Published in J Cell Biol on December 26, 2006
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Stathmin activity influences sarcoma cell shape, motility, and metastatic potential. Mol Biol Cell (2008) 1.62
Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis. Mol Biol Cell (2011) 1.54
Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction. FEBS J (2010) 1.53
The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells. Cell Mol Life Sci (2009) 1.52
Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells. Matrix Biol (2008) 1.49
The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition. Mol Cell Biol (2009) 1.43
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A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion. J Biol Chem (2009) 1.13
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Shining new light on 3D cell motility and the metastatic process. Trends Cell Biol (2009) 1.09
Regulation of RhoA-dependent ROCKII activation by Shp2. J Cell Biol (2008) 1.08
p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling. Mol Cell Biol (2010) 1.08
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The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation. Mol Cell Biol (2010) 0.95
A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC. J Biol Chem (2010) 0.94
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Ubiquitination of tumor necrosis factor receptor-associated factor 4 (TRAF4) by Smad ubiquitination regulatory factor 1 (Smurf1) regulates motility of breast epithelial and cancer cells. J Biol Chem (2013) 0.85
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Trading in your spindles for blebs: the amoeboid tumor cell phenotype in prostate cancer. Asian J Androl (2014) 0.83
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Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces. Clin Exp Metastasis (2015) 0.83
SMURF1 plays a role in EGF-induced breast cancer cell migration and invasion. Mol Cells (2013) 0.83
Plasticity in the macromolecular-scale causal networks of cell migration. PLoS One (2014) 0.82
Cell polarity signaling in the plasticity of cancer cell invasiveness. Oncotarget (2016) 0.82
Dia-interacting protein (DIP) imposes migratory plasticity in mDia2-dependent tumor cells in three-dimensional matrices. PLoS One (2012) 0.82
A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton. Oncogene (2010) 0.82
Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase. J Biol Chem (2012) 0.81
Smurf1 zaps the talin head. Nat Cell Biol (2009) 0.79
The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility. PLoS One (2013) 0.79
Loss of ERα induces amoeboid-like migration of breast cancer cells by downregulating vinculin. Nat Commun (2017) 0.78
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The cancer/testis antigen MAGEC2 promotes amoeboid invasion of tumor cells by enhancing STAT3 signaling. Oncogene (2016) 0.75
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Rho, ROCK and actomyosin contractility in metastasis as drug targets. F1000Res (2016) 0.75
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RHO-GTPases and cancer. Nat Rev Cancer (2002) 8.03
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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J (2003) 6.44
Rho GTPases and cell migration. J Cell Sci (2001) 5.66
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science (2003) 5.19
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science (2005) 4.70
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep (2003) 4.52
Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling. Cancer Res (2002) 3.95
ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Curr Biol (2006) 3.55
Mechanisms of cancer cell invasion. Curr Opin Genet Dev (2005) 3.47
ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. Cancer Cell (2003) 3.28
Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell (2005) 3.26
Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. Nat Cell Biol (2005) 3.02
Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO J (2001) 2.66
RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev (2005) 2.59
Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases. Mol Biol Cell (2001) 2.53
RhoA and ROCK promote migration by limiting membrane protrusions. J Biol Chem (2003) 2.17
Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy. BMC Biotechnol (2005) 1.93
Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation. Oncogene (2004) 1.90
Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis. Cancer Res (2004) 1.81
Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. J Biol Chem (2002) 1.61
Galpha12/13 is essential for directed cell migration and localized Rho-Dia1 function. J Biol Chem (2005) 1.51
The transcription factor AP-1 is required for EGF-induced activation of rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells. J Cell Biol (1998) 1.32
Purification of TAT-C3 exoenzyme. Methods Enzymol (2006) 0.96
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J (2003) 6.44
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol (2009) 4.95
JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell (2004) 3.30
ERK implication in cell cycle regulation. Biochim Biophys Acta (2006) 2.96
The role of erk1 and erk2 in multiple stages of T cell development. Immunity (2005) 2.96
Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron (2002) 2.93
Hypoxia and cancer. J Mol Med (Berl) (2007) 2.89
Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res (2009) 2.62
PHD2 mutation and congenital erythrocytosis with paraganglioma. N Engl J Med (2008) 2.56
Transcriptional regulation of the Vascular Endothelial Growth Factor gene--a concert of activating factors. Cardiovasc Res (2005) 2.52
Hypoxia signalling controls metabolic demand. Curr Opin Cell Biol (2007) 2.49
Hypoxia-induced autophagy: cell death or cell survival? Curr Opin Cell Biol (2009) 2.45
Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity (2008) 2.16
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer. J Cell Mol Med (2009) 2.13
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc Natl Acad Sci U S A (2011) 2.06
The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes (2005) 1.96
Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription. J Biol Chem (2002) 1.94
Disrupting proton dynamics and energy metabolism for cancer therapy. Nat Rev Cancer (2013) 1.93
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HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome. Int J Cancer (2007) 1.86
PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis. Proc Natl Acad Sci U S A (2008) 1.72
MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo. Circulation (2004) 1.69
Oxygen, a source of life and stress. FEBS Lett (2007) 1.67
Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels. Mol Cell Biol (2007) 1.62
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HIF at a glance. J Cell Sci (2009) 1.55
The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling. EMBO Rep (2006) 1.43
A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis. EMBO Rep (2010) 1.40
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Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications. Cell Signal (2005) 1.35
Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation. Mol Cell Biol (2005) 1.34
ERK nuclear translocation is dimerization-independent but controlled by the rate of phosphorylation. J Biol Chem (2009) 1.31
Harnessing the hypoxia-inducible factor in cancer and ischemic disease. Biochem Pharmacol (2006) 1.31
Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization. Circulation (2009) 1.29
p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis. Cancer Res (2006) 1.27
ERK2 but not ERK1 plays a key role in hepatocyte replication: an RNAi-mediated ERK2 knockdown approach in wild-type and ERK1 null hepatocytes. Hepatology (2007) 1.26
Regulation of tumor cell motility by ERK mitogen-activated protein kinases. Ann N Y Acad Sci (2004) 1.25
EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. J Cell Sci (2003) 1.24
HIF-1: master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs. Biochem Pharmacol (2004) 1.22
TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. J Biol Chem (2011) 1.21
The role of the hypoxia-inducible factor in tumor metabolism growth and invasion. Bull Cancer (2006) 1.20
Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha. Diabetes (2009) 1.19
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The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth. Cancer Res (2011) 1.17
Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells. J Cell Biol (2005) 1.14
Proton dynamics in cancer. J Transl Med (2010) 1.14
The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis. Blood (2010) 1.11
Regulatory mechanisms of fear extinction and depression-like behavior. Neuropsychopharmacology (2007) 1.11
p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol. Oncogene (2002) 1.10
Endothelial cells genetically selected from differentiating mouse embryonic stem cells incorporate at sites of neovascularization in vivo. J Cell Sci (2002) 1.09
A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor. EMBO Rep (2004) 1.08
Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival. Front Oncol (2012) 1.08
Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors. J Med Chem (2011) 1.05
SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity. Biochem Biophys Res Commun (2007) 1.05
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A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae. J Immunol (2007) 1.04
Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli. J Cell Physiol (2010) 1.03
ARDent about acetylation and deacetylation in hypoxia signalling. Trends Cell Biol (2006) 1.03
Deletion of ERK1 and ERK2 in the CNS causes cortical abnormalities and neonatal lethality: Erk1 deficiency enhances the impairment of neurogenesis in Erk2-deficient mice. J Neurosci (2011) 1.02
Gene regulation in response to graded hypoxia: the non-redundant roles of the oxygen sensors PHD and FIH in the HIF pathway. J Theor Biol (2009) 1.00
Membrane-bound carbonic anhydrases are key pH regulators controlling tumor growth and cell migration. Adv Enzyme Regul (2009) 0.99
A dialogue between the hypoxia-inducible factor and the tumor microenvironment. Cancer Microenviron (2008) 0.98
HIF-1alpha mediates the induction of IL-8 and VEGF expression on infection with Afa/Dr diffusely adhering E. coli and promotes EMT-like behaviour. Cell Microbiol (2009) 0.97
Total ERK1/2 activity regulates cell proliferation. Cell Cycle (2009) 0.97
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Expression of a truncated active form of VDAC1 in lung cancer associates with hypoxic cell survival and correlates with progression to chemotherapy resistance. Cancer Res (2012) 0.95
Hypoxia in cancer cell metabolism and pH regulation. Essays Biochem (2007) 0.94
Glucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells. PLoS One (2012) 0.94
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ERK1 plays a critical protective role against N-methyl-D-aspartate-induced retinal injury. J Neurosci Res (2008) 0.92
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Physical interactions and functional coupling between Daxx and sodium hydrogen exchanger 1 in ischemic cell death. J Biol Chem (2007) 0.88
Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels. J Cell Physiol (2013) 0.88
Implication of the ERK pathway on the post-transcriptional regulation of VEGF mRNA stability. Methods Mol Biol (2010) 0.86
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ERK1 and ERK2 are required for radial glial maintenance and cortical lamination. Genes Cells (2010) 0.86
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ERK1 regulates the hematopoietic stem cell niches. PLoS One (2012) 0.82
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HIF-prolyl hydroxylase 2 inhibition enhances the efficiency of mesenchymal stem cell-based therapies for the treatment of critical limb ischemia. Stem Cells (2014) 0.81
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