The regulation and regulatory activities of alternative splicing of the SMN gene.

Alternative splicing and disease. Biochim Biophys Acta (2008) 3.47

Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron. Mol Cell Biol (2006) 2.41

Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon. PLoS Biol (2007) 2.29

TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing. J Biol Chem (2008) 1.98

Modulating role of RNA structure in alternative splicing of a critical exon in the spinal muscular atrophy genes. Nucleic Acids Res (2006) 1.84

Delivery of bifunctional RNAs that target an intronic repressor and increase SMN levels in an animal model of spinal muscular atrophy. Hum Mol Genet (2009) 1.53

A short antisense oligonucleotide masking a unique intronic motif prevents skipping of a critical exon in spinal muscular atrophy. RNA Biol (2009) 1.46

A negatively acting bifunctional RNA increases survival motor neuron both in vitro and in vivo. Hum Gene Ther (2008) 1.13

A role for SC35 and hnRNPA1 in the determination of amyloid precursor protein isoforms. Mol Psychiatry (2007) 1.01

Antisense oligonucleotides for the treatment of spinal muscular atrophy. Hum Gene Ther (2013) 0.95

Control of alternative splicing by signal-dependent degradation of splicing-regulatory proteins. J Biol Chem (2009) 0.91

Targeting RNA-splicing for SMA treatment. Mol Cells (2012) 0.91

An antisense microwalk reveals critical role of an intronic position linked to a unique long-distance interaction in pre-mRNA splicing. RNA (2010) 0.89

Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA. J Biol Chem (2011) 0.89

The Silent Sway of Splicing by Synonymous Substitutions. J Biol Chem (2015) 0.84

Mechanistic principles of antisense targets for the treatment of spinal muscular atrophy. Future Med Chem (2015) 0.84

Identifying alternative hyper-splicing signatures in MG-thymoma by exon arrays. PLoS One (2008) 0.83

Diverse role of Survival Motor Neuron Protein. Biochim Biophys Acta (2017) 0.81

Therapeutic activity of modified U1 core spliceosomal particles. Nat Commun (2016) 0.81

ISS-N1 makes the First FDA-approved Drug for Spinal Muscular Atrophy. Transl Neurosci (2017) 0.77

Intra-domain Cross-talk Regulates Serine-arginine Protein Kinase 1-dependent Phosphorylation and Splicing Function of Transformer 2β1. J Biol Chem (2015) 0.76

How the discovery of ISS-N1 led to the first medical therapy for spinal muscular atrophy. Gene Ther (2017) 0.76

Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron. Mol Cell Biol (2006) 2.41

Modulating role of RNA structure in alternative splicing of a critical exon in the spinal muscular atrophy genes. Nucleic Acids Res (2006) 1.84

A transgene carrying an A2G missense mutation in the SMN gene modulates phenotypic severity in mice with severe (type I) spinal muscular atrophy. J Cell Biol (2003) 1.75

In vivo selection reveals combinatorial controls that define a critical exon in the spinal muscular atrophy genes. RNA (2004) 1.60

An extended inhibitory context causes skipping of exon 7 of SMN2 in spinal muscular atrophy. Biochem Biophys Res Commun (2004) 1.56

SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1. Hum Mol Genet (2002) 1.53

A short antisense oligonucleotide masking a unique intronic motif prevents skipping of a critical exon in spinal muscular atrophy. RNA Biol (2009) 1.46

Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism. Chem Biol (2004) 1.45

The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells. J Cell Sci (2006) 1.42

ChlR1 is required for loading papillomavirus E2 onto mitotic chromosomes and viral genome maintenance. Mol Cell (2006) 1.39

The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3. Cell Cycle (2012) 1.24

A direct interaction between the survival motor neuron protein and p53 and its relationship to spinal muscular atrophy. J Biol Chem (2001) 1.20

Genetic analysis of high-risk e6 in episomal maintenance of human papillomavirus genomes in primary human keratinocytes. J Virol (2002) 1.19

Human papillomavirus type 16 E6 amino acid 83 variants enhance E6-mediated MAPK signaling and differentially regulate tumorigenesis by notch signaling and oncogenic Ras. J Virol (2004) 1.10

The COPI vesicle complex binds and moves with survival motor neuron within axons. Hum Mol Genet (2011) 1.08

TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy. Mol Cell Biol (2010) 1.05

Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins. Antiviral Res (2006) 1.02

Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function. Mol Cell Biol (2010) 1.00

COPI transport complexes bind to specific RNAs in neuronal cells. Hum Mol Genet (2012) 0.99

Tax1BP1 interacts with papillomavirus E2 and regulates E2-dependent transcription and stability. J Virol (2008) 0.97

Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation. J Invest Dermatol (2013) 0.97

Binding of human papillomavirus type 16 E6 to E6AP is not required for activation of hTERT. J Virol (2007) 0.96

Functional characterization of alternatively spliced human SECISBP2 transcript variants. Nucleic Acids Res (2008) 0.95

Alternative splicing in spinal muscular atrophy underscores the role of an intron definition model. RNA Biol (2011) 0.93

Interaction of papillomavirus E2 protein with the Brm chromatin remodeling complex leads to enhanced transcriptional activation. J Virol (2006) 0.93

Spinal muscular atrophy: an update on therapeutic progress. Biochim Biophys Acta (2013) 0.93

The Ewing's sarcoma protein interacts with the Tudor domain of the survival motor neuron protein. Brain Res Mol Brain Res (2003) 0.92

A multi-exon-skipping detection assay reveals surprising diversity of splice isoforms of spinal muscular atrophy genes. PLoS One (2012) 0.92

PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy. Cell Cycle (2012) 0.91

Discovery, synthesis, and biological evaluation of novel SMN protein modulators. J Med Chem (2011) 0.91

Immortalization of human mammary epithelial cells is associated with inactivation of the p14ARF-p53 pathway. Mol Cell Biol (2004) 0.90

Advances in therapeutic development for spinal muscular atrophy. Future Med Chem (2014) 0.89

An antisense microwalk reveals critical role of an intronic position linked to a unique long-distance interaction in pre-mRNA splicing. RNA (2010) 0.89

Mitotic kinesin-like protein 2 binds and colocalizes with papillomavirus E2 during mitosis. J Virol (2006) 0.89

Determinants of stability for the E6 protein of papillomavirus type 16. J Mol Biol (2009) 0.89

hAda3 degradation by papillomavirus type 16 E6 correlates with abrogation of the p14ARF-p53 pathway and efficient immortalization of human mammary epithelial cells. J Virol (2008) 0.89

An intronic structure enabled by a long-distance interaction serves as a novel target for splicing correction in spinal muscular atrophy. Nucleic Acids Res (2013) 0.88

Transcriptional repression of E-cadherin by human papillomavirus type 16 E6. PLoS One (2012) 0.88

Dilysine motifs in exon 2b of SMN protein mediate binding to the COPI vesicle protein α-COP and neurite outgrowth in a cell culture model of spinal muscular atrophy. Hum Mol Genet (2013) 0.88

Identification of novel compounds that increase SMN protein levels using an improved SMN2 reporter cell assay. J Biomol Screen (2012) 0.86

Valproate and bone loss: iTRAQ proteomics show that valproate reduces collagens and osteonectin in SMA cells. J Proteome Res (2010) 0.86

Antisense oligonucleotide mediated therapy of spinal muscular atrophy. Transl Neurosci (2013) 0.85

Acetylation of conserved lysines in bovine papillomavirus E2 by p300. J Virol (2012) 0.85

Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds. EMBO Mol Med (2013) 0.84

Topography of bovine papillomavirus E2 protein on the viral genome during the cell cycle. Virology (2009) 0.83

Therapeutic strategies for the treatment of spinal muscular atrophy. Future Med Chem (2012) 0.81

Bovine papillomavirus type 1 E6-induced sensitization to apoptosis is distinct from its transforming activity. Virology (2002) 0.80

Splicing regulation in spinal muscular atrophy by an RNA structure formed by long-distance interactions. Ann N Y Acad Sci (2015) 0.79

Differential regulation of the SMN2 gene by individual HDAC proteins. Biochem Biophys Res Commun (2011) 0.79

Desulfurization of dibenzothiophene (DBT) by a novel strain Lysinibacillus sphaericus DMT-7 isolated from diesel contaminated soil. J Environ Sci (China) (2011) 0.78

Antisense methods to modulate pre-mRNA splicing. Methods Mol Biol (2014) 0.76

Opposing effects of bovine papillomavirus type 1 E6 and E7 genes on Fas-mediated apoptosis. Oncogene (2005) 0.75