Published in Otolaryngol Head Neck Surg on January 01, 2005
Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncol (2010) 1.53
Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell Biochem (2008) 1.49
AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. J Lipid Res (2009) 1.23
Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids. Bioorg Med Chem (2007) 1.20
Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents. Bioorg Med Chem (2007) 1.08
Increased tumour dihydroceramide production after Photofrin-PDT alone and improved tumour response after the combination with the ceramide analogue LCL29. Evidence from mouse squamous cell carcinomas. Br J Cancer (2009) 1.00
LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria. J Pharmacol Exp Ther (2012) 0.92
Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C₁₈-ceramide as a novel biomarker for monitoring response. Clin Cancer Res (2011) 0.91
Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis. J Lipid Res (2010) 0.88
Enhanced tumor cures after Foscan photodynamic therapy combined with the ceramide analog LCL29. Evidence from mouse squamous cell carcinomas for sphingolipids as biomarkers of treatment response. Int J Oncol (2010) 0.86
Inhibitory effects of dietary glucosylceramides on squamous cell carcinoma of the head and neck in NOD/SCID mice. Int J Clin Oncol (2010) 0.77
Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML. Blood (2016) 0.76
C6-pyridinium ceramide sensitizes SCC17B human head and neck squamous cell carcinoma cells to photodynamic therapy. J Photochem Photobiol B (2015) 0.75
Silencing of TMSG1 enhances metastasis capacity by targeting V-ATPase in breast cancer. Int J Clin Exp Pathol (2015) 0.75
Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol (2008) 12.34
Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer (2004) 5.63
Oral cancer and precancerous lesions. CA Cancer J Clin (2002) 4.76
The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem (2002) 4.52
Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods (2006) 4.31
Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Cell (2012) 3.23
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. Nature (2007) 3.13
The complex life of simple sphingolipids. EMBO Rep (2004) 3.10
EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res (2004) 2.78
Bioactive sphingolipids: metabolism and function. J Lipid Res (2008) 2.73
Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta (2002) 2.69
An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol (2010) 2.33
Many ceramides. J Biol Chem (2011) 2.31
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochim Biophys Acta (2008) 2.25
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem (2002) 2.24
The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal (2007) 2.16
PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem (2002) 2.11
The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J (2003) 2.10
Acid and neutral sphingomyelinases: roles and mechanisms of regulation. Biochem Cell Biol (2004) 2.06
Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Am J Physiol Endocrinol Metab (2009) 2.00
Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes (2006) 1.91
Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem (2004) 1.84
Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J (2005) 1.83
Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J (2009) 1.82
Role for sphingosine kinase 1 in colon carcinogenesis. FASEB J (2008) 1.78
Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae. Nature (2005) 1.76
Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2. J Biol Chem (2003) 1.76
Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem (2003) 1.75
Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J Biol Chem (2002) 1.74
Blood sphingolipidomics in healthy humans: impact of sample collection methodology. J Lipid Res (2010) 1.72
PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. J Clin Invest (2013) 1.72
A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. FASEB J (2008) 1.71
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. EMBO Mol Med (2012) 1.68
Consensus statement on the classification and terminology of neck dissection. Arch Otolaryngol Head Neck Surg (2008) 1.68
Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. J Clin Invest (2003) 1.66
A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. Biochim Biophys Acta (2006) 1.65
The extended family of neutral sphingomyelinases. Biochemistry (2006) 1.63
Roles and regulation of secretory and lysosomal acid sphingomyelinase. Cell Signal (2009) 1.62
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem (2005) 1.61
Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. J Biol Chem (2007) 1.61
Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. Biochim Biophys Acta (2004) 1.61
Comprehensive quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods Mol Biol (2009) 1.60
Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J (2005) 1.57
Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem J (2012) 1.57
Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. FASEB J (2008) 1.56
Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J Biol Chem (2008) 1.55
Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Mol Cancer Ther (2007) 1.55
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nat Chem Biol (2012) 1.55
Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncol (2010) 1.53
Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. J Biol Chem (2004) 1.52
The human FA2H gene encodes a fatty acid 2-hydroxylase. J Biol Chem (2004) 1.51
Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue. J Histochem Cytochem (2005) 1.51
Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell Biochem (2008) 1.49
Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation. J Biol Chem (2007) 1.49
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J Biol Chem (2003) 1.47
The mechanism of membrane targeting of human sphingosine kinase 1. J Biol Chem (2005) 1.44
Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity. J Biol Chem (2006) 1.43
Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway. Cancer Res (2010) 1.43
Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids. FEBS Lett (2009) 1.43
The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans. J Biol Chem (2004) 1.42
Sphingolipid analysis by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Adv Exp Med Biol (2010) 1.40
BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. J Biol Chem (2003) 1.39
Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis. Cell Res (2007) 1.38
Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J Biol Chem (2007) 1.38