Published in Free Radic Biol Med on May 15, 2003
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36
Regulation of apoptosis-associated lysosomal membrane permeabilization. Apoptosis (2010) 1.92
Lysosomes in iron metabolism, ageing and apoptosis. Histochem Cell Biol (2008) 1.60
Nitric oxide promotes caspase-independent hepatic stellate cell apoptosis through the generation of reactive oxygen species. Hepatology (2008) 1.41
Radiation protection following nuclear power accidents: a survey of putative mechanisms involved in the radioprotective actions of taurine during and after radiation exposure. Microb Ecol Health Dis (2012) 1.39
Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury. Hepatology (2008) 1.31
Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. Blood (2012) 1.28
Partial D-amino acid substitution: Improved enzymatic stability and preserved Ab recognition of a MUC2 epitope peptide. Proc Natl Acad Sci U S A (2005) 1.28
Constitutive reactive oxygen species generation from autophagosome/lysosome in neuronal oxidative toxicity. J Biol Chem (2009) 1.17
In Vivo Cellular Imaging for Translational Medical Research. Curr Med Imaging Rev (2009) 1.12
Role of compartmentalized redox-active iron in hydrogen peroxide-induced DNA damage and apoptosis. Biochem J (2005) 1.11
Metallothionein protects against oxidative stress-induced lysosomal destabilization. Biochem J (2006) 1.09
Mitochondrial DNA damage in iron overload. J Biol Chem (2008) 1.04
Oxygen free radicals and redox biology of organelles. Histochem Cell Biol (2004) 1.00
Does the calcein-AM method assay the total cellular 'labile iron pool' or only a fraction of it? Biochem J (2007) 0.99
Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death. Antioxid Redox Signal (2009) 0.99
Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage. Biochem J (2004) 0.98
Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation. Toxicol Sci (2011) 0.91
Role of intracellular labile iron, ferritin, and antioxidant defence in resistance of chronically adapted Jurkat T cells to hydrogen peroxide. Free Radic Biol Med (2013) 0.91
Radiation-induced cell death: importance of lysosomal destabilization. Biochem J (2005) 0.89
Signaling pathways of ESE-16, an antimitotic and anticarbonic anhydrase estradiol analog, in breast cancer cells. PLoS One (2013) 0.89
The involvement of lysosomes in myocardial aging and disease. Curr Cardiol Rev (2008) 0.88
Protective effects of crude garlic by reducing iron-mediated oxidative stress, proliferation and autophagy in rats. J Mol Histol (2010) 0.86
"Chelatable iron pool": inositol 1,2,3-trisphosphate fulfils the conditions required to be a safe cellular iron ligand. J Biol Inorg Chem (2008) 0.85
Iron-targeting antitumor activity of gallium compounds and novel insights into triapine(®)-metal complexes. Antioxid Redox Signal (2012) 0.84
Reduction in mitochondrial iron alleviates cardiac damage during injury. EMBO Mol Med (2016) 0.84
The real face of HIF1α in the tumor process. Cell Cycle (2012) 0.83
Oxidation of low-density lipoprotein by iron at lysosomal pH: implications for atherosclerosis. Biochemistry (2012) 0.83
Haptoglobin genotype-dependent differences in macrophage lysosomal oxidative injury. J Biol Chem (2014) 0.83
Crucial role of lysosomal iron in the formation of dinitrosyl iron complexes in vivo. J Biol Inorg Chem (2006) 0.82
Leaky lysosomes in lung transplant macrophages: azithromycin prevents oxidative damage. Respir Res (2012) 0.80
Autophagy of metallothioneins prevents TNF-induced oxidative stress and toxicity in hepatoma cells. Autophagy (2015) 0.80
Oxidative stress and the homeodynamics of iron metabolism. Biomolecules (2015) 0.79
Lysosome-targeted stress reveals increased stability of lipofuscin-containing lysosomes. Age (Dordr) (2008) 0.79
Streptococcus oralis Induces Lysosomal Impairment of Macrophages via Bacterial Hydrogen Peroxide. Infect Immun (2016) 0.77
How Heme Oxygenase-1 Prevents Heme-Induced Cell Death. PLoS One (2015) 0.77
Brain iron overload following intracranial haemorrhage. Stroke Vasc Neurol (2016) 0.77
Normoxic accumulation of HIF1α is associated with glutaminolysis. Clin Oral Investig (2016) 0.76
Iron-Mediated Lysosomal Membrane Permeabilization in Ethanol-Induced Hepatic Oxidative Damage and Apoptosis: Protective Effects of Quercetin. Oxid Med Cell Longev (2015) 0.75
Oxidant-induced autophagy and ferritin degradation contribute to epithelial-mesenchymal transition through lysosomal iron. J Inflamm Res (2017) 0.75
A Powerful Mitochondria-Targeted Iron Chelator Affords High Photoprotection against Solar Ultraviolet A Radiation. J Invest Dermatol (2016) 0.75
Sub-lethal oxidative stress induces lysosome biogenesis via a lysosomal membrane permeabilization-cathepsin-caspase 3-transcription factor EB-dependent pathway. Oncotarget (2017) 0.75
Increased Lysosomal Membrane Permeabilization in Oxidant-exposed Macrophages of Human Fibrotic Lungs. J Cell Death (2013) 0.75
CD163, a Hemoglobin/Haptoglobin Scavenger Receptor, After Intracerebral Hemorrhage: Functions in Microglia/Macrophages Versus Neurons. Transl Stroke Res (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Autophagy and aging: the importance of maintaining "clean" cells. Autophagy (2005) 4.61
Pro-oxidant and cytotoxic effects of circulating heme. Blood (2002) 2.45
Targeting aspartate aminotransferase in breast cancer. Breast Cancer Res (2008) 1.78
Autophagy in cardiac myocyte homeostasis, aging, and pathology. Cardiovasc Res (2005) 1.76
Lipofuscin. Int J Biochem Cell Biol (2004) 1.75
Nanomaterial cytotoxicity is composition, size, and cell type dependent. Part Fibre Toxicol (2010) 1.75
Oxidative stress, accumulation of biological 'garbage', and aging. Antioxid Redox Signal (2006) 1.74
What does the commonly used DCF test for oxidative stress really show? Biochem J (2010) 1.67
Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging. Antioxid Redox Signal (2010) 1.64
Lysosomes in iron metabolism, ageing and apoptosis. Histochem Cell Biol (2008) 1.60
Heme, heme oxygenase, and ferritin: how the vascular endothelium survives (and dies) in an iron-rich environment. Antioxid Redox Signal (2007) 1.55
Lysosomal destabilization in p53-induced apoptosis. Proc Natl Acad Sci U S A (2002) 1.54
Red cells, hemoglobin, heme, iron, and atherogenesis. Arterioscler Thromb Vasc Biol (2010) 1.44
Intralysosomal iron chelation protects against oxidative stress-induced cellular damage. FEBS J (2006) 1.43
The lysosomal-mitochondrial axis theory of postmitotic aging and cell death. Chem Biol Interact (2006) 1.38
Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis. Eur J Biochem (2003) 1.35
Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice. J Exp Med (2007) 1.32
Lysosomes and oxidative stress in aging and apoptosis. Biochim Biophys Acta (2008) 1.32
Prevention of oxidant-induced cell death by lysosomotropic iron chelators. Free Radic Biol Med (2003) 1.31
Autophagy, ageing and apoptosis: the role of oxidative stress and lysosomal iron. Arch Biochem Biophys (2007) 1.28
Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes. Cancer Res (2011) 1.28
Neuroprotection in cerebral ischemia by neutralization of 3-aminopropanal. Proc Natl Acad Sci U S A (2002) 1.23
Aging of cardiac myocytes in culture: oxidative stress, lipofuscin accumulation, and mitochondrial turnover. Ann N Y Acad Sci (2004) 1.17
Oxygen tolerance and coupling of mitochondrial electron transport. J Biol Chem (2004) 1.17
Control of tumor-associated macrophage alternative activation by macrophage migration inhibitory factor. J Immunol (2013) 1.15
Focus on the liver: alcohol use, highly active antiretroviral therapy, and liver disease in HIV-infected patients. Alcohol Res Health (2010) 1.13
Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis. Exp Gerontol (2003) 1.13
Myocyte aging and mitochondrial turnover. Exp Gerontol (2004) 1.09
Metallothionein protects against oxidative stress-induced lysosomal destabilization. Biochem J (2006) 1.09
Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II. Clin Cancer Res (2009) 1.09
Oxidized proteins: mechanisms of removal and consequences of accumulation. IUBMB Life (2009) 1.08
Mitochondrial metabolism underlies hyperoxic cell damage. Free Radic Biol Med (2004) 1.07
Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. Clin Cancer Res (2002) 1.07
Heme, heme oxygenase and ferritin in vascular endothelial cell injury. Mol Nutr Food Res (2005) 1.05
Histamine release and fibrinogen adsorption mediate acute inflammatory responses to biomaterial implants in humans. J Transl Med (2007) 1.05
The role of lysosomes in iron metabolism and recycling. Int J Biochem Cell Biol (2011) 1.04
Endosomal and lysosomal effects of desferrioxamine: protection of HeLa cells from hydrogen peroxide-induced DNA damage and induction of cell-cycle arrest. Free Radic Biol Med (2003) 1.04
Mitochondrial DNA damage in iron overload. J Biol Chem (2008) 1.04
Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDL. APMIS (2002) 1.03
Mitochondrial damage and intralysosomal degradation in cellular aging. Mol Aspects Med (2006) 1.01
Generation of oxidants by hypoxic human pulmonary and coronary smooth-muscle cells. Chest (2008) 1.01
Does the calcein-AM method assay the total cellular 'labile iron pool' or only a fraction of it? Biochem J (2007) 0.99
Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage. Biochem J (2004) 0.98
The aging myocardium: roles of mitochondrial damage and lysosomal degradation. Heart Lung Circ (2005) 0.97
Depletion of ascorbic acid restricts angiogenesis and retards tumor growth in a mouse model. Neoplasia (2007) 0.97
Testing the "garbage" accumulation theory of ageing: mitotic activity protects cells from death induced by inhibition of autophagy. Biogerontology (2005) 0.97
ARPE-19 retinal pigment epithelial cells are highly resistant to oxidative stress and exercise strict control over their lysosomal redox-active iron. Autophagy (2009) 0.96
Haem, haem oxygenase and ferritin in vascular endothelial cell injury. Nephrol Dial Transplant (2003) 0.95
3-Aminopropanal, formed during cerebral ischaemia, is a potent lysosomotropic neurotoxin. Biochem J (2003) 0.95
Aging of cultured retinal pigment epithelial cells: oxidative reactions, lipofuscin formation and blue light damage. Doc Ophthalmol (2003) 0.95
Cytochrome C oxidase activity and oxygen tolerance. J Biol Chem (2007) 0.94
Polydatin, a natural polyphenol, protects arterial smooth muscle cells against mitochondrial dysfunction and lysosomal destabilization following hemorrhagic shock. Am J Physiol Regul Integr Comp Physiol (2012) 0.94
CCR9 mediates PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide. Int J Cancer (2010) 0.93
Embryonic vaccines against cancer: an early history. Exp Mol Pathol (2009) 0.93
Chelation of lysosomal iron protects against ionizing radiation. Biochem J (2010) 0.92
Redox activity within the lysosomal compartment: implications for aging and apoptosis. Antioxid Redox Signal (2010) 0.92
Cytocidal effects of atheromatous plaque components: the death zone revisited. FASEB J (2006) 0.91
Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability. Biochem J (2002) 0.91
Vascular smooth muscle cell proliferation requires both p38 and BMK1 MAP kinases. Arch Biochem Biophys (2002) 0.91
Supression of hemin-mediated oxidation of low-density lipoprotein and subsequent endothelial reactions by hydrogen sulfide (H(2)S). Free Radic Biol Med (2008) 0.89
Radiation-induced cell death: importance of lysosomal destabilization. Biochem J (2005) 0.89
Mitochondrial dysfunction may explain the cardiomyopathy of chronic iron overload. Free Radic Biol Med (2010) 0.89
Cancer vaccines: Looking to the future. Oncoimmunology (2013) 0.88
The involvement of lysosomes in myocardial aging and disease. Curr Cardiol Rev (2008) 0.88
Cell sensitivity to oxidative stress is influenced by ferritin autophagy. Free Radic Biol Med (2011) 0.88
Globin attenuates the innate immune response to endotoxin. Shock (2002) 0.87
Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells. J Lipid Res (2012) 0.87
Human neuroblastoma (SH-SY5Y) cells are highly sensitive to the lysosomotropic aldehyde 3-aminopropanal. Brain Res (2004) 0.86
Haem oxygenase-1 overexpression alters intracellular iron distribution. Biochem J (2013) 0.86
Decreased apoptotic response of inclusion-cell disease fibroblasts: a consequence of lysosomal enzyme missorting? Exp Cell Res (2002) 0.86
Autophagy of HSP70 and chelation of lysosomal iron in a non-redox-active form. Autophagy (2009) 0.86
Aging as a catabolic malfunction. Int J Biochem Cell Biol (2004) 0.86
Titanium dioxide (TiO2) nanoparticles preferentially induce cell death in transformed cells in a Bak/Bax-independent fashion. PLoS One (2012) 0.85
Vaccination with embryonic stem cells protects against lung cancer: is a broad-spectrum prophylactic vaccine against cancer possible? PLoS One (2012) 0.84
Fenton chemistry and iron chelation under physiologically relevant conditions: Electrochemistry and kinetics. Chem Res Toxicol (2006) 0.84
Proteins containing oxidized amino acids induce apoptosis in human monocytes. Biochem J (2011) 0.83
Virus detection and identification using random multiplex (RT)-PCR with 3'-locked random primers. Virol J (2007) 0.82
Heterogeneous expression of apolipoprotein-E by human macrophages. Immunology (2004) 0.81
Induction of fibroblast apolipoprotein E expression during apoptosis, starvation-induced growth arrest and mitosis. Biochem J (2004) 0.81
Roles of mitogen-activated protein kinases in the modulation of endothelial cell function following thermal injury. Shock (2011) 0.81
Cytochrome c oxidase is activated by the oncoprotein Ras and is required for A549 lung adenocarcinoma growth. Mol Cancer (2012) 0.81
The radioprotective agent, amifostine, suppresses the reactivity of intralysosomal iron. Redox Rep (2003) 0.81
3-Aminopropanal is a lysosomotropic aldehyde that causes oxidative stress and apoptosis by rupturing lysosomes. APMIS (2003) 0.81
Natural history of the bruise: formation, elimination, and biological effects of oxidized hemoglobin. Oxid Med Cell Longev (2013) 0.80
Retracted Advanced glycation end products induce actin rearrangement and subsequent hyperpermeability of endothelial cells. APMIS (2006) 0.80
Divergent pathways for TNF and C(2)-ceramide toxicity in HTC hepatoma cells. Biochim Biophys Acta (2009) 0.80