Published in Biochemistry on March 02, 2010
Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development. Oncogene (2010) 1.21
The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity. Nat Med (2013) 1.20
Structural basis of protein phosphatase 2A stable latency. Nat Commun (2013) 1.03
The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation. J Biol Chem (2011) 1.02
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The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development. PLoS One (2014) 0.76
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Novel involvement of RhebL1 in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization: Binding to and activation of AKT1. Oncotarget (2017) 0.75
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Cardamonin Suppresses TGF-β1-Induced Epithelial Mesenchymal Transition via Restoring Protein Phosphatase 2A Expression. Biomol Ther (Seoul) (2015) 0.75
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Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4. Proc Natl Acad Sci U S A (2001) 1.13
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Metal chelation and inhibition of bacterial growth in tissue abscesses. Science (2008) 4.55
Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver. Proc Natl Acad Sci U S A (2003) 3.27
Calmodulin mutations associated with recurrent cardiac arrest in infants. Circulation (2013) 2.66
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Structural insights into the U-box, a domain associated with multi-ubiquitination. Nat Struct Biol (2003) 2.26
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Function of a conserved checkpoint recruitment domain in ATRIP proteins. Mol Cell Biol (2007) 2.02
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A superfamily of voltage-gated sodium channels in bacteria. J Biol Chem (2003) 1.84
S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway. J Leukoc Biol (2008) 1.82
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Target selectivity in EF-hand calcium binding proteins. Biochim Biophys Acta (2004) 1.72
An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase. J Biol Chem (2007) 1.71
The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis. Arthritis Res Ther (2006) 1.67
Physical interaction between replication protein A and Rad51 promotes exchange on single-stranded DNA. J Biol Chem (2004) 1.65
Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens. Proc Natl Acad Sci U S A (2013) 1.64
Independent and coordinated functions of replication protein A tandem high affinity single-stranded DNA binding domains. J Biol Chem (2003) 1.59
An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability. Nat Struct Mol Biol (2004) 1.59
Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt. J Biol Chem (2005) 1.53
Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain. J Biol Chem (2004) 1.52
The extracellular region of the receptor for advanced glycation end products is composed of two independent structural units. Biochemistry (2007) 1.51
Structural basis for ligand recognition and activation of RAGE. Structure (2010) 1.50
Insights into hRPA32 C-terminal domain--mediated assembly of the simian virus 40 replisome. Nat Struct Mol Biol (2005) 1.50
Identification of an Acinetobacter baumannii zinc acquisition system that facilitates resistance to calprotectin-mediated zinc sequestration. PLoS Pathog (2012) 1.47
Calcium-modulated S100 protein-phospholipid interactions. An NMR study of calbindin D9k and DPC. Biochemistry (2005) 1.46
Structural mechanisms of DNA replication, repair, and recombination. J Biol Chem (2004) 1.46
Structural and functional analysis of essential pre-mRNA splicing factor Prp19p. Mol Cell Biol (2005) 1.42
S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3. Cell Res (2009) 1.42
Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in Clostridium difficile toxin A. J Biol Chem (2009) 1.39
The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases. Biochemistry (2006) 1.38
Calcium-dependent regulation of the voltage-gated sodium channel hH1: intrinsic and extrinsic sensors use a common molecular switch. Proc Natl Acad Sci U S A (2006) 1.36
The glucose-6-phosphatase catalytic subunit gene promoter contains both positive and negative glucocorticoid response elements. Mol Endocrinol (2005) 1.34
Solution NMR structure of Apo-calmodulin in complex with the IQ motif of human cardiac sodium channel NaV1.5. J Mol Biol (2010) 1.32
Solution NMR structure of the C-terminal EF-hand domain of human cardiac sodium channel NaV1.5. J Biol Chem (2008) 1.32
Crystal structure of arrestin-3 reveals the basis of the difference in receptor binding between two non-visual subtypes. J Mol Biol (2011) 1.31
Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase. Biochemistry (2003) 1.30
Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes. J Biol Chem (2005) 1.29
Novel calmodulin mutations associated with congenital arrhythmia susceptibility. Circ Cardiovasc Genet (2014) 1.27
Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Circ Res (2014) 1.27
A developmentally regulated, neuron-specific splice variant of the variable subunit Bbeta targets protein phosphatase 2A to mitochondria and modulates apoptosis. J Biol Chem (2003) 1.26
Targeting protein serine/threonine phosphatases for drug development. Mol Pharmacol (2009) 1.25
Structural mechanism of RPA loading on DNA during activation of a simple pre-replication complex. EMBO J (2006) 1.25
S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis. Eur J Pharmacol (2009) 1.24
Functional Interactions between Distinct Sodium Channel Cytoplasmic Domains through the Action of Calmodulin. J Biol Chem (2009) 1.22
Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase. Proc Natl Acad Sci U S A (2010) 1.21
Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A. J Biol Chem (2009) 1.19
S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2. Biochim Biophys Acta (2007) 1.19
Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1. J Biol Chem (2010) 1.18
MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganese. Infect Immun (2013) 1.17
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Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A. J Biol Chem (2005) 1.13
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In support of the BMRB. Nat Struct Mol Biol (2012) 1.09
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Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling. J Exp Med (2012) 1.07
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Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers. Elife (2014) 1.06
Biochemical and structural domain analysis of xeroderma pigmentosum complementation group C protein. Biochemistry (2006) 1.05
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Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognition. Biochemistry (2008) 1.04
Implication of extracellular zinc exclusion by recombinant human calprotectin (MRP8 and MRP14) from target cells in its apoptosis-inducing activity. Mediators Inflamm (2002) 1.03
A high-throughput fluorescence polarization anisotropy assay for the 70N domain of replication protein A. Anal Biochem (2011) 1.03
Structural basis of protein phosphatase 2A stable latency. Nat Commun (2013) 1.03
The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation. J Biol Chem (2011) 1.02
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Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation. J Biol Chem (2006) 1.02
Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition. J Mol Biol (2005) 1.01
Structural and functional characterization of the monomeric U-box domain from E4B. Biochemistry (2010) 1.01
Calmodulin interacts with the V2 vasopressin receptor: elimination of binding to the C terminus also eliminates arginine vasopressin-stimulated elevation of intracellular calcium. J Biol Chem (2004) 1.00
Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex. J Biol Chem (2004) 1.00
Physical interactions between Mcm10, DNA, and DNA polymerase alpha. J Biol Chem (2009) 0.99
Human rotavirus VP6-specific antibodies mediate intracellular neutralization by binding to a quaternary structure in the transcriptional pore. PLoS One (2013) 0.98
Discovery of a potent stapled helix peptide that binds to the 70N domain of replication protein A. J Med Chem (2014) 0.97
E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP. J Biol Chem (2011) 0.97
Inhibition of protein phosphatase 2A activity by selective electrophile alkylation damage. Biochemistry (2006) 0.97
Structure of the N-terminal calcium sensor domain of centrin reveals the biochemical basis for domain-specific function. J Biol Chem (2005) 0.96
Structural and functional studies indicate that Shigella VirA is not a protease and does not directly destabilize microtubules. Biochemistry (2008) 0.96
Regulation of S100A8/A9 (calprotectin) binding to tumor cells by zinc ion and its implication for apoptosis-inducing activity. Mediators Inflamm (2005) 0.96
The mode of action of centrin. Binding of Ca2+ and a peptide fragment of Kar1p to the C-terminal domain. J Biol Chem (2004) 0.95
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Designing sequence to control protein function in an EF-hand protein. J Am Chem Soc (2004) 0.95
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A novel in vitro assay for deubiquitination of I kappa B alpha. Arch Biochem Biophys (2002) 0.94
Engineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transfer. J Biol Chem (2009) 0.94