Published in J Biol Chem on May 13, 2002
Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem (2010) 8.09
Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat Med (2005) 4.31
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev (2008) 3.80
The complex life of simple sphingolipids. EMBO Rep (2004) 3.10
Regulation of ceramide biosynthesis by TOR complex 2. Cell Metab (2008) 2.57
Many ceramides. J Biol Chem (2011) 2.31
Ceramides modulate programmed cell death in plants. Genes Dev (2003) 2.22
Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. J Lipid Res (2008) 2.03
Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Am J Physiol Endocrinol Metab (2009) 2.00
Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Chem Rev (2011) 1.93
Ceramides as modulators of cellular and whole-body metabolism. J Clin Invest (2011) 1.88
Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. Mol Cell Biol (2003) 1.81
Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero. Proc Natl Acad Sci U S A (2003) 1.79
Blood sphingolipidomics in healthy humans: impact of sample collection methodology. J Lipid Res (2010) 1.72
Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions. Biochem J (2005) 1.67
Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J Biol Chem (2008) 1.55
Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncol (2010) 1.53
Liver transcriptomic networks reveal main biological processes associated with feed efficiency in beef cattle. BMC Genomics (2015) 1.52
Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell Biochem (2008) 1.49
Mutation of CERKL, a novel human ceramide kinase gene, causes autosomal recessive retinitis pigmentosa (RP26). Am J Hum Genet (2003) 1.48
Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. Structure (2015) 1.45
Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth. Proc Natl Acad Sci U S A (2005) 1.44
Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway. J Cell Biol (2011) 1.42
Lip1p: a novel subunit of acyl-CoA ceramide synthase. EMBO J (2005) 1.41
Sphingolipids are essential for differentiation but not growth in Leishmania. EMBO J (2003) 1.40
Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development. Proc Natl Acad Sci U S A (2005) 1.39
Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J Biol Chem (2007) 1.38
Regulation and functional roles of sphingosine kinases. Naunyn Schmiedebergs Arch Pharmacol (2007) 1.38
Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice. J Clin Invest (2007) 1.36
Intramuscular lipid metabolism, insulin action, and obesity. IUBMB Life (2009) 1.33
Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol Aging (2007) 1.26
Nuclear envelope transmembrane proteins (NETs) that are up-regulated during myogenesis. BMC Cell Biol (2006) 1.26
Ceramide and ceramide 1-phosphate in health and disease. Lipids Health Dis (2010) 1.24
Is the mammalian serine palmitoyltransferase a high-molecular-mass complex? Biochem J (2007) 1.24
Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury. Am J Respir Cell Mol Biol (2010) 1.22
Multi-system disorders of glycosphingolipid and ganglioside metabolism. J Lipid Res (2010) 1.22
Ceramide, a target for antiretroviral therapy. Proc Natl Acad Sci U S A (2004) 1.22
Golgi fragmentation is associated with ceramide-induced cellular effects. Mol Biol Cell (2005) 1.21
Neutral sphingomyelinase 2 is activated by cigarette smoke to augment ceramide-induced apoptosis in lung cell death. Am J Physiol Lung Cell Mol Physiol (2009) 1.20
Multidrug resistance in fungi. Eukaryot Cell (2007) 1.20
Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. J Leukoc Biol (2008) 1.19
Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells. Mol Pharmacol (2008) 1.18
Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis. J Biol Chem (2012) 1.17
Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide. Am J Physiol Lung Cell Mol Physiol (2008) 1.17
Entry of muscle satellite cells into the cell cycle requires sphingolipid signaling. J Cell Biol (2006) 1.14
Genome-wide analysis of signaling networks regulating fatty acid-induced gene expression and organelle biogenesis. J Cell Biol (2008) 1.14
Ceramide function in the brain: when a slight tilt is enough. Cell Mol Life Sci (2012) 1.12
Sphingoid base is required for translation initiation during heat stress in Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.12
Steroidogenic factor-1 is a sphingolipid binding protein. Mol Cell Endocrinol (2006) 1.12
The carboxyl-terminal domain of atypical protein kinase Czeta binds to ceramide and regulates junction formation in epithelial cells. J Biol Chem (2009) 1.10
Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells. J Biol Chem (2008) 1.09
Transmembrane topology of ceramide synthase in yeast. Biochem J (2006) 1.09
An improved method to determine serine palmitoyltransferase activity. J Lipid Res (2009) 1.09
Consumption of a high-fat diet, but not regular endurance exercise training, regulates hypothalamic lipid accumulation in mice. J Physiol (2012) 1.07
Phospholipid and sphingolipid metabolism in Leishmania. Mol Biochem Parasitol (2009) 1.07
Killing tumours by ceramide-induced apoptosis: a critique of available drugs. Biochem J (2003) 1.06
Isc1 regulates sphingolipid metabolism in yeast mitochondria. Biochim Biophys Acta (2007) 1.06
Evolving concepts in cancer therapy through targeting sphingolipid metabolism. Biochim Biophys Acta (2013) 1.04
Ceramide and mitochondria in ischemia/reperfusion. J Cardiovasc Pharmacol (2009) 1.04
Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2). J Biol Chem (2010) 1.03
Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2. Histochem Cell Biol (2007) 1.03
Gene expression analysis of the biocontrol fungus Trichoderma harzianum in the presence of tomato plants, chitin, or glucose using a high-density oligonucleotide microarray. BMC Microbiol (2009) 1.03
Cell-nonautonomous function of ceramidase in photoreceptor homeostasis. Neuron (2008) 1.02
Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis. J Biol Chem (2010) 1.01
Annexin-phospholipid interactions. Functional implications. Int J Mol Sci (2013) 1.01
Sphingolipid C-9 methyltransferases are important for growth and virulence but not for sensitivity to antifungal plant defensins in Fusarium graminearum. Eukaryot Cell (2008) 1.00
Degradation of host sphingomyelin is essential for Leishmania virulence. PLoS Pathog (2009) 1.00
Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. J Immunol (2014) 0.99
Limited therapeutic effect of N-acetylcysteine on hepatic insulin resistance in an experimental model of alcohol-induced steatohepatitis. Alcohol Clin Exp Res (2011) 0.98
Ceramide-1-phosphate regulates migration of multipotent stromal cells and endothelial progenitor cells--implications for tissue regeneration. Stem Cells (2013) 0.97
Sphingolipids mediate formation of mRNA processing bodies during the heat-stress response of Saccharomyces cerevisiae. Biochem J (2010) 0.96
Differential regulation of ceramide synthase components LAC1 and LAG1 in Saccharomyces cerevisiae. Eukaryot Cell (2004) 0.96
Bax Inhibitor-1, a conserved cell death suppressor, is a key molecular switch downstream from a variety of biotic and abiotic stress signals in plants. Int J Mol Sci (2009) 0.95
Ceramide synthase 1 is regulated by proteasomal mediated turnover. Biochim Biophys Acta (2009) 0.95
Overexpression of CERKL, a gene responsible for retinitis pigmentosa in humans, protects cells from apoptosis induced by oxidative stress. Mol Vis (2009) 0.95
Glycosphingolipids and cell death. Glycoconj J (2004) 0.95
A novel membrane protein, VanJ, conferring resistance to teicoplanin. Antimicrob Agents Chemother (2012) 0.94
pH dependence of sphingosine aggregation. Biophys J (2009) 0.93
Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling. Mol Cell Biol (2013) 0.93
Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation. J Cancer Res Clin Oncol (2011) 0.93
Acyl chain specificity of ceramide synthases is determined within a region of 150 residues in the Tram-Lag-CLN8 (TLC) domain. J Biol Chem (2011) 0.93
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. Hum Genet (2012) 0.93
Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation. Biochim Biophys Acta (2009) 0.93
A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. Mol Cell Biol (2012) 0.93
Sphingosine 1-phosphate activates Weibel-Palade body exocytosis. Proc Natl Acad Sci U S A (2004) 0.92
Interruption of inositol sphingolipid synthesis triggers Stt4p-dependent protein kinase C signaling. J Biol Chem (2010) 0.92
Ceramide signaling in cancer and stem cells. Future Lipidol (2008) 0.92
Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death. Biochim Biophys Acta (2013) 0.91
Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK. Cell Cycle (2008) 0.91
Induction of membrane ceramides: a novel strategy to interfere with T lymphocyte cytoskeletal reorganisation in viral immunosuppression. PLoS Pathog (2009) 0.91
Fatty aldehyde and fatty alcohol metabolism: review and importance for epidermal structure and function. Biochim Biophys Acta (2013) 0.91
High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: interaction with IQ motif-containing factors. Cell Cycle (2013) 0.91
Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes. J Biol Chem (2009) 0.90
Autophagy regulates sphingolipid levels in the liver. J Lipid Res (2014) 0.90
Biophysics of cell membrane lipids in cancer drug resistance: Implications for drug transport and drug delivery with nanoparticles. Adv Drug Deliv Rev (2013) 0.90
Molecular cloning and characterization of OsCDase, a ceramidase enzyme from rice. Plant J (2008) 0.90
Glycosphingolipidoses: beyond the enzymatic defect. Glycoconj J (2004) 0.89
Autophagy paradox and ceramide. Biochim Biophys Acta (2013) 0.89
Lung injury and lung cancer caused by cigarette smoke-induced oxidative stress: Molecular mechanisms and therapeutic opportunities involving the ceramide-generating machinery and epidermal growth factor receptor. Antioxid Redox Signal (2014) 0.89
Identification of a novel amidase motif in neutral ceramidase. Biochem J (2006) 0.88
Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol (2008) 12.34
Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Cell (2012) 3.23
An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol (2010) 2.33
Many ceramides. J Biol Chem (2011) 2.31
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochim Biophys Acta (2008) 2.25
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem (2002) 2.24
PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem (2002) 2.11
The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J (2003) 2.10
Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem (2004) 1.84
Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J (2005) 1.83
Role for sphingosine kinase 1 in colon carcinogenesis. FASEB J (2008) 1.78
Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J Biol Chem (2002) 1.74
A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. FASEB J (2008) 1.71
A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. Biochim Biophys Acta (2006) 1.65
Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. J Biol Chem (2007) 1.61
Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. Biochim Biophys Acta (2004) 1.61
Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J (2005) 1.57
Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem J (2012) 1.57
Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. J Biol Chem (2004) 1.52
Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue. J Histochem Cytochem (2005) 1.51
The mechanism of membrane targeting of human sphingosine kinase 1. J Biol Chem (2005) 1.44
Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity. J Biol Chem (2006) 1.43
Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J Biol Chem (2007) 1.38
Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2. J Biol Chem (2007) 1.36
The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol Pharmacol (2005) 1.33
Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. J Biol Chem (2003) 1.31
Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. FASEB J (2006) 1.30
Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response. Biochem J (2009) 1.29
A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. Biochem J (2005) 1.28
Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function. Biochim Biophys Acta (2006) 1.28
The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biol Ther (2007) 1.27
Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. J Pharmacol Exp Ther (2006) 1.24
Tailoring structure-function and targeting properties of ceramides by site-specific cationization. Bioorg Med Chem (2006) 1.24
Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem (2003) 1.24
Positively charged ceramide is a potent inducer of mitochondrial permeabilization. J Biol Chem (2005) 1.23
Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism. J Lipid Res (2010) 1.23
Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. J Invest Dermatol (2007) 1.23
AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. J Lipid Res (2009) 1.23
Golgi fragmentation is associated with ceramide-induced cellular effects. Mol Biol Cell (2005) 1.21
Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Adv Enzyme Regul (2002) 1.21
Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacol Ther (2006) 1.20
Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors. Biochim Biophys Acta (2012) 1.20
Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood (2011) 1.19
Ceramide and apoptosis: exploring the enigmatic connections between sphingolipid metabolism and programmed cell death. Anticancer Agents Med Chem (2012) 1.19
Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation. Biochimie (2010) 1.19
JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction. J Biol Chem (2007) 1.18
Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. J Biol Chem (2006) 1.18
Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro. FASEB J (2010) 1.16
Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. EMBO Mol Med (2012) 1.16
Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis. J Immunol (2010) 1.16
Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide. J Biol Chem (2011) 1.15
Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. J Biol Chem (2004) 1.15
Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. Mol Cancer Ther (2006) 1.14
Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells. J Biol Chem (2008) 1.13
Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration. FASEB J (2007) 1.13
Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. J Biol Chem (2011) 1.13
The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis. J Biol Chem (2010) 1.12
A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury. FASEB J (2007) 1.10
Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. J Biol Chem (2009) 1.10
Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells. J Biol Chem (2008) 1.09
Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. J Biol Chem (2003) 1.09
Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. J Biol Chem (2005) 1.08
Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. J Biol Chem (2006) 1.08
Combination of C(17) sphingoid base homologues and mass spectrometry analysis as a new approach to study sphingolipid metabolism. Methods Enzymol (2007) 1.08
Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis. J Biol Chem (2010) 1.07
Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. J Biol Chem (2010) 1.07
Isc1 regulates sphingolipid metabolism in yeast mitochondria. Biochim Biophys Acta (2007) 1.06
Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages. Prostaglandins Other Lipid Mediat (2007) 1.05
Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis. J Biol Chem (2004) 1.05
Yeast sphingolipid metabolism: clues and connections. Biochem Cell Biol (2004) 1.05
A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet (2011) 1.05
Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2). J Biol Chem (2010) 1.03
A role of sphingosine kinase 1 in head and neck carcinogenesis. Cancer Prev Res (Phila) (2011) 1.03
Dihydroceramide-based response to hypoxia. J Biol Chem (2011) 1.02
Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells. Otolaryngol Head Neck Surg (2005) 1.02
Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors. J Biol Chem (2006) 1.02
Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: inhibition of SK1 translocation by Mycobacterium tuberculosis. J Immunol (2005) 1.01
Molecular targeting of acid ceramidase: implications to cancer therapy. Curr Drug Targets (2008) 1.01
Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis. J Biol Chem (2010) 1.01
Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion. FASEB J (2008) 1.00
Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells. Arch Biochem Biophys (2003) 0.99
The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages. J Biol Chem (2007) 0.99
Oxidized LDL immune complexes induce release of sphingosine kinase in human U937 monocytic cells. Prostaglandins Other Lipid Mediat (2006) 0.98
Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. J Biol Chem (2011) 0.98
Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis. J Lipid Res (2006) 0.98
Ceramidases in the regulation of ceramide levels and function. Subcell Biochem (2002) 0.98
ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae. J Biol Chem (2009) 0.97
Sphingosine-1-phosphate receptor 2. FEBS J (2013) 0.97
Sphingosine kinase 1 in cancer. Adv Cancer Res (2013) 0.97
The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells. J Biol Chem (2007) 0.96
Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. J Biol Chem (2011) 0.95
Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators. J Biol Chem (2003) 0.93
Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells. Exp Cell Res (2006) 0.93
De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. Prostaglandins Other Lipid Mediat (2008) 0.93
Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation. J Biol Chem (2009) 0.92
Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. Biochem J (2013) 0.92
Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy. Crit Rev Biochem Mol Biol (2011) 0.91
p53 and regulation of bioactive sphingolipids. Adv Enzyme Regul (2010) 0.90
Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells. J Biol Chem (2010) 0.90