Published in J Cell Biol on April 09, 2007
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell (2007) 22.89
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med (2009) 10.88
Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res (2009) 7.98
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev (2009) 4.29
Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Cell Stem Cell (2011) 4.08
Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res (2010) 3.40
Breast cancer: origins and evolution. J Clin Invest (2007) 3.31
Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A (2008) 2.99
In situ identification of bipotent stem cells in the mammary gland. Nature (2014) 2.71
Unraveling the microenvironmental influences on the normal mammary gland and breast cancer. Semin Cancer Biol (2008) 2.41
Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells. Cancer Res (2009) 2.28
Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland. Breast Cancer Res (2012) 2.18
The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia (2010) 2.12
Defining the cellular precursors to human breast cancer. Proc Natl Acad Sci U S A (2011) 2.01
Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis. Cancer Cell (2010) 1.92
Mechanisms of the epithelial-mesenchymal transition by TGF-beta. Future Oncol (2009) 1.90
Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell lines. Breast Cancer Res (2010) 1.90
Mammary stem cells and the differentiation hierarchy: current status and perspectives. Genes Dev (2014) 1.86
Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. Integr Biol (Camb) (2008) 1.82
The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis. Genes Dev (2009) 1.82
The molecular pathology of breast cancer progression. J Pathol (2010) 1.65
Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis. Cancer Cell (2012) 1.65
Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging. Histochem Cell Biol (2008) 1.55
Integrated morphodynamic signalling of the mammary gland. Nat Rev Mol Cell Biol (2011) 1.50
Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling. Stem Cells (2012) 1.37
MMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors. PLoS One (2009) 1.33
Stem cells in the human breast. Cold Spring Harb Perspect Biol (2010) 1.33
Breastmilk is a novel source of stem cells with multilineage differentiation potential. Stem Cells (2012) 1.31
Breast cancer stem cells: implications for therapy of breast cancer. Breast Cancer Res (2008) 1.26
Notch2 genetic fate mapping reveals two previously unrecognized mammary epithelial lineages. Nat Cell Biol (2013) 1.24
Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity. Proc Natl Acad Sci U S A (2012) 1.21
Accumulation of multipotent progenitors with a basal differentiation bias during aging of human mammary epithelia. Cancer Res (2012) 1.20
Hedgehog signalling in breast cancer. Carcinogenesis (2009) 1.18
Of microenvironments and mammary stem cells. Stem Cell Rev (2007) 1.14
Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells. Proc Natl Acad Sci U S A (2011) 1.11
Normal morphogenesis of epithelial tissues and progression of epithelial tumors. Wiley Interdiscip Rev Syst Biol Med (2011) 1.10
The difficulty of targeting cancer stem cell niches. Clin Cancer Res (2010) 1.08
Sustained activation of the HER1-ERK1/2-RSK signaling pathway controls myoepithelial cell fate in human mammary tissue. Genes Dev (2011) 1.07
Endothelial induced EMT in breast epithelial cells with stem cell properties. PLoS One (2011) 1.06
The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. Cancer Discov (2012) 1.06
Identification of the endostyle as a stem cell niche in a colonial chordate. Cell Stem Cell (2008) 1.04
Cytokeratin expression during mouse embryonic and early postnatal mammary gland development. Histochem Cell Biol (2009) 1.03
β4 Integrin signaling induces expansion of prostate tumor progenitors. J Clin Invest (2013) 1.03
Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features. BMC Med Genomics (2011) 1.02
Epithelial-stromal interaction 1 (EPSTI1) substitutes for peritumoral fibroblasts in the tumor microenvironment. Am J Pathol (2010) 1.01
Mapping mammary gland architecture using multi-scale in situ analysis. Integr Biol (Camb) (2008) 1.00
An "elite hacker": breast tumors exploit the normal microenvironment program to instruct their progression and biological diversity. Cell Adh Migr (2012) 0.99
Chromatin remodeling in mammary gland differentiation and breast tumorigenesis. Cold Spring Harb Perspect Biol (2010) 0.98
Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells. Int J Biol Sci (2008) 0.98
Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells. Stem Cell Reports (2014) 0.94
Progesterone regulation of stem and progenitor cells in normal and malignant breast. Mol Cell Endocrinol (2011) 0.93
Unravelling the mystery of stem/progenitor cells in human breast milk. PLoS One (2010) 0.93
Cisplatin induces differentiation of breast cancer cells. Front Oncol (2013) 0.92
Functional Role of the microRNA-200 Family in Breast Morphogenesis and Neoplasia. Genes (Basel) (2014) 0.92
Prdm14 initiates lymphoblastic leukemia after expanding a population of cells resembling common lymphoid progenitors. Oncogene (2011) 0.91
FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells. PLoS One (2013) 0.89
Differential expression of genes involved in the epigenetic regulation of cell identity in normal human mammary cell commitment and differentiation. Chin J Cancer (2014) 0.89
Response of estrogen receptor-positive breast cancer tumorspheres to antiestrogen treatments. PLoS One (2011) 0.89
Matrix compliance and RhoA direct the differentiation of mammary progenitor cells. Biomech Model Mechanobiol (2011) 0.89
Reprogramming stem cells is a microenvironmental task. Proc Natl Acad Sci U S A (2008) 0.88
Form and Function: how Estrogen and Progesterone Regulate the Mammary Epithelial Hierarchy. J Mammary Gland Biol Neoplasia (2015) 0.88
Progesterone-inducible cytokeratin 5-positive cells in luminal breast cancer exhibit progenitor properties. Horm Cancer (2012) 0.88
P-cadherin signals through the laminin receptor α6β4 integrin to induce stem cell and invasive properties in basal-like breast cancer cells. Oncotarget (2014) 0.87
Cell fate takes a slug in BRCA1-associated breast cancer. Breast Cancer Res (2011) 0.87
Cancer Stem Cell Hierarchy in Glioblastoma Multiforme. Front Surg (2016) 0.87
The expression of ALDH1 in cervical carcinoma. Med Sci Monit (2011) 0.85
Development of a screen to identify selective small molecules active against patient-derived metastatic and chemoresistant breast cancer cells. Breast Cancer Res (2013) 0.85
Mesenchymal precursor cells maintain the differentiation and proliferation potentials of breast epithelial cells. Breast Cancer Res (2014) 0.85
Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells. PLoS One (2012) 0.85
ROCK1 inhibition promotes the self-renewal of a novel mouse mammary cancer stem cell. Stem Cells (2013) 0.84
Age-related dysfunction in mechanotransduction impairs differentiation of human mammary epithelial progenitors. Cell Rep (2014) 0.84
The mammary cellular hierarchy and breast cancer. Cell Mol Life Sci (2014) 0.84
The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα. Nature (2017) 0.84
Fresh surgical specimens yield breast stem/progenitor cells and reveal their oncogenic abnormalities. Ann Surg Oncol (2011) 0.83
The role of Transposable Elements in shaping the combinatorial interaction of Transcription Factors. BMC Genomics (2012) 0.83
Models of breast morphogenesis based on localization of stem cells in the developing mammary lobule. Stem Cell Reports (2015) 0.83
The Year in Basic Science: update of estrogen plus progestin therapy for menopausal hormone replacement implicating stem cells in the increased breast cancer risk. Mol Endocrinol (2008) 0.82
Cell hierarchy and lineage commitment in the bovine mammary gland. PLoS One (2012) 0.82
Integration of microRNA signatures of distinct mammary epithelial cell types with their gene expression and epigenetic portraits. Breast Cancer Res (2015) 0.82
Distinct effects of EGFR ligands on human mammary epithelial cell differentiation. PLoS One (2013) 0.82
At the dawn of a new discovery: the potential of breast milk stem cells. Adv Nutr (2014) 0.82
Age and the means of bypassing stasis influence the intrinsic subtype of immortalized human mammary epithelial cells. Front Cell Dev Biol (2015) 0.82
Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobules. Breast Cancer Res (2014) 0.81
Expression and functional role of sprouty-2 in breast morphogenesis. PLoS One (2013) 0.81
Mammary development and breast cancer: the role of stem cells. Curr Mol Med (2011) 0.80
The network of pluripotency, epithelial-mesenchymal transition, and prognosis of breast cancer. Breast Cancer (Dove Med Press) (2015) 0.80
The Stem Cell Network model: clinical implications in cancer. Eur Arch Otorhinolaryngol (2008) 0.80
Steroid Hormones, Steroid Receptors, and Breast Cancer Stem Cells. J Mammary Gland Biol Neoplasia (2015) 0.80
Selection of a breast cancer subpopulation-specific antibody using phage display on tissue sections. Immunol Res (2015) 0.79
Gene expression signatures of breast cancer stem and progenitor cells do not exhibit features of Warburg metabolism. Stem Cell Res Ther (2015) 0.79
Comparative Multifractal Analysis of Dynamic Infrared Thermograms and X-Ray Mammograms Enlightens Changes in the Environment of Malignant Tumors. Front Physiol (2016) 0.79
Novel measurements of mammary stem cells in human umbilical cord blood as prospective predictors of breast cancer susceptibility in later life. Ann Oncol (2011) 0.79
Prospective isolation and characterization of committed and multipotent progenitors from immortalized mouse mammary epithelial cells with morphogenic potential. Breast Cancer Res (2011) 0.79
Differential in vivo tumorigenicity of distinct subpopulations from a luminal-like breast cancer xenograft. PLoS One (2014) 0.79
Breast and abdominal adipose multipotent mesenchymal stromal cells and stage-specific embryonic antigen 4 expression. Cells Tissues Organs (2012) 0.79
Fibroblasts prepared from different types of malignant tumors stimulate expression of luminal marker keratin 8 in the EM-G3 breast cancer cell line. Histochem Cell Biol (2012) 0.78
Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture. Nat Commun (2015) 0.78
The controversial clinicobiological role of breast cancer stem cells. J Oncol (2009) 0.78
Of Mice and Women: A Comparative Tissue Biology Perspective of Breast Stem Cells and Differentiation. J Mammary Gland Biol Neoplasia (2015) 0.77
Long-term cultures of stem/progenitor cells from lobular and ductal breast carcinomas under non-adherent conditions. Cytotechnology (2010) 0.77
Molecular portraits of human breast tumours. Nature (2000) 94.14
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev (2003) 20.77
Generation of a functional mammary gland from a single stem cell. Nature (2006) 18.30
Purification and unique properties of mammary epithelial stem cells. Nature (2006) 15.98
Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell (2005) 15.06
Defining the epithelial stem cell niche in skin. Science (2003) 14.93
Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell (2004) 10.79
Socializing with the neighbors: stem cells and their niche. Cell (2004) 9.40
Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc Natl Acad Sci U S A (1992) 8.69
Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med (2005) 8.01
Stem cells and their niches. Science (2006) 7.86
Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev (2002) 6.55
Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. J Cell Sci (2002) 4.25
Monoclonal antibodies provide specific intramolecular markers for the study of epithelial tonofilament organization. J Cell Biol (1982) 3.80
Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis. Carcinogenesis (2004) 3.66
Characterization and isolation of stem cell-enriched human hair follicle bulge cells. J Clin Invest (2006) 3.41
Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements. Proc Natl Acad Sci U S A (1990) 3.40
Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice. J Neurosci (2004) 3.40
Stem cell depletion through epidermal deletion of Rac1. Science (2005) 3.26
A putative human breast stem cell population is enriched for steroid receptor-positive cells. Dev Biol (2005) 3.19
Proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis. J Cell Biol (2002) 2.96
Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia. Lab Invest (1993) 2.89
Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue. Proc Natl Acad Sci U S A (2005) 2.77
On mammary stem cells. J Cell Sci (2005) 2.56
Functionally distinct human marrow stromal cell lines immortalized by transduction with the human papilloma virus E6/E7 genes. Blood (1995) 2.40
Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expression. Oncogene (2005) 2.37
Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept. Lab Invest (2002) 2.33
Human mammary luminal epithelial cells contain progenitors to myoepithelial cells. Dev Biol (1999) 2.31
Human embryonic stem cells derived without feeder cells. Lancet (2005) 2.24
Epidermal stem cells: markers, patterning and the control of stem cell fate. Philos Trans R Soc Lond B Biol Sci (1998) 2.19
Retention of intrinsic stem cell hierarchies in carcinoma-derived cell lines. Cancer Res (2005) 2.12
Distribution and isolation of four laminin variants; tissue restricted distribution of heterotrimers assembled from five different subunits. Cell Regul (1990) 2.02
Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells. Biochem Biophys Res Commun (2002) 1.89
Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites. Cancer Res (2000) 1.82
The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. J Biol Chem (2006) 1.80
The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy. Dev Biol (2006) 1.80
Human breast development. J Mammary Gland Biol Neoplasia (2000) 1.71
Proliferative heterogeneity in the human prostate: evidence for epithelial stem cells. Lab Invest (2000) 1.66
Will cancer stem cells provide new therapeutic targets? Carcinogenesis (2004) 1.64
Keratin 19: predicted amino acid sequence and broad tissue distribution suggest it evolved from keratinocyte keratins. J Invest Dermatol (1989) 1.61
Development of mouse mammary gland: identification of stages in differentiation of luminal and myoepithelial cells using monoclonal antibodies and polyvalent antiserum against keratin. J Histochem Cytochem (1986) 1.61
The mammary gland "side population": a putative stem/progenitor cell marker? J Mammary Gland Biol Neoplasia (2005) 1.57
Two types of normal human breast epithelial cells derived from reduction mammoplasty: phenotypic characterization and response to SV40 transfection. Carcinogenesis (1995) 1.56
Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation. Dev Biol (2005) 1.54
Differential keratin gene expression in developing, differentiating, preneoplastic, and neoplastic mouse mammary epithelium. Cell Growth Differ (1990) 1.53
Telomerase activity: a biomarker of cell proliferation, not malignant transformation. Proc Natl Acad Sci U S A (1997) 1.51
Contiguous patches of normal human mammary epithelium derived from a single stem cell: implications for breast carcinogenesis. Cancer Res (1996) 1.51
Epithelial cell differentiation pathways in the human prostate: identification of intermediate phenotypes by keratin expression. J Histochem Cytochem (2001) 1.50
Development of the human breast. Maturitas (2004) 1.50
Combination of hTERT and bmi-1, E6, or E7 induces prolongation of the life span of bone marrow stromal cells from an elderly donor without affecting their neurogenic potential. Mol Cell Biol (2005) 1.49
Growth factor control of myoepithelial-cell differentiation in cultures of human mammary gland. Differentiation (1988) 1.47
Stem cells and the development of mammary cancers in experimental rats and in humans. Cancer Metastasis Rev (1987) 1.45
Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis. Development (2003) 1.42
Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts. Am J Pathol (2002) 1.36
Restriction-site PCR: a direct method of unknown sequence retrieval adjacent to a known locus by using universal primers. PCR Methods Appl (1993) 1.35
The comparative pathology of human and mouse mammary glands. J Mammary Gland Biol Neoplasia (1999) 1.35
Deciphering the mammary epithelial cell hierarchy. Cell Cycle (2006) 1.34
A fibroblast-associated antigen: characterization in fibroblasts and immunoreactivity in smooth muscle differentiated stromal cells. J Histochem Cytochem (1992) 1.33
Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer. J Clin Oncol (2003) 1.24
Characterization in vitro of luminal and myoepithelial cells isolated from the human mammary gland by cell sorting. Differentiation (1991) 1.20
Long-term genome stability and minimal genotypic and phenotypic alterations in HPV16 E7-, but not E6-, immortalized human uroepithelial cells. Genes Dev (1994) 1.20
The effect of age and menstrual cycle upon proliferative activity of the normal human breast. Br J Cancer (1988) 1.19
Caveolin-1-deficient mice have an increased mammary stem cell population with upregulation of Wnt/beta-catenin signaling. Cell Cycle (2005) 1.15
Differential tumorigenicity of two autologous human breast carcinoma cell lines, HMT-3909S1 and HMT-3909S8, established in serum-free medium. Cancer Res (1990) 1.13
DNA replication licensing and cell cycle kinetics of normal and neoplastic breast. Br J Cancer (2005) 1.12
Keratin 6 is not essential for mammary gland development. Breast Cancer Res (2006) 1.10
Differential expression of laminin isoforms and alpha 6-beta 4 integrin subunits in the developing human and mouse intestine. Dev Dyn (1994) 1.10
Ignored hallmarks of carcinogenesis: stem cells and cell-cell communication. Ann N Y Acad Sci (2004) 1.10
Upper human hair follicle contains a subpopulation of keratinocytes with superior in vitro proliferative potential. J Invest Dermatol (1993) 1.09
Repression of DNA replication licensing in quiescence is independent of geminin and may define the cell cycle state of progenitor cells. Exp Cell Res (2005) 1.07
Comparative analysis of the distribution of laminin chains in the basement membranes in some malignant epithelial tumors: the alpha1 chain of laminin shows a selected expression pattern in human carcinomas. J Histochem Cytochem (2001) 1.05
The transdifferentiation potential of limbal fibroblast-like cells. Brain Res Dev Brain Res (2005) 1.04
Isolation and characterization of human mammary stem cells. Cell Prolif (2005) 1.03
Multilineage differentiation of adult human bone marrow progenitor cells transduced with human papilloma virus type 16 E6/E7 genes. Calcif Tissue Int (2002) 1.00
Expression of estrogen receptors in a normal human breast epithelial cell type with luminal and stem cell characteristics and its neoplastically transformed cell lines. Carcinogenesis (1997) 0.99
Mapping and analysis of HPV16 integration sites in a head and neck cancer cell line. Int J Cancer (2004) 0.97
Proliferative potential of different keratinocytes of plucked human hair follicles. J Invest Dermatol (1995) 0.96
Immunohistochemical analysis of Bcl-2 and Bax expression in relation to cell turnover and epithelial differentiation markers in the non-lactating human mammary gland epithelium. Cell Tissue Res (2000) 0.96
Identification of a stem cell candidate in the normal human prostate gland. Eur J Cell Biol (2005) 0.95
Stem cell properties and epithelial malignancies. Eur J Cancer (2006) 0.95
Differential alteration of stem and other cell populations in ducts and lobules of TGFalpha and c-Myc transgenic mouse mammary epithelium. Tissue Cell (2005) 0.95
Bypass of senescence, immortalization, and transformation of human hematopoietic progenitor cells. Stem Cells (2005) 0.95
Segment-specific but pathologic laminin isoform profiles in human labial salivary glands of patients with Sjogren's syndrome. Arthritis Rheum (2004) 0.88
Bcl-2 protein in normal, hyperplastic and neoplastic breast tissues. A metabolite of the putative stem-cell subpopulation of the mammary gland. Histol Histopathol (2004) 0.85
Differential expression of laminin alpha chains during proliferative and differentiation stages in a model for skin morphogenesis. Matrix Biol (2000) 0.85
Variation of bcl-2 expression in breast ducts and lobules in relation to plasma progesterone levels: overexpression and absence of variation in fibroadenomas. J Pathol (1997) 0.84
Expression of integrin subunits correlates with differentiation of epithelial cell lineages in developing human gastric mucosa. Anat Embryol (Berl) (2000) 0.80
Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods (2007) 7.43
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24
Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer. Annu Rev Cell Dev Biol (2006) 6.64
Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev (2002) 6.55
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol (2007) 5.81
beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell (2002) 5.56
The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation (2002) 4.64
Regulation of in situ to invasive breast carcinoma transition. Cancer Cell (2008) 4.46
Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. J Cell Sci (2002) 4.25
Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science (2006) 4.12
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 4.09
Modeling tissue-specific signaling and organ function in three dimensions. J Cell Sci (2003) 3.52
Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts. J Natl Cancer Inst (2002) 3.39
The perivascular niche regulates breast tumour dormancy. Nat Cell Biol (2013) 3.36
Breast cancer mortality in Copenhagen after introduction of mammography screening: cohort study. BMJ (2005) 3.21
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res (2009) 3.14
Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res (2003) 3.13
Tumor reversion: correction of malignant behavior by microenvironmental cues. Int J Cancer (2003) 3.02
Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. J Cell Biol (2004) 2.93
Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Res (2006) 2.86
Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J Cell Biol (2003) 2.68
Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell (2012) 2.61
MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits. Nat Cell Biol (2012) 2.61
Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin Cancer Biol (2005) 2.53
Unraveling the microenvironmental influences on the normal mammary gland and breast cancer. Semin Cancer Biol (2008) 2.41
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci U S A (2006) 2.41
HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res Treat (2009) 2.34
Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT? J Cell Biochem (2007) 2.32
Targeting TACE-dependent EGFR ligand shedding in breast cancer. J Clin Invest (2007) 2.29
Population-based study of peritumoral lymphovascular invasion and outcome among patients with operable breast cancer. J Natl Cancer Inst (2009) 2.28
Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression? Nat Clin Pract Oncol (2008) 2.18
Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets. PLoS One (2008) 2.12
Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma. Am J Pathol (2003) 2.06
The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium. Dev Biol (2007) 1.98
Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices. Cancer Metastasis Rev (2009) 1.93
Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia. J Mammary Gland Biol Neoplasia (2005) 1.92
Improving the reproducibility of diagnosing micrometastases and isolated tumor cells. Cancer (2005) 1.91
Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts. Cancer Res (2008) 1.83
Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. Integr Biol (Camb) (2008) 1.82
The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells. J Biol Chem (2007) 1.82
A human breast cell model of preinvasive to invasive transition. Cancer Res (2008) 1.79
The tumor microenvironment is a dominant force in multidrug resistance. Drug Resist Updat (2012) 1.77
Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. EMBO J (2008) 1.74
The dominance of the microenvironment in breast and ovarian cancer. Semin Cancer Biol (2002) 1.73
Targeting the tumor microenvironment. Front Biosci (2007) 1.72
Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer. Cancer Res (2006) 1.69
Myoepithelial cells: good fences make good neighbors. Breast Cancer Res (2005) 1.66
A role for dystroglycan in epithelial polarization: loss of function in breast tumor cells. Cancer Res (2002) 1.65
Cell shape regulates global histone acetylation in human mammary epithelial cells. Exp Cell Res (2007) 1.64
Cancer. Respect thy neighbor! Science (2004) 1.62
Breast cancer by proxy: can the microenvironment be both the cause and consequence? Trends Mol Med (2008) 1.60
Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. Cancer Res (2007) 1.60
Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells. Proc Natl Acad Sci U S A (2011) 1.58
Proteomic characterization of the interstitial fluid perfusing the breast tumor microenvironment: a novel resource for biomarker and therapeutic target discovery. Mol Cell Proteomics (2004) 1.57
β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib. Breast Cancer Res (2011) 1.56
Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging. Histochem Cell Biol (2008) 1.55
Expression of S100A4 by a variety of cell types present in the tumor microenvironment of human breast cancer. Int J Cancer (2007) 1.53
Dystroglycan loss disrupts polarity and beta-casein induction in mammary epithelial cells by perturbing laminin anchoring. J Cell Sci (2006) 1.49
CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression. Cancer Res (2013) 1.48
Long-term results of breast conserving surgery vs. mastectomy for early stage invasive breast cancer: 20-year follow-up of the Danish randomized DBCG-82TM protocol. Acta Oncol (2008) 1.47
Extracellular matrix-regulated gene expression requires cooperation of SWI/SNF and transcription factors. J Biol Chem (2007) 1.46
Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture. PLoS Comput Biol (2010) 1.46
Coherent angular motion in the establishment of multicellular architecture of glandular tissues. Proc Natl Acad Sci U S A (2012) 1.45
Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function. J Cell Biol (2009) 1.44
Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells. J Cell Biochem (2008) 1.41
Epithelial-mesenchymal transition and the stem cell phenotype. Cell Stem Cell (2008) 1.39
Self-organization of engineered epithelial tubules by differential cellular motility. Proc Natl Acad Sci U S A (2009) 1.36
Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors. Proc Natl Acad Sci U S A (2012) 1.36
Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts. Am J Pathol (2002) 1.36
Three-dimensional lithographically defined organotypic tissue arrays for quantitative analysis of morphogenesis and neoplastic progression. Nat Protoc (2008) 1.35
Proteolytic enzymes and altered glycosylation modulate dystroglycan function in carcinoma cells. Cancer Res (2004) 1.33
Identification of extracellular and intracellular signaling components of the mammary adipose tissue and its interstitial fluid in high risk breast cancer patients: toward dissecting the molecular circuitry of epithelial-adipocyte stromal cell interactions. Mol Cell Proteomics (2005) 1.32
Is CD133 a marker of metastatic colon cancer stem cells? J Clin Invest (2008) 1.32
Breast cancer cells in three-dimensional culture display an enhanced radioresponse after coordinate targeting of integrin alpha5beta1 and fibronectin. Cancer Res (2010) 1.32
Rhamm-/- fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair. J Cell Biol (2006) 1.28
Collagen-IV and laminin-1 regulate estrogen receptor alpha expression and function in mouse mammary epithelial cells. J Cell Sci (2003) 1.27
Three-dimensional culture of human breast epithelial cells: the how and the why. Methods Mol Biol (2013) 1.26
Stromal cells associated with early invasive foci in human mammary ductal carcinoma in situ coexpress urokinase and urokinase receptor. Int J Cancer (2007) 1.24
A role for ADAM12 in breast tumor progression and stromal cell apoptosis. Cancer Res (2005) 1.24
Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1. Development (2013) 1.23
Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. Cancer Res (2007) 1.22
Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer. Clin Cancer Res (2005) 1.21
Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity. Proc Natl Acad Sci U S A (2012) 1.21
Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases. Cold Spring Harb Perspect Biol (2012) 1.20
Dissecting regional variations in stress fiber mechanics in living cells with laser nanosurgery. Biophys J (2010) 1.20