Regulation of tumor cell motility by ERK mitogen-activated protein kinases.

The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells. J Biol Chem (2007) 1.82

Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development. Breast Cancer Res (2009) 1.40

Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking. Mol Biol Cell (2005) 1.30

Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells. Mol Cell Biol (2010) 1.28

Defining the expression pattern of the LGI1 gene in BAC transgenic mice. Mamm Genome (2007) 1.25

PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathways. Biochemistry (2009) 1.22

Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway. J Virol (2008) 1.18

Inhibition of metastasis, angiogenesis, and tumor growth by Chinese herbal cocktail Tien-Hsien Liquid. BMC Cancer (2010) 1.05

Toll-like receptor agonists stimulate human neutrophil migration via activation of mitogen-activated protein kinases. Immunology (2007) 0.96

Free edges in epithelial cell sheets stimulate epidermal growth factor receptor signaling. Mol Biol Cell (2010) 0.93

Reexpression of LGI1 in glioma cells results in dysregulation of genes implicated in the canonical axon guidance pathway. Genomics (2009) 0.91

Enhanced neutrophil motility by granulocyte colony-stimulating factor: the role of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. Immunology (2006) 0.91

The vaccinia virus O1 protein is required for sustained activation of extracellular signal-regulated kinase 1/2 and promotes viral virulence. J Virol (2011) 0.89

PI3K p110α isoform-dependent Rho GTPase Rac1 activation mediates H2S-promoted endothelial cell migration via actin cytoskeleton reorganization. PLoS One (2012) 0.89

Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell lines. Clin Exp Metastasis (2011) 0.88

H. pylori virulence factors: influence on immune system and pathology. Mediators Inflamm (2014) 0.88

DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer. J Biol Chem (2014) 0.87

Elevated expression of syntenin in breast cancer is correlated with lymph node metastasis and poor patient survival. Breast Cancer Res (2013) 0.86

HMMR maintains the stemness and tumorigenicity of glioblastoma stem-like cells. Cancer Res (2014) 0.86

Reactive oxygen species-mediated PKC and integrin signaling promotes tumor progression of human hepatoma HepG2. Clin Exp Metastasis (2011) 0.85

Expression of phosphorylated extracellular signal-regulated kinase at the invasive front of hepatic colorectal metastasis. Oncol Lett (2015) 0.85

Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer. Oxid Med Cell Longev (2015) 0.82

CCL2-CCR2 axis promotes metastasis of nasopharyngeal carcinoma by activating ERK1/2-MMP2/9 pathway. Oncotarget (2016) 0.81

Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells. Chem Res Toxicol (2015) 0.81

Lung-residing metastatic and dormant neuroblastoma cells. Am J Pathol (2011) 0.81

B-Raf regulation of integrin α4β1-mediated resistance to shear stress through changes in cell spreading and cytoskeletal association in T cells. J Biol Chem (2014) 0.79

Inhibitory effect of phytoglycoprotein (38 kDa) on expression of matrix metalloproteinase-9 in 12-O-tetradecanoylphorbol-13-acetate-treated HepG2cells. Naunyn Schmiedebergs Arch Pharmacol (2011) 0.79

Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristics. PLoS One (2014) 0.77

ERα-mediated repression of pro-inflammatory cytokine expression by glucocorticoids reveals a crucial role for TNFα and IL1α in lumen formation and maintenance. J Cell Sci (2012) 0.75

Abituzumab Targeting of AlphaV-class Integrins Inhibits Prostate Cancer Progression. Mol Cancer Res (2017) 0.75

G-protein coupled receptor kinase-2 is a critical regulator of TNFα signaling in colon epithelial cells. Biochem J (2017) 0.75

MEK inhibitor enhances sensitivity to chemotherapeutic drugs in multidrug resistant hepatocellular carcinoma cells. Oncol Lett (2017) 0.75

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J (2003) 6.44

Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol (2009) 4.95

JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell (2004) 3.30

ERK implication in cell cycle regulation. Biochim Biophys Acta (2006) 2.96

The role of erk1 and erk2 in multiple stages of T cell development. Immunity (2005) 2.96

Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron (2002) 2.93

Hypoxia and cancer. J Mol Med (Berl) (2007) 2.89

Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res (2009) 2.62

PHD2 mutation and congenital erythrocytosis with paraganglioma. N Engl J Med (2008) 2.56

Transcriptional regulation of the Vascular Endothelial Growth Factor gene--a concert of activating factors. Cardiovasc Res (2005) 2.52

Hypoxia signalling controls metabolic demand. Curr Opin Cell Biol (2007) 2.49

Hypoxia-induced autophagy: cell death or cell survival? Curr Opin Cell Biol (2009) 2.45

Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity (2008) 2.16

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer. J Cell Mol Med (2009) 2.13

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc Natl Acad Sci U S A (2011) 2.06

The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes (2005) 1.96

Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription. J Biol Chem (2002) 1.94

Disrupting proton dynamics and energy metabolism for cancer therapy. Nat Rev Cancer (2013) 1.93

Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms. J Biol Chem (2002) 1.90

HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome. Int J Cancer (2007) 1.86

Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility. J Cell Biol (2006) 1.76

PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis. Proc Natl Acad Sci U S A (2008) 1.72

MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo. Circulation (2004) 1.69

Oxygen, a source of life and stress. FEBS Lett (2007) 1.67

Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels. Mol Cell Biol (2007) 1.62

Hypoxia and energetic tumour metabolism. Curr Opin Genet Dev (2010) 1.61

HIF at a glance. J Cell Sci (2009) 1.55

The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling. EMBO Rep (2006) 1.43

A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis. EMBO Rep (2010) 1.40

Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF. J Biol Chem (2005) 1.38

Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications. Cell Signal (2005) 1.35

Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation. Mol Cell Biol (2005) 1.34

ERK nuclear translocation is dimerization-independent but controlled by the rate of phosphorylation. J Biol Chem (2009) 1.31

Harnessing the hypoxia-inducible factor in cancer and ischemic disease. Biochem Pharmacol (2006) 1.31

Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization. Circulation (2009) 1.29

p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis. Cancer Res (2006) 1.27

ERK2 but not ERK1 plays a key role in hepatocyte replication: an RNAi-mediated ERK2 knockdown approach in wild-type and ERK1 null hepatocytes. Hepatology (2007) 1.26

EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. J Cell Sci (2003) 1.24

HIF-1: master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs. Biochem Pharmacol (2004) 1.22

TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. J Biol Chem (2011) 1.21

The role of the hypoxia-inducible factor in tumor metabolism growth and invasion. Bull Cancer (2006) 1.20

Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha. Diabetes (2009) 1.19

Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia. Autophagy (2009) 1.18

The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth. Cancer Res (2011) 1.17

Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells. J Cell Biol (2005) 1.14

Proton dynamics in cancer. J Transl Med (2010) 1.14

The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis. Blood (2010) 1.11

Regulatory mechanisms of fear extinction and depression-like behavior. Neuropsychopharmacology (2007) 1.11

p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol. Oncogene (2002) 1.10

Endothelial cells genetically selected from differentiating mouse embryonic stem cells incorporate at sites of neovascularization in vivo. J Cell Sci (2002) 1.09

A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor. EMBO Rep (2004) 1.08

Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival. Front Oncol (2012) 1.08

Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors. J Med Chem (2011) 1.05

SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity. Biochem Biophys Res Commun (2007) 1.05

In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH. Int J Cancer (2011) 1.05

A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae. J Immunol (2007) 1.04

Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli. J Cell Physiol (2010) 1.03

ARDent about acetylation and deacetylation in hypoxia signalling. Trends Cell Biol (2006) 1.03

Deletion of ERK1 and ERK2 in the CNS causes cortical abnormalities and neonatal lethality: Erk1 deficiency enhances the impairment of neurogenesis in Erk2-deficient mice. J Neurosci (2011) 1.02

Gene regulation in response to graded hypoxia: the non-redundant roles of the oxygen sensors PHD and FIH in the HIF pathway. J Theor Biol (2009) 1.00

Membrane-bound carbonic anhydrases are key pH regulators controlling tumor growth and cell migration. Adv Enzyme Regul (2009) 0.99

A dialogue between the hypoxia-inducible factor and the tumor microenvironment. Cancer Microenviron (2008) 0.98

HIF-1alpha mediates the induction of IL-8 and VEGF expression on infection with Afa/Dr diffusely adhering E. coli and promotes EMT-like behaviour. Cell Microbiol (2009) 0.97

The hypoxia-inducible factor and tumor progression along the angiogenic pathway. Int Rev Cytol (2005) 0.97

Total ERK1/2 activity regulates cell proliferation. Cell Cycle (2009) 0.97

Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells. J Immunol (2009) 0.97

Expression of a truncated active form of VDAC1 in lung cancer associates with hypoxic cell survival and correlates with progression to chemotherapy resistance. Cancer Res (2012) 0.95

Hypoxia in cancer cell metabolism and pH regulation. Essays Biochem (2007) 0.94

Glucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells. PLoS One (2012) 0.94

HIF1 transcription factor regulates laminin-332 expression and keratinocyte migration. J Cell Sci (2008) 0.93

ERK1 plays a critical protective role against N-methyl-D-aspartate-induced retinal injury. J Neurosci Res (2008) 0.92

Characterization of the neuropilin-1 promoter; gene expression is mediated by the transcription factor Sp1. J Cell Biochem (2003) 0.92

Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2. Hepatology (2009) 0.92

Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia. Haematologica (2011) 0.92

Overexpression of carbonic anhydrase XII in tissues from resectable non-small cell lung cancers is a biomarker of good prognosis. Int J Cancer (2010) 0.90

Tie1 deficiency induces endothelial-mesenchymal transition. EMBO Rep (2012) 0.89

Study of MAPK signaling using knockout mice. Methods Mol Biol (2004) 0.89

Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system. Pain (2012) 0.89

Quantitative in vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis. Cancer Res (2013) 0.89

Physical interactions and functional coupling between Daxx and sodium hydrogen exchanger 1 in ischemic cell death. J Biol Chem (2007) 0.88

Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels. J Cell Physiol (2013) 0.88

Implication of the ERK pathway on the post-transcriptional regulation of VEGF mRNA stability. Methods Mol Biol (2010) 0.86

ERK1 and ERK2 are required for radial glial maintenance and cortical lamination. Genes Cells (2010) 0.86

Tumor hypoxia and metabolism -- towards novel anticancer approaches. Ann Endocrinol (Paris) (2013) 0.86

Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis. Front Oncol (2013) 0.86

When hypoxia signalling meets the ubiquitin-proteasomal pathway, new targets for cancer therapy. Crit Rev Oncol Hematol (2005) 0.82

Response of CAIX and CAXII to in vitro re-oxygenation and clinical significance of the combined expression in NSCLC patients. Lung Cancer (2013) 0.82

ERK1 regulates the hematopoietic stem cell niches. PLoS One (2012) 0.82

Positron emission tomography/computed tomography imaging of residual skull base chordoma before radiotherapy using fluoromisonidazole and fluorodeoxyglucose: potential consequences for dose painting. Int J Radiat Oncol Biol Phys (2012) 0.81

HIF-prolyl hydroxylase 2 inhibition enhances the efficiency of mesenchymal stem cell-based therapies for the treatment of critical limb ischemia. Stem Cells (2014) 0.81

ERK1 is important for Th2 differentiation and development of experimental asthma. FASEB J (2012) 0.80

Biochemical titration of glycogen in vitro. J Vis Exp (2013) 0.79

Major contribution of MEK1 to the activation of ERK1/ERK2 and to the growth of LS174T colon carcinoma cells. Biochem Biophys Res Commun (2008) 0.78

Complete structure of an increasing capillary permeability protein (ICPP) purified from Vipera lebetina venom. ICPP is angiogenic via vascular endothelial growth factor receptor signalling. J Biol Chem (2002) 0.77

[Hypoxia inducible factor 1a is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells]. Med Sci (Paris) (2006) 0.77

The silencing approach of the hypoxia-signaling pathway. Methods Enzymol (2007) 0.77

Gene disruption using zinc finger nuclease technology. Methods Mol Biol (2014) 0.76

[Metamorphoses]. Bull Cancer (2010) 0.75