--its clinicopathologic and biological significance. Int J Clin Exp Pathol (2012) 0.90
Flow cytometry analysis of neural differentiation markers expression in human glioblastomas may predict their response to chemotherapy. Cell Mol Neurobiol (2009) 0.90
CD133-positive cancer stem cells from Colo205 human colon adenocarcinoma cell line show resistance to chemotherapy and display a specific metabolomic profile. Genes Cancer (2014) 0.88
Aldehyde dehydrogenase as a marker and functional mediator of metastasis in solid tumors. Clin Exp Metastasis (2015) 0.85
Normal hematopoietic stem cells within the AML bone marrow have a distinct and higher ALDH activity level than co-existing leukemic stem cells. PLoS One (2013) 0.85
Cancer stem cells and side population cells in breast cancer and metastasis. Cancers (Basel) (2011) 0.84
Strategies for isolating and enriching cancer stem cells: well begun is half done. Stem Cells Dev (2013) 0.84
ALDH1 is an immunohistochemical diagnostic marker for solitary fibrous tumours and haemangiopericytomas of the meninges emerging from gene profiling study. Acta Neuropathol Commun (2013) 0.84
Acetaldehyde and retinaldehyde-metabolizing enzymes in colon and pancreatic cancers. Adv Exp Med Biol (2015) 0.84
Cell hierarchy and lineage commitment in the bovine mammary gland. PLoS One (2012) 0.82
The CD44+ ALDH+ population of human keratinocytes is enriched for epidermal stem cells with long-term repopulating ability. Stem Cells (2013) 0.82
Cancer stem cell-related marker expression in lung adenocarcinoma and relevance of histologic subtypes based on IASLC/ATS/ERS classification. Onco Targets Ther (2013) 0.82
ALDH expression characterizes G1-phase proliferating beta cells during pregnancy. PLoS One (2014) 0.81
Proliferating pancreatic beta-cells upregulate ALDH. Histochem Cell Biol (2014) 0.81
Isolation and characterization of a metastatic hybrid cell line generated by ER negative and ER positive breast cancer cells in mouse bone marrow. PLoS One (2011) 0.81
Biology of renal tumour cancer stem cells applied in medicine. Contemp Oncol (Pozn) (2015) 0.80
FoxO1-negative cells are cancer stem-like cells in pancreatic ductal adenocarcinoma. Sci Rep (2015) 0.80
Cancer stem cells in breast cancer. Cancers (Basel) (2011) 0.80
Aldehyde dehydrogenase 1 expression in primary and metastatic renal cell carcinoma: an immunohistochemistry study. World J Surg Oncol (2013) 0.80
Mammary development and breast cancer: the role of stem cells. Curr Mol Med (2011) 0.80
Aldehyde dehydrogenase activity enriches for proximal airway basal stem cells and promotes their proliferation. Stem Cells Dev (2014) 0.80
Transcriptional Profiling of Hypoxic Neural Stem Cells Identifies Calcineurin-NFATc4 Signaling as a Major Regulator of Neural Stem Cell Biology. Stem Cell Reports (2015) 0.79
Sarcoma stem cells: do we know what we are looking for? Sarcoma (2012) 0.79
A novel aldehyde dehydrogenase-3 activator (Alda-89) protects submandibular gland function from irradiation without accelerating tumor growth. Clin Cancer Res (2013) 0.79
Sca-1+ cells from fetal heart with high aldehyde dehydrogenase activity exhibit enhanced gene expression for self-renewal, proliferation, and survival. Oxid Med Cell Longev (2015) 0.78
Hematopoietic stem cells. Methods Enzymol (2006) 0.78
A red-shifted fluorescent substrate for aldehyde dehydrogenase. Nat Commun (2014) 0.78
In vitro models of cancer stem cells and clinical applications. BMC Cancer (2016) 0.77
Next generation of ALDH substrates and their potential to study maturational lineage biology in stem and progenitor cells. Am J Physiol Gastrointest Liver Physiol (2015) 0.75
Overcoming Therapeutic Resistance of Bone Sarcomas: Overview of the Molecular Mechanisms and Therapeutic Targets for Bone Sarcoma Stem Cells. Stem Cells Int (2016) 0.75
The role of mesenchymal stem/progenitor cells in sarcoma: update and dispute. Stem Cell Investig (2014) 0.75
Detection of ALDH1 activity in rabbit hepatic VX2 tumors and isolation of ALDH1 positive cancer stem cells. J Transl Med (2016) 0.75
Novel markers for circulating tumor stem cells in colorectal carcinoma. Am J Transl Res (2016) 0.75
Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cells. Mol Genet Metab (2016) 0.75
Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells. Oncotarget (2016) 0.75
Aldehyde dehydrogenase 1 (ALDH1) isoform expression and potential clinical implications in hepatocellular carcinoma. PLoS One (2017) 0.75
ABCG1 as a potential oncogene in lung cancer. Exp Ther Med (2017) 0.75
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol (2007) 9.36
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97
Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells. Immunity (2012) 3.58
The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency. J Exp Med (2011) 2.96
Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. Cell Stem Cell (2008) 2.74
The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis. Hum Mol Genet (2006) 2.41
Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages. Stem Cells (2005) 2.17
Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells. Stem Cells (2010) 2.17
Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proc Natl Acad Sci U S A (2008) 2.15
Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos. Curr Biol (2003) 2.14
Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells. Stem Cells (2007) 2.07
Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation. J Exp Med (2009) 1.96
The AMA proposal to mandate nicotine reduction in cigarettes: a simulation of the population health impacts. Prev Med (2005) 1.73
Efficient transgenesis in farm animals by lentiviral vectors. EMBO Rep (2003) 1.72
Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome. Hum Mol Genet (2007) 1.68
A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A. J Cell Biol (2009) 1.67
Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells. Stem Cells (2004) 1.67
Hair follicle dermal cells differentiate into adipogenic and osteogenic lineages. Exp Dermatol (2003) 1.62
A novel model of urinary tract differentiation, tissue regeneration, and disease: reprogramming human prostate and bladder cells into induced pluripotent stem cells. Eur Urol (2013) 1.51
An autogeneic feeder cell system that efficiently supports growth of undifferentiated human embryonic stem cells. Stem Cells (2005) 1.49
G1 to S phase cell cycle transition in somatic and embryonic stem cells. J Anat (2008) 1.48
Isolation of primordial germ cells from differentiating human embryonic stem cells. Stem Cells (2008) 1.43
Human-serum matrix supports undifferentiated growth of human embryonic stem cells. Stem Cells (2005) 1.39
Derivation of human embryonic stem cells from developing and arrested embryos. Stem Cells (2006) 1.37
Differentiation of human embryonic stem cells to regional specific neural precursors in chemically defined medium conditions. PLoS One (2008) 1.36
Concise review: Mesenchymal stem cell treatment of the complications of diabetes mellitus. Stem Cells (2011) 1.35
Differentiation of human embryonic stem cells into corneal epithelial-like cells by in vitro replication of the corneal epithelial stem cell niche. Stem Cells (2007) 1.33
Epigenetic modification is central to genome reprogramming in somatic cell nuclear transfer. Stem Cells (2005) 1.33
Derivation of a human blastocyst after heterologous nuclear transfer to donated oocytes. Reprod Biomed Online (2005) 1.28
Epigenetic marking prepares the human HOXA cluster for activation during differentiation of pluripotent cells. Stem Cells (2008) 1.27
Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells. Stem Cells (2012) 1.27
Corneal epithelial stem cells: characterization, culture and transplantation. Regen Med (2006) 1.26
13 years of cultured limbal epithelial cell therapy: a review of the outcomes. J Cell Biochem (2011) 1.26
Phenolic contents, antioxidant and anticholinesterase potentials of crude extract, subsequent fractions and crude saponins from Polygonum hydropiper L. BMC Complement Altern Med (2014) 1.25
Successful clinical implementation of corneal epithelial stem cell therapy for treatment of unilateral limbal stem cell deficiency. Stem Cells (2010) 1.21
Transplanted oligodendrocytes and motoneuron progenitors generated from human embryonic stem cells promote locomotor recovery after spinal cord transection. Stem Cells (2010) 1.21
A key role for telomerase reverse transcriptase unit in modulating human embryonic stem cell proliferation, cell cycle dynamics, and in vitro differentiation. Stem Cells (2008) 1.20
Derivation of human embryonic stem cells from day-8 blastocysts recovered after three-step in vitro culture. Stem Cells (2004) 1.19
catena-Poly[[tri-n-butyltin]-mu-N-(1-naphthyl)maleamato]. Acta Crystallogr C (2002) 1.19
Hair follicle dermal cells repopulate the mouse haematopoietic system. J Cell Sci (2002) 1.18
Challenges of stem cell therapy for spinal cord injury: human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells? Stem Cells (2010) 1.17
Perspectives and future directions of human pluripotent stem cell-based therapies: lessons from Geron's clinical trial for spinal cord injury. Stem Cells Dev (2013) 1.16
Activated spinal cord ependymal stem cells rescue neurological function. Stem Cells (2009) 1.14
FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. J Biol Chem (2009) 1.14
Hypoxia promotes efficient differentiation of human embryonic stem cells to functional endothelium. Stem Cells (2010) 1.11
Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease. Stem Cells (2012) 1.11
SCL/TAL1 regulates hematopoietic specification from human embryonic stem cells. Mol Ther (2012) 1.09
An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. Stem Cells (2011) 1.09
Pluripotent stem cell model reveals essential roles for miR-450b-5p and miR-184 in embryonic corneal lineage specification. Stem Cells (2012) 1.09
Concise review: putting a finger on stem cell biology: zinc finger nuclease-driven targeted genetic editing in human pluripotent stem cells. Stem Cells (2011) 1.08
Federal policy mandating safer cigarettes: a hypothetical simulation of the anticipated population health gains or losses. J Policy Anal Manage (2004) 1.07
Comparison of mosquito control programs in seven urban sites in Africa, the Middle East, and the Americas. Health Policy (2007) 1.06
Concise review: Therapeutic potential of mesenchymal stem cells for the treatment of acute liver failure and cirrhosis. Stem Cells (2014) 1.06
Putative role of hyaluronan and its related genes, HAS2 and RHAMM, in human early preimplantation embryogenesis and embryonic stem cell characterization. Stem Cells (2007) 1.04
Phytochemical and toxicological investigations of crude methanolic extracts, subsequent fractions and crude saponins of Isodon rugosus. Biol Res (2014) 1.04
Brief report: human pluripotent stem cell models of fanconi anemia deficiency reveal an important role for fanconi anemia proteins in cellular reprogramming and survival of hematopoietic progenitors. Stem Cells (2013) 1.03
Silencing of the expression of pluripotent driven-reporter genes stably transfected into human pluripotent cells. Regen Med (2008) 1.03
Derivation, growth and applications of human embryonic stem cells. Reproduction (2004) 1.02
Loss of corneal epithelial stem cell properties in outgrowths from human limbal explants cultured on intact amniotic membrane. Regen Med (2008) 1.01
Epigenetic landscaping during hESC differentiation to neural cells. Stem Cells (2009) 1.01
Regulatory T cells and cytokines in malignant pleural effusions secondary to mesothelioma and carcinoma. Cancer Biol Ther (2005) 1.00
Heavy metals analysis, phytochemical, phytotoxic and anthelmintic investigations of crude methanolic extract, subsequent fractions and crude saponins from Polygonum hydropiper L. BMC Complement Altern Med (2014) 0.99
Large-scale transcriptional profiling and functional assays reveal important roles for Rho-GTPase signalling and SCL during haematopoietic differentiation of human embryonic stem cells. Hum Mol Genet (2011) 0.99
Evaluation of epigenetic marks in human embryos derived from IVF and ICSI. Hum Reprod (2010) 0.97
Evaluating the impact of water conservation on fate of outdoor water use: a study in an arid region. J Environ Manage (2011) 0.96
Tissue-specific effects of in vitro fertilization procedures on genomic cytosine methylation levels in overgrown and normal sized bovine fetuses. Biol Reprod (2006) 0.96
Successful application of ex vivo expanded human autologous oral mucosal epithelium for the treatment of total bilateral limbal stem cell deficiency. Stem Cells (2014) 0.96
Plasticity of rodent and human hair follicle dermal cells: implications for cell therapy and tissue engineering. J Investig Dermatol Symp Proc (2005) 0.95