Published in Chem Biol on January 01, 2005
Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin. Chem Biol (2008) 1.71
Potent family-18 chitinase inhibitors: x-ray structures, affinities, and binding mechanisms. J Biol Chem (2011) 1.16
Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies. J Inherit Metab Dis (2011) 1.07
A novel family of lectins evolutionarily related to class V chitinases: an example of neofunctionalization in legumes. Plant Physiol (2006) 1.04
Repositioning of an existing drug for the neglected tropical disease Onchocerciasis. Proc Natl Acad Sci U S A (2010) 1.00
Fungal chitinases: diversity, mechanistic properties and biotechnological potential. Appl Microbiol Biotechnol (2011) 0.97
Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold. Org Biomol Chem (2008) 0.92
Comparative molecular evolution of trichoderma chitinases in response to mycoparasitic interactions. Evol Bioinform Online (2010) 0.88
Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds. FEBS Lett (2009) 0.87
A structural and biochemical model of processive chitin synthesis. J Biol Chem (2014) 0.84
Mutation of Trp137 to glutamate completely removes transglycosyl activity associated with the Aspergillus fumigatus AfChiB1. Glycoconj J (2008) 0.84
Toward the design of mutation-resistant enzyme inhibitors: further evaluation of the substrate envelope hypothesis. Chem Biol Drug Des (2009) 0.82
A computational analysis of the binding mode of closantel as inhibitor of the Onchocerca volvulus chitinase: insights on macrofilaricidal drug design. J Comput Aided Mol Des (2011) 0.81
Natural product-guided discovery of a fungal chitinase inhibitor. Chem Biol (2010) 0.81
Structural characteristics of an insect group I chitinase, an enzyme indispensable to moulting. Acta Crystallogr D Biol Crystallogr (2014) 0.79
Fully deacetylated chitooligosaccharides act as efficient glycoside hydrolase family 18 chitinase inhibitors. J Biol Chem (2014) 0.79
Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soil microorganisms. Proc Jpn Acad Ser B Phys Biol Sci (2010) 0.77
Molecular, Structural and Immunological Characterization of Der p 18, a Chitinase-Like House Dust Mite Allergen. PLoS One (2016) 0.75
Chitinases and peptide mimotopes. Chem Biol (2005) 0.75
Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors. FEBS Lett (2014) 0.75
Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor. Proc Natl Acad Sci U S A (2013) 0.75
Structure, catalysis and inhibition of OfChi-h, the Lepidoptera-exclusive insect chitinase. J Biol Chem (2017) 0.75
Total synthesis of the putative structure of the proposed Banyasin A. Front Chem (2015) 0.75
Expression, purification, crystallization and X-ray diffraction analysis of ChiL, a chitinase from Chitiniphilus shinanonensis. Acta Crystallogr F Struct Biol Commun (2015) 0.75
PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Acta Crystallogr D Biol Crystallogr (2004) 23.86
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature (2011) 13.30
Mouse genomic variation and its effect on phenotypes and gene regulation. Nature (2011) 10.66
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell (2009) 7.88
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat Biotechnol (2003) 7.84
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol (2010) 5.59
In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell (2011) 5.19
PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol (2004) 5.10
IFITM3 restricts the morbidity and mortality associated with influenza. Nature (2012) 4.66
Sequence-based characterization of structural variation in the mouse genome. Nature (2011) 3.48
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell (2013) 3.47
Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks. Cell (2008) 3.25
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature (2012) 3.23
TranscriptSNPView: a genome-wide catalog of mouse coding variation. Nat Genet (2006) 3.10
High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate. Curr Biol (2002) 2.92
PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice. Proc Natl Acad Sci U S A (2010) 2.91
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature (2010) 2.90
Elevated globotriaosylsphingosine is a hallmark of Fabry disease. Proc Natl Acad Sci U S A (2008) 2.87
The Ras-association domain family (RASSF) members and their role in human tumourigenesis. Biochim Biophys Acta (2007) 2.82
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia. Nat Genet (2011) 2.72
Treatment of Fabry disease with different dosing regimens of agalsidase: effects on antibody formation and GL-3. Mol Genet Metab (2008) 2.60
A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. Nature (2011) 2.58
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism. Proc Natl Acad Sci U S A (2010) 2.29
CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. PLoS Genet (2010) 2.20
The non-catalytic chitin-binding protein CBP21 from Serratia marcescens is essential for chitin degradation. J Biol Chem (2005) 2.18
Pound-wise but penny-foolish: How well do micromolecules fare in macromolecular refinement? Structure (2003) 2.14
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Science (2009) 2.13
Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project. Mamm Genome (2012) 2.12
Callosal neglect. Arch Neurol (2003) 2.09
Tools for targeted manipulation of the mouse genome. Physiol Genomics (2002) 2.08
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol (2013) 2.04
Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes. Genes Dev (2010) 2.04
Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis. Nat Genet (2011) 2.02
Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster. Mol Cell Biol (2008) 2.01
A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites. Nat Protoc (2009) 1.95
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site. EMBO J (2002) 1.93
Enzyme therapy for Fabry disease: neutralizing antibodies toward agalsidase alpha and beta. Kidney Int (2004) 1.89
Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol. Proc Natl Acad Sci U S A (2008) 1.88
Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase. J Antibiot (Tokyo) (2006) 1.84
Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc Natl Acad Sci U S A (2012) 1.82
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature (2006) 1.81
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates. EMBO J (2004) 1.77
Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity. Int Immunol (2005) 1.76
ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver. Circulation (2004) 1.76
Crystal structure and binding properties of the Serratia marcescens chitin-binding protein CBP21. J Biol Chem (2004) 1.76
Pseudokinases-remnants of evolution or key allosteric regulators? Curr Opin Struct Biol (2010) 1.76
Evolution of mammalian chitinase(-like) members of family 18 glycosyl hydrolases. Genetics (2007) 1.73
Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins. J Biol Chem (2002) 1.71
Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin. Chem Biol (2008) 1.71
High levels of RNA-editing site conservation amongst 15 laboratory mouse strains. Genome Biol (2012) 1.68
A gene cluster for biosynthesis of the sesquiterpenoid antibiotic pentalenolactone in Streptomyces avermitilis. Biochemistry (2006) 1.67
Analysis of the LKB1-STRAD-MO25 complex. J Cell Sci (2004) 1.65
Structural insights into mechanism and specificity of O-GlcNAc transferase. EMBO J (2008) 1.63
The genomic landscape shaped by selection on transposable elements across 18 mouse strains. Genome Biol (2012) 1.63
RetroSeq: transposable element discovery from next-generation sequencing data. Bioinformatics (2012) 1.63
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol Cell Biol (2008) 1.63
A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease. Mol Genet Metab (2007) 1.61
Commercially available outbred mice for genome-wide association studies. PLoS Genet (2010) 1.58
Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis. EMBO J (2006) 1.57
Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit. J Allergy Clin Immunol (2008) 1.56
The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models. Genome Biol (2013) 1.54
Force majeure: therapeutic measures in response to restricted supply of imiglucerase (Cerezyme) for patients with Gaucher disease. Blood Cells Mol Dis (2009) 1.54
The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angew Chem Int Ed Engl (2010) 1.54
Treatment of Fabry disease: outcome of a comparative trial with agalsidase alfa or beta at a dose of 0.2 mg/kg. PLoS One (2007) 1.54
Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat. Cell (2013) 1.53
Enhanced structural variant and breakpoint detection using SVMerge by integration of multiple detection methods and local assembly. Genome Biol (2010) 1.53
Cooperativity and rapid evolution of cobound transcription factors in closely related mammals. Cell (2013) 1.52
Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2. J Biol Chem (2006) 1.52
Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). Biochem Biophys Res Commun (2003) 1.52
Using next-generation sequencing for high resolution multiplex analysis of copy number variation from nanogram quantities of DNA from formalin-fixed paraffin-embedded specimens. Nucleic Acids Res (2010) 1.51
Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis. Brain (2005) 1.51
Impaired trafficking of mutants of lysosomal glucocerebrosidase in Gaucher's disease. Int J Biochem Cell Biol (2005) 1.50
The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells. J Neurosci (2007) 1.50
Assessing the statistical validity of proteomics based biomarkers. Anal Chim Acta (2007) 1.49
Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development. Genes Dev (2006) 1.49
Sequencing and characterization of the FVB/NJ mouse genome. Genome Biol (2012) 1.48
ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. PLoS Biol (2009) 1.47
Copy number variant detection in inbred strains from short read sequence data. Bioinformatics (2009) 1.45
Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response. Blood (2011) 1.45
BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm. Proc Natl Acad Sci U S A (2013) 1.44
Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase). Proc Natl Acad Sci U S A (2003) 1.44
Marked elevation of the chemokine CCL18/PARC in Gaucher disease: a novel surrogate marker for assessing therapeutic intervention. Blood (2003) 1.44
Deep short-read sequencing of chromosome 17 from the mouse strains A/J and CAST/Ei identifies significant germline variation and candidate genes that regulate liver triglyceride levels. Genome Biol (2009) 1.43
Next-generation sequencing of vertebrate experimental organisms. Mamm Genome (2009) 1.42
Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations. Open Biol (2011) 1.42
Glycosphingolipids--nature, function, and pharmacological modulation. Angew Chem Int Ed Engl (2009) 1.41
Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor. Nat Struct Mol Biol (2004) 1.41
Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. ACS Synth Biol (2013) 1.40
Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction. J Biol Chem (2005) 1.38
Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII. Proc Natl Acad Sci U S A (2005) 1.37