A new way APP mismetabolism can lead to Alzheimer's disease.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 3377077)

Published in EMBO Mol Med on April 27, 2011

Authors

John Hardy1, Rita Guerreiro

Author Affiliations

1: Reta Lilla Weston Laboratories and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK. j.hardy@ion.ucl.ac.uk

Articles by these authors

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15

Genotype, haplotype and copy-number variation in worldwide human populations. Nature (2008) 12.40

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23

Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease. Brain (2009) 4.01

DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA. Lancet Neurol (2008) 3.03

Familial frontotemporal dementia with amyotrophic lateral sclerosis and a shared haplotype on chromosome 9p. J Neurol (2010) 2.75

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS One (2010) 2.57

Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Hum Mol Genet (2012) 1.68

Complete screening for glucocerebrosidase mutations in Parkinson disease patients from Portugal. Neurobiol Aging (2007) 1.67

Use of next-generation sequencing and other whole-genome strategies to dissect neurological disease. Nat Rev Neurosci (2012) 1.58

Insights into TREM2 biology by network analysis of human brain gene expression data. Neurobiol Aging (2013) 1.49

NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases. Neurobiol Aging (2014) 1.32

Complement receptor 1 (CR1) and Alzheimer's disease. Immunobiology (2011) 1.30

Mutant ADA2 in vasculopathies. N Engl J Med (2014) 1.20

Screening for VPS35 mutations in Parkinson's disease. Neurobiol Aging (2011) 1.12

Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk. JAMA Neurol (2013) 1.09

PRNP allelic series from 19 years of prion protein gene sequencing at the MRC Prion Unit. Hum Mutat (2010) 1.07

TREM2 and neurodegenerative disease. N Engl J Med (2013) 1.06

SQSTM1 mutations in French patients with frontotemporal dementia or frontotemporal dementia with amyotrophic lateral sclerosis. JAMA Neurol (2013) 1.05

Duplication of amyloid precursor protein (APP), but not prion protein (PRNP) gene is a significant cause of early onset dementia in a large UK series. Neurobiol Aging (2010) 1.04

The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. J Alzheimers Dis (2012) 1.02

Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci. Ann Hum Genet (2013) 1.02

Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration. Neurobiol Aging (2009) 1.01

A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease. Hum Mol Genet (2012) 0.93

A novel A781V mutation in the CSF1R gene causes hereditary diffuse leucoencephalopathy with axonal spheroids. J Neurol Sci (2013) 0.91

Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2. BMC Neurol (2008) 0.91

Tau acts as an independent genetic risk factor in pathologically proven PD. Neurobiol Aging (2012) 0.86

NOTCH3 variants and risk of ischemic stroke. PLoS One (2013) 0.84

Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice. PLoS One (2012) 0.80

Genetic testing in familial and young-onset Alzheimer's disease: mutation spectrum in a Serbian cohort. Neurobiol Aging (2012) 0.78

Clusterin as an Alzheimer biomarker. Arch Neurol (2011) 0.77