Published in Cell on December 17, 2004
GammaH2AX and cancer. Nat Rev Cancer (2008) 9.77
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell (2008) 7.63
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev (2011) 5.60
ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Cell Res (2011) 4.91
Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res (2008) 4.79
Identification of multiple distinct Snf2 subfamilies with conserved structural motifs. Nucleic Acids Res (2006) 4.64
Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair. Cell (2008) 4.14
Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae. Nature (2005) 4.08
Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. J Cell Biol (2005) 3.69
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. J Cell Biol (2006) 3.63
The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat Rev Mol Cell Biol (2009) 3.50
DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol Cell Biol (2007) 3.03
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature (2008) 2.86
The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks. Cell Cycle (2010) 2.84
Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals. J Cell Biol (2007) 2.55
Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island. PLoS Genet (2008) 2.55
Recruitment of DNA methyltransferase I to DNA repair sites. Proc Natl Acad Sci U S A (2005) 2.50
Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9. Mol Cell Biol (2005) 2.48
Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair. Genes Dev (2005) 2.47
Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction. EMBO J (2006) 2.39
Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks. Genes Dev (2006) 2.27
Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks. EMBO J (2007) 2.23
Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair. Mol Cell Biol (2005) 2.23
Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes. Nat Rev Mol Cell Biol (2009) 2.23
Rad54: the Swiss Army knife of homologous recombination? Nucleic Acids Res (2006) 2.09
BRIT1/MCPH1 links chromatin remodelling to DNA damage response. Nat Cell Biol (2009) 2.06
The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage. J Cell Biol (2010) 2.06
Interplay between Ino80 and Swr1 chromatin remodeling enzymes regulates cell cycle checkpoint adaptation in response to DNA damage. Genes Dev (2006) 2.05
MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair. Mol Cell Biol (2010) 2.03
RSC mobilizes nucleosomes to improve accessibility of repair machinery to the damaged chromatin. Mol Cell Biol (2006) 1.94
Mechanisms of ATP dependent chromatin remodeling. Mutat Res (2007) 1.94
Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres. EMBO J (2008) 1.89
A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair. EMBO J (2010) 1.86
Epigenetic regulation of heterochromatic DNA stability. Curr Opin Genet Dev (2008) 1.80
The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair. J Cell Biol (2010) 1.80
ATP-dependent chromatin remodeling factors and DNA damage repair. Mutat Res (2007) 1.78
The yeast chromatin remodeler RSC complex facilitates end joining repair of DNA double-strand breaks. Mol Cell Biol (2005) 1.76
Chromatin and the genome integrity network. Nat Rev Genet (2013) 1.72
Heterochromatic genome stability requires regulators of histone H3 K9 methylation. PLoS Genet (2009) 1.69
A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. Nat Struct Mol Biol (2007) 1.68
Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage. Mol Cell Biol (2008) 1.66
Chromatin remodeling finds its place in the DNA double-strand break response. Nucleic Acids Res (2009) 1.66
Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast. EMBO Rep (2007) 1.66
RVB1/RVB2: running rings around molecular biology. Mol Cell (2009) 1.62
Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling. Trends Mol Med (2007) 1.59
Focus on histone variant H2AX: to be or not to be. FEBS Lett (2010) 1.56
An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans. Nucleic Acids Res (2007) 1.56
The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends. Nature (2012) 1.54
DNA-damage response and repair activities at uncapped telomeres depend on RNF8. Nat Cell Biol (2011) 1.49
Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer. Nat Rev Cancer (2012) 1.45
Arabidopsis SNI1 and RAD51D regulate both gene transcription and DNA recombination during the defense response. Proc Natl Acad Sci U S A (2007) 1.43
Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants. Mol Cell Biol (2008) 1.39
The INO80 ATP-dependent chromatin remodeling complex is a nucleosome spacing factor. Mol Cell Biol (2010) 1.39
Increased frequency of homologous recombination and T-DNA integration in Arabidopsis CAF-1 mutants. EMBO J (2006) 1.39
Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response. Cancer Res (2010) 1.34
Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling. Proc Natl Acad Sci U S A (2006) 1.32
Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex. Mol Cell Biol (2006) 1.30
INO80 subfamily of chromatin remodeling complexes. Mutat Res (2007) 1.29
Inositol polyphosphates: a new frontier for regulating gene expression. Chromosoma (2007) 1.29
The chromatin assembly factor subunit FASCIATA1 is involved in homologous recombination in plants. Plant Cell (2006) 1.28
Structural biochemistry of nuclear actin-related proteins 4 and 8 reveals their interaction with actin. EMBO J (2011) 1.28
Sequence and comparative genomic analysis of actin-related proteins. Mol Biol Cell (2005) 1.28
Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiae. Genetics (2014) 1.27
Modulation of nucleotide excision repair by mammalian SWI/SNF chromatin-remodeling complex. J Biol Chem (2009) 1.25
Involvement of a chromatin remodeling complex in damage tolerance during DNA replication. Nat Struct Mol Biol (2009) 1.24
The miR-99 family regulates the DNA damage response through its target SNF2H. Oncogene (2012) 1.24
Genome-wide association data reveal a global map of genetic interactions among protein complexes. PLoS Genet (2009) 1.23
Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. Genes Dev (2008) 1.23
A peek into the complex realm of histone phosphorylation. Mol Cell Biol (2011) 1.22
Perspectives on the DNA damage and replication checkpoint responses in Saccharomyces cerevisiae. DNA Repair (Amst) (2009) 1.22
The SWR1 histone replacement complex causes genetic instability and genome-wide transcription misregulation in the absence of H2A.Z. PLoS One (2010) 1.22
INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway. Proc Natl Acad Sci U S A (2010) 1.21
ATM-mediated transcriptional and developmental responses to gamma-rays in Arabidopsis. PLoS One (2007) 1.20
CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription. Mol Cell Biol (2007) 1.20
Methylated H3K4, a transcription-associated histone modification, is involved in the DNA damage response pathway. PLoS Genet (2010) 1.19
Regulation of nuclear positioning and dynamics of the silent mating type loci by the yeast Ku70/Ku80 complex. Mol Cell Biol (2008) 1.19
RSC functions as an early double-strand-break sensor in the cell's response to DNA damage. Curr Biol (2007) 1.19
Epigenetic modifications in double-strand break DNA damage signaling and repair. Clin Cancer Res (2010) 1.18
Chromatin structure and DNA damage repair. Epigenetics Chromatin (2008) 1.16
The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks. J Cell Biol (2012) 1.15
Histone phosphorylation: a chromatin modification involved in diverse nuclear events. Epigenetics (2012) 1.14
Role of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesis. Oncogene (2009) 1.14
Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast. Mol Cell Biol (2005) 1.13
Distinct chromatin modulators regulate the formation of accessible and repressive chromatin at the fission yeast recombination hotspot ade6-M26. Mol Biol Cell (2008) 1.12
Chromatin structure regulates gene conversion. PLoS Biol (2007) 1.12
ATP-dependent chromatin remodeling in the DNA-damage response. Epigenetics Chromatin (2012) 1.12
Checkpoint kinases and the INO80 nucleosome remodeling complex enhance global chromatin mobility in response to DNA damage. Genes Dev (2013) 1.12
Mammalian Ino80 mediates double-strand break repair through its role in DNA end strand resection. Mol Cell Biol (2011) 1.10
Proteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair. PLoS Genet (2010) 1.10
Cooperation between the INO80 complex and histone chaperones determines adaptation of stress gene transcription in the yeast Saccharomyces cerevisiae. Mol Cell Biol (2009) 1.09
DNA repair choice defines a common pathway for recruitment of chromatin regulators. Nat Commun (2013) 1.08
Retracted Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF). Proc Natl Acad Sci U S A (2009) 1.06
The Dot1 histone methyltransferase and the Rad9 checkpoint adaptor contribute to cohesin-dependent double-strand break repair by sister chromatid recombination in Saccharomyces cerevisiae. Genetics (2009) 1.06
Oxidative stress triggers the preferential assembly of base excision repair complexes on open chromatin regions. Nucleic Acids Res (2010) 1.06
Chromatin dynamics during repair of chromosomal DNA double-strand breaks. Epigenomics (2009) 1.05
The ageing epigenome: damaged beyond repair? Ageing Res Rev (2009) 1.05
Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex. Mol Cell Biol (2007) 1.05
Deregulation of DNA damage signal transduction by herpesvirus latency-associated M2. J Virol (2006) 1.04
DNA damage response. Cold Spring Harb Perspect Biol (2011) 1.03
Reading, writing, and repair: the role of ubiquitin and the ubiquitin-like proteins in DNA damage signaling and repair. Front Genet (2013) 1.02
Crosstalk between histone modifications during the DNA damage response. Trends Cell Biol (2009) 4.31
The nuclear envelope and transcriptional control. Nat Rev Genet (2007) 3.81
Transgeneration memory of stress in plants. Nature (2006) 3.67
Automatic tracking of individual fluorescence particles: application to the study of chromosome dynamics. IEEE Trans Image Process (2005) 3.64
Gene regulation through nuclear organization. Nat Struct Mol Biol (2007) 3.44
Nuclear pore association confers optimal expression levels for an inducible yeast gene. Nature (2006) 3.39
DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1. EMBO J (2003) 3.15
Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase. Science (2008) 3.09
Long-range compaction and flexibility of interphase chromatin in budding yeast analyzed by high-resolution imaging techniques. Proc Natl Acad Sci U S A (2004) 2.99
The histone code at DNA breaks: a guide to repair? Nat Rev Mol Cell Biol (2005) 2.97
Live imaging of telomeres: yKu and Sir proteins define redundant telomere-anchoring pathways in yeast. Curr Biol (2002) 2.92
Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery. Cell (2012) 2.67
Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins. EMBO J (2004) 2.47
ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase. Genes Dev (2002) 2.40
Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks. EMBO J (2007) 2.23
Heterochromatin protein 1: don't judge the book by its cover! Curr Opin Genet Dev (2006) 2.20
Descendants of primed Arabidopsis plants exhibit resistance to biotic stress. Plant Physiol (2011) 2.18
Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations. Genes Dev (2005) 2.17
Chromosome looping in yeast: telomere pairing and coordinated movement reflect anchoring efficiency and territorial organization. J Cell Biol (2005) 2.16
The function of nuclear architecture: a genetic approach. Annu Rev Genet (2004) 2.06
Sir-mediated repression can occur independently of chromosomal and subnuclear contexts. Cell (2004) 2.04
The spatial dynamics of tissue-specific promoters during C. elegans development. Genes Dev (2010) 2.00
Top 10 plant viruses in molecular plant pathology. Mol Plant Pathol (2011) 1.96
Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance. EMBO J (2004) 1.94
RecQ helicases: multiple roles in genome maintenance. Trends Cell Biol (2003) 1.91
Ino80 chromatin remodeling complex promotes recovery of stalled replication forks. Curr Biol (2008) 1.89
Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery. Nat Cell Biol (2012) 1.86
Pathogen stress increases somatic recombination frequency in Arabidopsis. Nat Genet (2002) 1.79
Pathogen-induced systemic plant signal triggers DNA rearrangements. Nature (2003) 1.77
The nuclear envelope--a scaffold for silencing? Curr Opin Genet Dev (2009) 1.65
ATR/Mec1: coordinating fork stability and repair. Curr Opin Cell Biol (2009) 1.64
Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro. Mol Cell (2009) 1.61
Yeast telomerase and the SUN domain protein Mps3 anchor telomeres and repress subtelomeric recombination. Genes Dev (2009) 1.59
Chromatin movement in the maintenance of genome stability. Cell (2013) 1.59
The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersion. Genome Res (2009) 1.56
An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing. Proc Natl Acad Sci U S A (2002) 1.55
Temporal separation of replication and recombination requires the intra-S checkpoint. J Cell Biol (2005) 1.54
Controlled exchange of chromosomal arms reveals principles driving telomere interactions in yeast. Genome Res (2007) 1.48
The origin recognition complex functions in sister-chromatid cohesion in Saccharomyces cerevisiae. Cell (2007) 1.47
An EDMD mutation in C. elegans lamin blocks muscle-specific gene relocation and compromises muscle integrity. Curr Biol (2011) 1.43
The budding yeast nucleus. Cold Spring Harb Perspect Biol (2010) 1.43
The INO80 protein controls homologous recombination in Arabidopsis thaliana. Mol Cell (2004) 1.41
Increased frequency of homologous recombination and T-DNA integration in Arabidopsis CAF-1 mutants. EMBO J (2006) 1.39
The dual nature of homologous recombination in plants. Trends Genet (2005) 1.37
Structure and function in the budding yeast nucleus. Genetics (2012) 1.37
Silent chromatin at the middle and ends: lessons from yeasts. EMBO J (2009) 1.36
Targeted INO80 enhances subnuclear chromatin movement and ectopic homologous recombination. Genes Dev (2012) 1.36
Myosin-like proteins 1 and 2 are not required for silencing or telomere anchoring, but act in the Tel1 pathway of telomere length control. J Struct Biol (2002) 1.34
Intracellular trafficking of yeast telomerase components. EMBO Rep (2002) 1.34
Identification of Arabidopsis rat mutants. Plant Physiol (2003) 1.32
Replication foci dynamics: replication patterns are modulated by S-phase checkpoint kinases in fission yeast. EMBO J (2007) 1.30
The processing of double-strand breaks and binding of single-strand-binding proteins RPA and Rad51 modulate the formation of ATR-kinase foci in yeast. J Cell Sci (2007) 1.28
ATP-dependent chromatin remodeling and DNA double-strand break repair. Cell Cycle (2005) 1.27
Interchromatid and interhomolog recombination in Arabidopsis thaliana. Plant Cell (2004) 1.26
Locking the genome: nuclear organization and cell fate. Curr Opin Genet Dev (2011) 1.22
Methods for visualizing chromatin dynamics in living yeast. Methods Enzymol (2004) 1.20
Nucleosome remodelers in double-strand break repair. Curr Opin Genet Dev (2013) 1.20
Regulation of nuclear positioning and dynamics of the silent mating type loci by the yeast Ku70/Ku80 complex. Mol Cell Biol (2008) 1.19
Actin-related proteins in the nucleus: life beyond chromatin remodelers. Curr Opin Cell Biol (2010) 1.18
Visualizing yeast chromosomes and nuclear architecture. Methods Enzymol (2010) 1.18
RecQ helicases: at the heart of genetic stability. FEBS Lett (2002) 1.17
CENTRIN2 modulates homologous recombination and nucleotide excision repair in Arabidopsis. Plant Cell (2004) 1.17
The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast. Nat Cell Biol (2011) 1.17
Nuclear organization and silencing: putting things in their place. Nat Cell Biol (2002) 1.14
Nuclear geometry and rapid mitosis ensure asymmetric episome segregation in yeast. Curr Biol (2010) 1.13
Promoter- and RNA polymerase II-dependent hsp-16 gene association with nuclear pores in Caenorhabditis elegans. J Cell Biol (2013) 1.13
Nuclear organization in genome stability: SUMO connections. Cell Res (2011) 1.13
Mechanisms of heterochromatin subnuclear localization. Trends Biochem Sci (2013) 1.12
Checkpoint kinases and the INO80 nucleosome remodeling complex enhance global chromatin mobility in response to DNA damage. Genes Dev (2013) 1.12
Modules for cloning-free chromatin tagging in Saccharomyces cerevisae. Yeast (2008) 1.12
TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks. Mol Cell (2013) 1.07
Multiple pathways tether telomeres and silent chromatin at the nuclear periphery: functional implications for sir-mediated repression. Novartis Found Symp (2005) 1.06
Multiple pathways for telomere tethering: functional implications of subnuclear position for heterochromatin formation. Biochim Biophys Acta (2004) 1.05
Dynamic response of plant genome to ultraviolet radiation and other genotoxic stresses. Mutat Res (2005) 1.04
A homotrimer-heterotrimer switch in Sir2 structure differentiates rDNA and telomeric silencing. Mol Cell (2006) 1.03
In and out of the replication factory. Cell (2006) 1.03
Isolation and characterization of the RAD54 gene from Arabidopsis thaliana. Plant J (2006) 1.01
SIR proteins and the assembly of silent chromatin in budding yeast. Annu Rev Genet (2013) 1.00
Subtelomeric factors antagonize telomere anchoring and Tel1-independent telomere length regulation. EMBO J (2006) 1.00
A dual role of H4K16 acetylation in the establishment of yeast silent chromatin. EMBO J (2011) 1.00
Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres. EMBO J (2011) 0.99
An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks. EMBO J (2012) 0.99
Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79. Genes Dev (2011) 0.98
Redundancy, insult-specific sensors and thresholds: unlocking the S-phase checkpoint response. Curr Opin Genet Dev (2004) 0.96
Actin-related protein Arp6 influences H2A.Z-dependent and -independent gene expression and links ribosomal protein genes to nuclear pores. PLoS Genet (2010) 0.94
Transcriptome profiling reveals similarities and differences in plant responses to cadmium and lead. Mutat Res (2005) 0.94
CENTRIN2 interacts with the Arabidopsis homolog of the human XPC protein (AtRAD4) and contributes to efficient synthesis-dependent repair of bulky DNA lesions. Plant Mol Biol (2006) 0.94
The VirE2 protein of Agrobacterium tumefaciens: the Yin and Yang of T-DNA transfer. FEMS Microbiol Lett (2003) 0.94
Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms. Epigenetics Chromatin (2011) 0.91
Cell cycle-dependent phosphorylation of Rad53 kinase by Cdc5 and Cdc28 modulates checkpoint adaptation. Cell Cycle (2010) 0.90
Epigenetics in Saccharomyces cerevisiae. Cold Spring Harb Perspect Biol (2013) 0.90
Replication stress leads to genome instabilities in Arabidopsis DNA polymerase delta mutants. Plant Cell (2009) 0.89
Early initiation of a replication origin tethered at the nuclear periphery. J Cell Sci (2010) 0.89
Tn5 transposase-mediated mouse transgenesis. Biol Reprod (2005) 0.88
Extremely complex pattern of microsatellite mutation in the germline of wheat exposed to the post-Chernobyl radioactive contamination. Mutat Res (2003) 0.88
RecQ helicases and genome stability: lessons from model organisms and human disease. Swiss Med Wkly (2002) 0.87