Published in Proc Natl Acad Sci U S A on January 03, 2005
Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity. PLoS One (2016) 1.40
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties. Immunobiology (2012) 1.39
Rationally designed peptide regulators of protein kinase C. Trends Endocrinol Metab (2008) 1.17
Strategic approaches to optimizing peptide ADME properties. AAPS J (2014) 1.14
Bacillus anthracis peptidoglycan stimulates an inflammatory response in monocytes through the p38 mitogen-activated protein kinase pathway. PLoS One (2008) 1.07
Metabolism of peptide reporters in cell lysates and single cells. Analyst (2012) 1.00
Basics and recent advances in peptide and protein drug delivery. Ther Deliv (2013) 0.98
Effects of cyclic lipodepsipeptide structural modulation on stability, antibacterial activity, and human cell toxicity. ChemMedChem (2012) 0.98
Introducing D-amino acid or simple glycoside into small peptides to enable supramolecular hydrogelators to resist proteolysis. Langmuir (2012) 0.97
Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model flies. PLoS One (2010) 0.93
De-novo design of antimicrobial peptides for plant protection. PLoS One (2013) 0.91
Improved tumor targeting of anti-HER2 nanobody through N-succinimidyl 4-guanidinomethyl-3-iodobenzoate radiolabeling. J Nucl Med (2014) 0.91
D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy. ACS Med Chem Lett (2012) 0.86
Initiating translation with D-amino acids. RNA (2008) 0.84
Post-translational Introduction of d-Alanine into Ribosomally Synthesized Peptides by the Dehydroalanine Reductase NpnJ. J Am Chem Soc (2015) 0.82
Structure-activity relationships of peptidomimetics that inhibit PPI of HER2-HER3. Biopolymers (2014) 0.82
Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J Biol Chem (2013) 0.81
Engineering the meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum by site saturation mutagenesis for D-phenylalanine synthesis. Appl Environ Microbiol (2013) 0.81
Peptide Backbone Composition and Protease Susceptibility: Impact of Modification Type, Position, and Tandem Substitution. Chembiochem (2015) 0.78
Novel Peptidomimetics for Inhibition of HER2:HER3 Heterodimerization in HER2-Positive Breast Cancer. Chem Biol Drug Des (2014) 0.78
Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3. Mar Drugs (2012) 0.77
Revised Backbone-Virtual-Bond-Angle Potentials to Treat the l- and d-Amino Acid Residues in the Coarse-Grained United Residue (UNRES) Force Field. J Chem Theory Comput (2014) 0.76
Microvascular NADPH oxidase in health and disease. Free Radic Biol Med (2017) 0.75
Development of a protease-resistant reporter to quantify BCR-ABL activity in intact cells. Analyst (2016) 0.75
Constrained Cyclic Peptides as Immunomodulatory Inhibitors of the CD2:CD58 Protein-Protein Interaction. ACS Chem Biol (2016) 0.75
l-Tyrosine Confers Residualizing Properties to a d-Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies. Mol Imaging (2016) 0.75
Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors. Curr Pharm Des (2015) 0.75
Inspiration from the mirror: D-amino acid containing peptides in biomedical approaches. Biomol Concepts (2016) 0.75
Inhibition of cell adhesion and immune responses in the mouse model of collagen-induced arthritis with a peptidomimetic that blocks CD2-CD58 interface interactions. Biopolymers (2015) 0.75
The Unexpected Advantages of Using D-Amino Acids for Peptide Self- Assembly into Nanostructured Hydrogels for Medicine. Curr Top Med Chem (2016) 0.75
Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes. Chem Rev (2017) 0.75
Multilayered Nanoparticles for Gene Delivery Used to Reprogram Human Foreskin Fibroblasts to Neurospheres. Tissue Eng Part C Methods (2015) 0.75
D-Amino Acid Substitution of Peptide-Mediated NF-κB Suppression in mdx Mice Preserves Therapeutic Benefit in Skeletal Muscle, but Causes Kidney Toxicity. Mol Med (2015) 0.75
Designer D-form self-assembling peptide scaffolds promote the proliferation and migration of rat bone marrow-derived mesenchymal stem cells. Int J Mol Med (2017) 0.75
Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides. Anal Biochem (1970) 8.87
Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem (1993) 2.93
Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism. J Biol Chem (1989) 2.57
p-alkoxybenzyl alcohol resin and p-alkoxybenzyloxycarbonylhydrazide resin for solid phase synthesis of protected peptide fragments. J Am Chem Soc (1973) 1.87
Intralysosomal iron: a major determinant of oxidant-induced cell death. Free Radic Biol Med (2003) 1.33
Antimicrobial activity and stability to proteolysis of small linear cationic peptides with D-amino acid substitutions. Microbiol Immunol (2002) 1.24
Antigenic mimicry of natural L-peptides with retro-inverso-peptidomimetics. Proc Natl Acad Sci U S A (1994) 1.17
Elevated lysosomal pH in Mucolipidosis type IV cells. Clin Chim Acta (1999) 1.16
Chemical and immunological differences between normal and tumoral colonic mucoprotein antigen. Nature (1975) 1.12
D-peptides as immunogens and diagnostic reagents. Curr Opin Biotechnol (1998) 1.11
A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate: in vitro and in vivo studies. Proc Natl Acad Sci U S A (1982) 1.01
A comparison of the immunogenicity of a pair of enantiomeric proteins. Proteins (1993) 1.01
Immune recognition of human colonic-tumour-associated MUC-2 mucins using an anti-peptide antibody. Int J Cancer (1993) 0.93
Different roles of D-amino acids in immune phenomena. FASEB J (1997) 0.93
Nociceptin/orphanin FQ metabolism and bioactive metabolites. Peptides (2000) 0.93
A retro-inverso peptide corresponding to the GH loop of foot-and-mouth disease virus elicits high levels of long-lasting protective neutralizing antibodies. Proc Natl Acad Sci U S A (1997) 0.91
Endomorphin-1 analogues containing beta-proline are mu-opioid receptor agonists and display enhanced enzymatic hydrolysis resistance. J Med Chem (2002) 0.88
Stoichiometry of the human lysosomal carboxypeptidase-beta-galactosidase complex. Biochem Biophys Res Commun (1993) 0.88
Dynamic measurements of the acute and chronic effects of lysosomotropic agents on hepatocyte lysosomal pH using flow cytometry. Hepatology (1995) 0.88
Kinetic analysis of synthetic analogues of linear-epitope peptides of glycoprotein D of herpes simplex virus type 1 by surface plasmon resonance. Eur J Biochem (1996) 0.85
Determinants for the drug release from T-0128, camptothecin analogue-carboxymethyl dextran conjugate. J Control Release (2000) 0.84
Stepwise transformation of a cholera toxin and a p24 (HIV-1) epitope into D-peptide analogs. Protein Eng (1998) 0.84
Liquid chromatographic study of the enzymatic degradation of endomorphins, with identification by electrospray ionization mass spectrometry. J Chromatogr A (1999) 0.83
Manipulation of epitope function by modification of peptide structure: a minireview. Biologicals (2002) 0.81
Effect of D-amino acid substitution in a mucin 2 epitope on mucin-specific monoclonal antibody recognition. Arch Biochem Biophys (2000) 0.80
In vitro stability of some reduced peptide bond pseudopeptide analogues of dynorphin A. Peptides (1995) 0.80
Production of monoclonal antibodies recognising the peptide core of MUC2 intestinal mucin. Eur J Cancer (1994) 0.79
Effect of solution conformation on antibody recognition of a protein core epitope from gastrointestinal mucin (MUC2). Arch Biochem Biophys (1999) 0.79
Inhibitors of metalloendopeptidase EC 3.4.24.15 and EC 3.4.24.16 stabilized against proteolysis by the incorporation of beta-amino acids. Biochemistry (2002) 0.79
A retro-inverso peptide analogue of influenza virus hemagglutinin B-cell epitope 91-108 induces a strong mucosal and systemic immune response and confers protection in mice after intranasal immunization. Mol Immunol (2002) 0.79
BR96 conjugates of highly potent anthracyclines. Bioorg Med Chem Lett (2003) 0.78
Localisation of a protein core-specific epitope from gastrointestinal mucin (MUC2). The effect of epitope immobilisation on antibody recognition. J Pept Sci (1998) 0.78
Aluminum inhibits the lysosomal proton pump from rat liver. Life Sci (2000) 0.78
Identification and solution conformation of multiple epitopes recognized by a MUC2 mucin-specific monoclonal antibody. Arch Biochem Biophys (2003) 0.78
On the sequential determinants of calpain cleavage. J Biol Chem (2004) 2.13
Bismuth-213 radioimmunotherapy with C595 anti-MUC1 monoclonal antibody in an ovarian cancer ascites model. Cancer Biol Ther (2007) 1.85
Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies. Neurobiol Dis (2004) 1.04
Differential recognition of altered peptide ligands distinguishes two functionally discordant (arthritogenic and nonarthritogenic) autoreactive T cell hybridoma clones. J Immunol (2003) 0.95
Isomer-dependent daunomycin release and in vitro antitumour effect of cis-aconityl-daunomycin. Biochem Biophys Res Commun (2003) 0.94
Cleavage site analysis of a serralysin-like protease, PrtA, from an insect pathogen Photorhabdus luminescens and development of a highly sensitive and specific substrate. FEBS J (2007) 0.91
Design and synthesis of mono- and multimeric targeted radiopharmaceuticals based on novel cyclen ligands coupled to anti-MUC1 aptamers for the diagnostic imaging and targeted radiotherapy of cancer. Bioconjug Chem (2007) 0.90
Synthesis, structure, and in vitro antitumor activity of some glycoside derivatives of ferrocenyl-chalcones and ferrocenyl-pyrazolines. ChemMedChem (2006) 0.90
Comparative analysis of linear antibody epitopes on human and mycobacterial 60-kDa heat shock proteins using samples of healthy blood donors. Int Immunol (2003) 0.89
Recognition of new citrulline-containing peptide epitopes by autoantibodies produced in vivo and in vitro by B cells of rheumatoid arthritis patients. Immunology (2014) 0.89
The effect of cyclization on the enzymatic degradation of herpes simplex virus glycoprotein D derived epitope peptide. J Pept Sci (2005) 0.88
In vitro degradation and antitumor activity of oxime bond-linked daunorubicin-GnRH-III bioconjugates and DNA-binding properties of daunorubicin-amino acid metabolites. Amino Acids (2010) 0.87
Global shortage of medical isotopes threatens nuclear medicine services. BMJ (2008) 0.85
Novel anti-cholesterol monoclonal immunoglobulin G antibodies as probes and potential modulators of membrane raft-dependent immune functions. J Lipid Res (2006) 0.85
The ubiquitin-proteasome system in Creutzfeldt-Jakob and Alzheimer disease: intracellular redistribution of components correlates with neuronal vulnerability. Neurobiol Dis (2005) 0.84
The antigen specificity of the rheumatoid arthritis-associated ACPA directed to citrullinated fibrin is very closely restricted. J Autoimmun (2011) 0.84
Binding-induced folding transitions in calpastatin subdomains A and C. Protein Sci (2003) 0.84
Enzymic characterization with progress curve analysis of a collagen peptidase from an enthomopathogenic bacterium, Photorhabdus luminescens. Biochem J (2004) 0.82
Novel cell-penetrating calpain substrate. Bioconjug Chem (2008) 0.82
A kinked antimicrobial peptide from Bombina maxima. I. Three-dimensional structure determined by NMR in membrane-mimicking environments. Eur Biophys J (2011) 0.82
Functional mapping of the Fc gamma RII binding site on human IgG1 by synthetic peptides. Eur J Immunol (2004) 0.82
Peptide based vaccine design: synthesis and immunological characterization of branched polypeptide conjugates comprising the 276-284 immunodominant epitope of HSV-1 glycoprotein D. J Pept Sci (2002) 0.82
Role of N- or C-terminal biotinylation in autoantibody recognition of citrullin containing filaggrin epitope peptides in rheumatoid arthritis. Bioconjug Chem (2013) 0.81
Synthesis and receptor binding of IgG1 peptides derived from the IgG Fc region. J Mol Recognit (2004) 0.81
Development of an oxime bond containing daunorubicin-gonadotropin-releasing hormone-III conjugate as a potential anticancer drug. Bioconjug Chem (2009) 0.81
Diagnostic imaging. Lancet (2012) 0.80
Synthesis and biological studies of nociceptin derivatives containing the DTPA chelating group for further labeling with therapeutic radionuclides. Peptides (2005) 0.80
Design, synthesis, and in vitro activity of novel drug delivery systems containing tuftsin derivatives and methotrexate. Bioconjug Chem (2008) 0.80
New biotin derivatives for labeling and solubilizing IgG peptides. Biopolymers (2009) 0.80
Update: aptamers as novel radiopharmaceuticals: their applications and future prospects in diagnosis and therapy. Cancer Biother Radiopharm (2007) 0.79
Comparison of epitope specificity of anti-heat shock protein 60/65 IgG type antibodies in the sera of healthy subjects, patients with coronary heart disease and inflammatory bowel disease. Cell Stress Chaperones (2011) 0.79
Peptide conjugates of therapeutically used antitubercular isoniazid-design, synthesis and antimycobacterial effect. J Pept Sci (2009) 0.79
In vitro cytotoxicity, chemotactic effect, and cellular uptake of branched polypeptides with poly[L-lys] backbone by J774 murine macrophage cell line. Bioconjug Chem (2008) 0.78
Characterization of a trypsin-like serine protease of activated B cells mediating the cleavage of surface proteins. Biochim Biophys Acta (2003) 0.78
Synthesis, conformation, and immunoreactivity of new carrier molecules based on repeated tuftsin-like sequence. Biopolymers (2004) 0.78
Identification and solution conformation of multiple epitopes recognized by a MUC2 mucin-specific monoclonal antibody. Arch Biochem Biophys (2003) 0.78
Mass spectrometric identification of the trypsin cleavage pathway in lysyl-proline containing oligotuftsin peptides. J Pept Sci (2007) 0.78
Synthesis of oligotuftsin-based branched oligopeptide conjugates for chemotactic drug targeting. J Pept Sci (2006) 0.78
A new daunomycin-peptide conjugate: synthesis, characterization and the effect on the protein expression profile of HL-60 cells in vitro. Bioconjug Chem (2011) 0.77
Antibody recognition and conformational flexibility of a plaque-specific beta-amyloid epitope modulated by non-native peptide flanking regions. J Med Chem (2008) 0.77
The effect of the structure of branched polypeptide carrier on intracellular delivery of daunomycin. Biochim Biophys Acta (2006) 0.77
Copper-induced oligomerization of peptides: a model study. Eur J Mass Spectrom (Chichester, Eng) (2007) 0.77
A new class of semisynthetic anthracycline glycoside antibiotics incorporating a squaric acid moiety. J Antibiot (Tokyo) (2005) 0.77
Structure, enzymatic stability and antitumor activity of sea lamprey GnRH-III and its dimer derivatives. Peptides (2007) 0.77
The effect of glycosylation on the antibody recognition of a MUC2 mucin epitope. Biopolymers (2014) 0.77
New daunomycin-oligoarginine conjugates: synthesis, characterization, and effect on human leukemia and human hepatoma cells. Biopolymers (2009) 0.77
Methotrexate conjugate with branched polypeptide influences Leishmania donovani infection in vitro and in experimental animals. Bioconjug Chem (2002) 0.76
Nanoparticle encapsulated lipopeptide conjugate of antitubercular drug isoniazid: in vitro intracellular activity and in vivo efficacy in a Guinea pig model of tuberculosis. Bioconjug Chem (2014) 0.76
Mass spectrometric and chemical stability of the Asp-Pro bond in herpes simplex virus epitope peptides compared with X-Pro bonds of related sequences. J Pept Sci (2002) 0.76
Simple objective measurement of the cutaneous delayed-type hypersensitivity reaction to tuberculin using spectrophotometry. Skin Res Technol (2002) 0.76
Antibodies against C-reactive protein cross-react with 60-kilodalton heat shock proteins. Clin Vaccine Immunol (2007) 0.76
Synthesis, solution structure analysis and antibody binding of cyclic epitope peptides from glycoprotein D of Herpes simplex virus type I. Biophys Chem (2003) 0.76
Baseline and early treatment factors are not clinically useful for predicting individual response to erythropoietin in anemic cancer patients. Oncologist (2003) 0.76
Enhanced cellular uptake of a new, in silico identified antitubercular candidate by peptide conjugation. Bioconjug Chem (2012) 0.76
Characterisation of the membrane affinity of an isoniazide peptide conjugate by tensiometry, atomic force microscopy and sum-frequency vibrational spectroscopy, using a phospholipid Langmuir monolayer model. Phys Chem Chem Phys (2010) 0.75
Effect of conjugation with polypeptide carrier on the enzymatic degradation of Herpes simplex virus glycoprotein D derived epitope peptide. Bioconjug Chem (2008) 0.75
Uptake of branched polypeptides with poly[L-lys] backbone by bone-marrow culture-derived murine macrophages: the role of the class a scavenger receptor. Bioconjug Chem (2005) 0.75
Synthesis and in vitro antitumor effect of vinblastine derivative-oligoarginine conjugates. Bioconjug Chem (2010) 0.75
Synthesis of enzymatically resistant nociceptin-related peptides containing a carbamic acid residue. J Pept Sci (2006) 0.75
Monitoring folding transitions of synthetic, branched-chain polypeptides by capillary zone electrophoresis. Electrophoresis (2003) 0.75
New m-calpain substrate-based azapeptide inhibitors. J Pept Sci (2013) 0.75
Interleukin-6 N-terminal peptides modulate the expression of junB protooncogene and the production of fibrinogen in HepG2 cells. Biol Chem (2003) 0.75
Interview. Nucl Med Commun (2014) 0.75
Polypeptide conjugates comprising a beta-amyloid plaque-specific epitope as new vaccine structures against Alzheimer's disease. Biopolymers (2004) 0.75
New ferrocene containing peptide conjugates: synthesis and effect on human leukemia (HL-60) cells. Biopolymers (2007) 0.75
Synthesis and cytotoxic activity of novel 5-substituted-1-(β-L-arabinofuranosyl) pyrimidine nucleosides. Nucleosides Nucleotides Nucleic Acids (2012) 0.75
Comparison of cathode ray tube and liquid crystal display stimulators for use in multifocal VEP. Doc Ophthalmol (2014) 0.75
Effect of SXWS/WSXWS peptides on chemotaxis and adhesion of the macrophage-like cell line J774. J Mol Recognit (2015) 0.75
Homology modeling and molecular dynamics simulations of MUC1-9/H-2K(b) complex suggest novel binding interactions. J Mol Model (2010) 0.75
Heteroclitic recognition of combinatorial TX1TX2T peptide mixtures by mucin-2 protein specific monoclonal antibody. J Pept Sci (2004) 0.75
Synthesis of linear, branched, and cyclic peptide chimera. Methods Mol Biol (2005) 0.75
Chemotaxis induced by SXWS tetrapeptides in Tetrahymena--overlapping chemotactic effects of SXWS sequences and their identical amino acids. J Mol Recognit (2012) 0.75
Chemotactic activity of oligopeptides containing an EWS motif on Tetrahymena pyriformis: the effect of amidation of the C-terminal residue. Cell Biochem Funct (2003) 0.75
Characterisation of combinatorial libraries of mucin-2 antigen peptides by high-resolution mass spectrometry. Rapid Commun Mass Spectrom (2002) 0.75
Detection of citrate synthase-reacting autoantibodies after heart transplantation: an epitope mapping study. Transpl Int (2005) 0.75
Effect of core epitope modification on the antibody recognition of a MUC2 mucin peptide. Mol Divers (2012) 0.75
Synthesis of oligopeptides with the sequence SXWS and their chemotactic effects on a ciliated protozoan Tetrahymena pyriformis. J Pept Sci (2002) 0.75
Mass spectrometric analysis of combinatorial peptide libraries derived from the tandem repeat unit of MUC2 mucin. J Pept Sci (2003) 0.75
Synthesis of cell-penetrating conjugates of calpain activator peptides. Bioconjug Chem (2007) 0.75
Synthesis, solution conformation, and antibody recognition of oligotuftsin-based conjugates containing a beta-amyloid(4-10) plaque-specific epitope. Bioconjug Chem (2005) 0.75
New pemetrexed-peptide conjugates: synthesis, characterization and in vitro cytostatic effect on non-small cell lung carcinoma (NCI-H358) and human leukemia (HL-60) cells. J Pept Sci (2011) 0.75
Modeling of main characteristics of bullous pemphigoid antigen-2 (BPAG2) peptide structure in serological recognition by autoantibodies. Pathol Oncol Res (2004) 0.75
Synthesis and comparison of antibody recognition of conjugates containing herpes simplex virus type 1 glycoprotein D epitope VII. Bioconjug Chem (2003) 0.75
Characterization of chemotactic ability of peptides containing N-formyl-methionyl residues in Tetrahymena fMLP as a targeting ligand. Cell Biol Int (2003) 0.75
In vitro T-cell immunogenicity of oligopeptides derived from the region 92-110 of the 16-kDa protein of Mycobacterium tuberculosis. Biopolymers (2004) 0.75
Synthesis and structural characterization of bioactive peptide conjugates using thioether linkage approaches. J Pept Sci (2004) 0.75
The mapping of linear B-cell epitope regions in the extracellular parts of the desmoglein 1 and 3 proteins: recognition of immobilized peptides by pemphigus patients' serum autoantibodies. J Pept Sci (2013) 0.75
Ferrocene-cinchona hybrids with triazolyl-chalcone linkers act as pro-oxidants and sensitize human cancer cell lines to paclitaxel. Metallomics (2017) 0.75
Solution structure of the all L- and D-amino acid-substituted mucin 2 epitope peptides. Biochem Biophys Res Commun (2007) 0.75
Leishmania braziliensis: cytotoxic, cytostatic and chemotactic effects of poly-lysine-methotrexate-conjugates. Exp Parasitol (2013) 0.75