Target selectivity in EF-hand calcium binding proteins.

Functions of S100 proteins. Curr Mol Med (2013) 2.43

Genetic polymorphism and protein conformational plasticity in the calmodulin superfamily: two ways to promote multifunctionality. Proc Natl Acad Sci U S A (2006) 1.54

Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J (2005) 1.53

The IQD gene family in soybean: structure, phylogeny, evolution and expression. PLoS One (2014) 1.45

Thermodynamic basis for the optimization of binding-induced biomolecular switches and structure-switching biosensors. Proc Natl Acad Sci U S A (2009) 1.40

Mouse ACF7 and drosophila short stop modulate filopodia formation and microtubule organisation during neuronal growth. J Cell Sci (2009) 1.28

S100A10/p11: family, friends and functions. Pflugers Arch (2007) 1.28

Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin. EMBO J (2005) 1.22

The NMDA receptor NR1 C1 region bound to calmodulin: structural insights into functional differences between homologous domains. Structure (2007) 1.13

The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies. J Mol Biol (2006) 1.06

Engineering biosensors with extended, narrowed, or arbitrarily edited dynamic range. J Am Chem Soc (2012) 1.04

Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognition. Biochemistry (2008) 1.04

Renal expression of parvalbumin is critical for NaCl handling and response to diuretics. Proc Natl Acad Sci U S A (2007) 1.03

Arabidopsis CAM7 and HY5 physically interact and directly bind to the HY5 promoter to regulate its expression and thereby promote photomorphogenesis. Plant Cell (2014) 1.01

Structure and dynamics of Ca2+-binding domain 1 of the Na+/Ca2+ exchanger in the presence and in the absence of Ca2+. J Mol Biol (2008) 1.00

Copper binding affinity of S100A13, a key component of the FGF-1 nonclassical copper-dependent release complex. Biophys J (2006) 0.99

Relating form and function of EF-hand calcium binding proteins. Acc Chem Res (2011) 0.99

Calcium/calmodulin inhibition of the Arabidopsis BRASSINOSTEROID-INSENSITIVE 1 receptor kinase provides a possible link between calcium and brassinosteroid signalling. Biochem J (2012) 0.98

The calmodulin-related calcium sensor CML42 plays a role in trichome branching. J Biol Chem (2009) 0.95

Nutritional Immunity: S100 Proteins at the Host-Pathogen Interface. J Biol Chem (2015) 0.95

Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chain. J Biol Chem (2008) 0.91

EF-hand protein dynamics and evolution of calcium signal transduction: an NMR view. J Biol Inorg Chem (2006) 0.90

S100P is a novel interaction partner and regulator of IQGAP1. J Biol Chem (2010) 0.89

Calcium- and magnesium-dependent interactions between calcium- and integrin-binding protein and the integrin alphaIIb cytoplasmic domain. Protein Sci (2005) 0.89

Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach. BMC Syst Biol (2008) 0.88

Annexin I and annexin II N-terminal peptides binding to S100 protein family members: specificity and thermodynamic characterization. Biochemistry (2009) 0.87

Anti-S100A4 antibody suppresses metastasis formation by blocking stroma cell invasion. Neoplasia (2012) 0.86

Enhancement of long-term memory retention and short-term synaptic plasticity in cbl-b null mice. Proc Natl Acad Sci U S A (2006) 0.86

Myocardial Hypertrophic Preconditioning Attenuates Cardiomyocyte Hypertrophy and Slows Progression to Heart Failure Through Upregulation of S100A8/A9. Circulation (2015) 0.86

Crystal structure of obelin after Ca2+-triggered bioluminescence suggests neutral coelenteramide as the primary excited state. Proc Natl Acad Sci U S A (2006) 0.86

S100 calcium binding proteins and ion channels. Front Pharmacol (2012) 0.86

Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently. J Biol Chem (2008) 0.85

Design of high-affinity S100-target hybrid proteins. Protein Sci (2009) 0.85

Stress signaling pathways for the pathogenicity of Cryptococcus. Eukaryot Cell (2013) 0.83

S100A13-lipid interactions-role in the non-classical release of the acidic fibroblast growth factor. Biochim Biophys Acta (2007) 0.83

Short Stat5-interacting peptide derived from phospholipase C-β3 inhibits hematopoietic cell proliferation and myeloid differentiation. PLoS One (2011) 0.82

Modulation of quaternary structure of S100 proteins by calcium ions. Biophys Chem (2010) 0.82

Why Calcium? How Calcium Became the Best Communicator. J Biol Chem (2016) 0.82

Electrostatic control of the overall shape of calmodulin: numerical calculations. Eur Biophys J (2007) 0.81

Gap junction regulation by calmodulin. FEBS Lett (2014) 0.80

Antithetical modes of and the Ca(2+) sensors targeting in ANF-RGC and ROS-GC1 membrane guanylate cyclases. Front Mol Neurosci (2012) 0.80

Exploring NMR ensembles of calcium binding proteins: perspectives to design inhibitors of protein-protein interactions. BMC Struct Biol (2011) 0.80

In vivo screening of S100B inhibitors for melanoma therapy. Methods Mol Biol (2013) 0.80

Structural insights into calcium-bound S100P and the V domain of the RAGE complex. PLoS One (2014) 0.80

Thermodynamics and molecular dynamics simulations of calcium binding to the regulatory site of human cardiac troponin C: evidence for communication with the structural calcium binding sites. J Biol Inorg Chem (2012) 0.80

S100A4 in Cancer Metastasis: Wnt Signaling-Driven Interventions for Metastasis Restriction. Cancers (Basel) (2016) 0.79

Cytosolic extensions directly regulate a rhomboid protease by modulating substrate gating. Nature (2015) 0.79

Microdomain calcium fluctuations as a colored noise process. Front Genet (2014) 0.78

Crystal Structure of Human Profilaggrin S100 Domain and Identification of Target Proteins Annexin II, Stratifin, and HSP27. J Invest Dermatol (2015) 0.77

The Neuronal Calcium Sensor protein Acrocalcin: a potential target of calmodulin regulation during development in the coral Acropora millepora. PLoS One (2012) 0.77

Genome-wide analysis of the IQD gene family in maize. Mol Genet Genomics (2015) 0.76

Ca2+ and Mg2+ modulate conformational dynamics and stability of downstream regulatory element antagonist modulator. Protein Sci (2015) 0.76

Binding of transition metals to S100 proteins. Sci China Life Sci (2016) 0.76

Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states. J Biol Inorg Chem (2009) 0.76

NMR studies of the interaction of calmodulin with IQ motif peptides. Methods Mol Biol (2013) 0.76

Calcium-dependent association of calmodulin with the rubella virus nonstructural protease domain. J Biol Chem (2010) 0.76

S100A1: A novel and essential molecular component for postischemic angiogenesis. Circ Res (2013) 0.75

Kinetic regulation of multi-ligand binding proteins. BMC Syst Biol (2016) 0.75

Structural and thermodynamic characterization of the recognition of the S100-binding peptides TRTK12 and p53 by calmodulin. Protein Sci (2014) 0.75

Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation. J Cell Sci (2016) 0.75

Blocking the Interactions between Calcium-Bound S100A12 Protein and the V Domain of RAGE Using Tranilast. PLoS One (2016) 0.75

Functional manipulation of a calcium-binding protein from Entamoeba histolytica guided by paramagnetic NMR. J Biol Chem (2013) 0.75

Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3. Biochim Biophys Acta (2017) 0.75

Soluble calcium-binding proteins (SCBPs) of the earthworm Lumbricus terrestris: molecular characterization and localization by FISH in muscle and neuronal tissue. Histochem Cell Biol (2016) 0.75

Metal chelation and inhibition of bacterial growth in tissue abscesses. Science (2008) 4.55

Calmodulin mutations associated with recurrent cardiac arrest in infants. Circulation (2013) 2.66

Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus. Cell Host Microbe (2011) 2.66

Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut. Cell Host Microbe (2012) 2.66

Structural insights into the U-box, a domain associated with multi-ubiquitination. Nat Struct Biol (2003) 2.26

The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling. Mol Cell Biol (2008) 2.17

Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases. Mol Cell (2012) 2.07

Function of a conserved checkpoint recruitment domain in ATRIP proteins. Mol Cell Biol (2007) 2.02

S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway. J Leukoc Biol (2008) 1.82

An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase. J Biol Chem (2007) 1.71

The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis. Arthritis Res Ther (2006) 1.67

Physical interaction between replication protein A and Rad51 promotes exchange on single-stranded DNA. J Biol Chem (2004) 1.65

Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens. Proc Natl Acad Sci U S A (2013) 1.64

Independent and coordinated functions of replication protein A tandem high affinity single-stranded DNA binding domains. J Biol Chem (2003) 1.59

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability. Nat Struct Mol Biol (2004) 1.59

Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain. J Biol Chem (2004) 1.52

The extracellular region of the receptor for advanced glycation end products is composed of two independent structural units. Biochemistry (2007) 1.51

Structural basis for ligand recognition and activation of RAGE. Structure (2010) 1.50

Insights into hRPA32 C-terminal domain--mediated assembly of the simian virus 40 replisome. Nat Struct Mol Biol (2005) 1.50

Identification of an Acinetobacter baumannii zinc acquisition system that facilitates resistance to calprotectin-mediated zinc sequestration. PLoS Pathog (2012) 1.47

Structural mechanisms of DNA replication, repair, and recombination. J Biol Chem (2004) 1.46

Calcium-modulated S100 protein-phospholipid interactions. An NMR study of calbindin D9k and DPC. Biochemistry (2005) 1.46

Structural and functional analysis of essential pre-mRNA splicing factor Prp19p. Mol Cell Biol (2005) 1.42

S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3. Cell Res (2009) 1.42

Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in Clostridium difficile toxin A. J Biol Chem (2009) 1.39

The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases. Biochemistry (2006) 1.38

Calcium-dependent regulation of the voltage-gated sodium channel hH1: intrinsic and extrinsic sensors use a common molecular switch. Proc Natl Acad Sci U S A (2006) 1.36

The glucose-6-phosphatase catalytic subunit gene promoter contains both positive and negative glucocorticoid response elements. Mol Endocrinol (2005) 1.34

Solution NMR structure of Apo-calmodulin in complex with the IQ motif of human cardiac sodium channel NaV1.5. J Mol Biol (2010) 1.32

Solution NMR structure of the C-terminal EF-hand domain of human cardiac sodium channel NaV1.5. J Biol Chem (2008) 1.32

Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase. Biochemistry (2003) 1.30

Novel calmodulin mutations associated with congenital arrhythmia susceptibility. Circ Cardiovasc Genet (2014) 1.27

Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Circ Res (2014) 1.27

Structural mechanism of RPA loading on DNA during activation of a simple pre-replication complex. EMBO J (2006) 1.25

S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis. Eur J Pharmacol (2009) 1.24

Functional Interactions between Distinct Sodium Channel Cytoplasmic Domains through the Action of Calmodulin. J Biol Chem (2009) 1.22

Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase. Proc Natl Acad Sci U S A (2010) 1.21

Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A. J Biol Chem (2009) 1.19

S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2. Biochim Biophys Acta (2007) 1.19

Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1. J Biol Chem (2010) 1.18

MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganese. Infect Immun (2013) 1.17

The EF-hand domain: a globally cooperative structural unit. Protein Sci (2002) 1.17

Structural basis for DNA binding by replication initiator Mcm10. Structure (2008) 1.14

A new structural framework for integrating replication protein A into DNA processing machinery. Nucleic Acids Res (2013) 1.12

In support of the BMRB. Nat Struct Mol Biol (2012) 1.09

Unique features in the C-terminal domain provide caltractin with target specificity. J Mol Biol (2003) 1.09

NMR analysis of the architecture and functional remodeling of a modular multidomain protein, RPA. J Am Chem Soc (2009) 1.08

Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling. J Exp Med (2012) 1.07

Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol (2013) 1.07

Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination. Biochemistry (2010) 1.06

Biochemical and structural domain analysis of xeroderma pigmentosum complementation group C protein. Biochemistry (2006) 1.05

Structural dynamics and single-stranded DNA binding activity of the three N-terminal domains of the large subunit of replication protein A from small angle X-ray scattering. Biochemistry (2010) 1.04

Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognition. Biochemistry (2008) 1.04

Implication of extracellular zinc exclusion by recombinant human calprotectin (MRP8 and MRP14) from target cells in its apoptosis-inducing activity. Mediators Inflamm (2002) 1.03

A high-throughput fluorescence polarization anisotropy assay for the 70N domain of replication protein A. Anal Biochem (2011) 1.03

Engineering and design of ligand-induced conformational change in proteins. Curr Opin Struct Biol (2002) 1.02

Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition. J Mol Biol (2005) 1.01

Structural and functional characterization of the monomeric U-box domain from E4B. Biochemistry (2010) 1.01

Calmodulin interacts with the V2 vasopressin receptor: elimination of binding to the C terminus also eliminates arginine vasopressin-stimulated elevation of intracellular calcium. J Biol Chem (2004) 1.00

Physical interactions between Mcm10, DNA, and DNA polymerase alpha. J Biol Chem (2009) 0.99

Chemical burn from topical apple cider vinegar. J Am Acad Dermatol (2012) 0.98

Discovery of a potent stapled helix peptide that binds to the 70N domain of replication protein A. J Med Chem (2014) 0.97

E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP. J Biol Chem (2011) 0.97

Structure of the N-terminal calcium sensor domain of centrin reveals the biochemical basis for domain-specific function. J Biol Chem (2005) 0.96

Regulation of S100A8/A9 (calprotectin) binding to tumor cells by zinc ion and its implication for apoptosis-inducing activity. Mediators Inflamm (2005) 0.96

The mode of action of centrin. Binding of Ca2+ and a peptide fragment of Kar1p to the C-terminal domain. J Biol Chem (2004) 0.95

Designing sequence to control protein function in an EF-hand protein. J Am Chem Soc (2004) 0.95

Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A. ACS Med Chem Lett (2013) 0.95

Evidence for differing roles for each lobe of the calmodulin-like domain in a calcium-dependent protein kinase. J Biol Chem (2004) 0.94

Engineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transfer. J Biol Chem (2009) 0.94

Activation of UbcH5c~Ub is the result of a shift in interdomain motions of the conjugate bound to U-box E3 ligase E4B. Biochemistry (2013) 0.94

Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS One (2013) 0.93

Structural independence of the two EF-hand domains of caltractin. J Biol Chem (2002) 0.93

Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach. J Med Chem (2013) 0.93

The modular structure of SIP facilitates its role in stabilizing multiprotein assemblies. Biochemistry (2005) 0.92

BID binds to replication protein A and stimulates ATR function following replicative stress. Mol Cell Biol (2011) 0.91

A structural basis for S100 protein specificity derived from comparative analysis of apo and Ca(2+)-calcyclin. J Mol Biol (2002) 0.91

Zinc piracy as a mechanism of Neisseria meningitidis for evasion of nutritional immunity. PLoS Pathog (2013) 0.91

Replication protein A stimulates the Werner syndrome protein branch migration activity. J Biol Chem (2009) 0.90

Solution NMR structure of the C-terminal DNA binding domain of Mcm10 reveals a conserved MCM motif. J Biol Chem (2010) 0.90

Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol (2015) 0.88

The Prp19 WD40 domain contains a conserved protein interaction region essential for its function. Structure (2010) 0.88

Xeroderma pigmentosum complementation group C protein (XPC) serves as a general sensor of damaged DNA. DNA Repair (Amst) (2013) 0.88

Human DNA helicase B (HDHB) binds to replication protein A and facilitates cellular recovery from replication stress. J Biol Chem (2011) 0.87

The biochemical effect of Ser167 phosphorylation on Chlamydomonas reinhardtii centrin. Biochem Biophys Res Commun (2006) 0.86

Dynamics of hydrogen-deuterium exchange in Chlamydomonas centrin. Biochemistry (2005) 0.86

S100 calcium binding proteins and ion channels. Front Pharmacol (2012) 0.86

Characterization of binding-induced changes in dynamics suggests a model for sequence-nonspecific binding of ssDNA by replication protein A. Protein Sci (2002) 0.86

NMR study on the interaction between RPA and DNA decamer containing cis-syn cyclobutane pyrimidine dimer in the presence of XPA: implication for damage verification and strand-specific dual incision in nucleotide excision repair. Nucleic Acids Res (2003) 0.85

Structure of a DNA polymerase alpha-primase domain that docks on the SV40 helicase and activates the viral primosome. J Biol Chem (2010) 0.85

Cutaneous Rosai-Dorfman disease of the right ear responsive to radiotherapy. J Am Acad Dermatol (2012) 0.85

Surface reengineering of RPA70N enables cocrystallization with an inhibitor of the replication protein A interaction motif of ATR interacting protein. Biochemistry (2013) 0.84

Redefining the DNA-binding domain of human XPA. J Am Chem Soc (2014) 0.83

Effects of calcium binding on the side-chain methyl dynamics of calbindin D9k: a 2H NMR relaxation study. J Mol Biol (2006) 0.83

Structural analysis of replication protein A recruitment of the DNA damage response protein SMARCAL1. Biochemistry (2014) 0.83

Calcium-driven changes in S100A11 structure revealed. Structure (2003) 0.81

Serum sickness-like reaction: histopathology and case report. J Am Acad Dermatol (2011) 0.81

1H, 13C and 15N assignments of single-stranded DNA binding domains from the 70 kDa subunit of human replication protein A. J Biomol NMR (2004) 0.81

Nascent structure in the kinase anchoring domain of microtubule-associated protein 2. Biochem Biophys Res Commun (2003) 0.79