Published in J Neurochem on December 01, 2004
TACE (ADAM17) inhibits Schwann cell myelination. Nat Neurosci (2011) 1.14
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation. EMBO Mol Med (2011) 1.11
Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1. J Biol Chem (2011) 0.86
Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers. EMBO Mol Med (2012) 0.84
A new way APP mismetabolism can lead to Alzheimer's disease. EMBO Mol Med (2011) 0.75
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron (2005) 7.53
In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life. J Neurosci (2003) 5.00
A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system. Ann Neurol (2009) 4.59
ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron (2004) 4.21
Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. Nat Struct Mol Biol (2007) 4.10
Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology (2005) 3.83
Stable-isotope dimethyl labeling for quantitative proteomics. Anal Chem (2003) 2.97
Modulation of blood pressure by central melanocortinergic pathways. N Engl J Med (2008) 2.86
gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science (2009) 2.43
Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor. J Biol Chem (2003) 2.22
Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta. J Neurosci (2005) 2.21
Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor. J Neurosci (2011) 1.96
Safety, tolerability, and effects on plasma and cerebrospinal fluid amyloid-beta after inhibition of gamma-secretase. Clin Neuropharmacol (2007) 1.81
Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho. Science (2003) 1.77
Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers. Clin Neuropharmacol (2005) 1.65
Molecular mechanism of lipopeptide presentation by CD1a. Immunity (2005) 1.41
Biochemical regulation of mammalian AMP-activated protein kinase activity by NAD and NADH. J Biol Chem (2004) 1.35
Pharmacologic characterization of the cloned human trace amine-associated receptor1 (TAAR1) and evidence for species differences with the rat TAAR1. J Pharmacol Exp Ther (2006) 1.26
A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes. J Neurochem (2004) 1.23
Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Eukaryot Cell (2004) 1.19
Beyond quantitative proteomics: signal enhancement of the a1 ion as a mass tag for peptide sequencing using dimethyl labeling. J Proteome Res (2005) 1.18
Akt activation, but not extracellular signal-regulated kinase activation, is required for SDF-1alpha/CXCR4-mediated migration of epitheloid carcinoma cells. Mol Cancer Res (2005) 1.15
Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists. Bioorg Med Chem Lett (2004) 1.14
Dimethyl multiplexed labeling combined with microcolumn separation and MS analysis for time course study in proteomics. Electrophoresis (2006) 1.14
Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors. Biochem Biophys Res Commun (2003) 1.14
Utilization of microbial iron assimilation processes for the development of new antibiotics and inspiration for the design of new anticancer agents. Biometals (2009) 1.12
Development of semagacestat (LY450139), a functional gamma-secretase inhibitor, for the treatment of Alzheimer's disease. Expert Opin Pharmacother (2009) 1.07
A systematic MS-based approach for identifying in vitro substrates of PKA and PKG in rat uteri. J Proteome Res (2007) 1.07
The folding nucleus of the insulin superfamily: a flexible peptide model foreshadows the native state. J Biol Chem (2006) 1.05
A pharmacophore for human pregnane X receptor ligands. Drug Metab Dispos (2002) 1.03
Quantitation of protein phosphorylation in pregnant rat uteri using stable isotope dimethyl labeling coupled with IMAC. Proteomics (2006) 1.01
Stable permanently hydrophilic protein-resistant thin-film coatings on poly(dimethylsiloxane) substrates by electrostatic self-assembly and chemical cross-linking. Anal Chem (2005) 0.99
Lessons in molecular recognition. 2. Assessing and improving cross-docking accuracy. J Chem Inf Model (2007) 0.98
pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity. Peptides (2007) 0.97
Dimethyl isotope-coded affinity selection for the analysis of free and blocked N-termini of proteins using LC-MS/MS. Anal Chem (2007) 0.97
Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5. FEBS Lett (2003) 0.96
Enhanced a1 fragmentation for dimethylated proteins and its applications for N-terminal identification and comparative protein quantitation. J Proteome Res (2007) 0.95
HIP1-ALK, a novel ALK fusion variant that responds to crizotinib. J Thorac Oncol (2014) 0.93
Mitsunobu approach to the synthesis of optically active alpha,alpha-disubstituted amino acids. Org Lett (2009) 0.93
P4 and P1' optimization of bicycloproline P2 bearing tetrapeptidyl alpha-ketoamides as HCV protease inhibitors. Bioorg Med Chem Lett (2004) 0.92
Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors. Brain Res (2002) 0.92
Proteomic analysis of proteins from bronchoalveolar lavage fluid reveals the action mechanism of ultrafine carbon black-induced lung injury in mice. Proteomics (2007) 0.90
A global comparability approach for biosimilar monoclonal antibodies using LC-tandem MS based proteomics. J Pharm Biomed Anal (2013) 0.90
Cyclopropanecarboxylic acid esters as potential prodrugs with enhanced hydrolytic stability. Org Lett (2008) 0.90
Preproghrelin-derived peptide, obestatin, fails to influence food intake in lean or obese rodents. Obesity (Silver Spring) (2007) 0.89
A novel and selective beta-melanocyte-stimulating hormone-derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats. Endocrinology (2005) 0.89
Integrated isotachophoretic stacking and gel electrophoresis on a plastic substrate and variations in detection dynamic range. Electrophoresis (2008) 0.88
Synthesis, crystallization, and biological evaluation of an orally active prodrug of gemcitabine. J Med Chem (2009) 0.88
P1 and P3 optimization of novel bicycloproline P2 bearing tetrapeptidyl alpha-ketoamide based HCV protease inhibitors. Bioorg Med Chem Lett (2004) 0.88
Apolipoprotein E alters the processing of the beta-amyloid precursor protein in APP(V717F) transgenic mice. Brain Res (2002) 0.88
Amyloid-β(1-15/16) as a marker for γ-secretase inhibition in Alzheimer's disease. J Alzheimers Dis (2012) 0.88
Melanocortin-4 receptor agonists for the treatment of obesity. Curr Top Med Chem (2007) 0.88
Rational design, synthesis, and structure-activity relationships of aryltriazoles as novel corticotropin-releasing factor-1 receptor antagonists. J Med Chem (2005) 0.87
Discovery of a novel bicycloproline P2 bearing peptidyl alpha-ketoamide LY514962 as HCV protease inhibitor. Bioorg Med Chem Lett (2004) 0.87
Long-term affinity modification on poly(dimethylsiloxane) substrate and its application for ELISA analysis. Anal Chem (2008) 0.87
Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1. J Biol Chem (2011) 0.86
Safety profile of semagacestat, a gamma-secretase inhibitor: IDENTITY trial findings. Curr Med Res Opin (2014) 0.86
Heat shock protein 90 stabilizes nucleolin to increase mRNA stability in mitosis. J Biol Chem (2011) 0.86
Development of an immunofluorometric assay and quantification of human kallikrein 7 in tissue extracts and biological fluids. Clin Chem (2004) 0.85
Magnetic bead-based hydrophilic interaction liquid chromatography for glycopeptide enrichments. J Chromatogr A (2011) 0.85
Detection and control of aspartimide formation in the synthesis of cyclic peptides. Bioorg Med Chem Lett (2005) 0.85
Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor. J Med Chem (2004) 0.85
Application of the Dakin-West reaction for the synthesis of oxazole-containing dual PPARalpha/gamma agonists. J Org Chem (2003) 0.85
The effects of anti-histone H1 antibody on immune cells responsible for rejection reaction. Mol Immunol (2005) 0.85
In-depth comparative characterization of hemoglobin glycation in normal and diabetic bloods by LC-MSMS. J Am Soc Mass Spectrom (2014) 0.85
Human rhinovirus 3C protease as a potential target for the development of antiviral agents. Curr Protein Pept Sci (2007) 0.85
Microchip electrophoresis with hydrodynamic injection and waste-removing function for quantitative analysis. J Chromatogr A (2004) 0.84
Hypophysectomy prevents ghrelin-induced adiposity and increases gastric ghrelin secretion in rats. Obes Res (2002) 0.84
Quantitative nanoproteomics for protein complexes (QNanoPX) related to estrogen transcriptional action. Mol Cell Proteomics (2009) 0.84
Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol (2004) 0.84
Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors. Bioorg Med Chem (2011) 0.84
Synthesis of dideoxymycobactin antigens presented by CD1a reveals T cell fine specificity for natural lipopeptide structures. J Biol Chem (2009) 0.84
Validation of ELISA methods for quantification of total tau and phosporylated-tau181 in human cerebrospinal fluid with measurement in specimens from two Alzheimer's disease studies. J Alzheimers Dis (2011) 0.84
The effect of exogenous histone H1 on rat adipose-derived stem cell proliferation, migration, and osteogenic differentiation in vitro. J Cell Physiol (2012) 0.83
Community and proteomic analysis of methanogenic consortia degrading terephthalate. Appl Environ Microbiol (2012) 0.83
Quantitative phosphoproteomics studies using stable isotope dimethyl labeling coupled with IMAC-HILIC-nanoLC-MS/MS for estrogen-induced transcriptional regulation. J Proteome Res (2011) 0.83
Chip-based microfluidic devices coupled with electrospray ionization-mass spectrometry. Electrophoresis (2005) 0.83
Derivation and characterization of monoclonal antibodies against human folypolyglutamate synthetase. Hybridoma (Larchmt) (2007) 0.82
Rapid and recurrent neutrophil mobilization regulated by T134, a CXCR4 peptide antagonist. Exp Hematol (2008) 0.82
Potent, orally active corticotropin-releasing factor receptor-1 antagonists containing a tricyclic pyrrolopyridine or pyrazolopyridine core. J Med Chem (2005) 0.82
P4 cap modified tetrapeptidyl alpha-ketoamides as potent HCV NS3 protease inhibitors. Bioorg Med Chem Lett (2004) 0.81
Gold nanoparticle-assisted protein enrichment and electroelution for biological samples containing low protein concentration--a prelude of gel electrophoresis. J Proteome Res (2006) 0.81
Nano-titanium dioxide composites for the enrichment of phosphopeptides. J Chromatogr A (2006) 0.81
Improved N(α)-acetylated peptide enrichment following dimethyl labeling and SCX. J Proteome Res (2013) 0.80
Role of biochemical Alzheimer's disease biomarkers as end points in clinical trials. Biomark Med (2010) 0.80
Functionalized 3D-hydrogel plugs covalently patterned inside hydrophilic poly(dimethylsiloxane) microchannels for flow-through immunoassays. Anal Chem (2009) 0.80
Synthesis and SAR of 8-arylquinolines as potent corticotropin-releasing factor1 (CRF1) receptor antagonists. Bioorg Med Chem Lett (2003) 0.80
Outcome and risk factors associated with surgical site infections after cardiac surgery in a Taiwan medical center. J Microbiol Immunol Infect (2010) 0.80
Use of trichloroacetimidate linker in solid-phase Peptide synthesis. J Org Chem (2003) 0.79
Gold nanoparticles for microfluidics-based biosensing of PCR products by hybridization-induced fluorescence quenching. Electrophoresis (2005) 0.79
Quantitative shot-gun proteomics and MS-based activity assay for revealing gender differences in enzyme contents for rat liver microsome. J Proteomics (2011) 0.79
Concise synthetic routes to human insulin. Org Lett (2013) 0.78
Detection of total and A1c-glycosylated hemoglobin in human whole blood using sandwich immunoassays on polydimethylsiloxane-based antibody microarrays. Anal Chem (2012) 0.78
Design and synthesis of statine-containing BACE inhibitors. Bioorg Med Chem Lett (2003) 0.78
Semihydrodynamic injection for high salt stacking and sweeping on microchip electrophoresis and its application for the analysis of estrogen and estrogen binding. Anal Chem (2007) 0.78
Design and synthesis of tricyclic imidazo[4,5-b]pyridin-2-ones as corticotropin-releasing factor-1 antagonists. J Med Chem (2005) 0.78
Quantitative analysis of estrogens and estrogen metabolites in endogenous MCF-7 breast cancer cells by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2011) 0.78